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| 1 | Performance of Transient Elastography for the Staging of Liver Fibrosis: A Meta-Analysis显示文摘 | Mireen Friedrich–Rust Mei–Fang Ong Swantje Martens Christoph Sarrazin Joerg Bojunga Stefan Zeuzem Eva Herrmann | 2008 | Gastroenterology2008，，4： | 6 |
| 2 | Decoding altitude-activated regulatory mechanisms occurring during apple peel ripening显示文摘Apple(Malus domestica Borkh)is an important fruit crop cultivated in a broad range of environmental conditions.Apple fruit ripening is a physiological process,whose molecular regulatory network response to different environments is still not sufficiently investigated and this is particularly true of the peel tissue.In this study,the influence of environmental conditions associated with low(20 m)and high(750 m)altitude on peel tissue ripening was assessed by physiological measurements combined with metabolomic and proteomic analyses during apple fruit development and ripening.Although apple fruit ripening was itself not affected by the different environmental conditions,several key color parameters,such as redness and color index,were notably induced by high altitude.Consistent with this observation,increased levels of anthocyanin and other phenolic compounds,including cyanidin-3-O-galactoside,quercetin-3-O-rhamnoside,quercetin-3-O-rutinoside,and chlorogenic acid were identified in the peel of apple grown at high altitude.Moreover,the high-altitude environment was characterized by elevated abundance of various carbohydrates(e.g.,arabinose,xylose,and sucrose)but decreased levels of glutamic acid and several related proteins,such as glycine hydroxymethyltransferase and glutamate–glyoxylate aminotransferase.Other processes affected by high altitude were the TCA cycle,the synthesis of oxidative/defense enzymes,and the accumulation of photosynthetic proteins.From the obtained data we were able to construct a metabolite-protein network depicting the impact of altitude on peel ripening.The combined analyses presented here provide new insights into physiological processes linking apple peel ripening with the prevailing environmental conditions. | Evangelos Karagiannis Michail Michailidis Georgia Tanou Federico Scossa Eirini Sarrou George Stamatakis Martina Samiotaki Stefan Martens Alisdair R.Fernie Athanassios Molassiotis | 2020 | Horticulture Research2020，7，1： | 3 |
| 3 | Major-effect candidate genes identified in cultivated strawberry(Fragaria×ananassa Duch.)for ellagic acid deoxyhexoside and pelargonidin-3-O-malonylglucoside biosynthesis,key polyphenolic compounds显示文摘Strawberries are rich in polyphenols which impart health benefits when metabolized by the gut microbiome,including anti-inflammatory,neuroprotective,and antiproliferative effects.In addition,polyphenolic anthocyanins contribute to the attractive color of strawberry fruits.However,the genetic basis of polyphenol biosynthesis has not been extensively studied in strawberry.In this investigation,ripe fruits from three cultivated strawberry populations were characterized for polyphenol content using HPLC-DAD-MSn and genotyped using the iStraw35k array.GWAS and QTL analyses identified genetic loci controlling polyphenol biosynthesis.QTL were identified on four chromosomes for pelargonidin-3-O-malonylglucoside,pelargonidin-3-O-acetylglucoside,cinnamoyl glucose,and ellagic acid deoxyhexoside biosynthesis.Presence/absence of ellagic acid deoxyhexoside and pelargonidin-3-O-malonylglucoside was found to be under the control of major gene loci on LG1X2 and LG6b,respectively,on the F.×ananassa linkage maps.Interrogation of gene predictions in the F.vesca reference genome sequence identified a single candidate gene for ellagic acid deoxyhexoside biosynthesis,while seven malonyltransferase genes were identified as candidates for pelargonidin-3-O-malonylglucoside biosynthesis.Homologous malonyltransferase genes were identified in the F.×ananassa‘Camarosa’genome sequence but the candidate for ellagic acid deoxyhexoside biosynthesis was absent from the‘Camarosa’sequence.This study demonstrated that polyphenol biosynthesis in strawberry is,in some cases,under simple genetic control,supporting previous observations of the presence or absence of these compounds in strawberry fruits.It has also shed light on the mechanisms controlling polyphenol biosynthesis and enhanced the knowledge of these biosynthesis pathways in strawberry.The above findings will facilitate breeding for strawberries enriched in compounds with beneficial health effects. | Jahn Davik Kjersti Aaby Matteo Buti Muath Alsheikh NadaŠurbanovski Stefan Martens Dag Røen Daniel James Sargent | 2020 | Horticulture Research2020，7，1： | 2 |
| 4 | Low serum neutralizing anti-SARS-CoV-2 S antibody levels in mildly affected COVID-19 convalescent patients revealed by two different detection methods显示文摘Neutralizing antibodies targeting the receptor-binding domain(RBD)of the SARS-CoV-2 spike(S)block severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)entry into cells via surface-expressed angiotensin-converting enzyme 2(ACE2).We used a surrogate virus neutralization test(sVNT)and SARS-CoV-2 S protein-pseudotyped vesicular stomatitis virus(VSV)vector-based neutralization assay(pVNT)to assess the degree to which serum antibodies from coronavirus disease 2019(COVID-19)convalescent patients interfere with the binding of SARS-CoV-2 S to ACE2.Both tests revealed neutralizing anti-SARS-CoV-2 S antibodies in the sera of ~90% of mildly and 100% of severely affected COVID-19 convalescent patients.Importantly,sVNT and pVNT results correlated strongly with each other and to the levels of anti-SARS-CoV-2 S1 IgG and IgA antibodies.Moreover,levels of neutralizing antibodies correlated with the duration and severity of clinical symptoms but not with patient age.Compared to pVNT,sVNT is less sophisticated and does not require any biosafety labs.Since this assay is also much faster and cheaper,sVNT will not only be important for evaluating the prevalence of neutralizing antibodies in a population but also for identifying promising plasma donors for successful passive antibody therapy. | Berislav Bosnjak Saskia Catherina Stein Stefanie Willenzon Anne Katrin Cordes Wolfram Puppe Gunter Bernhardt Inga Ravens Christiane Ritter Christian R.Schultze-Florey Nina Godecke Jorg Martens Hannah Kleine-Weber Markus Hoffmann Anne Cossmann Mustafa Yilmaz Isabelle Pink Marius M.Hoeper Georg M.N.Behrens Stefan Pohlm ann Rainer Blasczyk Thomas F.Schulz Reinhold Forster | 2021 | Cellular & Molecular Immunology2021，18，4： | 2 |
| 5 | Modification of flower color and fragrance by antisense suppression of the flavanone 3-hydroxylase gene显示文摘 | Amir Zuker Tzvi Tzfira Hagit Ben-Meir Marianna Ovadis Elena Shklarman Hanan Itzhaki Gert Forkmann Stefan Martens Inbal Neta-Sharir David Weiss Alexander Vainstein | 2002 | Molecular Breeding2002，，1： | 1 |
| 6 | Modification of flower color and fragrance by antisense suppression of the flavanone 3-hydroxylase gene显示文摘 | Amir Zuker Tzvi Tzfira Hagit Ben-Meir Marianna Ovadis Elena Shklarman Hanan Itzhaki Gert Forkmann Stefan Martens Inbal Neta-Sharir David Weiss Alexander Vainstein | 2002 | Molecular Breeding2002，，1： | 1 |
| 7 | Modification of flower color and fragrance by antisense suppression of the flavanone 3-hydroxylase gene显示文摘 | Amir Zuker Tzvi Tzfira Hagit Ben-Meir Marianna Ovadis Elena Shklarman Hanan Itzhaki Gert Forkmann Stefan Martens Inbal Neta-Sharir David Weiss Alexander Vainstein | 2002 | Molecular Breeding2002，，1： | 1 |
| 8 | Flavones and flavone synthase显示文摘 | Stefan Martens Axel Mithofer | 2005 | Phytochemistry2005，66，20： | 1 |
| 9 | Synthesis and shape-selective properties of ZSM-22 显示文摘 | Stefan Ernst Jens Weitkamp Johan A Martens | 1989 | Applied Catalysis1989，48，： | 1 |
| 10 | (MC2) 2: criteria, re- quirements and a software prototype for cloud infrastruc- ture decisions 显示文摘 | Michael M Marten S Stefan T | 2011 | Software: Practice and Experience2011，43，11： | 1 |
| 11 | Upgraded Biogasfor Transport in Sweden-effects of Policy Instruments on Produc-tion ,Infrastructure Deployment and Vehicle Sales 显示文摘 | Marten Larsson Stefan Gronkvist Per Alvfors | 2016 | Journal ofCleaner Production2016，112，5： | 1 |
| 12 | Effects of a fulvic acid on the adsorption of mercury and cadmium on goethite 显示文摘 | Mattias Backstrom Marten Dario Stefan Karlsson | 2003 | The Science of The Total Environment2003，304，： | 1 |
| 13 | Molecular characterization of circulating tumor cells in large quantities of contaminating leukocytes by a multiplex real-time PCR显示文摘 | Anieta M. Sieuwerts Jaco Kraan Joan Bolt-de Vries Petra Spoel Bianca Mostert John W. M. Martens Jan-Willem Gratama Stefan Sleijfer John A. Foekens | 2009 | Breast Cancer Research and Treatment2009，，3： | 1 |
| 14 | Flavones and flavone synthases显示文摘 | STEFAN MARTEN AXEL MITHOFER | 2005 | Phytochemistry2005，66，： | 1 |
| 15 | Metabolic engineering and ap-plications of flavonoids显示文摘 | Gert Forkmann Stefan Martens | 2001 | Elsevier Science Ltd2001，12，2： | 1 |
| 16 | Synthe- sis and shape-selective properties of ZSM-22 显示文摘 | Ernst Stefan Weitkamp Jens Martens Johan A | 1989 | Applied Catalysis1989，48，： | 1 |
| 17 | Effects of a fulvic acid on the adsorption of mercury and cadmium on goethite 显示文摘 | Mattias Backstrom Marten Dario Stefan Karlsson | 2003 | The Science of the Total Environment2003，304，13： | 1 |
| 18 | Performance of Transient Elastography for the Staging of Liver Fibrosis: A Meta-Analysis显示文摘 | Mireen Friedrich–Rust Mei–Fang Ong Swantje Martens Christoph Sarrazin Joerg Bojunga Stefan Zeuzem Eva Herrmann | 2008 | Gastroenterology2008，，4： | 1 |
| 19 | Metabolic engineering and applications of flavonoids显示文摘 | Gert Forkmann Stefan Martens | 2001 | Current Opinion in Biotechnology2001，，2： | 1 |
| 20 | Performance of Transient Elastography for the Staging of Liver Fibrosis: A Meta-Analysis显示文摘 | Mireen Friedrich–Rust Mei–Fang Ong Swantje Martens Christoph Sarrazin Joerg Bojunga Stefan Zeuzem Eva Herrmann | 2008 | Gastroenterology2008，，4： | 1 |
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