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| 1 | Mycophenolate mofetil for drug-induced vanishing bile duct syndrome显示文摘Amoxicillin/clavulanate is associated with liver injury, mostly of a cholestatic pattern. While outcomes are usually benign, progression to cirrhosis and death has been reported. The role of immunosuppressive therapy for patients with a protracted course is unclear. We report the case of an elderly patient who developed prolonged cholestasis secondary to amoxicillin/clavulanate. Vanishing bile duct syndrome was confirmed by sequential liver biopsies. The patient responded to prednisone treatment, but could not be weaned off corticosteroids, even when azathioprine was added. Complete withdrawal of both prednisone and azathioprine was possible by using mycophenolate mofetil, an inosine monophosphate dehydrogenase inhibitor. Sustained remission has been maintained for more than 3 years with low-dose mycophenolate mofetil. | S Simona Jakab A Brian West Dennis M Meighan Robert S Brown Jr William B Hale | 2007 | World Journal of Gastroenterology2007，13，45： | 8 |
| 2 | 大气二氧化氮与每日总死亡率、心血管和呼吸系统疾病死亡率的短期关联:398个城市的多中心分析显示文摘目的:采用统一的分析方案,评估全球多个国家/地区的二氧化氮(NO_(2))与总死亡率、心血管和呼吸系统疾病死亡率之间的短期关联。研究设计:采用两阶段的时间序列分析方法、过度离散的广义线性模型和多水平meta分析。研究地点:22个低到高收入国家/地区的398个城市。主要结局指标:1973—2018年逐日总死亡人数(6280万人)、心血管疾病死亡人数(1970万人)和呼吸系统疾病死亡人数(550万人)。结果:平均而言,NO_(2)浓度在滞后1天(前1天)每增加10μg/m^(3),会导致总死亡率、心血管和呼吸系统疾病死亡率分别增加0.46%(95%可信区间0.36%~0.57%)、0.37%(0.22%~0.51%)、0.47%(0.21%~0.72%)。在对共污染物(PM_(10)、PM_(2.5)、臭氧、二氧化硫和一氧化碳)进行调整后,这些关联仍然很稳定。所有3种死因的暴露-反应曲线几乎是线性的,没有明显的阈值。在398个城市中,可归因于高过假定零水平的NO_(2)浓度造成的死亡比例为1.23%(95%可信区间0.96%~1.51%)。结论:这项多中心研究提供了关于NO_(2)短期暴露与总死亡率、心血管和呼吸系统死亡风险之间的独立和线性关联的关键证据,说明通过加强NO_(2)的控制和监管限制标准,可获得人群水平的健康收益。 | 孟夏 刘聪(校) 陈仁杰 郑湃(译) 阚海东(校) Francesco Sera Ana Vicedo-Cabrera Ai Milojevic Maria Guo Yuming Tong Shilu Micheline de Sousa Zanotti Stagliorio Coelh Paulo Hilario Nascimento Saldiva Eric Lavigne Patricia Matus Correa Nicolas Valdes Ortega Samuel Osorio Garcia Jan Kysely Ales Urban Hans Orru Marek Maasikmets Jouni J K Jaakkola Niilo Ryti Veronika Huber Alexandra Schneider Klea Katsouyanni Antonis Analitis Masahiro Hashizume Yasushi Honda Chris Fook Sheng Ng Baltazar Nunes João Paulo Teixeira Iulian Horia Holobaca Simona Fratianni Ho Kim Aurelio Tobias Carmeníniguez Bertil Forsberg ChristoferÅström Martina S Ragettli Yue-Liang Leon Guo Shih-Chun Pan Shanshan Li Michelle L Bell Antonella Zanobetti Joel Schwartz Tangchun Wu Antonio Gasparrini | 2021 | 英国医学杂志中文版2021，24，8： | 7 |
| 3 | Innate immunity–the hallmark of Helicobacter pylori infection in pediatric chronic gastritis显示文摘BACKGROUND Innate immunity was found to be associated with both persistence of Helicobacter pylori(H.pylori)infection and increased risk of gastric cancer.AIM To identify the risk factors associated with H.pylori infection and to establish the role of TLR9 rs352140 in suppressing or promoting inflammation related to this infection in children.METHODS We performed a study of 155 children with digestive symptoms,who were divided into two groups according to the histopathological exam:Group 1–48 children with H.pylori-induced chronic gastritis,and Group 2–control group.RESULTS Rural area and poor living conditions were significantly associated with H.pylori chronic gastritis(P=0.0042/P<0.0001).Both positive immunoglobulin A anti H.pylori and the rapid urease test were significantly associated with H.pylori infection(P<0.0001).Significantly higher values of leukocytes and neutrophils within the peripheral blood were found in children with H.pylori chronic gastritis(P=0.111/P=0.284).We found a significant positive correlation between the variant TT genotype of TLR9 rs352140 polymorphism and both leucocytes and neutrophils(P=0.0225/P=0.0292).CONCLUSION Variant TT genotype carriers of the TLR9 rs352140 gene polymorphism might have a more severe degree of inflammation. | Lorena Elena Meliț Cristina Oana Mărginean Maria Oana Săsăran Simona Mocan Dana Valentina Ghiga Alina Bogliş Carmen Duicu | 2021 | World Journal of Clinical Cases2021，9，23： | 2 |
| 4 | Catalytic Combustion of Volatile Organic Compounds on Gold/Iron Oxide Catalysts显示文摘 | SALVATORE S CARMELO C | 2000 | Applied Catalysis B:Environmental2000，28，： | 1 |
| 5 | Catalytic Combustion of Volatile Organic Compounds over Group IB Metal Catalysts an Fe2O3显示文摘 | SIMONA M CARMELO C | 2001 | Catalysis Communications2001，2，： | 1 |
| 6 | 显示文摘 | Simona S Giancarlo F Sandro C | 2007 | Journal of Molecu lar Catalysis B: Enzymatic2007，44，3： | 1 |
| 7 | Catalytic Combustion of Volatile Organic Compounds on Gold/Cerium Oxide Catalysts显示文摘 | SIMONA M CARMELO C | 2003 | Applied Catalysis B:Environmental2003，40，： | 1 |
| 8 | The polymorphism at codon 54 of the FABP2 gene increase fat absorption in human intestinal explants显示文摘 | Emile LD Daniel M Simona S | 2001 | J Biol Chem2001，276，39： | 1 |
| 9 | The perception of risks associated with food- related hazards and the perceived reliability of sources of information 显示文摘 | Simona R Anna S | 2004 | International Journal of Food Science & Technology2004，39，5： | 1 |
| 10 | Knock Investiga- tion by Flame and Radical Species Detection in Spark Ignition Engine for Different Fuels 显示文摘 | Merola Simona S Vaglieco Bianca M | 2007 | Energy Conversion and Management2007，48，11： | 1 |
| 11 | Influence of Catalyst Pretrestments on Volatile Organic Compounds Oxidation over Cold/Iron Oxide显示文摘 | SALVATORE S CARMELO C | 2001 | Applied Catalysis A:General2001，34，： | 1 |
| 12 | Complex dynamical behaviours in two non-linearly coupled Chua's circuits显示文摘 | Silvano C Simona D S | 2004 | Chaos Solitons and Fractals2004，21，3： | 1 |
| 13 | Appl Catal A显示文摘 | Salvatore S Simona M Carmdo C | 2002 | 235(1-2):21-312002，235，12： | 1 |
| 14 | Characterization of genes associated with induced resistance against Penicillium expansum in apple fruit treated with quercetin显示文摘 | SIMONA M S LEONARDO S ANNALISA D G | 2010 | Postharvest Biology and Technology2010，56，1： | 1 |
| 15 | Fluorousmaterials in microbubble engineering science and techno-logy-Design and development of new bubble preparation andsizing technologies显示文摘 | Simona R Csongor S Frédéric G | 2011 | J Fluorine Chem2011，15，2： | 1 |
| 16 | Via in Vitro Cytotoxic Activities of2-Alkyl-4, 6-Diheteroalkyl-1, 3, 5-Triazines: New MoleculesinAnticancerResearch显示文摘 | Rita M Simona S Giovanni S | 2004 | JMedChem2004，47，19： | 1 |
| 17 | High chromosome instability and occasional R249S TP53 Mutation characterize hepatocellular carcinoma in Romania显示文摘 | Agnès Marchio Anna-Maria Tanase Traian Dumitrascu Mariana Mihaila Simona Dima Anne Dejean Irine Popescu Gabriela Oprisan Pascal Pineau | 2010 | Cancer Genetics and Cytogenetics2010，，1： | 1 |
| 18 | Effects of deficit irriga-tion on biomass, yield, water productivity and fruit qua-lity of processing tomato under semi - arid mediterraneanclimate conditions 显示文摘 | Cristina P Simona T Orazio S | 2011 | Scientia Horticulturae2011，129，： | 1 |
| 19 | Properties and flocculation efficiency of highly cationized starch derivatives 显示文摘 | Dirk-Oliver K Clandia L Simona S | 2006 | Starch/Starke2006，58，： | 1 |
| 20 | Cytochrome b Gene Structure and Consequences for Resistance to Qo Inhibitor Fungicides in Plant Pathogens显示文摘 | VALERIA G SIMONA P HELGE S | 2006 | Pest Manag Sci2006，62，： | 1 |
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