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| 1 | The role of AGFA high-energy CR in the calibration and quality con-trol of multileaf collimators(MLC)显示文摘Linear accelerators equipped with multileaf collimators (MLC) are becoming more common and are widely used in the intensity-modulated radiotherapy (IMRT). There is an imperative need to ensure the commissioning specification of the linear accelerators for the sake of quality assurance (QA) and quality control (QC). This paper is aimed to investigate the role of AGFA high-energy CR (Computed Radiography) in calibrating dynamic multileaf col- limators and evaluating the accuracy of the leaf position. The result shows that AGFA high-energy CR can easily and conveniently be used to calibrate MLC and verify its position. Hence, the application of AGFA high-energy CR is proved to be an accurate and time-saving method for routine MLC QC, especially when MLC calibration adjustments are required. | LI Zhaobin XIONG Fei HUANG Guofeng CAO Zheng JIANG Ruiyao FU Shen | 2007 | Nuclear Science and Techniques2007，18，3： | 3 |
| 2 | Anti-tumor responses to hypofractionated radiation in mice grafted with triple negative breast cancer is associated with decorin induction in peritumoral muscles显示文摘Triple negative breast cancer (TNBC)is the most lethal one for all types of breast cancer.Though radiotherapy is an efficient treatment,long-term survival rate of TNBC patients is still suboptimal. Hyprofractionated radiotherapy,an improved radiotherapy,has made an inspiring result in clinic. However,the mechanism underlying TNBC treated with hyprofractionated radiotherapy is not clear.Decorin (DCN)is a small poteoglycan of matrix which has an inhibitory effect on the breast cancer and is secreted by muscle under certain conditions.In this study,we demonstrated that peritumoral muscles secrete more DCN at higher dose irradiation than that at conventional irradiation dose in TNBC tumor-bearing mice.Thus,it indicates that DCN secreted from peritumoral muscle may be one of the reasons why hyprofractionated radiotherapy could inhibit the growth of TNBC more effectively.Moreover,we also indicated that the up-regulated DCN attenuated lung metastasis of TNBC.In conclusion,we demonstrated that hypofractionated radiation promotes the secretion of DCN in peritumoral muscle,thus enhancing the inhibitory effect on TNBC,which might help to optimize the strategy of radiotherapy for TNBC patients in the future. | Qi Yu Kedao Xin Yu Miao Zhaobin Li Shen Fu Shudong Hu Qing Zhang Shumin Zhou | 2018 | Acta Biochimica et Biophysica Sinica2018，50，11： | 1 |
| 3 | DFT Studies on Second-order Nonlinear Optical Response of Ir(C∧N)2(pic)Complexes显示文摘Density flmctional theory(DFT)was employed to calculate the geometrical structures,UV-Vis absorption spectra and second-order nonlinear optical(NLO)properties of a family of iridium(Ⅲ)complexes,which possess of different cyclometallated ligands(C∧N)and ancillary ligands[pyridme-2-carboxylate(pic)].It was found that the mo-dification of the LUMO energy levels was achieved by changing pic ligands and the energy gaps between the HOMO and LUMO were notably increased or decreased.In addition,the degree of conjugation was significantly changed with the substituent groups varied,which led to that the first hyperpolarizabilityβcould be effectively modulated.Through the analysis of time-dependent DFT(TD-DFT)results,we predicted that these studied complexes withπ→π^*charge transfer was beneficial to the large second-order NLO properties.Therefore,we hope that these studied iridium(III)complexes can be considered as versatile second-order NLO materials. | WANG Huiying SHEN Zhaobin YE Jinting WANG Hongqiang QIU Yongqing | 2019 | Chemical Research in Chinese Universities2019，35，2： | 0 |
| 4 | A preliminary clinic dosimetry study for synchrotron radiation therapy at SSRF显示文摘Synchrotron radiation(SR)represents a unique and innovative anti-cancer treatment due to its unique physical features,including high flux density,and tunable and collimated radiation generation.The aim of this work is to assess the dosimetric properties of SR in Shanghai Synchrotron Radiation Facility(SSRF)for potential applications to clinical radiation oncology.The experiments were performed with 34 and 50 keV X-rays on the BL13W biomedical beamline of SSRF and the 6 MV X-rays from ARTISTE linac for the dosimetry study.The percentage depth dose(PDD)and the surface dose of the SR X-rays and the 6 MV photon beams were performed in solid water phantom with Gafchromic EBT3 films.All curves are normalized to the maximum calculated dose.The depth of full dose buildup is about 10μm deeper for the monoenergetic X-ray beams of 34 and 50 keV.The beam transmits through the phantom,with a linear attenuation coefficient.The profile in the horizontal plane shows that the dose distribution is uniform within the facula,while the vertical profile shows a Gaussian distribution of the dose.The penumbra is less than 0.2 mm in the horizontal profile.Gafchromic EBT film may be a useful and convenient tool for dose measurement and quality control for the high space and density resolution.It is therefore important to gain a thorough understanding about the physical features of SR before this novel technology can be applied to clinical practice. | LI Zhaobin SHI Zeliang ZHANG Qing WANG Yong FU Shen | 2013 | Nuclear Science and Techniques2013，24，6： | 0 |
| 5 | The role of high-energy computed radiography(CR)in radiotherapy显示文摘Computed radiography(CR)imaging has high irradiation tolerance and it is easy to archive CR images along with other image information by Digital Imaging and Communications in Medicine(DICOM)format,and to process them.CR can be used in radiation Quality Control(QC)task and verification of treatment setting-up.In this paper,the role of high-energy CR in radiation oncology is studied.The patients were imaged by CR system and EPID before radiotherapy.All verification images were acquired with 1–2 MU(Monitor Unit)using 6 MV X-rays.QC for a linac was done with film and high-energy CR to collect the data on daily,weekly and monthly basis.The QC included Multileaf Collimators(MLC)calibration and mechanical iso-centre check.CR was also adapted to verify patient position,the film was used to compare with digitally reconstructed radiographs(DRR)and portal image from EPID. Treatment setting-up was verified based on the result of comparison.High quality verification images could be acquired by the CR system.Comparing to EPID,the results showed that the system was suitable for practical use to acquire daily verification images,and it was useful to fulfill part of quality assurance(QA)in radiation oncology.The quality of image acquired by the high-energy CR system is comparable or even better than DRRs and portal images. The final treatment set-up for the patients could be verified more accurately with the CR system. | LI Zhaobin SUN Yi LU Yaohong FU Shen | 2009 | Nuclear Science and Techniques2009，20，1： | 0 |
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