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| 1 | Gastrointestinal B-cell lymphomas:From understanding B-cell physiology to classification and molecular pathology显示文摘The gut is the most common extranodal site where lymphomas arise. Although all histological lymphoma types may develop in the gut, small and large B-cell lymphomas predominate. The sometimes unexpected finding of a lymphoid lesion in an endoscopic biopsy of the gut may challenge both the clinician (who is not always familiar with lymphoma pathogenesis) and the pathologist (who will often be hampered in his/her diagnostic skill by the limited amount of available tissue). Moreover, the past 2 decades have spawned an avalanche of new data that encompasses both the function of the reactive B-cell as well as the pathogenic pathways that lead to its neoplastic counterpart, the B-cell lymphoma. Therefore, this review aims to offer clinicians an overview of B-cell lymphomas in the gut, and their pertinent molecular features that have led to new insights regarding lymphomagenesis. It addresses the question as how to incorporate all presently available information on normal and neoplastic B-cell differentiation, and how this knowledge can be applied in daily clinical practice (e.g., diagnostic tools, prognostic biomarkers or therapeutic targets) to optimalise the managment of this heterogeneous group of neoplasms. | Xavier Sagaert Thomas Tousseyn Rhonda K Yantiss | 2012 | World Journal of Gastrointestinal Oncology2012，4，12： | 2 |
| 2 | Forkhead Box Protein P1 Expre- ssion in Mucosa-Associated Lymphoid Tissue Lymphomas Predicts Poor Prognosis and Transformation to Diffuse Large B-Cell Lympho- ma 显示文摘 | Sagaert X Paepe P Libbrecht L | 2006 | J Clin Oncol2006，24，16： | 1 |
| 3 | Deficiency of gelati-nase B/MMP-9 aggravates lpr-induced lymphoprolifera-tion and lupus-like systemic autoimmune disease显示文摘 | Cauwe B Martens E Sagaert X | 2011 | JAutoimmun2011，36，34： | 1 |
| 4 | Prognostic biomarkers in colorectal cancer: where do we stand? 显示文摘 | Sagaert X | 2014 | Virchows Arch2014，464，37： | 1 |
| 5 | Single-center analysis of biopsy-confirmed posttransplant lymphoproliferative disorder: incidence, clinicopathological characteristics and prognostic factors显示文摘 | Daan Dierickx Thomas Tousseyn Xavier Sagaert Steffen Fieuws Iwona Wlodarska Julie Morscio Lieselot Brepoels Dirk Kuypers Johan Vanhaecke Frederik Nevens Geert Verleden Rita Van Damme-Lombaerts Marleen Renard Jacques Pirenne Christiane De Wolf-Peeters Greg | 2013 | Leukemia & Lymphoma2013，，11： | 1 |
| 6 | Forkhead box protein P1 expression in mucosa-associated lymphoid tissue lymphomas predicts poor prognosis and transformation to diffuse large B-cell lymphoma显示文摘 | Sagaert X de Paepe P Libbrecht L | 2006 | Journal of Clinical Oncology2006，24，16： | 1 |
| 7 | Forkhead box protein P1expression in mucosa-associated lymphoid tissue lymphomas pre-dicts poor prognosis and transformation to diffuse large B-celllymphoma显示文摘 | Sagaert X Paepe PD Libbrecht L | 2006 | J Clin Oncol2006，24，16： | 1 |
| 8 | Gastric MALT lymphorna: a modal ff chronic inflammation-induced tumor development 显示文摘 | Sagaert X Van Cutsem E De I-Iertosh G | 2010 | Nat Rev Gastroenterol Hepatol2010，7，6： | 1 |
| 9 | Single-center analy-sis of biopsy-confirmed posttransplant lymphoproliferative disor-der; Incidence, clinico-pathological characteristics and prognosticfactors显示文摘 | Dierickx D Tousseyn T Sagaert X | 2013 | Leuk Lymphoma2013，54，11： | 1 |
| 10 | MALT1 and BCL10 aberrations in MALT lymphomas and their effect on the expression of BCL10 in the tumour cells 显示文摘 | Sagaert X Laurent M Baens M | 2006 | Mod Pathol2006，19，2： | 1 |
| 11 | The use of FDG-PET/CT and diffusion-weighted magnetic resonance imaging for response prediction before, during and after preoperative chemoradiotherapy for rectal cancer显示文摘 | Maarten Lambrecht Christophe Deroose Sarah Roels Vincent Vandecaveye Freddy Penninckx Xavier Sagaert Eric van Cutsem Frederik de Keyzer Karin Haustermans | 2010 | Acta Oncologica2010，，： | 1 |
| 12 | Forkhead box protein P1 expression in mucosa-associated lymphoid tissue lymphomas predicts poor prognosis and transformation to diffuse Xarge B-cell lymphoma 显示文摘 | SAGAERT X PAEPE P D LIBBRECHT L | 2006 | J Clin Oncol2006，24，16： | 1 |
| 13 | Fork-head box protein P1 expression in mucosa-associated lymphoid tissue lymphomas predicts poor prognosis and transformation to diffuse large B-cell lymphoma 显示文摘 | SAGAERT X DE PAEPE P LIBBRECHT L | 2006 | J Clin Oncol2006，24，16： | 1 |
| 14 | Forkhead box protein P1 expression in mucosa-associated lymphoid tissue lymphomas predicts poor prognosis and transformation to diffuse large B-cell lymphoma显示文摘 | Sagaert X De Paepe P Libbrecht L | 2006 | J Clin Oncol2006，24，16： | 1 |
| 15 | Gastric malt Iymphoma:a model of chronic inflammation induced tumor development 显示文摘 | Sagaert X Van Cutsem E De Hertogh G | 2010 | Nat Rev Gastroenterol Hepatol2010，7，6： | 1 |
| 16 | Gastric MALT lymphoma:a model of chronic inflammation-in- duced tumor development显示文摘 | Sagaert X Van Cutsem E De Hertogh G | 2010 | Nat Rev Gastroenterol Hepatol2010，7，6： | 1 |
| 17 | T(11;18)(q21;q21)-positive gastrointestinal MALT lymphomas are heterogeneous with respect to the V_H gene mutation status显示文摘AIM: To investigate how t(11;18)(q21;q21)-positive gastrointestinal MALT lymphomas relate to other marginal zone lymphomas with respect to the somatic mutation pattern of the VH genes and the expression of the marker CD27. METHODS: The VH gene of 7 t(11;18)(q21;q21)- positive gastrointestinal MALT lymphomas was amplif iedby PCR using family specif ic VH primers and a consensus JH primer. PCR products were sequenced and mutation analysis of the CDR and the FR regions was performed. All cases were immunostained for CD27. RESULTS: One case showed unmutated VH genes while the others showed mutated VH genes with mutation frequencies ranging from 1.3 to 14.7% and with evidence of antigen selection in 2 cases. These data suggest that the translocation t(11;18)(q21;q21) can target either B-cells at different stages of differentiation or naive B-cells that retain the capacity to differentiate upon antigen stimulation. All cases but one displayed weak to strong CD27 expression which did not correlate with the VH gene mutation status. CONCLUSION: t(11;18)(q21;q21)-positive gastrointestinal MALT lymphomas are heterogeneous with respect to the VH mutation status and CD27 is not a marker of somatically mutated B-cells. | Xavier Sagaert Vera Vanhentenrijk Gert De Hertogh Karel Geboes Thomas Tousseyn Brigitte Maes Mathijs Baens Eric Van Cutsem | 2011 | World Journal of Gastrointestinal Oncology2011，3，2： | 0 |
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