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| 1 | Extensively drug-resistant bacteria are an independent predictive factor of mortality in 130 patients with spontaneous bacterial peritonitis or spontaneous bacteremia显示文摘AIM: To evaluate the epidemiology and outcomes of culture-positive spontaneous bacterial peritonitis(SBP) and spontaneous bacteremia(SB) in decompensated cirrhosis.METHODS: We prospectively collected clinical, laboratory characteristics, type of administered antibiotic, susceptibility and resistance of bacteria to antibiotics in one hundred thirty cases(68.5% males) with positive ascitic fluid and/or blood cultures during the period from January 1, 2012 to May 30, 2014. All patients with SBP had polymorphonuclear cell count in ascitic fluid > 250/mm3. In patients with SB a thorough study did not reveal any other cause of bacteremia. The patients were followed-up for a 30-d periodfollowing diagnosis of the infection. The final outcome of the patients was recorded in the end of follow-up and comparison among 3 groups of patients according to the pattern of drug resistance was performed.RESULTS: Gram-positive-cocci(GPC) were found in half of the cases. The most prevalent organisms in a descending order were Escherichia coli(33), Enterococcus spp(30), Streptococcus spp(25), Klebsiella pneumonia(16), S. aureus(8), Pseudomanas aeruginosa(5), other Gram-negative-bacteria(GNB)(11) and anaerobes(2). Overall, 20.8% of isolates were multidrug-resistant(MDR) and 10% extensively drugresistant(XDR). Health-care-associated(HCA) and/or nosocomial infections were present in 100% of MDR/XDR and in 65.5% of non-DR cases. Meropenem was the empirically prescribed antibiotic in HCA/nosocomial infections showing a drug-resistance rate of 30.7% while third generation cephalosporins of 43.8%. Meropenem was ineffective on both XDR bacteria and Enterococcus faecium(E. faecium). All but one XDR were susceptible to colistin while all GPC(including E. faecium) and the 86% of GNB to tigecycline. Overall 30-d mortality was 37.7%(69.2% for XDR and 34.2% for the rest of the patients)(log rank, P = 0.015). In multivariate analysis, factors adversely affecting outcome included XDR infection(HR = 2.263, 95%CI: 1.005-5.095, P = 0.049), creatinine(HR = 1.125, 95%CI: 1.024-1.236, P = 0.015) and INR(HR =1.553, 95%CI: 1.106-2.180, P = 0.011).CONCLUSION: XDR bacteria are an independent lifethreatening factor in SBP/SB. Strategies aiming at restricting antibiotic overuse and rapid identification of the responsible bacteria could help improve survival. | Alexandra Alexopoulou Larisa Vasilieva Danai Agiasotelli Kyriaki Siranidi Sophia Pouriki Athanasia Tsiriga Marina Toutouza Spyridon P Dourakis | 2016 | World Journal of Gastroenterology2016，22，15： | 19 |
| 2 | No Significant Association of 14 Candidate Genes With Schizophrenia in a Large European Ancestry Sample: Implications for Psychiatric Genetics显示文摘 | Sanders Alan R Duan Jubao Levinson Douglas F Shi Jianxin He Deli Hou Cuiping Burrell Gregory J Rice John P Nertney Deborah A Olincy Ann Rozic Pablo Vinogradov Sophia Buccola Nancy G Mowry Bryan J Freedman Robert Amin Farooq Black Donald W | 2008 | The American Journal of Psychiatry2008，，4： | 1 |
| 3 | Gustatory perception alterations in obesity: An fMRI study显示文摘 | Csaba Szalay Mihály Aradi Attila Schwarcz Gergely Orsi Gábor Perlaki Lívia Németh Sophia Hanna Gábor Takács István Szabó László Bajnok András Vereczkei Tamás Dóczi József Janszky Sámuel Komoly Péter ?rs Horváth László Lénárd Zoltán Karadi | 2012 | Brain Research2012，，： | 1 |
| 4 | Maker movement spreads innovation one project at a time显示文摘 | Kylie P Sophia B | 2013 | Phi Delta Kappan2013，，3： | 1 |
| 5 | Production of activated carbon from bagasse and rice husk by a single-stage chemical activation method at low retention times显示文摘 | Dimitrios K Sophia B Panagiota P | 2008 | Bioresource Technology2008，99，： | 1 |
| 6 | The product of X-linked Kallmann's syndrome gene (KAL1) affects the migratory activity of gonadotropin-releasing hormone(GnRH)-producing neuronsHum 显示文摘 | Anna C Federica P Sophia C | 2004 | Molgenet2004，13，11： | 1 |
| 7 | Development and Structure of Drought-tolerant Leaves of the Mediterranean Shrub Capparis spinosa L显示文摘 | SOPHIA R GEORGE K P | 2003 | Annals of Botany2003，92，： | 1 |
| 8 | Environmental condition which mucoid conversion in pseudomonas aerugionosa PA01 显示文摘 | James M T Sophia E P Stephen J M | 1991 | Infect Immun1991，59，2： | 1 |
| 9 | Production of activated carbon from bagasse and rice husk by a single-stage chemical acti- vated method at low retention times 显示文摘 | Dimitrios K Sophia B Pauagiona P | 2008 | Bioresource Technology2008，99，15： | 1 |
| 10 | Triggering of TLR7 and TLR8 expressed by human lung cancer cells induces cell survival and chemoresistance显示文摘 | Julien C V Sophia P MI G | 2010 | J Clinical Investigation2010，120，4： | 1 |
| 11 | Quantitative analysis of a certified email protocol in mobile environments: A probabilistic model checking ap- proach显示文摘 | Stylianos B Sophia P Nikolaos A GeorgiosP Panagio- tis K | 2011 | Computers & Security2011，30，4： | 1 |
| 12 | Intraplearal streptokinase versas urkinase in the treatment of complicated parapneunonic effusions a prospectine doubleblind study显示文摘 | Demosthenes B Sophia S George P | 1997 | Am J Respir Crit Care Med1997，155，： | 1 |
| 13 | A liposomal formulation of doxoru- bicin, composed of hexadecylphosphocholine (HePC): physicochemical characterization and cytotoxic activity against human cancer cell lines 显示文摘 | Aristarchos P Sophia H | 2005 | Biomedi Phamracothe2005，60，： | 1 |
| 14 | Severe Hypoglycemia and Risks of Vascular Events and Death显示文摘 | Sophia Z Anushka P John C | | 0，，： | 1 |
| 15 | Fas ligand expression in thyroid follicular cells from patients with thionamide -treated Graves'disease显示文摘 | Nicholas M Vassilidi P Sophia TB | 2000 | Thyroid2000，10，7： | 1 |
| 16 | A clustering-driven medium access control protocol for WDM star networks显示文摘 | SOPHIA P G PANAGIOTIS S G GEORGIOS P I | 2009 | Optics & Laser Technology2009，41，1： | 1 |
| 17 | Protection of chickens against H5N1 highly pathogenic avian influenza virus infection by live vaccination with infectious laryngotracheitis virus recombinants expressing H5 hemagglutinin and N1 neuraminidase显示文摘 | Sophia P Pavlova Jutta Veits Günther M Keil | 2009 | Vaccine2009，27，： | 1 |
| 18 | Telomere length eariation and telomerase activity expression in patients with congenital and acquired aplastic anemia 显示文摘 | Sophia P Paraskevi K | 2004 | Acta Haematol2004，111，： | 1 |
| 19 | Protection of chickens against H5N1 highly pathogenic avian influenza virus in- fection by live vaccination with infectious laryngotracheitis virus re- combinants expressing H5 hemagglutinin and N1 neuraminidase 显示文摘 | SOPHIA P P JUTTA V GUNTHER M K | 2009 | Vaccine2009，27，： | 1 |
| 20 | Prolonged beta-catenin stabilization and tcf-dependent transcriptional activation in hyperplastic cutaneous wounds 显示文摘 | Sophia C Roon P Chunying Y | 2005 | Laboratory Investigation2005，85，： | 1 |
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