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| 1 | Evaluation of VEGF gene polymorphisms and proliferative diabetic retinopathy in Mexican population显示文摘● AIM: To assess if the included vascular endothelial growth factor(VEGF) polymorphisms rs3025035, rs3025021 and rs2010963 are associated to proliferative retinopathy in a Mexican population with type 2 diabetes mellitus(T2DM).● METHODS: A case-control study was conducted in adult individuals with T2 DM associated to proliferative retinopathy or non-proliferative retinopathy from Oct. 2014 to Jun. 2015 from the Retina Department of the Asociation to Prevent Blindness in Mexico. The selected patients were adults with a diagnosis of T2 DM ≥5y. All subjects had a comprehensive ocular examination and the classification of the retinopathy severity was made considering the Early Treatment Diabetic Retinopathy Study(ETDRS) standardization protocols. Genomic DNA was extracted from whole fresh blood. All samples were genotyped by q PCR for selected VEGF polymorphisms. Hardy-Weinberg equilibrium was calculated by comparing Chi-square values between the expected and the observed values for genotype counts.● RESULTS: In total 142 individuals were enrolled, 71 individuals with T2 DM and associated proliferative retinopathy and 71 individuals with non-proliferative retinopathy. One-sided Fisher's exact test was performed for rs3025021[OR(95% CI)=0.44(0.08-2.2); P=0.25] and rs2010963 [OR(95% CI)=0.63(0.25-1.6); P=0.23]. The minor allelic frequencies obtained were 26% for rs3025021, 10% for rs3025035 and 61% for rs2010963. The pairwise linkage disequilibrium between the three SNP was assessed, and was as follows: rs3025021 vs rs3025035: D'=1.0, r^2=0.1043, P≤0.0001; rs3025021 vs rs2010963: D'=0.442, r^2=0.0446, P=0.149; rs3025035 vs rs2010963: D'=0.505, r^2=0.0214, P=0.142.● CONCLUSION: This is the first analysis involving VEGFA polymorphisms and proliferative diabetic retinopathy in a Mexican population. A major finding of the present study is that none of the polymorphisms studied was significantly associated with proliferative retinopathy. Based on these results, we can infer that different populations have different associations for the same polymorphisms. | Roberto Gonzalez-Salinas Maria C Garcia-Gutierrez Gerardo Garcia-Aguirre Virgilio Morales-Canton Raul Velez-Montoya Vidal R Soberon-Ventura Victoria Gonzalez Rodrigo Lechuga Pablo Garcia-Solis David G Garcia-Gutierrez Marco Vinicio Garcia-Solis Manuel Saenz de Viteri Juan C Solis-S | 2017 | International Journal of Ophthalmology(English edition)2017，10，1： | 12 |
| 2 | Mod- eling and control of a wind turbine driven doubly fed induction generator 显示文摘 | TAPIA A TAPIA G OSTOLAZA J X SAENZ J R | 2003 | IEEE Transactions on Energy Conversion2003，18，2： | 1 |
| 3 | Transcriptional regulation by Poly(ADP-ribose) polymerase-1 during T cell activation显示文摘 | Saenz L Lozano J J Valdor R | 2008 | BMC Genomics2008，9，171： | 1 |
| 4 | Equivalent models of wind farms by using aggregated wind turbines and equivalent winds显示文摘 | Fernandez L M Garcia C A Saenz J R | 2009 | Energy Conversion and Management2009，50，3： | 1 |
| 5 | Dynamic models of wind farms with fixed peed wind turbines显示文摘 | Fernandez L M Saenz J R Jurado F | 2006 | Renewable Energy2006，31，8： | 1 |
| 6 | The major genetic determinants of HIV-1control affect HLA class I peptide presentation显示文摘 | International HIV Controllers Study Pereyra F Jia X McLaren P J Telenti A de Bakker P I Walker B D Ripke S Brumme C J Pulit S L Carrington M Kadie C M Carlson J M Heckerman D Graham R R Plenge R M Deeks S G Gianniny L Crawford G Sullivan J Gonzalez E Davies L Camargo A Moore JM Beattie N Gupta S Crenshaw A Burtt N P Guiducci C Gupta N Gao X Qi Y Yuki Y Piechocka-Trocha A Cutrell E Rosenberg R Moss K L Lemay P O'Leary J Schaefer T Verma P Toth I Block B Baker B Rothchild A Lian J Proudfoot J Alvino D M Vine S Addo M M Allen T M Altfeld M Henn M R Le Gall S Streeck H Haas D W Kuritzkes D R Robbins G K Shafer R W Gulick R M Shikuma C M Haubrich R Riddler S Sax P E Daar E S Ribaudo H J Agan B Agarwal S Ahern R L Allen B L Altidor S Altschuler E L Ambardar S Anastos K Anderson B Anderson V Andrady U Antoniskis D Bangsberg D Barbaro D Barrie W Bartczak J Barton S Basden P Basgoz N Bazner S Bellos N C Benson A M Berger J Bernard N F Bernard A M Birch C Bodner S J Bolan R K Boudreaux E T Bradley M Braun J F Brndjar J E Brown S J Brown K Brown S T Burack J Bush LM Cafaro V Campbell O Campbell J Carlson R H Carmichael J K Casey K K Cavacuiti C Celestin G Chambers S T Chez N Chirch L M Cimoch P J Cohen D Cohn LE Conway B Cooper D A Cornelson B Cox D T Cristofano M V Cuchural G Jr Czartoski J L Dahman J M Daly J S Davis B T Davis K Davod S M DeJesus E Dietz C A Dunham E Dunn M E Ellerin T B Eron J J Fangman J J Farel C E Ferlazzo H Fidler S Fleenor-Ford A Frankel R Freedberg K A French N K Fuchs JD Fuller J D Gaberman J Gallant J E Gandhi R T Garcia E Garmon D Gathe J C Jr Gaultier C R Gebre W Gilman F D Gilson I Goepfert P A Gottlieb M S Goulston C Groger R K Gurley T D Haber S Hardwicke R Hardy W D Harrigan P R Hawkins T N Heath S Hecht F M Henry W K Hladek M Hoffman R P Horton J M Hsu R K Huhn G D Hunt P Hupert M J Illeman M L Jaeger H Jellinger R M John M Johnson J A Johnson K L Johnson H Johnson K Joly J Jordan W C Kauffman C A Khanlou H Killian R K Kim A Y Kim D D Kinder C A Kirchner J T Kogelman L Kojic E M Korthuis P T Kurisu W Kwon D S LaMar M Lampiris H Lanzafame M Lederman M M Lee D M Lee J M Lee M J Lee E T Lemoine J Levy J A Llibre J M Liguori M A Little S J Liu A Y Lopez A J Loutfy M R Loy D Mohammed D Y Man A Mansour M K Marconi V C Markowitz M Marques R Martin J N Martin H L Jr Mayer K H McElrath M J McGhee T A McGovern B H McGowan K McIntyre D Mcleod GX Menezes P Mesa G Metroka CE Meyer-Olson D Miller A O Montgomery K Mounzer K C Nagami E H Nagin I Nahass R G Nelson M O Nielsen C Norene D L O'Connor D H Ojikutu B O Okulicz J Oladehin O O Oldfield E C Olender S A Ostrowski M Owen WF Jr Pae E Parsonnet J Pavlatos A M Perlmutter A M Pierce M N Pincus J M Pisani L Price L J Proia L Prokesch R C Pujet H C Ramgopal M Rathod A Rausch M Ravishankar J Rhame F S Richards C S Richman D D Rodes B Rodriguez M Rose R C 3rd Rosenberg E S Rosenthal D Ross P E Rubin D S Rumbaugh E Saenz L Salvaggio M R Sanchez WC Sanjana V M Santiago S Schmidt W Schuitemaker H Sestak P M Shalit P Shay W Shirvani V N Silebi V I Sizemore J M Jr Skolnik P R Sokol-Anderson M Sosman J M Stabile P Stapleton J T Starrett S Stein F Stellbrink H J Sterman FL Stone V E Stone D R Tambussi G Taplitz R A Tedaldi E M Telenti A Theisen W Torres R Tosiello L Tremblay C Tribble M A Trinh P D Tsao A Ueda P Vaccaro A Valadas E Vanig T J Vecino I Vega V M Veikley W Wade B H Walworth C Wanidworanun C Ward D J Warner D A Weber R D Webster D Weis S Wheeler D A White D J Wilkins E Winston A Wlodaver C G van't Wout A Wright D P Yang O O Yurdin D L Zabukovic B W Zachary K C Zeeman B Zhao M | 2010 | Science2010，330，6010： | 1 |
| 7 | Equivalent models of wind farms by using aggregated wind turbines and equivalent winds显示文摘 | FERNáNDEZ L M GARCíA C A SAENZ J R | 2009 | Energy Conversion and Management2009，50，3： | 1 |
| 8 | The incidence of nosocomial infection in the Intensive Care Unit显示文摘 | Valero Juan LF Campos R M Saenz MC | 1996 | Rev Clin Esp1996，196，5： | 1 |
| 9 | Equivalent models of wind farms by using aggregated wind turbines and equivalent winds显示文摘 | FERNANDEZ L M GARCIA C A SAENZ J R | 2009 | Energy Conversion and Management2009，50，3： | 1 |
| 10 | Dynamic models of wind farms with fixed speed wind turbines显示文摘 | FERNANDEZ L M SAENZ J R JURADO F | 2006 | Renewable Energy2006，31，8： | 1 |
| 11 | Comparison of the permeability properties and post-thaw motility of ejaculated and epididymal bovine spermatozoa 显示文摘 | Alapati R Stout M Saenz J | 2009 | Cryobiology2009，59，2： | 1 |
| 12 | Safety and efficacy of colistin in Acinetobacter and Pseudomonas infections: a prospective cohort study 显示文摘 | Reina R Estenssoro E Saenz G | 2005 | Intensive Care Med2005，31，8： | 1 |
| 13 | Pilot studyprospectively evaluating the use of the measurement of preopera-tive sonographic endometrial thickness in postmenopausal patientswith endometrial cancer显示文摘 | EITAN R SAENZ CC VENKATRAMAN ES | 2005 | Menopause2005，12，1： | 1 |
| 14 | Use of botulinum toxin type A on orthopedics: a case report 显示文摘 | Saenz A Avellanet M Garreta R | 2003 | Arch Phys Med Rehabil2003，84，7： | 1 |
| 15 | Equivalem models of wind farms by using aggregated wind turbines and equivalent wind显示文摘 | Fernandez L M Garcia C A saenz J R | 2009 | Energy Conversion and Management2009，，50： | 1 |
| 16 | Treatment of terminal peritoneal carcinomatosis by a transducible p53-activating peptide 显示文摘 | SnyderE L Meade B R Saenz C C Dowdy S F | 2004 | PLoS Biol2004，2，： | 1 |
| 17 | Estrogen contributes to structural recovery after a lesion 显示文摘 | Saenz C Dominguez R de Lacalle S | 2006 | Neurosci Lett2006，392，3： | 1 |
| 18 | Modeling and control of a wind turbine driven doubly fed induction generator显示文摘 | TAPIA A G OSTOLAZA J X Saenz J R | 2003 | IEEE ransactions on Energy Conversion2003，8，2： | 1 |
| 19 | Aggregated dynamic model for wind farms with doubly fed induction generator wind turbines显示文摘 | Fernandez L M Jurado F Saenz J R | 2008 | Renewable Energy2008，33，3： | 1 |
| 20 | Treatment of terminal peritoneal carcinomatosis by a transducible p53-activating peptide显示文摘 | SNYDER E L MEADE B R SAENZ C C | 2004 | PLos Biol2004，2，2： | 1 |
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