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| 1 | Features of extrahepatic metastasis after radiofrequency ablation for hepatocellular carcinoma显示文摘BACKGROUND Extrahepatic metastasis(EHM)of hepatocellular carcinoma(HCC)is associated with poor outcomes.However,the clinical features and risk factors of EHM of HCC after radiofrequency ablation(RFA)remain unclear.AIM To elucidate the characteristics and risk factors of EHM after RFA for HCC.METHODS From January 2008 to December 2017,we retrospectively enrolled 661 patients who underwent RFA as first-line treatment for HCC at 2 tertiary hospitals.The inclusion criteria were age≥18 years,a diagnosis of HCC,and treatment-naivety.Abdominal computed tomography(CT)or magnetic resonance imaging(MRI)and alpha-fetoprotein measurements were routinely performed at 1 mo after RFA and followed-up at intervals of 3-6 mo.Univariate analyses were performed using the chi-squared test or Student’s t-test,and univariate and multivariate analyses were performed via logistic regression,as appropriate.RESULTS EHM was diagnosed in 44 patients(6.7%)during a median follow-up period of 1204 days.The 10-year cumulative rate of HCC recurrence and EHM was 92.7%and 33.7%,respectively.Initial recurrence was most often intrahepatic,and the rate of extrahepatic recurrence at initial recurrence was only 1.2%.The median time to the diagnosis of EHM was 2.68 years,and 68.2%of patients developed EHM within 2 years of the first recurrence,regardless of recurrence-free survival and 75.0%of patients developed EHM within 5 years after first recurrence.EHM was mostly diagnosed via abdominal CT/MRI in 33(75.0%)and 38 of 44 patients(86.4%)with EHM had either positive abdominal CT scan results or serum AFP level elevation.In multivariate analysis,recurrence-free survival<2 years,ablation zone/tumor size<2,and alpha-fetoprotein level>400 IU/mL were associated with a high EHM risk.CONCLUSION EHM occurs following multiple intrahepatic recurrences after RFA and combined contrast-enhanced abdominal CT and serum AFP were useful for surveillance.Patients especially with high-risk factors require close follow-up for EHM. | Jae H Yoon Young J Goo Chae-Jun Lim Sung K Choi Sung B Cho Sang S Shin Chung H Jun | 2020 | World Journal of Gastroenterology2020，26，32： | 3 |
| 2 | Position control of a two-link flexible manipulator featuring piezoelectric actuators and sensors显示文摘 | Shin H C Choi S B | 2001 | Mechatronics2001，，11： | 2 |
| 3 | Transmit power allocation for a modified V-BLAST system显示文摘 | Nam S H Shin O S Lee K B | 2004 | IEEE Transactions on Communications2004，52，7： | 1 |
| 4 | An anti-apoptotic protein human survivin is a direct inhibitor of Caspase-3 and-7显示文摘 | Sung B J Cho YS Kim H J Ha NC Hwang JI | 2001 | Biochenistry2001，40，4： | 1 |
| 5 | Anti-allergic effects of Sanguisorba officinalis on animal models of allergic reactions显示文摘 | SHIN T Y LEE K B KIM S H TA Y | 2002 | Immunopharmacology & Immunotoxicology2002，24，3： | 1 |
| 6 | AtMYB21,a gene encoding a flower-specific transcription factor,is regulated by COP1显示文摘 | Shin B Choi G Yi H | 2002 | The Plant Journal2002，30，1： | 1 |
| 7 | Medullary thyroid carcinoma: comparison with papillary thyroid carcinoma and application of current sonographic cdteria显示文摘 | Lee S Shin J H Han B K | 2010 | AJR Am J Roentgenol2010，194，4： | 1 |
| 8 | Synthesis, characterization and liquid-crystal-aligning properties of novel aromatic polypyromellitimides bearing (n-alkyloxy)biphenyloxy side chains显示文摘 | Lee S B Shin G J Chi J H | 2006 | Polymer2006，47，19： | 1 |
| 9 | Mist- CVD Growth of High Quality nnO Thin Films at Low Temperature for Inverted Organic Solar Cells 显示文摘 | Kim K H Shin K S Kumar B | 2010 | Journal of Nanoelectronics and Optoelectronics2010，5，2： | 1 |
| 10 | Pediatric pineal tumors: need for a drect surgical approach and compilcations of the occiptal transtentorial approch显示文摘 | SHIN H J CHO B K JUNG H W | 1998 | Childs Nerv Syst1998，14，： | 1 |
| 11 | Galactosylated chitosan-graft-dextran as hepatocyte-targeting DNA carrier 显示文摘 | Park Y K Park Y H Shin B A | 2000 | Journal of Controlled Release2000，69，： | 1 |
| 12 | Modified Hodge and EDTA-disk synergy tests to screen metallo-beta-lactamase-producing strains of Pseudomonas and Acinetobacter species显示文摘 | Lee K Y·Chong H·B·Shin Y·A·Kim D·Yong and J·H·Yum | 2001 | Clin Microbiol Infect2001，7，： | 1 |
| 13 | Anthocyanin content in rice is related to expression levels of anthocyanin biosynthetic genes显示文摘 | Kim B G Kim J H Min S Y Shin K H Kim J H Kim H Y Ryu S N Ahn J H | 2007 | J Plant Biol2007，50，2： | 1 |
| 14 | 查看详情显示文摘 | (e) Kim D C Lee Y R Yang B -S Shin K J Kim D J Chung B Y Yoo K H | | 0，，： | 1 |
| 15 | Simulation of deformation twins and deformation texture in an AZ31 Mg alloy under uniaxial compression 显示文摘 | CHOI S H SHIN E J SEONG B S | 2007 | Acta Materialia2007，55，12： | 1 |
| 16 | Cloning and expression of a full-length glutamate deearboxylase gene from Lactobacillus brevis BH2显示文摘 | KIM S H SHIN B H | 2007 | Bioteehnology and Biopmeess Engineering2007，12，6： | 1 |
| 17 | Partition Property of 5-Nitrothiopyrimidine Nucleside显示文摘 | LEE B H SHIN J H LIMMK | 1997 | Bull Korean Chem Soc1997，18，7： | 1 |
| 18 | Mobilized CD34^+ cells as a biomarker candidate for the efficacy of combined maximal tolerance dose and continuous infusional chemotherapy and G CSF surge in gastric cancer显示文摘 | Shin S J Jeung H C Ahn J B et al | 2008 | Cancer Lett2008，270，2： | 1 |
| 19 | Transmit power allocation for a modified V-BLAST system显示文摘 | Nam S H Shin O S Lee K B | 2004 | IEEE Transactions on Communications2004，52，7： | 1 |
| 20 | Phospholipase Cgammal stimulates transcriptional activation of the matrix metalloproteinase-3 gene via the protein kinase C/Raf/ERK cascade 显示文摘 | Shin S Y Choi H Y Aim B H | 2007 | Biochem Biophys Res Commun2007，353，3： | 1 |
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