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| 1 | Collagen/hyaluronan based hydrogels releasing sulfated hyaluronan improve dermal wound healing in diabetic mice via reducing inflammatory macrophage activity显示文摘Sustained inflammation associated with dysregulated macrophage activation prevents tissue formation and healing of chronic wounds.Control of inflammation and immune cell functions thus represents a promising approach in the development of advanced therapeutic strategies.Here we describe immunomodulatory hyaluronan/collagen(HA-AC/coll)-based hydrogels containing high-sulfated hyaluronan(sHA)as immunoregulatory component for the modulation of inflammatory macrophage activities in disturbed wound healing.Solute sHA downregulates inflammatory activities of bone marrow-derived and tissue-resident macrophages in vitro.This further affects macrophage-mediated pro-inflammatory activation of skin cells as shown in skin ex-vivo cultures.In a mouse model of acute skin inflammation,intradermal injection of sHA downregulates the inflammatory processes in the skin.This is associated with the promotion of an anti-inflammatory gene signature in skin macrophages indicating a shift of their activation profile.For in vivo translation,we designed HA-AC/coll hydrogels allowing delivery of sHA into wounds over a period of at least one week.Their immunoregulatory capacity was analyzed in a translational experimental approach in skin wounds of diabetic db/db mice,an established model for disturbed wound healing.The sHA-releasing hydrogels improved defective tissue repair with reduced inflammation,augmented pro-regenerative macrophage activation,increased vascularization,and accelerated new tissue formation and wound closure. | Sophia Hauck Paula Zager Norbert Halfter Elke Wandel Marta Torregrossa Ainur Kakpenova Sandra Rother Michelle Ordieres Susann Räthel Albrecht Berg Stephanie Möller Matthias Schnabelrauch Jan C.Simon Vera Hintze Sandra Franz | 2021 | Bioactive Materials2021，6，12： | 7 |
| 2 | No Significant Association of 14 Candidate Genes With Schizophrenia in a Large European Ancestry Sample: Implications for Psychiatric Genetics显示文摘 | Sanders Alan R Duan Jubao Levinson Douglas F Shi Jianxin He Deli Hou Cuiping Burrell Gregory J Rice John P Nertney Deborah A Olincy Ann Rozic Pablo Vinogradov Sophia Buccola Nancy G Mowry Bryan J Freedman Robert Amin Farooq Black Donald W | 2008 | The American Journal of Psychiatry2008，，4： | 1 |
| 3 | Variability of global left ventricular deformation analysis using vendor dependent and independent two-dimensional speckle-tracking software in adults显示文摘 | Niels R Sophia A Niels T | 2012 | Journal of the American Society of Echocardiography2012，25，11： | 1 |
| 4 | WNT7A regulates tumor growth and progression in ovarian cancer through the WNT/β-catenin pathway显示文摘 | Yoshioka S Mandy LK Sophia R | 2012 | Mol Cancer Res2012，10，3： | 1 |
| 5 | Empathic accuracy in coach-athlete dyads who participate in team and individual sports显示文摘 | Lorimer R Sophia J | 2009 | Psychology of Sport and Exercise2009，10，： | 1 |
| 6 | Removal of Pb(ll) from aqueous solution using carbon derived from agricultural wastes 显示文摘 | SWAMINATHAN K AYYAPPAN R CARMAL1N SOPHIA A SANDHYA S | 2005 | Process Biochemistry2005，40，34： | 1 |
| 7 | Basin-scale diagenetic alteration of shoreface sandstones in the Upper Cretaceous Spring Canyon and Aberdeen Members,Blackhawk Formation,Book Cliffs,Utah显示文摘 | Taylor K G Gawthorpe R L Sophia F H | 2004 | Sedimentary Geology2004，172，： | 1 |
| 8 | Antiangiogenic forms of antithrombin specifically bind to the anticoagu lant heparin sequence 显示文摘 | Sophia SW Richard B Hjelm R | 2008 | Biochemistry2008，47，13： | 1 |
| 9 | Development and Structure of Drought-tolerant Leaves of the Mediterranean Shrub Capparis spinosa L显示文摘 | SOPHIA R GEORGE K P | 2003 | Annals of Botany2003，92，： | 1 |
| 10 | Distribution of human papillom avirus in a family planning population in nairobi, kenya显示文摘 | HUGO D SOPHIA S T LIEVE V R | 2003 | Sexually Transmitted Diseases2003，30，2： | 1 |
| 11 | Risk factors for otitis media among preschool,rural Indian children显示文摘 | Sophia A Isaac R Rebekah G | 2010 | Int J Pediatr Otorhinolaryngol2010，74，： | 1 |
| 12 | Time trends in warfarin -associated hemorrhage显示文摘 | Nils Kucher Luis R Castellanos Rene Quiroz Sophia Koo John Fanikos Samuel Z Goldhaber | 2004 | The American Journal of Cardiology2004，，3： | 1 |
| 13 | Overcoming bioanalytical challenges in an Onglyza<sup>®</sup> intravenous [<sup>14</sup>C]microdose absolute bioavailability study with accelerator MS显示文摘 | Xiaohui (Sophia) Xu Stephen R Dueker Lisa J Christopher Pete N Lohstroh Chi Fung (Anther) Keung Kai (Kevin) Cao Samuel J Bonacorsi Laura Cojocaru Jim X Shen W Griffith Humphreys Bruce Stouffer Mark E Arnold | 2012 | Bioanalysis2012，，15： | 1 |
| 14 | Amono clonal antibody that blocks VEGF binding to VEGF2(KDR/Flkl) inhibits vascular expression of Flkl and tumor growth inanorth to pic human breast cancer model显示文摘 | Wei Z Sophia R Sambe M | 2002 | Angiogenesis2002，5，12： | 1 |
| 15 | The nurse manager:Job satisfaction,the nursing shortage and retention显示文摘 | Diane R Sophia FD | | 0，，04： | 1 |
| 16 | Risk factors for otitis media among preschool, rural Indian children显示文摘 | Sophia A Isaac R Rebekah G | 2010 | Int J Pe- diatr Otorhinolaryngol2010，74，6： | 1 |
| 17 | Cellular Pathways Regulating Responses to Compatible and Self-Incompatible Pollen in Brassica and Arabidopsis Stigmas Intersect at Exo70A1, a Putative Component of the Exocyst Complex(W)显示文摘 | Samuel Marcus A Chong Yolanda T Haasen Katrina E Aldea-Brydges May Grace Stone Sophia L Goring Daphne R | 2009 | Plant Cell2009，，9： | 1 |
| 18 | A survey of adaptive dis-tributed clustering algorithms for wireless sensornetworks显示文摘 | Prabhu S R B Sophia S | 2011 | International Journal of Computer Sci-ence and Engineering2011，2，4： | 1 |
| 19 | Risk factors for otitis media among preschool, rural Indian children显示文摘 | SOPHIA A ISAA R REBEKAH G | 2010 | Int J Pediatr Otorhinolaryngol2010，74，： | 1 |
| 20 | Effect of sintering temperature on the properties and leaching of incinerator bottom ash 显示文摘 | Sophia Bethanis Cheeseman C R Sonars C J | 2004 | Waste Manage & Reaearch2004，22，： | 1 |
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