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| 1 | Hypoglycemic and anti-hyperglycemic study of Gynura procumbens leaf extracts显示文摘Objective:To study the antidiabetic activity of Gynura procumbens(G.procumbens)used in the traditional management of diabetes in Southern Asia.Methods:G.procumbens leaves were extracted sequentially with graded percentage of ethanol in water(95%,75%,50%,25%and 0%),and the extracts were tested for antidiabetic activity using acute(7 h),subcutaneous glucose tolerance test and sub-chronic(14 d)test in non-diabetic and streptozotocin-induced diabetic rats.The extracts were further subjected to phytochemical studies.Results:In acute dose(1 g/kg),the extracts significantly lowered fasting blood glucose(FBG)in streptozotocin-induced diabetic rats(P<0.05).However,the FBG-lowering effect of the 25%extract compared to the other extracts,was rapid(47%after 2 h)and the highest:53%,53%and 60%in the 3rd,5th,and 7th h,respectively(P<0.05),comparable only to the effect of metformin.Furthermore,the extracts suppressed peak FBG in subcutaneous glucose tolerance test,but only the 0%and 25%extracts,and metformin sustained the decrease until the 90th min(P<0.05).Moreover,in the 14 days study,the 25%extract exerted the highest FBG-lowering effect,namely 49.38%and 65.43%on days 7 and 14,respectively(P<0.05),similar to the effect of metformin(46.26%and 65.42%).Total flavanoid and phenolic contents in the extracts were found to decrease with increase in polarity of extraction solvents.The composition of reference compounds(chlorogenic acid,rutin,astragalin and kaempferol-3-O-nrtinoside)followed a similar trend.Conclusions:G.procumbens contains antidiabetic principles,most extracted in 25%ethanol.Interaction among active components appears to determine the antidiabetic efficacy,achieved likely by a metformin-like mechanism. | Khalid Algariri Kuong Y Meng Item J Atangwho Mohd Z Asmawi Amirin Sadikun Vikneswaran Murugaiyah Norhyati Ismail | 2013 | Asian Pacific Journal of Tropical Biomedicine2013，3，5： | 4 |
| 2 | Havonoid identification and hypoglyeaemie studies of the butanol fractionfrom Gynura procumbens显示文摘 | Akowuah GA Sadikun A Mariam A | 2002 | Pharm Biol2002，40，6： | 1 |
| 3 | Flavonoid iden- tification and hypoglycaemic studies of the butanol fraction from Gynura procumbens 显示文摘 | Akowuah G A Sadikun A Mariam A | 2002 | Pharm Biol2002，40，6： | 1 |
| 4 | In vitro α-glucosidase and or-amylase enzyme inhibitory effects of Andrographis paniculata extract and andrographolide显示文摘 | Subramanian R Asmawi M Z Sadikun A | 2008 | Acta Biochim Pol2008，55，2： | 1 |
| 5 | Toxicology evaluation of standardized methanol extract of Gynura procumbens 显示文摘 | Rosidah Yam M F Sadikun A | 2009 | J Ethnopharmacol2009，123，2： | 1 |
| 6 | Susceptibility of mycobacterium tuberculosis to isoniazid and its derivative, 1-isonicotinyl-2-nonanoyl hydrazine: investigation at cellular level 显示文摘 | Suriyati M Pazirah I Sadikun A | 2004 | Tuberculosis2004，84，： | 1 |
| 7 | Flavonoid Identification and Hypoglyeaemic Studies of the Butanol Fraction from Gynura proeumbens显示文摘 | Akowuah GA Sadikun A Marriam A | 2002 | Pharmaceutical Biology2002，40，6： | 1 |
| 8 | In vitro α-glucosidase and a-amylase enzyme inhibitory effects of Andrographis paniculata extract and andrographolide 显示文摘 | Subramanian R Asmawi M Z Sadikun A | 2008 | Acta Biochim Pol2008，55，2： | 1 |
| 9 | Antioxidant, anti-TB activities, phenolic and amide contents of standardised extracts of Piper sarmentosum Roxb 显示文摘 | I-Iussain K Ismail Z Sadikun A | 2009 | Nat Prod Res2009，23，3： | 1 |
| 10 | Flavonoid identification and hypoglycaemic studies of the butanol fractionfrom Gynura procumbens显示文摘 | AKOWUAH G A SADIKUN A MARIAM A | 2002 | Pharmaceutical Biology2002，，： | 1 |
| 11 | Pharmacological mechanisms underlying the vascular activities of Loranthus ferrugineus Roxb. in rat thoracic aorta显示文摘 | Omar Z. Ameer Ibrahim M. Salman Mohammad Jamshed A. Siddiqui Mun F. Yam Raghava N. Sriramaneni Ali J. Mohamed Amirin Sadikun Zhari Ismail Amin M. Shah Mohd. Z. Asmawi | 2009 | Journal of Ethnopharmacology2009，，1： | 1 |
| 12 | Flavonoid iden- tification and hypoglycaemic studies of the butanol fraction from Gynura procumbens显示文摘 | AKOWUAH G A SADIKUN A MARIAM A | 2002 | Pharmaceutical Biology2002，40，6： | 1 |
| 13 | Studies on diuretic and hypouricemic effects of Orthosiphon stamineus methanol extracts in rats 显示文摘 | Ararat O M Tham S Y Sadikun A | 2008 | J Ethnopharmacol2008，118，： | 1 |
| 14 | Antioxidant Potential of Gynura procumbens显示文摘 | Rosidah Mun Yam Amirin Sadikun Mohd. Asmawi | 2008 | Pharmaceutical Biology2008，，9： | 1 |
| 15 | Flavonoid Identification and Hypoglycaemic Studies of the Butanol Fraction from Gynura procumbens显示文摘 | Akowuah GA Sadikun A Marriam A | 2002 | Pharmaceutical Biology''2002，40，6： | 1 |
| 16 | Antioxidant potential of Gynura procumbens 显示文摘 | YAM M SADIKUN A ASMAWI M | 2008 | Pharmaceutical Biology2008，46，9： | 1 |
| 17 | A bitter plant with a sweet future? A comprehensive review of an oriental medic- inal plant: Andrographis paniculata 显示文摘 | R Subramanian Mohd Zaini Asmawi A Sadikun | 2012 | Phytochem Rev2012，11，1： | 1 |
| 18 | Flavonoid identification and hypoglycaemic studies of the butanol fraction from Gynura procumbens显示文摘 | Akowuah GA Sadikun A Mariam A | 2002 | Pharmaceutical Biology2002，40，： | 1 |
| 19 | Hypoglycaemic activity of the aqueous extract of Orthosiphon stamineus 显示文摘 | Mariam A Amawi M Z Sadikun A | 1996 | Fitoterapia1996，67，： | 1 |
| 20 | The effects of different extraction solvents of varying polarities on polyphenols of Orthosiphon stamineus and evaluation of the free radical-scavenging activity显示文摘 | G.A. Akowuah Z. Ismail I. Norhayati A. Sadikun | 2004 | Food Chemistry2004，，2： | 1 |
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