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| 1 | 在 7T 的多原子的磁性的回声光谱学的应用显示文摘 AIM: To discuss the advantages of ultra-high field (7T) for 1H and 13C magnetic resonance spectroscopy (MRS) studies of metabolism.made at both 3 and 7T using 1H MRS. Measurements of glycogen and lipids in muscle were measured using 13C and 1H MRS respectively. RESULTS: In the brain, increased signal-to-noise ratio (SNR) and dispersion allows spectral separation of the amino-acids glutamate, glutamine and γ-aminobutyric acid (GABA), without the need for sophisticated editing sequences. Improved quantification of these me-tabolites is demonstrated at 7T relative to 3T. SNR was 36% higher, and measurement repeatability (% coefficients of variation) was 4%, 10% and 10% at 7T, vs 8%, 29% and 21% at 3T for glutamate, glutamine and GABA respectively. Measurements at 7T were used to compare metabolite levels in the anterior cingulate cortex (ACC) and insula. Creatine and glutamate levels were found to be significantly higher in the insula compared to the ACC (P < 0.05). In muscle, the increased SNR and spectral resolution at 7T enables interleaved studies of glycogen (13C) and intra-myocellular lipid (IMCL) and extra-myocellular lipid (EMCL) (1H) following exercise and refeeding. Glycogen levels were sig-nificantly decreased following exercise (-28% at 50% VO2 max; -58% at 75% VO2 max). Interestingly, levels of glycogen in the hamstrings followed those in the quadriceps, despite reduce exercise loading. No changes in IMCL and EMCL were found in the study. CONCLUSION: The demonstrated improvements in brain and muscle MRS measurements at 7T will increase the potential for use in investigating human metabolism and changes due to pathologies. | Mary C Stephenson Frances Gunner Antonio Napolitano Paul L Greenhaff Ian A MacDonald Nadeem Saeed William Vennart Susan T Francis Peter G Morris | 2011 | World Journal of Radiology2011，3，4： | 2 |
| 2 | Performance of floating and sunken media biological aerated filters under unsteady state conditions显示文摘 | Mann A T Mendoza-Espinosa L Stephenson T | 1999 | Water Research1999，33，4： | 1 |
| 3 | Repetitive functionalization of water-soluble single-walled carbon nanotubes: Addition of acid-sensitive addends 显示文摘 | Stephenson J J Hudson J L Leonard A D | 2007 | Chem-istry of Materials2007，19，14： | 1 |
| 4 | Life-cy- cle Assessment of Potential Algal Biodiesel Production in the United Kingdom:A Comparison of Raceways and Air-lift Tubular Bioreactors显示文摘 | STEPHENSON A L KAZAMIA E DENNIS J S | 2010 | Energy & Fuels2010，24，7： | 1 |
| 5 | High-resolution ^13C CP/MAS NMR spectra of solid cellulose oligomers and the structure of cellulose II显示文摘 | DUDLEY R L FYFE C A STEPHENSON P J | 1983 | Journal of the American Chemical Society1983，105，8： | 1 |
| 6 | A comparison of floating and sunken media biological aerated filters for nitrification 显示文摘 | Mann A Mendoza-Espinosa L Stephenson T | 1998 | Journal of Chemical Technology and Biotechnology1998，72，3： | 1 |
| 7 | Glutathione conjugation: a detoxification pathway for fenoxapropethyl in barley, crabgrass, oat and wheat显示文摘 | TAL J A ROMANO M L STEPHENSON G R | 1993 | Pestic Biochem Physiol1993，46，： | 1 |
| 8 | Mycorrhizae form Denali National Park and Reserve, Alaska 显示文摘 | Treu R Laursen G A Stephenson S L | 1996 | Mycorrhiza1996，6，： | 1 |
| 9 | C-Clbond fission,HCl elimination,and secondary radical decomposition in the 193 nm photodissociation of allyl chloride显示文摘 | Morton M L Butler L J Stephenson T A | 2002 | Journal of Chemical Physics2002，116，： | 1 |
| 10 | Improvement of surface flatness in face milling based on 3-D holographic laser metrology显示文摘 | Tai B L Stephenson D A Shih A J | 2011 | International Journal of Machine Tools&Manufacture2011，51，6： | 1 |
| 11 | Modulation of monocyte function by activated protein C,a natural anticoagulant显示文摘 | Stephenson D A Toltl L J Beaudin S | 2006 | J Immunol2006，177，4： | 1 |
| 12 | Netol as- sociates with the NMDA reeeptor/amyloid precur- sor protein complex显示文摘 | Cousins S L Innocent N Stephenson F A | 2013 | Journal of Neuroehemistry2013，126，5： | 1 |
| 13 | Identification of Reaction Products From Phosphate Fertilizers in Soils 显示文摘 | LINDSAY W L FRAZIER A W STEPHENSON H F | 1962 | Soil Science Society of America Proceedings1962，26，5： | 1 |
| 14 | Performance of floating and sunken media biological aerated filters under unsteady state conditions 显示文摘 | MANN A T MENDOZA - ESPINOSA L STEPHENSON T | 1999 | Wat Res1999，33，4： | 1 |
| 15 | Global maintrition 显示文摘 | Stephenson L S Lathean M C Ottesen E A | 2000 | Parasitology2000，，121： | 1 |
| 16 | Performance of floating and sunken media biological aerated filters under unsteady state conditions 显示文摘 | Mann A T Mendoza-Espinosa L Stephenson T | 1999 | Water Res1999，33，4： | 1 |
| 17 | Life- cycle assessment of potential algal biodiesel produc- tion in the United Kingdom: A comparison of race- ways and air-lift tubular bioreactors显示文摘 | Stephenson A L Kazamia E Dennis J S etal | 2010 | Energ Fuel2010，24，： | 1 |
| 18 | Cellular proliferative Fraction of metastatic lymph Nodes predicts survival in stage D1(TxN+M0)Prostate cancer显示文摘 | Cher M L Robert A Stephenson Brent C | 1996 | J Urology1996，155，5： | 1 |
| 19 | NMR magnetic dipolar spectral density functions for two-dimensional lattice diffusion 显示文摘 | Stephenson P C L Sholl C A | 1993 | J Phys : Condens Matter1993，5，7： | 1 |
| 20 | Effect of molasses, sodium bentonite and zealot on urea toxicity 显示文摘 | Stephenson R G A Huff J L Krebs G | 1992 | Austr J Agric Res1992，43，2： | 1 |
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