| 1 | The ChinaMAP analytics of deep whole genome sequences in 10,588 individuals显示文摘Metabolic diseases are the most common and rapidly growing health issues worldwide.The massive population-based human genetics is crucial for the precise prevention and intervention of metabolic disorders.The China Metabolic Analytics Project(ChinaMAP)is based on cohort studies across diverse regions and ethnic groups with metabolic phenotypic data in China.Here,we describe the centralized analysis of the deep whole genome sequencing data and the genetic bases of metabolic traits in 10,588 individuals from the ChinaMAP.The frequency spectrum of variants,population structure,pathogenic variants and novel genomic characteristics were analyzed.The individual genetic evaluations of Mendelian diseases,nutrition and drug metabolism,and traits of blood glucose and BMI were integrated.Our study establishes a large-scale and deep resource for the genetics of East Asians and provides opportunities for novel genetic discoveries of metabolic characteristics and disorders. | Yanan Cao Lin Li Min Xu Zhimin Feng Xiaohui Sun Jieli Lu Yu Xu Peina Du Tiange Wang Ruying Hu Zhen Ye Lixin Shi Xulei Tang Li Yan Zhengnan Gao Gang Chen Yinfei Zhang Lulu Chen Guang Ning Yufang Bi Weiqing Wang The ChinaMAP Consortium | 2020 | Cell Research2020，30，9： | 20 |
| 2 | Concentrations of Heavy Metals in Suburban Horticultural Soils and Their Uptake by Artemisia selengensis显示文摘A total of 222 surface soil samples and 40 plant samples were collected to investigate the spatial distribution and possible sources of soil heavy metals and to know the uptake and translocation of heavy metals from roots to different plant parts in a representative vegetable production area in the Baguazhou Island, a suburb of Nanjing City, East China. The arithmetic mean values of total Cd, Cr,Cu, Ni, Pb, and Zn concentrations in the soils were 0.314, 133, 41.0, 58.0, 31.8, and 114 mg kg-1, respectively. All of these values were above the topsoil background values in the Nanjing area. Multivariate and geostatistical analyses showed that soil Cd contamination was derived mainly from agricultural practices. In contrast, Cu and Zn were derived mainly from soil parent materials and Pb from atmospheric deposition from highway gasoline stations. Artemisia selengensis, a locally important specialty vegetable, accumulated heavy metals primarily in the edible leaves. The general distribution of heavy metal concentrations in this plant species showed that the highest occurred in the leaves, intermediate in the stems and lowest in the roots. Cd had the highest concentration factor(root-to-soil ratio) and may pose increased health risks in the future to the local population through the consumption of contaminated vegetables. | CUI Xu SUN Xulei HU Pengjie YUAN Cheng LUO Yongming WU Longhua Peter CHRISTIE | 2015 | Pedosphere2015，25，6： | 6 |
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