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| 1 | Femtosecond laser-mediated anchoring of polymer layers on the surface of a biodegradable metal显示文摘Mg has received much attention as a next-generation implantable material owing to its biocompatibility,bone-like mechanical properties,and biodegradability in physiological environments.The application of various polymer coatings has been conducted in the past to reduce the rapid formation of hydrogen gas and the local change in pH during the initial phase of the chemical reaction with the body fluids.Here,we propose femtosecond(fs)laser-mediated Mg surface patterning for significant enhancement of the binding strength of the coating material,which eventually reduces the corrosion rate.Analyses of the structural,physical,crystallographic,and chemical properties of the Mg surface have been conducted in order to understand the mechanism by which the surface adhesion increases between Mg and the polymer coating layer.Depending on the fs laser conditions,the surface structure becomes rough owing to the presence of several microscaled pits and grooves of nanoporous MgO,resulting in a tightly bonded poly(lactic-co-glycolic acid)(PLGA)layer.The corrosion rate of the PLGA-coated,fs laser-treated Mg is considerably slow compared with the non-treated Mg;the treated Mg is also more biocompatible compared with the non-treated Mg.The fs laser-based surface modification technique offers a simple and quick method for introducing a rough coating on Mg;further,it does not require any chemical treatment,thereby overcoming a potential obstacle for its clinical use. | Jaeho Park Bo-In Park Young Ju Son Sun Hee Lee Seung-Hoon Um Yu-Chan Kim Myoung-Ryul Ok Jeong-Yun Sun Hyung-Seop Han Hojeong Jeon | 2021 | Journal of Magnesium and Alloys2021，9，4： | 2 |
| 2 | Bioconversion of Linoleic acid into conjugated linoleic acid dureri显示文摘 | Sun Ok Lee Chang Sup Kim Cho Ha Jong Choi | 2003 | Biotechnology Letters2003，25，： | 1 |
| 3 | Role of Phe-99 and Trp-196 of sepiapterin reductase from Chlorobium tepidum in the production of L-threo-tetrahydrobiopterin显示文摘从 Chlorobium 的 Sepiapterin reductase 微温嗯(cSR ) 催化不同 tetrahydrobiopterin (BH4 ) 的合成, L-threo-BH4,与哺乳动物的酶产品不同。cSR 的 3-D 水晶结构表明了产品配置由在保存得好的催化三个一组以内的底层绑定模式完全是坚定的。在 cSR, sepiapterin 在 Phe-99 和 Trp-196 的二芳香的侧链之间被叠并且旋转在从在老鼠 sepiapterin reductase 的位置的活性部位附近的约 180 度。在底层绑定证实他们的角色,我们变异 Phe-99 或 Trp-196 到丙氨酸(F99A, W196A ) 由指导地点的傻瓜发育不全和由动力学分析和微分扫描热量测定的净化的蛋白质的比较地检验的底层绑定。这些异种比野类型有更高的 K-m 价值。显著地, W196A 变化与 F99A 变化相比导致了更高的 K-m 增加。与结果一致,融化的温度(T-m ) 在变异的蛋白质面对 sepiapterin 是更低的,最糟是 W196A。这些调查结果显示二残余为在 cSR 的底层绑定是不可缺少的,并且 Trp-196 是比为不同立体异构生产的 Phe-99 更重要的。 | Supangat Sun Ok Park Kyung Hye Seo Sang Yeol Lee Young Shik Park Kon Ho Lee | 2008 | Acta Biochimica et Biophysica Sinica2008，40，6： | 1 |
| 4 | Prediction on the chiral behaviors of drugs with amine moiety on the chiral cellobiohy- drolase stationary phase using a partial least square method 显示文摘 | Sun Ok Choi Seok Ho Lee Hea-Young | 2004 | Archives of Pharmacal Re- search2004，10，： | 1 |
| 5 | Upregulation of phytosterol and triterpene biosynthesis in Centella asiatica hairy roots overexpressed ginseng farnesyl diphosphate synthase显示文摘 | Ok Tae Kim Sun Hee Kim Kiyoshi Ohyama Toshiya Muranaka Yong Eui Choi Hyeon Yong Lee Min Young Kim Baik Hwang | 2010 | Plant Cell Reports2010，，4： | 1 |
| 6 | A Computer Vision System for RieeKernel Quality Evaluation显示文摘 | Hong-- sun Yun Won-- ok Lee Hoon Chung | 2002 | Computer and Electronics in Argrieulture2002，37，2： | 1 |
| 7 | Maintaining mobile transactional consistency in hybrid broadcast environments显示文摘 | SungSuk Kim Sun Ok Yang SangKeun Lee | 2004 | Acta Informatica2004，41，23： | 1 |
| 8 | Bioconversion of linoleic acid into conjugated linoleic acid during fementation and by washed cells of Lactobacillus reuteri显示文摘 | SUN OK LEE CHANG SUP KIM | 2003 | Biotechnology Letters2003，25，： | 1 |
| 9 | Monitoring of 14 sulfonamide antibiotic residues in marine products using HPLC-PDA and LC-MS/MS显示文摘 | So Young Won Chang Hee Lee Hye Sook Chang Su Ok Kim Sun Hee Lee Dong Sul Kim | 2011 | Food Control2011，，7： | 1 |
| 10 | Bioconversion of linoleic acid into conjugated linoleic acid during fermentation and by washed cells of lactobacillus reuteri 显示文摘 | Sun Ok Lee Chang Sup Kim Somi Kim Cho | 2003 | Biotechnology Letters2003，25，： | 1 |
| 11 | Synthesis of carbon nanotubes with identical dimensions using an anodic aluminum oxide template on a silicon wafer显示文摘 | Ok Joo Lee Sun Kyu Hwang Soo Hwan Jeong | 2005 | Synthetic Metals2005，148，： | 1 |
| 12 | Asymmetric activation of extracellular signal-regulated kinase 1/2 in rat vestibular nuclei by unilateral labyrinthectomy显示文摘 | Min Sun Kim Myoung Ae Choi Dong Ok Choi Moon Young Lee Kwang Yong Kim Jeong Kyun Rhee Yuan Zhe Jin Byung Rim Park | 2004 | Brain Research2004，，2： | 1 |
| 13 | Bioconversion of linoleic acid into conjugated linoleic acid by Immobilized Lactobacillus reuteri 显示文摘 | Sun - Ok Lee Geun - Wha Hong Deok - Kun Oh | 2003 | Bioteehnol Prong2003，19，3： | 1 |
| 14 | A case of rapidly progressing leiomyosarcoma combined with squamous cell carcinoma in the esophagus显示文摘Esophageal leiomyosarcoma is a rare tumor that accounts for less than 1%of all malignant esophageal tumors.Esophageal leiomyosarcoma combined with squamous cell carcinoma is even rarer than solitary leiomyosarcoma.We experienced a case of leiomyosarcoma combined with squamous cell carcinoma that progressed very rapidly. | Su Sun Jang Woo Tae Kim Bong Suk Ko Eun Hae Kim Jong Ok Kim Kuhn Park Seung Woo Lee | 2013 | World Journal of Gastroenterology2013，19，32： | 0 |
| 15 | Improving hydroxyapatite coating ability on biodegradable metal through laser-induced hydrothermal coating in liquid precursor:Application in orthopedic implants显示文摘During the past decade,there has been extensive research toward the possibility of exploring magnesium and its alloys as biocompatible and biodegradable materials for implantable applications.Its practical medical application,however,has been limited to specific areas owing to rapid corrosion in the initial stage and the consequent complications.Surface coatings can significantly reduce the initial corrosion of Mg alloys,and several studies have been carried out to improve the adhesion strength of the coating to the surfaces of the alloys.The composition of hydroxyapatite(HAp)is very similar to that of bone tissue;it is one of the most commonly used coating materials for bone-related implants owing to favorable osseointegration post-implantation.In this study,HAp was coated on Mg using nanosecond laser coating,combining the advantages of chemical and physical treatments.Photothermal heat generated in the liquid precursor by the laser improved the adhesion of the coating through the precipitation and growth of HAp at the localized nanosecond laser focal area and increased the corrosion resistance and cell adhesion of Mg.The physical,crystallographic,and chemical bondings were analyzed to explore the mechanism through which the surface adhesion between Mg and the HAp coating layer increased.The applicability of the coating to Mg screws used for clinical devices and improvement in its corrosion property were confirmed.The liquid environment-based laser surface coating technique offers a simple and quick process that does not require any chemical ligands,and therefore,overcomes a potential obstacle in its clinical use. | Jaeho Park Seung-Hoon Um Youngmin Seo Jaehong Lee Yu-Chan Kim Myoung-Ryul Ok Suk-Won Hwang Jeong-Yun Sun Hyung-Seop Han Hojeong Jeon | 2023 | Bioactive Materials2023，，7： | 0 |
| 16 | Delivery of nitric oxide-releasing silica nanoparticles for in vivo revascularization and functional recovery after acute peripheral nerve crush injury显示文摘Nitric oxide(NO)has been shown to promote revascularization and nerve regeneration after peripheral nerve injury.However,in vivo application of NO remains challenging due to the lack of stable carrier materials capable of storing large amounts of NO molecules and releasing them on a clinically meaningful time scale.Recently,a silica nanoparticle system capable of reversible NO storage and release at a controlled and sustained rate was introduced.In this study,NO-releasing silica nanoparticles(NO-SNs)were delivered to the peripheral nerves in rats after acute crush injury,mixed with natural hydrogel,to ensure the effective application of NO to the lesion.Microangiography using a polymer dye and immunohistochemical staining for the detection of CD34(a marker for revascularization)results showed that NO-releasing silica nanoparticles increased revascularization at the crush site of the sciatic nerve.The sciatic functional index revealed that there was a significant improvement in sciatic nerve function in NO-treated animals.Histological and anatomical analyses showed that the number of myelinated axons in the crushed sciatic nerve and wet muscle weight excised from NO-treated rats were increased.Moreover,muscle function recovery was improved in rats treated with NO-SNs.Taken together,our results suggest that NO delivered to the injured sciatic nerve triggers enhanced revascularization at the lesion in the early phase after crushing injury,thereby promoting axonal regeneration and improving functional recovery. | Jung Il Lee Ji Hun Park Yeong-Rim Kim Kihak Gwon Hae Won Hwang Gayoung Jung Joo-Yup Lee Jeong-Yun Sun Jong Woong Park Jae Ho Shin Myoung-Ryul Ok | 2022 | Neural Regeneration Research2022，17，9： | 0 |
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