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| 1 | Targeting of the AKT/m-TOR Pathway: Biomarkers of Resistance to Cancer Therapy——AKT/m-TOR Pathway and Resistance to Cancer Therapy显示文摘Resistance to cancer therapy continues to be a major limitation for the successful treatment of cancer. There are many published studies on therapy resistance in breast and prostate cancers; however, there are currently no data on molecular markers associated with resistance. The conflicting data were reported regarding the AKT/m-TOR signaling pathway components as markers predicting resistance. The AKT/m-TOR signaling pathway is involved in the development of many human cancers; its activation is related to cell proliferation, angiogenesis, apoptosis, as well as to therapy resistance. Molecular alterations in the AKT/m-TOR signaling pathway provide a platform to identify universal markers associated with the development of resistance to cancer therapy. | Liudmila V SPIRINA Irina V KONDAKOVA Natalia V TARASENKO Elena M SLONIMSKAYA Evgeny A USYNIN Alexey K GORBUNOV Zahar A YURMAZOV Svetlana Yu CHIGEVSKAYA | 2018 | 中国肺癌杂志2018，21，1： | 18 |
| 2 | Compliance and adherence to oral anticoagulation therapy in elderly patients with atrial fibrillation in the era of direct oral anticoagulants显示文摘 | Svetlana V Garkina Tatiana V Vavilova Dmitry S Lebedev Evgeny N Mikhaylov | 2016 | Journal of Geriatric Cardiology2016，13，9： | 4 |
| 3 | Value of two-phase dynamic multidetector computed tomography in differential diagnosis of post-inflammatory strictures from esophageal cancer显示文摘AIM: To characterize the computed tomography(CT) findings in patients with post-inflammatory esophageal strictures(corrosive and peptic) and reveal the optimal scanning phase protocols for distinguishing postinflammatory esophageal stricture and esophageal cancer.METHODS: Sixty-five patients with esophageal strictures of different etiology were included in this study: 24 patients with 27 histopathologically confirmed corrosive strictures, 10 patients with 12 peptic strictures and 31 patients with esophageal cancer were evaluated with a two-phase dynamic contrast-enhanced MDCT. Arterial and venous phases at 10 and 35 s after the attenuation of 200 HU were obtained at the descending aorta, with a delayed phase at 6-8 min after the start of injection of contrast media. For qualitative analysis, CT scans of benign strictures were reviewed for the presence/absence of the following features: 'target sign', luminal mass, homogeneity of contrast medium uptake, concentric wall thickening, conically shapedsuprastenotic dilatation, smooth boundaries of stenosis and smooth mucous membrane at the transition to stenosis, which were compared with a control group of 31 patients who had esophageal cancer. The quantitative analysis included densitometric parameter acquisition using regions-of-interest measurement of the zone of stenosis and normal esophageal wall and the difference between those measurements(ΔCT) at all phases of bolus contrast enhancement. Esophageal wall thickening, length of esophageal wall thickening and size of the regional lymph nodes were also evaluated. RESULTS: The presence of a concentric esophageal wall, conically shaped suprastenotic dilatation, smooth upper and lower boundaries, 'target sign' and smooth mucous membrane at the transition to stenosis were suggestive of a benign cause, with sensitivities of 92.31%, 87.17%, 94.87%, 76.92% and 82.05%, respectively, and specificities of 70.96%, 89.66%, 80.65%, 96.77% and 93.55%, respectively. The features that were most suggestive of a malignant cause were eccentric esophageal wall thickening, tuberous upper and lower boundaries of stenosis, absence of mucous membrane visualization, rupture of the mucous membrane at the upper boundary of stenosis, cup-shaped suprastenotic dilatation, luminal mass and enlarged regional lymph nodes with specificities of 92.31% 94.87%, 67.86%, 100%, 97.44%, 94.87% and 82.86%, respectively and sensitivities of 70.97%, 80.65%, 96.77%, 80.65%, 54.84%, 87.10% and 60%, respectively. The highest tumor attenuation occurred in the arterial phase(mean attenuation 74.13 ± 17.42 HU), and the mean attenuation difference between the tumor and the normal esophageal wall(mean ΔCT) in the arterial phase was 23.86 ± 19.31 HU. Here, 11.5 HU of ΔCT in the arterial phase was the cut-off value used to differentiate esophageal cancer from post-inflammatory stricture(P = 0.000). The highest attenuation of postinflammatory strictures occurred in the delayed phase(mean attenuation 71.66 ± 14.28 HU), and the mean ΔCT in delayed phase was 34.03 ± 15.94 HU. Here, 18.5 HU of ΔCT in delayed phase was the cut-off value used to differentiate post-inflammatory stricture from esophageal cancer(P < 0.0001).CONCLUSION: The described imaging findings reveal high diagnostic significance in the differentiation of benign strictures from esophageal cancer. | Grigory G Karmazanovsky Svetlana A Buryakina Evgeny V Kondratiev Qin Yang Dmitry V Ruchkin Dmitry V Kalinin | 2015 | World Journal of Gastroenterology2015，21，29： | 3 |
| 4 | Linagliptin alleviates fatty liver disease in diabetic db/db mice显示文摘AIM To study the effects of linagliptin on the structural signs of non-alcoholic fatty liver disease(NAFLD) in db/db mice. METHODS Male diabetic db /db mice(BKS.Cg-Dock7m+/+Leprdb/J) aged 10 wk received the dipeptidyl peptidase 4(DPP4) inhibitor linagliptin(10 mg/kg) or saline as a placebo once per day by gavage for 8 wk. Intact db/db mice served as controls. Structural changes in the liver were analyzed from light and electron microscopic images of sections from intact, placebo-treated and linagliptin-treated animals. We estimated the changes in hepatocytes, sinusoidal cells, liver microvasculature and lymphatic roots. Hepatic staining for lymphatic vessel endothelial hyaluronan receptor-1(LYVE-1) was assessed by immunohistochemistry. RESULTS In 18-wk-old diabetic mice, liver steatosis(predominantly microvesicular and mediovesicular steatosis) was accompanied by dilation of the roots of the lymphatic system, interlobular blood vessels and bile canaliculi. Compared to saline-treated mice, linagliptin-treated mice exhibited a reduction in the mean numeral densities of hepatocytes with lipid droplets(92.4% ± 1.7% vs 64.9% ± 5.8% per field of view, P = 0.0002) and a lower proportion of hepatocytes with a high density of lipid droplets(20.7% ± 3.6% vs 50.4% ± 3.1%, P = 0.0007). We observed heterogeneous hepatocytes and relatively preserved cell structures in the linagliptin group. Dilation of blood and lymphatic vessels, as well as ultrastructural changes in the hepatocyte endoplasmic reticulum and mitochondria, were alleviated by linagliptin treatment. In intact and placebo-treated mice, immunohistochemical staining for LYVE-1 was observed in the endothelial cells of interlobular lymphatic vessels and on the membranes of some endothelial sinusoidal cells. We observed an enlarged LYVE-1 reaction area in linagliptin-treated mice compared to intact and placebo-treated mice. The improvement in the structural parameters of the liver in linagliptin-treated mice was independent to changes in the plasma glucose levels. CONCLUSION The DPP4 inhibitor linagliptin alleviates liver steatosis and structural changes in the hepatic microvasculature and lymphatic roots in a model of NAFLD in diabetic db/db mice. | Svetlana V Michurina Irina Ju Ishenko Vadim V Klimontov Sergey A Archipov Natalia E Myakina Marina A Cherepanova Eugenii L Zavjalov Galina V Koncevaya Vladimir I Konenkov | 2016 | World Journal of Diabetes2016，7，19： | 2 |
| 5 | A facile synthesis of annulated thiatriazine dioxides 显示文摘 | Alexander N K Alexander N S Svetlana V S | 2010 | Journal of Synthetic Organic Chemistry2010，，1： | 1 |
| 6 | Vague nerve stimulation attenuates the systemic inflammatory response to endotoxin 显示文摘 | Lyudmila V Borovikova V Svetlana L | 2000 | Nature2000，405，6785： | 1 |
| 7 | Signaling mechanism of relaxin H2 action显示文摘 | Alexande S Marianna A P Svetlana V | 2005 | Annals of the New York Academy of Sciences2005，1041，1： | 1 |
| 8 | Detection of spring viraemia of carp virus isolates by hybridization with non-radiocative probes and amplification by polymerase chain reaction显示文摘 | Svetlana F Oreshkova Igor S Shchelkunov Nina V Tikunova | | 0，，1： | 1 |
| 9 | Optical Properties of Cadmium SuLfide Colloidal Dispersions Prepared by Interphase Synthesis 显示文摘 | Alexander N K Svetlana A V Anatoly I L | 2008 | OpticalMatedals2008，30，8： | 1 |
| 10 | Citrobacter freundii as a cause of disease in fish显示文摘 | Svetlana J Dobrila J D Lj V | 2003 | Acta Veterinaria2003，53，56： | 1 |
| 11 | Influence of PAHs on ligninolytic enzymes of the fungus Pleurotus ostreatus D1 显示文摘 | Natalia N Svetlana V Olga V | 2010 | Central Euro- pean Journal of Biology2010，5，1： | 1 |
| 12 | Kinetic model for batch cellulase production by Trichoderma reesei RUT C30显示文摘 | SVETLANA V MARK R M DAVID F O | 1997 | Journal of Biotochnology1997，54，： | 1 |
| 13 | Differentiation of immunostimulatory stem-cell and monocyte-derived dendritic cells involves maturation of intracellular compartments responsible for antigen presentation and secretion 显示文摘 | Svetlana N Bykovskala Y Galina V | 2002 | Stem Cells2002，20，2： | 1 |
| 14 | Synthesis and in vitro antiprotozoal activities of dicationic 3,5-diphenylisoxazoles显示文摘 | Stanislav A Bakunov Svetlana M Bakunova E V K Suresh Kumar et al | 2007 | J Med Chem2007，50，： | 1 |
| 15 | Decade of Low Frequency Pulsar Polarimetry at PRAO: a Review of the MainResults显示文摘 | Suleymanova Svetlana A Pugachev V D A | 2000 | ASPC2000，202，： | 1 |
| 16 | Homogeneous Oxidation of Aromatics in Nucleus with Peracetic Acid Catalyzed by Iron and Manganese Phthalocyanine Complexes显示文摘 | Svetlana V B Valentina M C Olga V D | 1996 | Tetrahedron Letter1996，37，10： | 1 |
| 17 | Mechanism of zeolite A nanocrystal growth from colloids at room temperature显示文摘 | Svetlana M Norman H O Valentin V | | 0，，： | 1 |
| 18 | Citrobacterfreundii as a cause of disease in fish 显示文摘 | Svetlana J Dobrila J D Lj V | 2003 | Acta Veterinaria2003，53，： | 1 |
| 19 | Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin 显示文摘 | Lyudmila V Boroviko VA Svetlana L | 2000 | Na ture2000，405，： | 1 |
| 20 | Layer-by-layer preparation of zeolite coatings of nanosized crystals显示文摘 | Valentin V Svetlana M | 2001 | Microporous and Mesoporous Materials2001，43，1： | 1 |
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