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	题名	作者	年代	出处	被引量
1	Enhanced chemosensitivity of p73α gene transferred into H1299 cell line of human lung adenocarcinoma显示文摘Objective: To study the effects of transferred wild type p73α gene on the sensitivity to the chemotherapeutic agents and the growth of p53-null H1299 cells of human lung adenocarcinoma. Methods: The pcDNA3-HA-p73α plasmid was transferred into the cultured p53-null H1299 cells of human lung adenocarcinoma with the mediation of Dosper liposome; The cells resistant to G418 were selected. The expression of p73α gene in the cells was examined with Western blot. MTT assay was used to analyze the response of the transfected cells to cis-dichlorodiamine platinum (cDDP) and adriamycin (ADM). The rate of drug-induced apoptosis of the transfected cells was determined with flow cytometry and DNA fragmentation assay. The changes of the biological behaviors were observed with colony formation assay. Results: The transfected H1299 cells of human lung adenocarcinoma over-expressed p73α protein stably. MTT assay showed that the IC 50 values of cDDP and ADM were reduced by approximately 7 fold and 130 fold respectively in the transfected cells as compared with the untransfected ones. Lower concentration of the chemotherapeutic agents (1.25 μmol/L of cDDP and 0.05 μmol/L of ADM) could be employed to suppress markedly the growth of the transfected H1299 cells. The apoptotic rate induced by cDDP was increased from 10.1% to 38 4% (P<0.01) and that of ADM from 12.1% to 49.3% (P<0.01). The clonogenecity after the administration of chemotherapeutic agents was significantly lower in the transfected H1299 cells than in the parental cells (P<0.01). The sensitive enhancement ratios were 1.8 and 2.6 for cDDP and ADM respectively. Conclusion: The transfection of H1299 cells with wild type p73α gene results in an increase of the sensitivity of the cells to chemotherapeutic agents.	何勇范士志 Kalkunte S Srivenugopal 蒋耀光秦川	2004	Journal of Medical Colleges of PLA(China)2004，19，3：	2
2	Promoter methylation and silencing of the tissue factor pathway inhibitor-2, a gene encoding an inhibitor of matrix metalloproteinases in human glioma cells显示文摘	Konduri S D Srivenugopal K S Yanamandra N	2003	Oncogene2003，22，29：	1
3	The DNA repair protein,O6-meth-ylguanine-DNA methyltransferase is a proteolytic target for the E6human papillomavirus oncoprotein显示文摘	Srivenugopal KS Ali-Osman F	2002	Oncogene2002，21，38：	1
4	Promoter methylation and silencing of the tissue factor pathway inhibitor-2, a gene encoding an inhibitor of matrix metalloproteinases in human glioma cells显示文摘	Konduri SD Srivenugopal KS Yanamandra N	2003	Oncogene2003，22，29：	1
5	Targeting MDM2 - p53 interaction for cancer therapy : Are we there yet 显示文摘	Nag S Zhang X Srivenugopal KS	2014	Cun: Med Chem2014，21，5：	1
6	The DNA repair potein O^6-methylguanine-DNA methyltransferase is a pfoteolytic target for the E6 human papillomavirus oneopmtein显示文摘	Srivenugopal KS Ali-Osman F	2002	Oncogene2002，21，38：	1
7	Conditional expression of type 2 angiotensin II receptor in rat vascular smooth muscle ceils reveals the interplay of angiotensin system in matrix metalloproteinase 2 expression and vascular remodeling显示文摘	Jing T Wang H Srivenugopal KS	2009	Int J Mol Med2009，24，1：	1
8	The DNA repair protein O6-methylguanine DNA methyltransferase is a target for the damage of human papillomavirus显示文摘	ALI-OSMAN F SRIVENUGOPAL K S	2002	Oncogene2002，21，38：	1
9	Enforced expression of wlid-type P53 curtails the transcription of the O6-methylguanine DNA methyltransferase gene in human tumor cells and enhances their sensitivity to alkylating agents显示文摘	Srivenugopal KS Shou J Mullapudi SR	2001	Clin Cancer Res2001，7，：	1
10	The DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents显示文摘	Ali-osman F Srivenugopal K Sawaya R	2001	N Engl J Med2001，344，9：	1
11	Protein phosphorylation is a regulatory mechanism for O 6-alkylguanine-DNA alkyltransferase in human brain tumor cells显示文摘	Mullapudi SR Shou J	2000	Cancer Res2000，60，2：	1
12	Conditional expression of type 2 angiotensin II receptor in rat vascular smooth muscle ceils reveals the interplay of the angiotensin system in matrix metalloproteinase 2 expression and vascular remodeLing 显示文摘	JING T WANG H SRIVENUGOPAL KS	2009	Int J Mol Med2009，24，1：	1
13	Ubiquitination-dependent proteolysis of O6-methylguanine-DNA methyltransferase in human and murine tumor cells following inactivation with O6-benzylguanine or 1,3-bis(2-chloroethyl)-1-nitrosoures显示文摘	Srivenugopal K Yuan X Friedman H		0，，04：	1
14	Ubiquitina- tion-dependent proteolysis of O6-methylguanine-DNA methyl- transferase in human and murine tumor cells following inactivation with O6-benzylguanine or 1,3-bis(2-chloroethyl)- 1-nitrosourea显示文摘	Srivenugopal KS Yuan XH Friedman HS	1996	Biochemistry1996，35，4：	1
15	Conditional expression of type 2 angiotensin U receptor in rat vascular smooth muscle cells reveals the interplay of the angiotensin system in matrix metalloproteinase 2 expression and vascular remodeling显示文摘	Jing T Wang H Srivenugopal K S	2009	Int J Mol Med2009，24，1：	1
16	Degradation of NF-KB, p53 and other regulatory redox- sensitive proteins by thiolconjugating and nitrosylating drugs in human tumor cells 显示文摘	AMEYA PARANJPE KALKUNTE S SRIVENUGOPAL	2013	Carcinogenesis2013，34，5：	1
17	Promoter methylation and silencing of the tissue factor pathway inhibitor-2, a gene encoding an inhibitor of matrix metallopro- teinases in human glioma cells 显示文摘	Konduri S D Srivenugopal K S Yanamandra N	2003	Oncogene2003，22，29：	1
18	Conditional expression of type 2 angiotensin II receptor in rat vascular smooth muscle cells reveals the interplay of the angiotensin system in matrix metaUoproteinase 2 expression and vascular remodeling 显示文摘	Jing T Wang H Srivenugopal K S	2009	Int J Mol Med2009，24，1：	1
19	Oral delivery of low-molecular-weight heparin using sodium caprate as absorption enhancer reaches therapeutic levels显示文摘	Motlekar N A Srivenugopal K S Wachtel M S et a l	2005	J Drug Target2005，13，10：	1
20	Pro moter methylation and silencing of the tissue factor pathway inhibitor-2, a gene encoding an inhibitor of matrix metalloproteinases in human glioma cells显示文摘	Konduri SD Srivenugopal KS Yanamandra N	2003	Oneogene2003，22，：	1

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