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| 1 | Risk stratification in symptomatic intracranial atherosclerotic disease with conventional vascular risk factors and cerebral haemodynamics显示文摘Background and purpose Symptomatic intracranial atherosclerotic stenosis(sICAS)is associated with a considerable risk of recurrent stroke despite contemporarily optimal medical treatment.Severity of luminal stenosis in sICAS and its haemodynamic significance quantified with computational fluid dynamics(CFD)models were associated with the risk of stroke recurrence.We aimed to develop and compare stroke risk prediction nomograms in sICAS,based on vascular risk factors and these metrics.Methods Patients with 50%-99%sICAS confirmed in CT angiography(CTA)were enrolled.Conventional vascular risk factors were collected.Severity of luminal stenosis in sICAS was dichotomised as moderate(50%-69%)and severe(70%-99%).Translesional pressure ratio(PR)and wall shear stress ratio(WSSR)were quantified via CTA-based CFD modelling;the haemodynamic status of sICAS was classified as normal(normal PR&WSSR),intermediate(otherwise)and abnormal(abnormal PR&WSSR).All patients received guideline-recommended medical treatment.We developed and compared performance of nomograms composed of these variables and independent predictors identified in multivariate logistic regression,in predicting the primary outcome,recurrent ischaemic stroke in the same territory(SIT)within 1 year.Results Among 245 sICAS patients,20(8.2%)had SIT.The D2H2A nomogram,incorporating diabetes,dyslipidaemia,haemodynamic status of sICAS,hypertension and age≥50 years,showed good calibration(P for Hosmer-Lemeshow test=0.560)and discrimination(C-statistic 0.73,95%CI 0.60 to 0.85).It also had better performance in risk reclassification and provided larger net benefits in decision curve analysis,compared with nomograms composed of conventional vascular risk factors only,and plus the severity of luminal stenosis in sICAS.Sensitivity analysis in patients with anterior-circulation sICAS showed similar results.Conclusions The D2H2A nomogram,incorporating conventional vascular risk factors and the haemodynamic significance of sICAS as assessed in CFD models,could be a useful tool to stratify sICAS patients for the risk of recurrent stroke under contemporarily optimal medical treatment. | Xuan Tian Hui Fang Linfang Lan Hing Lung Ip Jill Abrigo Haipeng Liu Lina Zheng Florence S Y Fan Sze Ho Ma Bonaventure Ip Bo Song Yuming Xu Jingwei Li Bing Zhang Yun Xu Yannie O Y Soo Vincent Mok Ka Sing Wong Thomas W Leung Xinyi Leng | 2023 | Stroke & Vascular Neurology2023，8，1： | 2 |
| 2 | Improved Boosting Algorithms Using Confidence-rated Predictions显示文摘 | SCHAPIRE R E SINGE Y | 1999 | Machine Learning1999，37，3： | 1 |
| 3 | Long-term outcomes of laparoscopic resection of gastric gastrointestinal stromal tumors显示文摘 | Novitsky Y W Kercher K W Sing R F | 2006 | Ann Surg2006，243，6： | 1 |
| 4 | Traffic Measurementand Vehicle Classification with a Single MagneticSensor 显示文摘 | SING Y C SINEM C BARIS D | 2005 | Journal of the Transportation ResearchBoard2005，1917，： | 1 |
| 5 | Development of dominant rice blast resistance Pi - ta gene markers 显示文摘 | Jia Y L Wang Z H Sing H P | 2002 | Crop Science2002，42，： | 1 |
| 6 | Determination of synthetic phenolic antioxidants in food items using reversed-phase HPLC显示文摘 | SAAD B SING Y Y NAWI M A | | 0，，： | 1 |
| 7 | Baicalin upregulates the genetic expression of antioxidant enzymes in Type - 2 diabetic Goto - Kakizaki rats 显示文摘 | Viduranga Y Waisundara Sing Yung Siu | 2011 | Life Sciences2011，88，2324： | 1 |
| 8 | Spousal renal donor transplantation in Chinese subjects: a 10 - year experience from a single centre 显示文摘 | SYDNEY T SING L L CHI Y L | 2004 | Nephrol Dial Transplant2004，19，： | 1 |
| 9 | Long-term outcomesoflaparoscopic resection of gastric gastrointestinal stromal tumors显示文摘 | Novitsky Y W Kercher K W Sing R F | 2009 | Ann Surg2009，243，6： | 1 |
| 10 | Long-term outcomes of laparoscopic resection of gastric gastrointestinal stromal tumors 显示文摘 | NOVITSKY Y W KERCHER K W SING R F | 2006 | Ann Surg2006，243，6： | 1 |
| 11 | Bi-directional effects on the response of an isolated bridge显示文摘 | Ghosh G Sing Y | 2009 | International Journal of Recent Trends in Engineering2009，1，6： | 1 |
| 12 | Intensity and timing options for investments in a less than perfectly competitive market显示文摘 | Chu Y Sing T F | 2004 | Madison:University of Wisconsin School of Business2004，7，9： | 1 |
| 13 | Determination of synthetic phenolic antioxidants in food items using reversedphase HPLC显示文摘 | SAM) B SING Y NAWI M A | 2006 | Food Chemistry2006，125，： | 1 |
| 14 | Cryptococcal inflammatory pseudotumors 显示文摘 | Sing Y tamdial PK | 2007 | Am J Surg Pathol2007，31，： | 1 |
| 15 | Development of dominant rice blast Pi-ta resistance gene markers显示文摘 | Jia Y Wang Z Sing P | 2002 | Crop Science2002，42，： | 1 |
| 16 | Development of dominant rice blast Pita resistance gene markers 显示文摘 | JIA Y WANG Z SING P | 2002 | Crop Science2002，42，6： | 1 |
| 17 | Long-term outcomes of laparoseopie resection of gastric gastrointestinal stromal tumors显示文摘 | Novitsky Y W Kereher K W Sing R F | 2006 | Ann Surg2006，243，6： | 1 |
| 18 | Pan-cultural explanations for lifesatisfaction:Adding relationship harmony to self--esteem显示文摘 | Bond M H Singelis T M | 1997 | Journal of Personaliy and Social Psy-chology1997，73，： | 1 |
| 19 | Determination of synthetic phenolic antioxidants in food Items using reversed-phase HPLC显示文摘 | SAAD B SING Y Y NAWI M A | 2006 | Food Chemistry2006，105，1： | 1 |
| 20 | Negative shear lag in framed-tube buildings显示文摘 | Sing Y Nagpal A K | 1994 | Journal of Structural Engineering1994，120，11： | 1 |
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