| 4 | Association of apolipoprotein E-219T>G promoter polymorphism with primary open angle glaucoma in Turkish population显示文摘AIM:To investigate the association between apolipoprotein E(APOE)-219 T>G promoter polymorphism and primary open angle glaucoma(POAG).METHODS:Patients and healthy subjects were genotyped with polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP).Genotype/allele frequencies were compared between 122 healthy subjects and in 75 POAG patients using Chi-square test.RESULTS:Although the frequency of APOE-219 GG genotype was higher in POAG group(13.3%)than in control group(6.6%),this finding was not statistically significant(P=0.09).In glaucoma patients carrying GG genotype,mean linear C/D ratio was higher and progression was more compared to glaucoma patients with GT genotype.CONCLUSION:APOE-219 T>G polymorphism does not seem to be a risk factor for the presence of glaucoma,but might play a role in deterioration of the disease,which needs further evaluation. | Emel Saglar Banu Bozkurt Murat Irkec | 2014 | International Journal of Ophthalmology(English edition)2014，7，3： | 0 |
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