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| 1 | 欧洲新生儿呼吸窘迫综合征防治指南-2010版显示文摘呼吸窘迫综合征(RDS)是由于肺表面活性物质(PS)缺乏及肺结构发育不成熟所致,多见于早产儿,自然病程为生后当时或很快发病,并在生后2d内进行性恶化,如不及时治疗,因进行性缺氧和呼吸衰竭而死亡,存活者,在生后2—4d病情开始改善。胎龄越小,RDS发生率越高,2006年EuroNeoStat的数据显示:胎龄23~25周的早产儿RDS发生率为91%, | Sweet DG Carnielli V Greisen G Hallman M Ozek E Plavka R Saugstad OD Simeoni U Speer CP Halliday HL 袁琳(翻译) 陈超(审校) | 2011 | 中华儿科杂志2011，49，1： | 137 |
| 2 | 欧洲早产儿呼吸窘迫综合征防治共识指南(2013版)显示文摘本次指南更新包括了自2010年以来Cochrane系统评价和医学文献中的最新证据,并采纳了一种新的证据评估分级系统(GRADE)。以往关于早期肺表面活性物质和持续气道正压通气治疗的推荐目前拥有了更坚定的循证依据。对产房复苏、稳定生命体征等内容进行了较大扩充。生命体征稳定后的氧疗目前仍存在一定的争议,但是在获得更多的证据之前,血氧饱和度的目标范围不应低于90%,支持治疗对于超早早产儿仍然极为重要。指南对其他注意事项进行了缩减。 | Sweet D Carnielli V Greisen G Hallman M Ozek E Plavka R Saugstad OD Simeoni U Speer CP Halliday HL 王敏婕 袁琳 陈超 | 2014 | 中华儿科杂志2014，52，10： | 34 |
| 3 | Senescent human hepatocytes express a unique secretory phenotype and promote macrophage migration显示文摘AIM:To develop a model of stress-induced senescence to study the hepatocyte senescence associated secretory phenotype(SASP).METHODS:Hydrogen peroxide treatment was used to induce senescence in the human Hep G2 hepatocyte cell line.Senescence was confirmed by cytochemical staining for a panel of markers including Ki67,p21,heterochromatin protein 1β,and senescence-associated-β-galactosidase activity.Senescent hepatocytes were characterised by gene expression arrays and quantitative polymerase chain reaction(q PCR),and conditioned media was used in proteomic analyses,a human chemokine protein array,and cell migration assays to characterise the composition and function of the hepatocyte SASP.RESULTS:Senescent hepatocytes induced classical markers of senescence(p21,heterochromatin protein1β,and senescence-associated-β-galactosidase activity);and downregulated the proliferation marker,Ki67.Hepatocyte senescence induced a 4.6-fold increase in total secreted protein(P=0.06)without major alterations in the protein profile.Senescence-induced genes were identified by microarray(Benjamini Hochbergcorrected P<0.05);and,consistent with the increase in secreted protein,gene ontology analysis revealed a significant enrichment of secreted proteins among inducible genes.The hepatocyte SASP included characteristic factors such as interleukin(IL)-8 and IL-6,as well as novel components such as SAA4,IL-32and Fibrinogen,which were validated by q PCR and/or chemokine protein array.Senescent hepatocyteconditioned medium elicited migration of inflammatory(granulocyte-macrophage colony stimulating factor,GM-CSF-derived),but not non-inflammatory(CSF-1-derived)human macrophages(P=0.022),which could contribute to a pro-inflammatory microenvironment in vivo,or facilitate the clearance of senescent cells.CONCLUSION:Our novel model of hepatocyte senescence provides insights into mechanisms by which senescent hepatocytes may promote chronic liver disease pathogenesis. | Katharine M Irvine Richard Skoien Nilesh J Bokil Michelle Melino Gethin P Thomas Dorothy Loo Brian Gabrielli Michelle M Hill Matthew J Sweet Andrew D Clouston Elizabeth E Powell | 2014 | World Journal of Gastroenterology2014，20，47： | 2 |
| 4 | BIL- SAT,l: A low-cost, agile, earth observation microsatel- lite for turkey显示文摘 | BRADFORD A GOMES L M SWEETING M | 2003 | Acta astronautica2003，，53： | 1 |
| 5 | Perform-ance Analysis of the Segment npn Anode LIGBT显示文摘 | GREEN D W SWEET M VERSHININ K V | 2005 | ElectronDevices IEEE Transactions on2005，52，11： | 1 |
| 6 | Fundamental principles and practices of team based learning 显示文摘 | Michaelsen LK Sweet M | 2008 | Sterling (VA) : Stylus Publishing :2008，931，： | 1 |
| 7 | Managed care per- spective on three new agents for type 2 diabetes显示文摘 | VanDeKoppel S Choe H M Sweet B V | 2008 | J Manag Care Pharm2008，14，4： | 1 |
| 8 | Genesis field, gulf of Mexico:recognizing reservoir compartments on geologic and production time scales in deep-water reservoirs显示文摘 | Sweet M L Sumpter L T | 2007 | AAPG Bulletin2007，91，12： | 1 |
| 9 | A novel pathway regulatillg lipopolysaccharide-indued shock by ST2/T1 via inhibition of loll-like receptor 4 expression显示文摘 | Sweet M J Leung BP Kang D | 2001 | J lmmunol2001，166，： | 1 |
| 10 | Management strategies forneonatal hypoglycemia 显示文摘 | Sweet CB Grayson S Polak M | 2013 | J Pediatr Pharmacol Ther2013，18，3： | 1 |
| 11 | Very small-satellite design for distributed space missions显示文摘 | Barnhart D J Vladimirova T Sweeting M N | | 0，，06： | 1 |
| 12 | An improved method to recover saliva from human skin:the double swab technique显示文摘 | Lorente M Lorente J A | 1997 | J Forensic Sci1997，42，： | 1 |
| 13 | Limestone Landscape of South China显示文摘 | Sweeting M M | 1986 | Geology Today1986，，： | 1 |
| 14 | External fixation for ineter articular fractures of the distal radius显示文摘 | Jakim HS Pleterse M BE Sweet | 1991 | Britsh Editorial Society of Bone and Joint Surgery1991，73，3： | 1 |
| 15 | Effect of alkali metal impurities on the low temperature thermal stability of 2090 Al-Cu-Li alloys显示文摘 | Kerr M J Sweet E D Bennett C G | 1996 | Mater Forum1996，21，7222： | 1 |
| 16 | Modeling heterogeneity in a low-permeability gas reservoir using geostatistical techniques, Hyde field, Southern North Sea显示文摘 | SWEET M L BLEWDEN C J CARTER A M | 1996 | AAPG Bulletin1996，80，11： | 1 |
| 17 | Disseminated neonatal Trichosporon beigelii infection;successful treatment with liposomal ampnotericin B显示文摘 | Sweet D Reid M | 1998 | J Infect1998，36，： | 1 |
| 18 | The essential elements ofteam-based learning 显示文摘 | Michaelsen L K Sweet M | 2008 | New Dir Teach Learn2008，，116： | 1 |
| 19 | Fundamental principles and practices of team based learning显示文摘 | Michaelsen LK Sweet M | 2008 | Stylus Publishing2008，3，2： | 1 |
| 20 | Parkinson' s disease and megacolon: concentric hyaline inclusions(Lewy bodies) in enteric ganglion ceils显示文摘 | Kupsky W J Grimes M M Sweeting J | 1987 | Neurology1987，37，： | 1 |
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