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| 1 | Surgery for inflammatory bowel disease in the era of laparoscopy显示文摘During the course of inflammatory bowel disease (IBD), surgery may be needed. Approximately 20% of patients with ulcerative colitis (UC) will require surgery, whereas up to 80% of Crohn's disease (CD) patients will undergo an operation during their lifetime. For UC patients requiring surgery, total proctocolectomy and ileoanal pouch anastomosis (IPAA) is the operation of choice as it provides a permanent cure and good quality of life. Nevertheless a permanent stoma is a good option in selected patients, especially the elderly. Minimally invasive surgery has replaced the conventional open approach in many specialized centres worldwide. Laparoscopic colectomy and restorative IPAA is rapidly becoming the standard of care in the treatment of UC requiring surgery, whilst laparoscopic ileo-cecal resection is already the new gold standard in the treatment of complicated CD of terminal ileum. Short term advantages of laparoscopic surgery includes faster recovery time and reduced requirement for analgesics. It is, however, in the long term that minimally invasive surgery has demonstrated its superiority over the open approach. A better cosmesis, a reduced number of incisional hernias and fewer adhesions are the long term advantages of laparoscopy in IBD surgery. A reduction in abdominal adhesions is of great benefit when a second operation is needed in CD and this influences positively the pregnancy rate in young women undergoing restorative IPAA. In developing the therapeutic plan for IBD patients it should be recognized that the surgical approach to the abdomen has changed and that surgical treatment of complicated IBD can be safely performed with a true minimally invasive approach with great patient satisfaction. | Giuseppe S Sica Livia Biancone | 2013 | World Journal of Gastroenterology2013，19，16： | 10 |
| 2 | Comparative study of laparoscopic vs open gastrectomy in gastric cancer management显示文摘AIM:To compare long-term results of gastric cancer patients undergoing laparoscopic and open gastrec-tomy in a single unit.METHODS:From February 2000 to September 2004,all patients with adenocarcinoma of the stomach were assessed to entry in this longitudinal prospective non-randomized trial.Primary endpoint was cancer-related survival and secondary endpoints were overall survival,evaluation of surgical complications and mortality.RESULTS:Fifty-eight patients were enrolled.Forty-seven patients were followed-up(range 11-103,me-dian 38 mo).Four patients were lost at follow up.Twenty-two patients underwent a laparoscopic gastric surgery(LGS)and 25 had a standard open procedure(OGS).No statistical difference was found between the two groups in terms of 5 years cancer-related mortality rate(50% vs 52%,P = 1),and 5 years overall mortal-ity rate(54.5% vs 56%,P = 1).Accordingly,cancer-related and overall survival probability by Kaplan-Meier method showed comparable results(P = 0.81 and P = 0.83,respectively).We found no differences in surgical complications in the 2 groups.There was no conversion to open surgery in this series.CONCLUSION:LGS is as effective as OGS in the man-agement of advanced gastric cancer.However LGS can-not be recommended routinely over OGS for the treat-ment of advanced gastric cancer. | Giuseppe S Sica Edoardo Iaculli Livia Biancone Sara Di Carlo Rosa Scaramuzzo Cristina Fiorani Paolo Gentileschi Achille L Gas-pari | 2011 | World Journal of Gastroenterology2011，17，41： | 9 |
| 3 | Treatment of peri-anal fistula in Crohn's disease显示文摘Anal fistulas are a common manifestation of Crohn's disease(CD). The first manifestation of the disease is often in the peri-anal region, which can occur years before a diagnosis, particularly in CD affecting the colon and rectum. The treatment of peri-anal fistulas is difficult and always multidisciplinary. The European guidelines recommend combined surgical and medical treatment with biologic drugs to achieve best results. Several different surgical techniques are currently em-ployed. However, at the moment, none of these tech-niques appear superior to the others in terms of healing rate. Surgery is always indicated to treat symptomatic, simple, low intersphincteric fistulas refractory to medi-cal therapy and those causing disabling symptoms. Ut-most attention should be paid to correcting the balance between eradication of the fistula and the preservationof fecal continence. | Giuseppe S Sica Sara Di Carlo Giorgia Tema Fabrizio Montagnese Giovanna Del Vecchio Blanco Valeria Fiaschetti Giulia Maggi Livia Biancone | 2014 | World Journal of Gastroenterology2014，20，37： | 8 |
| 4 | Goserelin as ovarian protection in the adjuvant treatment of premenopausal breast cancer:a phase Ⅱ pilot study显示文摘 | Recchia F Sica G De Filippis S | | 0，，04： | 1 |
| 5 | Chemo-immunotherapy in advanced head and neck cancer 显示文摘 | Recchia F Sica G DeFilippis S | 1999 | Anticancer Res1999，19，1： | 1 |
| 6 | The ehemokine system in diverse forms of macrophage activation and polarization显示文摘 | Sica A Sozzani S | 2004 | Trends Immunol2004，25，： | 1 |
| 7 | Effect of all-trans retinoic acid on procoagulant and fibrinolytic activities of cultured blast cells from patients with acute promyelocytic leukemia显示文摘 | DE STEFANO V TEOFILI L SICA S | | 0，，： | 1 |
| 8 | Quercetin Inhibits the Growth of Leukemic Progenitors and Induces the Expression of Transforming Growth Factor-β1 in These Cells 显示文摘 | Larocca L M Teofili L Sica S | 1995 | Blood1995，，： | 1 |
| 9 | Melatonin reduces bacterial translocation after intestinal ischemia-reperfusion injury 显示文摘 | Sileri P Sica G S Gentileschi P | 2004 | Transplant Proc2004，36，10： | 1 |
| 10 | Clinical pharmacokinetics of losartan 显示文摘 | Sica DA Gehr TW Ghosh S | 2005 | Clin Pharmacokinet2005，44，8： | 1 |
| 11 | Therapeutic effects of concurrent autologous bone marrow cell infusion and metabolic intervention in ischemia-induced angiogenesis in the hypercholesterolemic mouse hindlimb显示文摘 | De Nigris F Williams-Ignarro S Sica V | 2007 | Int J Cardiol2007，117，2： | 1 |
| 12 | Bacterial translocation and intestinal morphological findings in jaundiced rats显示文摘 | Sileri P Morini S Sica GS | 2002 | Dig Dis Sci2002，47，4： | 1 |
| 13 | Thechemokine system in diverse forms of macrophageactivation and polarization 显示文摘 | MANTOVANI A SICA A SOZZANI S | 2004 | Trends Immunol2004，25，12： | 1 |
| 14 | The chemokine system in diverse forms of macrophage activation and polarization显示文摘 | Mantovani A Sica A Sozzani S | 2004 | Trends Immunol2004，25，12： | 1 |
| 15 | Transient Kinematic Pile Bending in Two-layer Soil显示文摘 | Sica S Mylonakis G Simonelli A L | 2011 | Soil Dynamics and Earthquake Engineering2011，31，7： | 1 |
| 16 | The chemokine system in diverse forms of macrophage activation and polarization显示文摘 | Mantovani A Sica A Sozzani S | 2004 | Trends Immunol2004，25，12： | 1 |
| 17 | The chemokine systemin diverse forms of macrophage activation and polarization显示文摘 | Mantovani A Sica A Sozzani S | 2004 | Trends Immunol?2004，25，12： | 1 |
| 18 | Trisomy 4 in acute myeloblastic and acute lymphoblastic leukemia显示文摘 | ZOLLINO M LEONE G SICA S | | Cancer Genetics Cytogenetics0，65，： | 1 |
| 19 | Bacterial translocation and intestinal morphological finding in jaundiced显示文摘 | Sileri P Morini S Sica GS | 2002 | Dig Dis Sci2002，47，4： | 1 |
| 20 | Eftect of chronic resistive loading on hypoxic ventilatory responsiveress 显示文摘 | GREENBERG H E RAO R S SICA A L | 1997 | Appl Physiol1997，82，： | 1 |
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