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| 1 | Genome Characteristics and Evolution of Pseudorabies Virus Strains in Eastern China from 2017 to 2019显示文摘Since late 2011,outbreaks of pseudorabies virus(PRV)have occurred in southern China causing major economic losses to the pig industry.We previously reported that variant PRV forms and recombination in China could be the source of continued epidemics.Here,we analyzed samples from intensive pig farms in eastern China between 2017 and 2019,and sequenced the main glycoproteins(gB,gC,gD,and gE)to study the evolution characteristics of PRV.Based on the gC gene,we found that PRV variants belong to clade 2 and detected a founder effect during by the PRV epidemic.In addition,we detected inter-and intra-clade recombination;in particular,inter-clade recombination in the gB genes of strains FJ-ZXF and FJ-W2,which were recombinant with clade 1 strains.We also found specific amino-acid changes and positively selected sites,possibly associated with functional changes.This analysis of the emergence of PRV in China illustrates the need for continuous monitoring and the development of vaccines against specific variants of PRV. | Xiaofeng Zhai Wen Zhao Kemang Li Cheng Zhang Congcong Wang Shuo Su Jiyong Zhou Jing Lei Gang Xing Haifeng Sun Zhiyu Shi Jinyan Gu | 2019 | Virologica Sinica2019，34，6： | 12 |
| 2 | Side Effects during Treatment of Advanced Gastric Carcinoma by Chemotherapy Combined with CIK-cell Transfusion in Elderly People显示文摘OBJECTIVE To study the side effects and therapeutic results of autologous cytokine-induced killer(CIK)cell treatment in elderly patients with advanced gastric cancer. METHODS CIK cells were induced and cultured using biotechnics in vitro,and then the cells were infused back into the patients.Sixty elderly gastric cancer patients treated by chemotherapy(FOLFOX4 protocol)were followed-up.Among them,29 patients were treated with CIK cells during application of chemotherapy.Short-term curative effects and adverse events from the CIK transfusion and chemotherapy were observed. RESULTS Eight cases developed partial remission(PR),9 cases moderate remission(MR),7 cases stable disease(SD)and 5 cases progressive disease(PD).Out of a total of 29 patients who received chemotherapy combined with autologous CIK therapy, the total remission rate(PR+MR)was 58.6%.The total remission rate following chemotherapy alone was 45.2%,including 5 PR cases,9 MR cases,7 SD cases,and 10 PD cases.There was a relatively lower rate of severe chemotherapic toxicities in the CIK- cell transfusion group.Side e?ects of autologous CIK transfusion included chills(13 cases),fever(9 cases),nausea and vomiting (1 case)and general malaise(3 cases).Side effects were treated with conventional therapy resulting in their amelioration.No patients developed shock,blood capillary leakage syndrome,or abnormalities in routine blood,urine,liver and renal function tests. CONCLUSION Adoptive immunotherapy with autologous CIK cells may decrease the clinical signs and symptoms of elderly patients who suffer from advanced gastric cancer.Adverse reactions of patients can be alleviated by conventional therapy. Autologous CIK-cell transfusion may improve endurance to chemotherapy. | Jingting Jiang Changping Wu Liangrong Shi Ning Xu Haifeng Deng Mingyang Lu Mei Ji Hbei Zhu Xueguang Zhang | 2008 | Chinese Journal of Clinical Oncology2008，5，2： | 10 |
| 3 | The frequency and skewed T-cell receptor beta-chain variable patterns of peripheral CD4+CD25+ regulatory T-cells are associated with hepatitis B e antigen seroconversion of chronic hepatitis B patients during antiviral treatment显示文摘 | Jiezuan Yang Guoping Sheng Dangsheng Xiao Haiyan Shi Wei Wu Haifeng Lu Ping Yi Hongcui Cao Lanjuan Li | 2016 | Cellular & Molecular Immunology2016，13，5： | 9 |
| 4 | May-June mean maximum temperature change during 1360-2005 as reconstructed by tree rings of Sabina Tibetica in Zaduo,Qinghai Province显示文摘Based on tree-ring samples collected from Zaduo area in southern Qinghai Province, a 646-year ring-width series was established. Using response function, correlation function and partial correlation analysis we found that the ring-width series is sensitive most to May and June mean maximum air temperature at Zaduo meteorological stations and the correlation is significantly negative. Therefore, May-June mean maximum air temperature in Zaduo area since 1360 is reconstructed using this ring-width series. The regression equation was cross-validated in the calibration period of 1961-2005. The calibration equation can explain 59.8% of the total variance. Since high temperature could reinforce evapotranspiration and result in water stress, the high values are more reliable than the low values in the reconstructed series. By further analyzing upon the reconstructed series, it shows that on the in-ter-annual scale there are 6 periods with higher temperature: 1438-1455, 1572-1612, 1684-1700, 1730-1754, 1812-1829 and 1853-1886; while there are 5 periods with lower temperature: 1547-1571, 1701-1729, 1755-1777, 1830-1852 and 1887-1910. There is no significant rising of temperature in recent 50 years. By comparison with the rings-width series nearby which are also sensitive to the mean maximum air temperature and the mean maximum temperature reconstruction by ring-widths, it is found that the variation of inter-annual scale is fairly common in the region. | SHI XingHe QIN NingSheng ZHU HaiFeng SHAO XueMei WANG QingChun ZHU XiDe | 2010 | Chinese Science Bulletin2010，55，26： | 8 |
| 5 | Cascade effects of crop species richness on the diversity of pest insects and their natural enemies显示文摘Understanding how plant species richness influences the diversity of herbivorous and predatory/parasitic arthropods is central to community ecology.We explore the effects of crop species richness on the diversity of pest insects and their natural enemies.Using data from a four-year experiment with five levels of crop species richness,we found that crop species richness significantly affected the pest species richness,but there were no significant effects on richness of the pests’natural enemies.In contrast,the species richness of pest insects significantly affected their natural enemies.These findings suggest a cascade effect where trophic interactions are strong between adjacent trophic levels,while the interactions between connected but nonadjacent trophic levels are weakened by the intermediate trophic level.High crop species richness resulted in a more stable arthropod community compared with communities in monoculture crops.Our results highlight the complicated cross-trophic interactions and the crucial role of crop diversity in the food webs of agro-ecosystems. | SHI PeiJian HUI Cang MEN XingYuan ZHAO ZiHua OUYANG Fang GE Feng JIN XianShi CAO HaiFeng LI B.Larry | 2014 | Science China(Life Sciences)2014，57，7： | 6 |
| 6 | Three-dimensional printing technique assisted cognitive fusion in targeted prostate biopsy显示文摘Objective:To explore the effect of 3-dimensional(3D)printing-assisted cognitive fusion on improvement of the positive rate in prostate biopsy.Methods:From August to December 2014,16 patients with suspected prostatic lesions detected by multiparametric magnetic resonance imaging(MRI)were included.Targeted prostate biopsy was performed with the use of prostate 3D reconstruction modeling,computersimulated biopsy,3D printing,and cognitive fusion biopsy.All patients had received 3.0 T multiparametric MRI before biopsy.The DICOM MRI files were imported to medical imaging processing software for 3D reconstruction modeling to generate a printable.stl file for 3D printing with use of transparent resin as raw material.We further performed a targeted 2-to 3-core biopsy at suspected lesions spotted on MRI.Results:For the 16 patients in the present study,3D modeling with cognitive fusion-based targeted biopsy was successfully performed.For a single patient,1e2 lesions(average:1.1 lesions)were discovered,followed by 2-6 cores(average:2.4 cores)added as targeted biopsy.Systematic biopsies accounted for 192 cores in total,with a positive rate of 22.4%;targeted biopsies accounted for 39 cores in total,with a positive rate of 46.2%.Among these cases,10 patients(62.5%)were diagnosed with prostate adenocarcinoma,in which seven were discovered by both systematic and targeted biopsy,one was diagnosed by systematic biopsy only,and two were diagnosed by targeted biopsy only.For systematic biopsy,Gleason score ranged from 6 to 8(average:7),while that for targeted biopsy ranged from 6 to 9(average:7.67).Among the seven patients that were diagnosed by both systematic and targeted biopsy,three(42.8%)were reported with a higher Gleason score in targeted therapy than in systematic biopsy.Conclusion:3D printing-assisted cognitive fusion technique markedly promoted positive rate in prostate biopsy,and reduced missed detection in high-risk prostate cancer. | Yan Wang Xu Gao Qingsong Yang Haifeng Wang Ting Shi Yifan Chang Chuanliang Xu Yinghao Sun | 2015 | Asian Journal of Urology2015，2，4： | 6 |
| 7 | Anlotinib as third- or further-line therapy for short-term relapsed small-cell lung cancer: subgroup analysis of a randomized phase 2 study (ALTER1202)显示文摘Patients with small-cell lung cancer (SCLC) relapse within months after completing previous therapies. This study aimed to investigate the efficacy and safety of anlotinib as third- or further-line therapy in patients with short-term relapsed SCLC from ALTER1202. Patients with short-term relapsed SCLC (disease progression within 3 months after completing ≥ two lines of chemotherapy) in the anlotinib (n = 67) and placebo (n = 34) groups were analyzed. The primary endpoint was progression-free survival (PFS). The secondary endpoints included overall survival, objective response rate (ORR), disease control rate, and safety. Anlotinib significantly improved median PFS/OS (4.0 vs. 0.7 months, P < 0.0001)/(7.3 vs. 4.4 months, P = 0.006) compared with placebo. The ORR was 4.5%/2.9% in the anlotinib/placebo group (P = 1.000). The DCR in the anlotinib group was higher than that in the placebo group (73.1% vs. 11.8%, P < 0.001). The most common adverse events (AEs) were hypertension (38.8%), loss of appetite (28.4%), and fatigue (22.4%) in the anlotinib group and gamma-glutamyl transpeptidase elevation (20.6%) in the placebo group. No grade 5 AEs occurred. For patients with short-term relapsed SCLC, third- or further-line anlotinib treatment was associated with improved survival benefit. Further studies are warranted in this regard. | Jianhua Shi Ying Cheng Qiming Wang Kai Li Lin Wu Baohui Han Gongyan Chen Jianxing He Jie Wang Haifeng Qin Xiaoling Li | 2022 | Frontiers of Medicine2022，16，5： | 5 |
| 8 | Au-Ag alloy nanoparticles with tunable cavity for plasmon-enhanced photocatalytic H2 evolution显示文摘Au-Ag alloy nanoparticles with different cavity sizes have great potential for improving photocatalytic performance due to their tunable plasmon effect.In this study,galvanic replacement was combined with co-reduction with the reaction kinetics processes regulated to rapidly synthesize Au-Ag hollow alloy nanoparticles with tunable cavity sizes.The position of the localized surface plasmon resonance(LSPR)peak could be effectively adjusted between 490 nm and 713 nm by decreasing the cavity size of the Au-Ag hollow nanoparticles from 35 nm to 20 nm.The plasmon-enhanced photocatalytic H2 evolution of alloy nanoparticles with different cavity sizes was investigated.Compared with pure P25(TiO2),intact and thin-shelled Au-Ag hollow nanoparticles(HNPs)-supported photocatalyst exhibited an increase in the photocatalytic H2 evolution rate from 0.48μmol h^−1 to 4μmol h^−1 under full-spectrum irradiation.This improved photocatalytic performance was likely due to the plasmon-induced electromagnetic field effect,which caused strong photogenerated charge separation,rather than the generation of hot electrons. | Xuanyu Yue Juan Hou Haifeng Zhao Pengcheng Wu Yali Guo Qin Shi Long Chen Shanglong Peng Zhiyong Liu Guozhong Cao | 2020 | Journal of Energy Chemistry2020，29，10： | 4 |
| 9 | Cryo-self-assembled silk fibroin sponge as a biodegradable platform for enzyme-responsive delivery of exosomes显示文摘Although advances in protein assembly preparation have provided a new platform for drug delivery during tissue engineering,achieving long-term controlled exosome delivery remains a significant challenge.Diffusion-dominated exosome release using protein hydrogels results in burst release of exosomes.Here,a fibroin-based cryo-sponge was developed to provide controlled exosome release.Fibroin chains can self-assemble into silk I structures under ice-cold conditions when annealed above the glass transition temperature.Exosome release is enzyme-responsive,with rates primarily determined by enzymatic degradation of the scaffolds.In vivo experiments have demonstrated that exosomes remain in undigested sponge material for two months,superior to their retention in fibrin glue,a commonly used biomaterial in clinical practice.Fibroin cryo-sponges were implanted subcutaneously in nude mice.The exosome-containing sponge group exhibited better neovascularization and tissue ingrowth effects,demonstrating the efficacy of this exosome-encapsulating strategy by realizing sustained release and maintaining exosome bioactivity.These silk fibroin cryo-sponges containing exosomes provide a new platform for future studies of exosome therapy. | Muyang Sun Qi Li Huilei Yu Jin Cheng Nier Wu Weili Shi Fengyuan Zhao Zhenxing Shao Qingyang Meng Haifeng Chen Xiaoqing Hu Yingfang Ao | 2022 | Bioactive Materials2022，7，2： | 4 |
| 10 | 2D/2D Bi_(2)MoO_(6)/g-C_(3)N_(4) S-scheme heterojunction photocatalyst with enhanced visible-light activity by Au loading显示文摘A novel 2D/2D Bi_(2)MoO_(6)/g-C_(3)N_(4) step-scheme(S-scheme)composite by loading Au as cocatalyst was successfully fabricated using a photoreduction and hydrothermal route.The obtained Bi_(2)MoO_(6)/g-C_(3)N_(4)/Au photocatalysts were characterized by X-ray diffraction(XRD),transmission electron microscope(TEM),X-ray photo-electron spectroscopy(XPS),UV–vis diffuse reflectance spectra(UV–vis),Fourier transform infrared spectroscopy(FTIR),photoluminescence(PL),photocurrent response(I-t),and electrochemical impedance spectroscopy(EIS).The HRTEM images revealed that an intimate interface in composites were formed.The optimum photocatalytic activity of Rhodamine B degradation over Bi_(2)MoO_(6)/g-C_(3)N_(4)/Au was about 9.7 times and 13.1 times as high as those of Bi_(2)MoO_(6) and g-C_(3)N_(4),respectively.The notably improved photocatalytic activity of Bi_(2)MoO_(6)/g-C_(3)N_(4)/Au could be mainly ascribed to the abundant active sites and the enhanced separation efficiency of photogenerated carriers in Bi_(2)MoO_(6)/g-C_(3)N_(4) S-scheme system.Notably,Au nanoparticles could act as a co-catalyst to further promote electron transfer and separation from the conduction band of g-C_(3)N_(4).Additionally,a possible step-scheme photocatalytic reaction mechanism of Rh B degradation over Bi_(2)MoO_(6)/g-C_(3)N_(4)/Au was tentatively proposed.PL and transient photocurrent analysis implied that Bi_(2)MoO_(6)/g-C_(3)N_(4)/Au photocatalysts possessed the lower recombination rate of photogenerated carriers compared with pure Bi_(2) MoO_(6) and g-C_(3)N_(4),respectively.The present work is expected to provide useful information in designing 2D/2D S-scheme heterojunction photocatalysts. | Qiaoqiao Li Wenli Zhao Zicheng Zhai Kaixu Ren Tingyu Wang Hao Guan Haifeng Shi | 2020 | Journal of Materials Science & Technology2020，56，21： | 4 |
| 11 | Materials Experiment on Tiangong-2 Space Laboratory显示文摘During the China's Tiangong-2(TG-2) flight mission, the experiments of 18 kinds of material samples were conducted in space by using a Multiple Materials Processing Furnace(MMPF) mounted in the orbital module of the TG-2 space laboratory. After the experiments of 12 kinds of samples of the first and second batches were completed successfully, astronauts packed and brought them back to the ground by ShenzhouII spacecraft. By studying processing and formation on semiconductor and optoelectronics materials, metal alloys and metastable materials, functional single-crystal, micro-and nano-composite materials encapsulated in sample ampoules both in space and on Earth, we expect to explore some physical and chemical processes and mechanism of the materials formation that are normally obscured and therefore are difficult to study quantitatively on the ground due to the gravity-induced convection, to obtain the processing and synthesis technology for preparing high quality materials, and lead to the improvement and development of materials processing techniques on Earth, and also develop the experiment device and comprehensive ability for materials experiment in microgravity environment. This report briefly introduces the main points of each research work and preliminary comparative analysis results of 12 samples carried out by scientists undertaking research task. | LI Xiangyang LU Ye MENG Xiangjian WANG Jianlu WANG Reng CHEN Lidong HUA Zile LI Xiaoya SHI Jianlin LIU Jinfeng XU Guisheng WEI Bingbo XIE Wenjun YIN Zhigang ZHANG Xingwang JIANG Hongxiang LI Hong LUO Xinghong ZHANG Haifeng ZHAO Jiuzhou WANG Binbin PAN Mingxiang | 2018 | 空间科学学报2018，38，5： | 4 |
| 12 | In vivo degradation and endothelialization of an iron bioresorbable scaffold显示文摘Detection of in vivo biodegradation is critical for development of next-generation medical devices such as bioresorbable stents or scaffolds(BRSs).In particular,it is urgent to establish a nondestructive approach to examine in vivo degradation of a new-generation coronary stent for interventional treatment based on mammal experiments;otherwise it is not available to semi-quantitatively monitor biodegradation in any clinical trial.Herein,we put forward a semi-quantitative approach to measure degradation of a sirolimus-eluting iron bioresorbable scaffold(IBS)based on optical coherence tomography(OCT)images;this approach was confirmed to be consistent with the present weight-loss measurements,which is,however,a destructive approach.The IBS was fabricated by a metal-polymer composite technique with a polylactide coating on an iron stent.The efficacy as a coronary stent of this new bioresorbable scaffold was compared with that of a permanent metal stent with the name of trade mark Xience,which has been widely used in clinic.The endothelial coverage on IBS was found to be greater than on Xience after implantation in a rabbit model;and our well-designed ultrathin stent exhibited less individual variation.We further examined degradation of the IBSs in both minipig coronary artery and rabbit abdominal aorta models.The present result indicated much faster iron degradation of IBS in the rabbit model than in the porcine model.The semi-quantitative approach to detect biodegradation of IBS and the finding of the species difference might be stimulating for fundamental investigation of biodegradable implants and clinical translation of the next-generation coronary stents. | Wenjiao Lin Hongjie Zhang Wanqian Zhang Haiping Qi Gui Zhang Jie Qian Xin Li Li Qin Haifeng Li Xiang Wang Hong Qiu Xiaoli Shi Wei Zheng Deyuan Zhang Runlin Gao Jiandong Ding | 2021 | Bioactive Materials2021，6，4： | 3 |
| 13 | Distributed Contact Plan Design for Multi-Layer Satellite-Terrestrial Network显示文摘In multi-layer satellite-terrestrial network, Contact Graph Routing(CGR) uses the contact information among satellites to compute routes. However, due to the resource constraints in satellites, it is extravagant to configure lots of the potential contacts into contact plans. What's more, a huge contact plan makes the computing more complex, which further increases computing time. As a result, how to design an efficient contact plan becomes crucial for multi-layer satellite network, which usually has a large scaled topology. In this paper, we propose a distributed contact plan design scheme for multi-layer satellite network by dividing a large contact plan into several partial parts. Meanwhile, a duration based inter-layer contact selection algorithm is proposed to handle contacts disruption problem. The performance of the proposed design was evaluated on our Identifier/Locator split based satellite-terrestrial network testbed with 79 simulation nodes. Experiments showed that the proposed design is able to reduce the data delivery delay. | Wenfeng Shi Deyun Gao Huachun Zhou Bohao Feng Haifeng Li Guanwen Li Wei Quan | 2018 | China Communications2018，15，1： | 3 |
| 14 | Application of Scanning Tunneling Microscopy in Electrocatalysis and Electrochemistry显示文摘Scanning tunneling microscopy(STM)has gained increasing attention in the field of electrocatalysis due to its ability to reveal electrocatalyst surface structures down to the atomic level in either ultra-high-vacuum(UHV)or harsh electrochemical conditions.The detailed knowledge of surface structures,surface electronic structures,surface active sites as well as the interaction between surface adsorbates and electrocatalysts is highly beneficial in the study of electrocatalytic mechanisms and for the rational design of electrocatalysts.Based on this,this review will discuss the application of STM in the characterization of electrocatalyst surfaces and the investigation of electrochemical interfaces between electrocatalyst surfaces and reactants.Based on different operating conditions,UHV-STM and STM in electrochemical environments(EC-STM)are discussed separately.This review will also present emerging techniques including high-speed EC-STM,scanning noise microscopy and tip-enhanced Raman spectroscopy. | Haifeng Feng Xun Xu Yi Du Shi Xue Dou | 2021 | Electrochemical Energy Reviews2021，4，2： | 2 |
| 15 | 3D-printed bioactive ceramic scaffolds with biomimetic micro/nano-HAp surfaces mediated cell fate and promoted bone augmentation of the bone-implant interface in vivo显示文摘Calcium phosphate bio-ceramics are osteo-conductive,but it remains a challenge to promote the induction of bone augmentation and capillary formation.The surface micro/nano-topography of materials can be recognized by cells and then the cell fate are mediated.Traditional regulation methods of carving surface structures on bio-ceramics employ mineral reagents and organic additives,which might introduce impurity phases and affect the biological results.In a previous study,a facile and novel method was utilized with ultrapure water as the unique reagent for hydrothermal treatment,and a uniform hydroxyapatite(HAp)surface layer was constructed on composite ceramics(β-TCP/CaSiO_(3))in situ.Further combined with 3D printing technology,biomimetic hierarchical structure scaffolds were fabricated with interconnected porous composite ceramic scaffolds as the architecture and micro/nano-rod hybrid HAp as the surface layer.The obtained HAp surface layer favoured cell adhesion,alleviated the cytotoxicity of precursor scaffolds,and upregulated the cellular differentiation of mBMSCs and gene expression of HUVECs in vitro.In vivo studies showed that capillary formation,bone augmentation and new bone matrix formation were upregulated after the HAp surface layer was obtained,and the results confirmed that the fabricated biomimetic hierarchical structure scaffold could be an effective candidate for bone regeneration. | Xiao Liu Yali Miao Haifeng Liang Jingjing Diao Lijing Hao Zhifeng Shi Naru Zhao Yingjun Wang | 2022 | Bioactive Materials2022，7，6： | 2 |
| 16 | Effect of manufacturing parameters on the release profiles of casein-loaded alginate microspheres prepared by emulsification/internal gelation显示文摘 | Ranran Li Xingxiang Zhang Haifeng Shi | 2011 | Journal of Controlled Release2011，，： | 2 |
| 17 | Integrating Oxaliplatin with Highly Luminescent Carbon Dots: An Unprecedented Theranostic Agent for Personalized Medicine显示文摘 | Min Zheng Shi Liu Jing Li Dan Qu Haifeng Zhao Xingang Guan Xiuli Hu Zhigang Xie Xiabin Jing Zaicheng Sun | 2014 | Mater2014，，21： | 2 |
| 18 | Ubiquitin-mediated NFκB degradation pathway显示文摘原子因素 κ B (NFκ B ) 抄写因素在发炎和免疫起关键作用。NFκ 的 dysregulation; B 与煽动性、自体免疫的疾病和癌症被联系。NFκ B 激活被 ubiquitin 依赖的 proteasomal 降级小径否定地调整。在现在的评论,我们在我们理解讨论最近的进展 ubiquitin ligases 调整 NFκ B 降级小径。 | Huimin Xu Mengli You Haifeng Shi Yongzhong Hou | 2015 | Cellular & Molecular Immunology2015，12，6： | 2 |
| 19 | A new photothermal conversion and thermo-regulated fibers显示文摘 | SHI Haifeng ZHANG Xingxiang WANG Xuechen | 2004 | Indian Journal of Fiber Textile Research2004，29，1： | 1 |
| 20 | Nanoconfinement crystallization of frustrated alkyl groups: Crossover of mesophase to crystalline structure 显示文摘 | Shi Haifeng Wang Haixia Xin H J | 2011 | Chemical Communication2011，47，13： | 1 |
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