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| 1 | Pathogenesis of achalasia cardia显示文摘Achalasia cardia is one of the common causes of motor dysphagia.Though the disease was first described more than 300 years ago,exact pathogenesis of this condition still remains enigmatic.Pathophysiologically,achalasia cardia is caused by loss of inhibitory ganglion in the myenteric plexus of the esophagus.In the initial stage,degeneration of inhibitory nerves in the esophagus results in unopposed action of excitatory neurotransmitters such as acetylcholine,resulting in high amplitude non-peristaltic contractions(vigorous achalasia);progressive loss of cholinergic neurons over time results in dilation and low amplitude simultaneous contractions in the esophageal body(classic achalasia).Since the initial description,several studies have attempted to explore initiating agents that may cause the disease,such as viral infection,other environmental factors,autoimmunity,and genetic factors.Though Chagas disease,which mimics achalasia,is caused by an infective agent,available evidence suggests that infection may not be an independent cause of primary achalasia.A genetic basis for achalasia is supported by reports showing occurrence of disease in monozygotic twins,siblings and other first-degree relatives and occurrence in association with other genetic diseases such as Down's syndrome and Parkinson's disease.Polymorphisms in genes encoding for nitric oxide synthase,receptors for vasoactive intestinal peptide,interleukin 23 and the ALADIN gene have been reported.However,studies on larger numbers of patients and controls from different ethnic groups are needed before definite conclusions can be obtained.Currently,the disease is believed to be multi-factorial,with autoimmune mechanisms triggered by infection in a genetically predisposed individual leading to degeneration of inhibitory ganglia in the wall of the esophagus. | Uday C Ghoshal Sunil B Daschakraborty Renu Singh | 2012 | World Journal of Gastroenterology2012，18，24： | 20 |
| 2 | Mortalin imaging in normal and cancer cells with quantum dot immuno conjugates显示文摘Quantum dots are the nanoparticles that are recently emerging as an alternative to organic fluorescence probes in cell biology and biomedicine,and have several predictive advantages.These include their i)broad absorption spectra allowing visualization with single light source,ii)exceptional photo-stability allowing long term studies and iii)narrow and symmetrical emission spectrum that is controlled by their size and material composition.These unique properties allow simultaneous excitation of different size of quantum dots with a single excitation light source,their simultaneous resolution and visualization as different colors.At present there are only a few studies that have tested quantum dots in cellular imaging.We describe here the use of quantum dots in mortalin imaging of normal and cancer cells.Mortalin staining pattern with quantum dots in both normal and cancer cells mimicked those obtained with organic florescence probes and were considerably stable. | ZEENIA KAUL TOMOKO YAGUCHI SUNIL C KAUL TAKASHI HIRANO RENU WADHWA KAZUNARI TAIRA | 2003 | Cell Research2003，13，6： | 14 |
| 3 | Virological course of hepatitis A virus as determined by real time RT-PCR: Correlation with biochemical, immunological and genotypic profiles显示文摘瞄准:承担肝炎 A 的分析,并且相关病毒的负担,丙氨酸 aminotransferase (中高音) ,和有病毒血的持续时间的病毒的遗传型有控制调停房间的免疫的 CD4 (+)/ CD8 (+) 淋巴细胞人口的这些参数。方法:房间计数用用荧光在乙二胺四乙酸小瓶收集的新鲜全血被执行激活的房间 sorter。肝炎 A 病毒(HAV ) RNA 从血浆液被提取,抄录进 cDNA 并且由实时聚合酶链反应确定了并且是 genotyped 的颠倒。结果:在 11 个病人之中, 10 能完全被分析。这些, 3 有严重尖锐肝炎(s -- 啊) 并且剩余物有自我限制尖锐肝炎 A (啊哈) ,在第 4 d 上与有暴发性的疾病(脑病等级 IV ) 的一个病人一起死。中高音水平在啊哈两个都是显著地更高的(1070.9 +/- 894.3;P = 0.0014 ) 并且 s -- 啊(1713.9 +/- 886.3;P = 0.001 ) 与正常控制相比(23.6 +/- 7.2 ) 。在 s 的前凝血酶时间 -- 啊病人(21.0 +/- 2.0;P = 0.02 ) 比在啊哈显著地高(14.3 +/- 1.1;P = 0.44 ) 。在啊哈病人的 CD4 (+)/CD8 (+) 比率(1.17 +/- 0.11;P = 0.22 ) 并且 s -- 啊(0.83 +/- 0.12;P = 0.0002 ) 比在正常健康控制(1.52 ) 看低。有的自我限制盒子达到顶点在分析的开始的病毒的负担当时在 s -- 啊病人这发生在第 15 或第 30 d。在敏锐、严格的组,一耐心的各个属于遗传型 IA,与仍然是 8 个盒子属于遗传型 IIIA。唯一的暴发性的肝的失败大小写属于遗传型 IA。在自我限制感染的全部功课期间收集的 HAV 病毒的负担和中高音价值直接为 s 被相关,但是这不是事实 -- 啊病人。结论:基于小规模的研究, s 的固执地更高的病毒的负担 -- 啊可能由于减少的细胞免疫和溶血。病毒血的持续时间依赖于主人,当病毒的遗传型没在 AVH 和 s 的临床的结果有明显的角色 -- 啊盒子。 | Zahid Hussain Bhudev C Das Syed A Husain Sunil K Polipalli Tanzeel Ahmed Nargis Begum Subhash Medhi Alice Verghese Mohammad Raish Apiradee Theamboonlers Yong Poovorawan Premashis Kar | 2006 | World Journal of Gastroenterology2006，12，29： | 10 |
| 4 | NIH 3T3 cells malignantly transformed by mot-2 showinactivation and cytoplasmic sequestration of the p53protein显示文摘INTRODUCTIONInvolvementandinactivationofp53,atumorsuppressorandcellulartranscriptionfactorincellularimmortalizationhasbeenwelldocumented[1-4].Variousactivitiesofp53proteininvolveitsfunctionaldomains,viz.,anamino--terminustransactivationdomain(aminoac... | WADHIVA RENU SYIJICHI TAKANO YOUJIMITSUI SUNIL C KAUL( Chugai Research Institute for Molecular Medicine,153-2 Nagai, Niihari-Mura, Ibaraki 300-41, Japan)( National Institute of Bioscience and Hunan-Technology, AIST, 1-1 Higashi, Tsukusa, Ibaraki 305-85 | 1999 | Cell Research1999，9，4： | 3 |
| 5 | Expression of flavonoid biosynthesis genes vis-à-vis rutin content variation in different growth stages of Fagopyrum species显示文摘 | NIDHI G SUNIL K S JAI C R | | 0，，： | 1 |
| 6 | Managing Risk to Avoid supply-Chain Breakdown显示文摘 | SUNIL C MANMOHAN S S | 2004 | MIT Sloam Management Review2004，，3： | 1 |
| 7 | Macrophages and tissue injury:agents of defense or destruction显示文摘 | Laskin D L Sunil V R Gardner C R | 2011 | Annu Rev Pharmacol Toxicol2011，51，： | 1 |
| 8 | Radial basis function neural network for approximation and estimation of nonlinear stochastic dynamic systems 显示文摘 | YUNG C S | 1994 | IEEE Trans on Neural Networks1994，5，4： | 1 |
| 9 | Evaluating novel mi-crobe amended composts as biocontrol agents in tomato 显示文摘 | Ajinath S D Radha P Sunil C D | 2011 | Crop Protection2011，30，4： | 1 |
| 10 | Comparative study of uhra- sound-guided paravertebral block with ropivacaine versus bupivacaine for post-operative pain relief in children undergoing thoracotonay for patent ductus arteriosus l igationsurgery 显示文摘 | Chalam KS Patnaik SS Sunil C eL al | 2015 | Indian J A naesth2015，59，8： | 1 |
| 11 | Managing Risk to Avoid Supply-Chain Breakdown显示文摘 | MANMOHAN S S | 2004 | MIT Sloam Management Review2004，46，1： | 1 |
| 12 | Impact assessment of soils treat- ed with refinery effluent显示文摘 | Rajesh D Sunil C Lalita R | 2009 | European Journal of Soil Biology2009，45，56： | 1 |
| 13 | Potential use of mine tailings and fly ash in concrete 显示文摘 | Sunil B M Manjunatha L S Lolitha Ravi Subhash C Yaragal | 2015 | Advances in Concrete Construction2015，3，1： | 1 |
| 14 | In vitro antioxi- dant and antihyperlipidemic activities of Toddalia asiatica (L) Lam:Leaves in Triton WR-1339 and highfat diet induced hy- perlipidemic rats 显示文摘 | Irudayaraj SS Sunil C Duraipandiyan V | 2013 | Food Chem Toxicol2013，60，10： | 1 |
| 15 | Radial basis function neural network fox approximation and estimation of nonlinear stochastic dynamic systems显示文摘 | V T Sunil Elanayar Yung C Shin | 1994 | IEEE Transactions on Neural Network1994，5，4： | 1 |
| 16 | Fire load in residential build- ings显示文摘 | Sunil Kumar Kameswara C V S K | 1995 | Building and Environment1995，30，2： | 1 |
| 17 | Artificial neural network prediction models for soil compaction and permeability显示文摘 | SUNIL K SINHA L MIAN C | 2008 | Geotechnical and Geological Engineering2008，26，1： | 1 |
| 18 | Effects of N-doping on the microstructure, mechanical and tribological behavior of Cr-DLC films显示文摘 | Sunil K P JIANG J C Efstathios I | 2007 | Meletis Surf Coat Technol2007，201，： | 1 |
| 19 | Near-infrared Fluorescent Type Ⅱ Quantum Dots for Sentinel Lymph Node Mapping显示文摘 | SUNGJEE K TOMOKO Y SUNIL C K | 2004 | Nature Biotechnology2004，22，： | 1 |
| 20 | Production of cellulases through solid state fermentation using kinnow pulp as amajor substrate显示文摘 | Harinder O Yogita C Sunil B Gurpreet D | 2010 | FoodBioprocessTechno2010，3，52： | 1 |
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