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| 1 | Numerical analysis of ossicular chain lesion of human ear显示文摘ossicular 链的损害是损害听觉的感觉的普通耳朵疾病。人的耳朵的一个全面数字模型能提供健全传播的更好的理解。在这研究,我们建议合并运河,鼓膜的膜, ossicular 骨头,中耳悬带系带 / 肌肉,中耳洞和内耳液体的人的耳朵的一个三维的有限元素模型。数字分析被进行并且采用了预言中耳洞,锤骨柄缺点,砧骨的长过程的发育不全,和镫骨的脚的效果在健全传播上背叛。现在的有限元素模型被显示在预言人的耳朵的 ossicular 力学讲理。 | Yingxi Liu Sheng Li Xiuzhen Sun | 2009 | Acta Mechanica Sinica2009，25，2： | 12 |
| 2 | Histone methyltransferase G9a contributes to H3K27 methylation in vivo显示文摘 | Hui Wu Xiuzhen Chen Jun Xiong Yingfeng Li Hong Li Xiaojun Ding Sheng Liu She Chen Shaorong Gao Bing Zhu | 2011 | Cell Research2011，21，2： | 8 |
| 3 | Histopathological Observation of Lymphocystis Disease and Lymphocystis Disease Virus (LCDV) Detection in Cultured Diseased Sebastes schlegeli显示文摘Lymphocystis nodules occurring in the cultured sting fish Sebastes schlegeli were observed under light and electron microscope. Lymphocystis disease virus (LCDV) in the tissues of diseased fish was detected with indirect immunofluorescence test (IFAT). Results showed that lymphocystis cells had overly irregular nuclei, basophilic intracytoplasmic inclusion bodies with virions budding from the surface, and hyaline capsules outside the cell membrane. Numerous virus particles about 200 nm in diameter scat- tered in the cytoplasm, electron-dense particles 70-80 nm in diameter filled in perinuclear cisterna, and membrane-enveloped parti- cles with electron-dense core of 70-80 nm appeared around cellular nucleus. IFAT using monoclonal antibody against LCDV from Paralichthys olivaceus revealed that specific green fluorescence was present in the cytoplasm of lymphocystis cells, epithelium of stomach, gill lamellae, and muscular fibers under epidermis of S. schlegeli, just as that in the cytoplasm of lymphocystis cells of P. olivaceus, suggesting the presence of LCDV in these tissues. | SHENG Xiuzhen ZHAN Wenbin XU Songjuan CHENG Shunfeng | 2007 | Journal of Ocean University of China2007，6，4： | 6 |
| 4 | Production, characterisation and applicability of monoclonal antibodies to immunoglobulin of Japanese flounder ( Paralichthys olivaceus )显示文摘 | Qiang Li Wenbin Zhan Jing Xing Xiuzhen Sheng | 2007 | Fish and Shellfish Immunology2007，，5： | 1 |
| 5 | Development and application of antibody microarray for lymphocystis disease virus detection in fish显示文摘 | Xiuzhen Sheng Xiaoli Xu Wenbin Zhan | 2013 | Journal of Virological Methods2013，，2： | 1 |
| 6 | Waterlogging risk assessment for winter wheat using multi-source data in the middle and lower reaches of Yangtze River显示文摘Waterlogging is a serious agro-meteorological disaster caused by excessive soil water,which usually causes tremendous crop yield losses.The region of middle and lower reaches of Yangtze River in China is an important production base of winter wheat,and is an area prone to waterlogging.The risk assessment of winter wheat waterlogging can provide more thorough understanding about the risk-prone environment related with food safety in this region.This study combined a variety of environmental and agricultural factors and assessed the waterlogging risk of winter wheat from the aspects of sensitivity of hazard formative environments,hazard risk,and vulnerability of hazard-affected body using multi-source data.Furthermore,it constructed a compound waterlogging risk assessment model to classify the study area into high,relatively high,moderate,and low risky areas,respectively.The results showed that the proposed model could more comprehensively reflect the occurrence mechanism of winter wheat waterlogging by synchronizing geographical,agricultural,and meteorological factors.The waterlogging regionalization based on the model could reasonably represent the spatial distribution and differentiate regional characteristics of winter wheat waterlogging in the study area. | Yuanyuan Chen Jingfeng Huang Xiaodong Song Hongyan Wu Shaoxue Sheng Zhixiong Liu Xiuzhen Wang | 2018 | International Journal of Agricultural and Biological Engineering2018，11，5： | 0 |
| 7 | Localization and Dynamic Expression of a 27.8kDa Receptor Protein for Lymphocystis Disease Virus Infection in Sea Bass(Lateolabrax japonicus) Tissues显示文摘Lymphocystis disease virus(LCDV) infects target cells by attaching to a 27.8 k Da receptor(27.8R) protein in flounder Paralichthys olivaceus, and anti-27.8R monoclonal antibodies(MAbs) have been developed. However, the 27.8R existence in tissues of sea bass(Lateolabrax japonicus) and its role in LCDV infection have remained unclear. In this study, the results of western blotting demonstrated that the same 27.8R was shared by flounder and sea bass. LCDV-free sea bass individuals were intramuscularly injected with LCDV, and viral copies were detected in tissues from 3 h post infection and showed a time-dependent increase during 9 days infection. Distribution and synthesis of 27.8R in sea bass tissues were investigated by using anti-27.8R MAbs as probes. It was found that 27.8R was distributed in all the tested tissues. The levels of 27.8R protein were highest in gill and skin, then a bit lowly in stomach, head kidney and heart, followed by spleen, intestine, blood cells, gonad and liver, and least in kidney and brain in healthy sea bass. Upon LCDV infection, 27.8R synthesis was up-regulated in each tissue, and higher in the tissues with higher LCDV copies. The 27.8R and LCDV were detected in some peripheral blood leukocytes but not in red blood cells. These results suggested that 27.8R was widely distributed in sea bass tissues, and it served as a receptor and correlated with tissue tropism of LCDV infection. Furthermore, leukocytes had the potential of being a LCDV carrier and were responsible for a systemic infection of LCDV in sea bass. | WU Ronghua SHENG Xiuzhen TANG Xiaoqian XING Jing ZHAN Wenbin | 2017 | Journal of Ocean University of China2017，16，5： | 0 |
| 8 | Distributed Truss Computation in Dynamic Graphs显示文摘Large-scale graphs usually exhibit global sparsity with local cohesiveness,and mining the representative cohesive subgraphs is a fundamental problem in graph analysis.The k-truss is one of the most commonly studied cohesive subgraphs,in which each edge is formed in at least k 2 triangles.A critical issue in mining a k-truss lies in the computation of the trussness of each edge,which is the maximum value of k that an edge can be in a k-truss.Existing works mostly focus on truss computation in static graphs by sequential models.However,the graphs are constantly changing dynamically in the real world.We study distributed truss computation in dynamic graphs in this paper.In particular,we compute the trussness of edges based on the local nature of the k-truss in a synchronized node-centric distributed model.Iteratively decomposing the trussness of edges by relying only on local topological information is possible with the proposed distributed decomposition algorithm.Moreover,the distributed maintenance algorithm only needs to update a small amount of dynamic information to complete the computation.Extensive experiments have been conducted to show the scalability and efficiency of the proposed algorithm. | Ziwei Mo Qi Luo Dongxiao Yu Hao Sheng Jiguo Yu Xiuzhen Cheng | 2023 | Tsinghua Science and Technology2023，28，5： | 0 |
| 9 | Two bicistronic DNA vaccines against Vibrio anguillarum and the immune eff ects on flounder Paralichthys olivaceus显示文摘Chemokines are cytokines that can promote the activation and migration of immune cells,and increase the recognition of antigen by antigen-presenting cells(APC).Previous studies showed that a DNA vaccine can induce humoral and cellular immune responses of flounder after immunization.To explore the improvement of chemokines on the efficiency of OmpK vaccine,two bicistronic DNA candidate vaccines were constructed and the immune responses they induced in the flounder were investigated by reverse transcription polymerase chain reaction(RT-PCR),indirect immunofl uorescent assay(IFA),H&E staining,fl ow cytometry(FCM),and quantifi cational real-time polymerase chain reaction(qRT-PCR).pBudCE4.1 plasmid as an expression vector,bicistronic DNA vaccines encoding OmpK gene and CC-motif ligand 4 gene(p-OmpK-CCL4),or Ompk gene and CC-motif ligand 19 gene(p-OmpK-CCL19)were successfully constructed.The results showed that two bicistronic DNA vaccines expressed Ompk protein of Vibrio anguillarum and CCL4/CCL19 proteins of fl ounder both in vitro and in vivo.After immunization,a large number of leucocytes in muscle were recruited at the injection site in treatment groups.The constructed vaccines induced signifi cant increases in CD4-1^(+) and CD4-2^(+) T lymphocytes,and sIgM^(+) B lymphocytes in peripheral blood,spleen,and head kidney.The percentage of T lymphocytes peaked on the 14^(th) post-vaccination day whereas that of B lymphocytes peaked in the 6^(th) post-vaccination week.Moreover,the expression profi les of 10 immune-related genes increased in muscles around the injection site,spleen,and head kidney.After the challenge,p-OmpK-CCL4 and p-OmpK-CCL19 conferred a relative percentage survival(RPS)of 74.1%and 63.3%,respectively,higher than p-OmpK alone(40.8%).In conclusion,both CCL4 and CCL19 can improve the protection of p-OmpK via evoking local immune response and then humoral and cellular immunity.CCL4 and CCL19 will be potential molecular adjuvants for use in DNA vaccines. | Hanlin LI Jing XING Xiaoqian TANG Xiuzhen SHENG Heng CHI Wenbin ZHAN | 2022 | Journal of Oceanology and Limnology2022，40，2： | 0 |
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