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| 1 | Evaluation of the anti-diabetic properties of Mucuna pruriens seed extract显示文摘Objective:To explore the antidiabetic properties of Mucuna pruriens(M.pruriens).Methods: Diabetes was induced in Wistar rats by single intravenous injection of 120 mg/kg of alloxan monohydrate and different doses of the extract were administered to diabetic rats.The blood glucose level was determined using a glucometer and results were compared with normal and untreated diabetic rats.The acute toxicity was also determined in albino mice.Results:Results showed that the administration of 5,10,20,30,40,50,and 100 mg/kg of the crude ethanolic extract of M.pruriens seeds to alloxan-induced diabetic rats(plasma glucose > 450 mg/dL) resulted in 18.6%,24.9%,30.8%,41.4%,49.7%,53.1%and 55.4%reduction,respectively in blood glucose level of the diabetic rats after 8h of treatment while the administration of glibenclamide (5 mg/kg/day) resulted in 59.7%reduction.Chronic administration of the extract resulted in a significant dose dependent reduction in the blood glucose level(P<0.001).It also showed that the antidiabetic activity of M.pruriens seeds resides in the methanolic and ethanolic fractions of the extract.Acute toxicity studies indicated that the extract was relatively safe at low doses,although some adverse reactions were observed at higher doses(8-32 mg/kg body weight),no death was recorded.Furthermore,oral administration of M.pruriens seed extract also significandy reduced the weight loss associated with diabetes.Conclusions:The study clearly supports the traditional use of M.pruriens for the treatment of diabetes and indicates that the plant could be a good source of potent antidiabetic drug. | Stephen O Majekodunmi Ademola A Oyagbemi Solomon Umukoro Oluwatoyin A Odeku | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，8： | 8 |
| 2 | Slowing Production Deline and Extending the Economic Life of an Oil Field:New MEOR Technology 显示文摘 | Brown L R Vadie A A Stephens J O | | SPE0，，： | 2 |
| 3 | The effect of O-methylation on chemical shifts in the ^1H-NMR and ^13C-NMR spectra of cyclic polyols 显示文摘 | STEPHEN J A LEON O | 1983 | Carbohydrate Research1983，123，： | 1 |
| 4 | Deriving value from social commerce networks 显示文摘 | Stephen A T Toubia O | 2010 | Journal of Marketing Re- search2010，47，2： | 1 |
| 5 | Dihydrofluorescein diacetate is superior for detecting intracellular oxidants: comparison with 2′,7′-dichlorodihydrofluorescein diacetate, 5(and 6)-carboxy-2′,7′-dichlorodihydrofluorescein diacetate, and dihydrorhodamine 123显示文摘 | Stephen L Hempel Garry R Buettner Yunxia Q O’Malley Duane A Wessels Dawn M Flaherty | 1999 | Free Radical Biology and Medicine1999，，1： | 1 |
| 6 | Assessment of weed species composition and species diversity in some fruit orchards显示文摘 | Patience O Stephen T Olawale A | 2013 | Albanian Journal of Agricultural Sciences2013，12，2： | 1 |
| 7 | Explaining the power - law degree distribu- tion in a social commerce network 显示文摘 | Stephen A T Toubia O | 2009 | Social Networks2009，31，4： | 1 |
| 8 | Deriving Value from Social Commerce Networks 显示文摘 | Stephen A T Toubia O | 2010 | Journal of Marketing Research2010，47，2： | 1 |
| 9 | Optimal annual routines: New tools forconservation biology? 显示文摘 | Fer6 O Stephens P A Barta Z Parkhurst D F (Ed) | 2008 | Ecological Applications2008，18，6： | 1 |
| 10 | Microbial population changes during bioremediation of an experimental oil spill显示文摘 | Macnaughton S J Stephen J R Venosa A O | 1999 | Appl Environ Microbiol1999，65，35： | 1 |
| 11 | ABO Blood Group Phenotypes and Plasmodium falciparum Malaria: Unlocking a Pivotal Mechanism显示文摘 | María‐Paz Loscertales Stephen Owens James O'Donnell James Bunn Xavier Bosch‐Capblanch Bernard J. Brabin | 2007 | Advances in Parasitology2007，，： | 1 |
| 12 | A new strategy for harnessing knowledge management in e-commerce显示文摘 | STEPHEN A O DAVID C Y JEFFREY W M | 2005 | Technology in Society2005，27，： | 1 |
| 13 | Rationally designed inhibitors identify STAT3 N-do- main as a promising anticancer drug target 显示文摘 | TIMOFEEVA O A VADIM G STEPHEN J L | 2007 | ACS Chemical Biology2007，2，12： | 1 |
| 14 | Nitrogen cycling in the soil-plant system along a precipitation gradient in the Kalahari sands显示文摘 | Julieta N A Luanne O Stephen A M | 2004 | Global Change Biology2004，10，： | 1 |
| 15 | Weed and crop allelopathy显示文摘 | Weston Leslie A Duck Stephen O | 2003 | Critical Reviews in Plant Science2003，22，34： | 1 |
| 16 | Molecular genetic diversity and evolution at the MHC DQB locus in four species of pinnipeds 显示文摘 | Hoelzel A R Stephens J C O'Brien S J | 1999 | Molecular Biology and Evolution1999，16，5： | 1 |
| 17 | The Proapoptotic Activity of the Bcl-2 Family Member Bim Is Regulated by Interaction with the Dynein Motor Complex显示文摘 | Hamsa Puthalakath David C.S Huang Lorraine A O’Reilly Stephen M King Andreas Strasser | 1999 | Molecular Cell1999，，3： | 1 |
| 18 | Book rate-of-return and prediction of earnings changes: an empirical investigation显示文摘 | ROBERT N F JAMES A O STEPHEN H P | 1982 | Journal of Accounting Research1982，20，： | 1 |
| 19 | Molecular genetic diversity and evolution at the MHC DQB locus in four species of pinnipeds显示文摘 | Hoelzel A R Stephens J C O'Brien S J | 1999 | Molecular Biology and Evolution1999，16，： | 1 |
| 20 | Al- lergen immunotherapy for house dust mite:clinical efficacy and immunological mechanisms in allergic rhinitis and asthma 显示文摘 | Aarif O Eifan Moises A Calderon Stephen R Durham | 2013 | Expert Opin Biol Ther2013，13，11： | 1 |
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