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| 1 | Increased susceptibility for intrahepatic cholestasis of pregnancy and contraceptive-induced cholestasis in carriers of the 1331T>C polymorphism in the bile salt export pump显示文摘AIM: To study the association of three common ABCB11 and ABCC2 polymorphisms (ABCB11: 1331T>C V444A; ABCC2: 3563T>A V1188E and 4544G>A C1515Y) with intrahepatic cholestasis of pregnancy (ICP) and contraceptive-induced cholestasis (CIC). METHODS: ABCB11 and ABCC2 genotyping data were available from four CIC patients and from 42 and 33 ICP patients, respectively. Allele-frequencies of the studied polymorphisms were compared with those in healthy pregnant controls and Caucasian individuals. Furthermore, serum bile acid levels were correlated with the presence or absence of the 1331 C allele.RESULTS: The ABCB11 1331T>C polymorphism was significantly more frequent in cholestatic patients than in pregnant controls: C allele 76.2% (CI, 58.0-94.4) vs 51.3% (CI 35.8-66.7), respectively (P = 0.0007); and CC allele 57.1% (CI 36.0-78.3) vs 20% (CI 7.6-32.4), respectively (P = 0.0065). All four CIC patients were homozygous carriers of the C allele. In contrast, none of the studied ABCC2 polymorphism was overrepresented in ICP or CIC patients. Higher serum bile acid levels were found in carriers of the 1331CC genotype compared to carriers of the TT genotype.CONCLUSION: Our data support a role for the ABCB11 1331T>C polymorphism as a susceptibility factor for the ←←← development of estrogen-induced cholestasis, whereas no such association was found for ABCC2. Serum bile acid and γ-glutamyl transferase levels might help to distinguish ABCB4- and ABCB11-related forms of ICP and CIC. | Yvonne Meier Tina Zodan Carmen Lang Roland Zimmermann Gerd A Kullak-Ublick Peter J Meier Bruno Stieger Christiane Pauli-Magnus | 2008 | World Journal of Gastroenterology2008，14，1： | 20 |
| 2 | 镁合金压铸笔记本电脑外壳显示文摘 | Heinz Stieger | 2000 | 特种铸造及有色合金2000，20，z1： | 4 |
| 3 | Physiological and Biochemical Basis of Clinical Liver Function Tests: A Review显示文摘 | Lisette T. Hoekstra Wilmar de Graaf Geert A. A. Nibourg Michal Heger Roelof J. Bennink Bruno Stieger Thomas M. van Gulik | 2013 | Annals of Surgery2013，，1： | 3 |
| 4 | Structure of human NTCP reveals the basis of recognition and sodium-driven transport of bile salts into the liver显示文摘Dear Editor,The sodium taurocholate(TC)co-transporting polypeptide NTCP(SLC10A1)is a secondary active membrane transport protein that mediates the uptake of bile salts from the portal blood plasma into the cytoplasm of liver cells.NTCP was originally cloned from rat and demonstrated to be localized in the basolateral membrane.1 Its activity is a key component of bile acid homeostasis and enterohepatic circulation of bile salts(Fig.1a),a process that includes at least three additional transporter proteins,namely BSEP,ASBT and OSTα/β.2,3 In addition to its role in mediating bile salt uptake,NTCP also serves as the receptor of the human hepatitis B and D viruses.4 The mechanism by which NTCP recognizes and transports bile salts is not understood,in part because no structural insight into the interaction of NTCP with its substrates is available.While recent studies reported structures of NTCP bound to inhibitory nanobodies5 or Fab fragments,6,7 no substrate-binding pockets were identified. | Hongtao Liu Rossitza N.Irobalieva Rose Bang-Sørensen Kamil Nosol Somnath Mukherjee Parth Agrawal Bruno Stieger Anthony A.Kossiakoff Kaspar P.Locher | 2022 | Cell Research2022，32，8： | 2 |
| 5 | Genetic variations of bile salt transporters as predisposing factors for drug-induced cholestasis, intrahepatic cholestasis of pregnancy and therapeutic response of viral hepatitis 显示文摘 | Stieger B Geier A | 2011 | Expert Opin Drug Metab Toxicol2011，7，4： | 1 |
| 6 | Hepatocyte transplantation;potentioal of hepatocyte progenitor cells and bone marrow deriverd stem cells显示文摘 | Stieger B Peters R Sidler MA | 2006 | Swiss Med Wkly2006，136，3536： | 1 |
| 7 | The fracture of particulate-filled epoxide resins显示文摘 | MOLONEY A.C KAUSCH H.H STIEGER H.R | | 0，，04： | 1 |
| 8 | Genetic determinants of drug-induced cholestasis and intrahepatic cholestasis of pregnancy显示文摘 | Pauli-Magnus C Meier PJ Stieger B | | 0，，02： | 1 |
| 9 | Effect of NaCl and sucrose tastants on protein composition of oral fluid analysed by SEL- DI-TOF-MS显示文摘 | Silletti E Bult J H Stieger M | 2012 | Arch Oral Biol2012，57，9： | 1 |
| 10 | The dorsal tangential X-ray view to determine dorsal screw penetration during volar plating of distal radius fractures显示文摘 | Brtmner A Siebert C Stieger C | 2015 | J Hand Surg Am2015，40，1： | 1 |
| 11 | Gender difference in the Oatp1-mediated tubular reabsorption of estradiol 17beta-D-glucuronide in rats显示文摘 | GOTOH Y KATO Y STIEGER B | 2002 | Am J Physiol Endocrinol Metab2002，282，6： | 1 |
| 12 | Genetic variations of bile salt transporters as predisposing factors for drug-induced cholestasis,intrahepatic cholestasis of pregnancy and therapeutic response of viral hepatitis显示文摘 | Stieger B Geier A | | 0，，04： | 1 |
| 13 | The sister of P-glycoprotein represents the canalicular bile salt export pump of mammalion liver显示文摘 | Stieger b Hagenbuch B | 1998 | Biol Chem1998，273，10： | 1 |
| 14 | The auxin influx carrier is essential for correct leaf positioning显示文摘 | Stieger P.A Reinhardt D Kuhlemeier C | | 0，，04： | 1 |
| 15 | The role of metabolic and haemodynamic factors in podocyte injury in diabetes显示文摘 | Stieger N Worthmann N Schiffer M | 2011 | Diabe tes Metab Res Rev2011，27，： | 1 |
| 16 | The rise of reticulated platelets after intensive chemotherapy for AML reduces the need for platelet transfusions 显示文摘 | Stohlawetz P Stieger G Knobl P | 1999 | Annals of Hematology1999，78，6： | 1 |
| 17 | Enterohepatic bilesalt trans- porters in norm al physiology and liver disease显示文摘 | Kullakublick GA Stieger B Meier PJ | 2004 | Gastroenterology2004，126，1： | 1 |
| 18 | A common polymorphism in the AB-CB11 gene is associated with advanced fibrosis in hepatitis C but not in non-alcoholic fatty liver disease显示文摘 | Iwata R Baur K Stieger B | | 0，，： | 1 |
| 19 | Small-angle neutron scattering study of structural changes in temperature sensitive microgel colloids显示文摘 | Stieger M Richtering W Pedersen JS | 2004 | J Chem Phys2004，120，13： | 1 |
| 20 | Saltiness reduction in bread by inhomogeneous spatial distribution of sodium chloride 显示文摘 | NOORT M W J BULT J H F STIEGER M | 2010 | Journal of Cereal Science2010，52，3： | 1 |
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