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| 1 | Correlation of N-myc downstream-regulated gene 1 expression with clinical outcomes of colorectal cancer patients of different race/ethnicity显示文摘AIM: To evaluate the role of N-myc downstream-regulated gene 1 (NDRG1) expression in prognosis and survival of colorectal cancer patients with different ethnic backgrounds. METHODS: Because NDRG1 is a downstream target of p53 and hypoxia inducible factor-1α (HIF-1α),we examined NDRG1 expression together with p53 and HIF-1α by immunohistochemistry. A total of 157 colorectal cancer specimens including 80 from Japanese patients and 77 from US patients were examined. The correlation between protein expression with clinicopathological features and survival after surgery was analyzed.in colorectal tumor compared with normal epithelium in both Japanese and US patient groups. Expression of NDRG1 protein was significantly correlated with lymphatic invasion,venous invasion,depth of invasion,histopathological type,and Dukes' stage in Japanese colorectal cancer patients. NDRG1 expression was correlated to histopathological type,Dukes' stage and HIF-1α expression in US-Caucasian patients but not in US-African American patients. Interestingly,Kaplan-Meier survival analysis demonstrated that NDRG1 expression correlated significantly with poorer survival in US-African American patients but not in other patient groups. However,in p53-positive US cases,NDRG1 positivity correlated significantly with better survival. In addition,NDRG1 expression also correlated significantly with improved survival in US patients with stages Ⅲ and Ⅳ tumors without chemotherapy. In Japanese patients with stages Ⅱ and Ⅲ tumors,strong NDRG1 staining in p53-positive tumors correlated significantly with improved survival but negatively in patients without chemotherapy. CONCLUSION: NDRG1 expression was correlated with various clinicopathological features and clinical outcomes in colorectal cancer depending on the race/ethnicity of the patients. NDRG1 may serve as a biological basis for the disparity of clinical outcomes of colorectal cancer patients with different ethnic backgrounds. | Minori Koshiji Kensuke Kumamoto Keiichirou Morimura Yasufumi Utsumi Michiko Aizawa Masami Hoshino Shinji Ohki Seiichi Takenoshita Max Costa Thérèse Commes David Piquemal Curtis C Harris Kam-Meng Tchou-Wong | 2007 | World Journal of Gastroenterology2007，13，20： | 25 |
| 2 | Cloning and functional analysis of BAG-1: A novel Bcl-2-binding protein with anti-cell death activity显示文摘 | Shinichi Takayama Takaaki Sato Stanislaw Krajewski Kristine Kochel Shinji Irie Juan A Milian John C Reed | 1995 | Cell1995，，2： | 2 |
| 3 | Design of synthesis of phthalimide-type histone deacelase inhibitors 显示文摘 | Shinji C Nakamura T Maseda S | 2005 | Bioorg &Med Chem Lett2005，15，： | 1 |
| 4 | Prolongation of life span of Stroke-prone spontaneously hypertensive rats (SHRSP) ingesting persimmon tarnin显示文摘 | Shinji U C Hisashi O Masami N | 1990 | Chem Pharm Bull1990，38，4： | 1 |
| 5 | Design, synthe- sis, and evaluation of cyclic amide/imide-bearinghydroxamic acid derivatives as class-selective histone deacetylase ( HDAC ) inhibitors 显示文摘 | SHINJI C MAEDA S IMAI K | 2006 | Bioorg Med Chem2006，14，22： | 1 |
| 6 | Isolation of a benzoate-utilizing pseudomonas strain from soil and production of catechol from benzoate by transpositional mutants 显示文摘 | Wang C L Shinji Takenaka Shuichiro Murakami | 2001 | Microbiol Res2001，156，： | 1 |
| 7 | Production of catechol from benzoate by the wild strain ralstonia species Ba-0323 and characterization of its catechol 1,2-dioxygenase显示文摘 | Wang C L Shinji Takenaka Shuichiro Murakami | 2001 | Biosci Biotechnol Biochem2001，65，9： | 1 |
| 8 | Production of catechol from benzoate by the wild strain Ralsito Nia species Ba 0323 and characterization of its catechol 1,2-dioxygenase显示文摘 | Wang C L Takenaka Shinji Murakami Shuichiro | 2001 | Biosci Bimechnol Biochem2001，65，9： | 1 |
| 9 | Astrocytic gap junctions composed of connexin 43 reduce apoptotic neuronal damage in cerebral ischemia显示文摘 | Taizen N Shinji F Christian C | 2003 | Stroke2003，34，2： | 1 |
| 10 | Astrocytic Gap Junctions, Composed of Connexin 43 Reduce Apoptotic Neuronal Damage in Cerebral Ischemia 显示文摘 | Taizen Nakase Shinji Fushiki Christian C | 2003 | Stroke2003，34，9： | 1 |
| 11 | Isolation of a benzoateutilizing pseudomonas strain from soil and production of catechol from benzoate by transpositional mutants显示文摘 | WANG C L TAKENAKA SHINJI MURAKAMI SHUICHIRO | 2001 | Microbiol Res2001，156，： | 1 |
| 12 | Production of catechol from benzoate by the wild strain ralstonia species Ba20323 and characterization of its catechol,22dioxygenase显示文摘 | WANG C L TAKENAKA SHINJI MURAKAMI SHUICHIRO | 2001 | Bilsci Biotechnol Biochem2001，65，9： | 1 |
| 13 | Design of piezoelectric multi-actuated microtools using topology optimization显示文摘 | Ronny C Carbonari Emilio C N Silva Shinji Nishiwaki | 2005 | Smart Materials and Structures2005，，14： | 1 |
| 14 | Optimum placement of piezoelectric material in pi- ezoactuator design显示文摘 | Ronny C Carbonari Emilio C N Silva Shinji Nishiwaki | 2007 | Smart Materials and Structures2007，，16： | 1 |
| 15 | Globalization, naturalization and identity: the case of borderless elite athletes in japan 显示文摘 | NAOKI C OSAMU E SHINJI M | 2001 | Intemational Review for the Sociology of Sport2001，36，： | 1 |
| 16 | Isolation of a benzoate2utilizing pseudomonas strain from soiland production of catechol from benzoate by transpositionalmutants显示文摘 | Wang C L Shinji Takenaka Shuichiro Murakami | 2001 | Microbiol Res2001，156，： | 1 |
| 17 | Production of catechol from benzoate by the wild strain ralsto2nia species Ba20323 and characterization of its catechol 1,22dioxygenase显示文摘 | Wang C L Shinji Takenaka Shuichiro Murakami | 2001 | Biosci Biotechnol Biochem2001，65，9： | 1 |
| 18 | 显示文摘 | Iwkura C Shinji N Naoji F | 2002 | Solid State Ionics2002，148，34： | 1 |
| 19 | Decomposition of CO2 E- mission Change from Energy Consumption in Brazil: Challenges and Policy Implications显示文摘 | Luciano C F Shinji K | 2011 | Energy Policy2011，，3： | 1 |
| 20 | Decomposing the decoupling of CO2 emissions and economic growth in Brazil显示文摘 | Luciano C de F Shinji K | 2011 | Ec- ological Economics2011，70，6： | 1 |
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