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| 1 | Linagliptin alleviates fatty liver disease in diabetic db/db mice显示文摘AIM To study the effects of linagliptin on the structural signs of non-alcoholic fatty liver disease(NAFLD) in db/db mice. METHODS Male diabetic db /db mice(BKS.Cg-Dock7m+/+Leprdb/J) aged 10 wk received the dipeptidyl peptidase 4(DPP4) inhibitor linagliptin(10 mg/kg) or saline as a placebo once per day by gavage for 8 wk. Intact db/db mice served as controls. Structural changes in the liver were analyzed from light and electron microscopic images of sections from intact, placebo-treated and linagliptin-treated animals. We estimated the changes in hepatocytes, sinusoidal cells, liver microvasculature and lymphatic roots. Hepatic staining for lymphatic vessel endothelial hyaluronan receptor-1(LYVE-1) was assessed by immunohistochemistry. RESULTS In 18-wk-old diabetic mice, liver steatosis(predominantly microvesicular and mediovesicular steatosis) was accompanied by dilation of the roots of the lymphatic system, interlobular blood vessels and bile canaliculi. Compared to saline-treated mice, linagliptin-treated mice exhibited a reduction in the mean numeral densities of hepatocytes with lipid droplets(92.4% ± 1.7% vs 64.9% ± 5.8% per field of view, P = 0.0002) and a lower proportion of hepatocytes with a high density of lipid droplets(20.7% ± 3.6% vs 50.4% ± 3.1%, P = 0.0007). We observed heterogeneous hepatocytes and relatively preserved cell structures in the linagliptin group. Dilation of blood and lymphatic vessels, as well as ultrastructural changes in the hepatocyte endoplasmic reticulum and mitochondria, were alleviated by linagliptin treatment. In intact and placebo-treated mice, immunohistochemical staining for LYVE-1 was observed in the endothelial cells of interlobular lymphatic vessels and on the membranes of some endothelial sinusoidal cells. We observed an enlarged LYVE-1 reaction area in linagliptin-treated mice compared to intact and placebo-treated mice. The improvement in the structural parameters of the liver in linagliptin-treated mice was independent to changes in the plasma glucose levels. CONCLUSION The DPP4 inhibitor linagliptin alleviates liver steatosis and structural changes in the hepatic microvasculature and lymphatic roots in a model of NAFLD in diabetic db/db mice. | Svetlana V Michurina Irina Ju Ishenko Vadim V Klimontov Sergey A Archipov Natalia E Myakina Marina A Cherepanova Eugenii L Zavjalov Galina V Koncevaya Vladimir I Konenkov | 2016 | World Journal of Diabetes2016，7，19： | 2 |
| 2 | Optimization of the conditions for the Cr (Ⅲ) adsorption on activated carbon显示文摘 | Lyubchik Svetlana B Perepichka Irene I | 2005 | Adsorption2005，11，56： | 1 |
| 3 | Biorational insecticides: mechanism and cross resistance 显示文摘 | Isaac I Svetlana K Rami H | 2005 | Archives lnsec Bio Phy2005，58，： | 1 |
| 4 | Preparative isolation and purifieation of ginsenosides Re from the roots of panax gin- seng with a salt containing solvent system and flow step - gradient 显示文摘 | Qi x c Svetlana I Luo G | 2010 | J Chromatogr A2010，1217，： | 1 |
| 5 | Optical Properties of Cadmium SuLfide Colloidal Dispersions Prepared by Interphase Synthesis 显示文摘 | Alexander N K Svetlana A V Anatoly I L | 2008 | OpticalMatedals2008，30，8： | 1 |
| 6 | Application of dynamic neural networks in the modeling of drug release from polyethylene oxide matrix tablets显示文摘 | Jelena Petrovi? Svetlana Ibri? Gabriele Betz Jelena Paroj?i? Zorica ?uri? | 2009 | European Journal of Pharmaceutical Sciences2009，，2： | 1 |
| 7 | An investigation into the usefulness of generalized regression neural network analysis in the development of level A in vitro - in vivo correlation 显示文摘 | JELENA P SVETLANA I ZORICA D | 2007 | European Journal of Pharmaceutical Sciences2007，30，34： | 1 |
| 8 | Solvent extraction of amino acids into a room temperature ionic liquid with dicyclohexano-18-crown-6显示文摘 | Smirnova Svetlana V Torocheshnikova Irina I Formanovsky Andrey A | 2004 | Analytical and BioanalyticalChemistry2004，378，5： | 1 |
| 9 | Where polyelectrolyte multilayers and polyelectrolyte complexes meet显示文摘 | Svetlana A Eugenia K Vladimir I | 2006 | Macromolecules2006，，39： | 1 |
| 10 | Toxicity of metalaxyl, azoxystrobin, dimethomorph, cymoxanil, zoxamide and mancozeb to Phytophthora infestans isolates from Serbia显示文摘 | Emil Rekanovi? Ivana Poto?nik Svetlana Milija?evi?-Mar?i? Milo? Stepanovi? Biljana Todorovi? Milica Mihajlovi? | 2012 | Journal of Environmental Science and Health Part B2012，，5： | 1 |
| 11 | Simulating separated flows using the k-ε model显示文摘 | SVETLANA P GIANLUCA I | 2001 | Center for Turbulence Research Annual Research Briefs2001，32，5： | 1 |
| 12 | The combined GnRHagonist and intrauterine levonorgestrel-releasing system treatment of complicated atypical hyperplasia and endometrial cancer:a pilot study显示文摘 | Alexandr I Vitaly B Svetlana V | 2012 | Gynecol Endocrinol2012，28，7： | 1 |
| 13 | Influence of the zeolite synthesis route on its catalytic properties in the methanol to olefin reaction 显示文摘 | SVETLANA I CHARLINE L ESTELLE V | 2009 | J Catal2009，265，1： | 1 |
| 14 | Application of alumina supported gold - based catalysts in total oxidation of CO and light hydrocarbons mixture 显示文摘 | Svetlana I Corinne P Veronique P | 2006 | Catalysis Today2006，113，： | 1 |
| 15 | New 18-l process-scale counter-current chromatography centrifuge显示文摘 | Sutherland I Hewitson P Svetlana Ignatova | 2009 | Journal of Chromatography A2009，1216，： | 1 |
| 16 | Chemically assisted microbial production of suecinie aeidby the yeast Yarrowia lipolytica grown on ethanol显示文摘 | Svetlana V K Alsu I Y Natalia G V | 2009 | Appl Microbiol Biotechnol2009，83，： | 1 |
| 17 | Application of alumina supported gold-based catalysts in total oxidation of CO and light hydrocarbons mixture 显示文摘 | Svetlana I Corinne P Veronique P | 2006 | Catalysis Today2006，，113： | 1 |
| 18 | Experimental Myocardial Infarction Upregulates Circulating Fibroblast Growth Factor -23显示文摘 | Olena A Svetlana S Kathrin I | 2015 | J Bone Miner Res2015，30，10： | 1 |
| 19 | Solvent extraction and extraction-voltammetric determination of phenols using room temperature ionic liquid 显示文摘 | Kristine S K Svetlana V S Irina I T | 2005 | Analytical and Bioanalytical Chemistry2005，381，2： | 1 |
| 20 | Free radicals and photo- oxidation of an altemating copolymer of ethylene and carbon monoxide显示文摘 | SVETLANA I KJZINA ANATOLIY P PIVOVAROV and ALFA I | 2000 | European polymer journal2000，36，5： | 1 |
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