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| 1 | Association of comorbidities with increasing severity of peripheral neuropathy in diabetes mellitus显示文摘AIM: To analyze a large population of patients with diabetes and peripheral neuropathy(PN) to determine other meaningful comorbid etiologies for PN.METHODS: Peripheral Neuropathy is a common complication of type 1 and 2 diabetes mellitus;however,other potential causes for PN may be co-existing in patients with diabetes.A prospective cohort study was performed to assess patients with diabetes and PN.We compared patients having PN due solely to diabetes with patients possessing co-existing comorbidities,performing clinical(Toronto Clinical Scoring System and the Utah Early Neuropathy Scale),laboratory and electrophysiological assessments in all patients.RESULTS: Patients with either type 1 or 2 diabetes mellitus and co-existing comorbidities did not have more severe clinical or electrophysiological PN phenotypes overall.However,in patients with type 1 diabetes,presence of a lipid disorder was associated with greater PN severity.In type 2 diabetes patients,both a lipid disorder and cobalamin deficiency were associated with greater PN severity.There was no additive effect upon PN severity with presence of three or more comorbid etiologies.CONCLUSION: The presence of specific,and not general,comorbidities in patients with type 1 or 2 diabetes corresponds with greater PN severity. | Shafna Sachedina Cory Toth | 2013 | World Journal of Diabetes2013，4，4： | 7 |
| 2 | Performance assessment of the Medtronic-MiniMed continuous glucose monitoring system and its use for measurement of glycaemic control in Type 1 diabetic subjects显示文摘 | Sachedina N Pickup J C | 2003 | Diabet Med2003，20，12： | 1 |
| 3 | Paediatric mortality related to pandemic influenza A H1N1 infection in England: an observational population-based study显示文摘 | Nabihah Sachedina Liam J Donaldson | 2010 | The Lancet2010，，9755： | 1 |
| 4 | A unique case of diffuse metastatic neuroendocrine cancer with subcutaneous nodules on 18F-fluorodeoxyglucose positron emission tomography/computer assisted tomography显示文摘 | Johnston MJ Sachedina A McDonald JE | 2015 | World J Nucl Med2015，14，2： | 1 |
| 5 | Performance assessment of the-edtronic MiniMed continuous glucose monitoring system and its use for measurement of glycaemic control in type 1 diabetic subjects显示文摘 | Sachedina Pickup JC | 2003 | Diabet Med2003，20，： | 1 |
| 6 | Performance assessment of the Medtronic-MiniMed Continuous Glucose Monitoring System and its use for measurement of glycaemic control in Type 1 diabetic subjects显示文摘 | Sachedina N Pickup J C | 2003 | Diabet Med2003，20，12： | 1 |
| 7 | Performance assessment of the Medtronic-MiniMed continuous glucose monitoring system and its use for measurement of glycsemic control in Type 1 diabetic subjects 显示文摘 | Sachedina N Pickup JC | 2003 | Diabet Med2003，20，12： | 1 |
| 8 | Performance assessment of the medtronic-minimed continuous glucose monitoring system and its use for measurement of glycaemic control in type 1 diabetic subjects显示文摘 | Sachedina N Pickup J C | 2003 | Diabet Med2003，20，12： | 1 |
| 9 | Performance assessment of the Medtronic-MiniMed continuous glucose monitoring system and its use for measurement of glycaemic control in Type 1 diabetic subjects显示文摘 | Sachedina N Pickup JC | 2003 | Diabet Med2003，20，12： | 1 |
| 10 | Performance assessment of the mdtronic - minmmed continuous glucose monitoring system and its use for measurement of glycaemic control in type 1 diabetic subjects 显示文摘 | Sachedina N Pickup JC | 2003 | Diabet Meal2003，20，12： | 1 |
| 11 | Mechanisms and clinical implications in renal carcinoma resistance:narrative review of immune checkpoint inhibitors显示文摘Clear cell renal cell carcinoma(ccRCC)is the most common histological subtype of renal cell carcinoma.The prognosis for patients with ccRCC has improved over recent years with the use of combination therapies with an anti-programmed death-1(PD-1)backbone.This has enhanced the quality of life and life expectancy of patients with this disease.Unfortunately,not all patients benefit;eventually,most patients will develop resistance to therapy and progress.Recent molecular,biochemical,and immunological research has extensively researched antiangiogenic and immune-based treatment resistance mechanisms.This analysis offers an overview of the principles underpinning the resistance pathways related to immune checkpoint inhibitors(ICIs).Additionally,novel approaches to overcome resistance that may be considered for the trial context are discussed. | Sunil Samnani Faraz Sachedina Mehul Gupta Edward Guo Vishal Navani | 2023 | Cancer Drug Resistance2023，6，2： | 0 |
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