|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Sharing Clinical Trial Data: A Proposal from the International Committee of Medical Journal Editors显示文摘The International Committee of Medical Journal Editors (ICMJE) believes that there is an ethical obligation to responsibly share data generated by interventional clinical trials because participants have put themselves at risk.In a growing consensus,many funders around the world-foundations,government agencies,and industry-now mandate data sharing.Here,we outline ICMJE's proposed requirements to help meet this obligation.We encourage feedback on the proposed requirements.Anyone can provide feedback at www.icmje.org by April 18,2016. | Darren B Taichman Joyce Backus Christopher Baethge Howard Bauchner Peter W de Leeuw Jeffrey M Drazen John Fletcher Frank Frizelle Irish Groves Abraham Haileamlak Astrid James Christine Laine Larry Peiperl Anja Pinborg Peush Sahni Si-Nan Wu | 2016 | Chinese Medical Journal2016，，2： | 20 |
| 2 | Differentiating Crohn's disease from intestinal tuberculosis显示文摘Differentiating Crohn's disease(CD) and intestinal tuberculosis(ITB) has remained a dilemma for most of the clinicians in the developing world, which are endemic for ITB, and where the disease burden of inflammatory bowel disease is on the rise. Although, there are certain clinical(diarrhea/hematochezia/perianal disease common in CD; fever/night sweats common in ITB), endoscopic(longitudinal/aphthous ulcers common in CD; transverse ulcers/patulous ileocaecal valve common in ITB), histologic(caseating/confluent/large granuloma common in ITB; microgranuloma common in CD), microbiologic(positive stain/culture for acid fast-bacillus in ITB), radiologic(long segment involvement/comb sign/skip lesions common in CD; necrotic lymph node/contiguous ileocaecal involvement common in ITB), and serologic differences between CD and ITB, the only exclusive features are caseation necrosis on biopsy, positive smear for acid-fast bacillus(AFB) and/or AFB culture, and necrotic lymph node on cross-sectional imaging in ITB. However,these exclusive features are limited by poor sensitivity, and this has led to the development of multiple multi-parametric predictive models. These models are also limited by complex formulae, small sample size and lack of validation across other populations. Several new parameters have come up including the latest Bayesian meta-analysis, enumeration of peripheral blood T-regulatory cells, and updated computed tomography based predictive score. However, therapeutic anti-tubercular therapy(ATT) trial, and subsequent clinical and endoscopic response to ATT is still required in a significant proportion of patients to establish the diagnosis. Therapeutic ATT trial is associated with a delay in the diagnosis of CD, and there is a need for better modalities for improved differentiation and reduction in the need for ATT trial. | Saurabh Kedia Prasenjit Das Kumble Seetharama Madhusudhan Siddhartha Dattagupta Raju Sharma Peush Sahni Govind Makharia Vineet Ahuja | 2019 | World Journal of Gastroenterology2019，25，4： | 19 |
| 3 | 烟酰胺磷酸核糖基转移酶促进肺血管重塑,是肺动脉高压的治疗靶点显示文摘肺动脉高压(pulmonary arterial hypertension,PAH)是一种严重的进行性疾病,其标志之一是肺血管重塑。烟酰胺磷酸核糖基转移酶(nicotinamide phosphoribosyl transferase,NAMPT)是调节细胞内烟酰胺腺嘌呤二核苷酸水平、细胞氧化还原状态,调节组蛋白脱乙酰酶,促进细胞增殖和抑制凋亡的一种细胞酶。研究人员假设NAMPT可促进肺血管重塑, | Chen J Sysol JR Singla S Zhao S Yamamura A Valdez-Jasso D Abbasi T Shioura KM Sahni S Reddy V Sridhar A Gao H Torres J Camp SM Tang H Ye SQ Comhair S Dweik R Hassoun P Yuan JX Garcia JG Machado RF 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，2： | 10 |
| 4 | Endovascular management in abdominal visceral arterial aneurysms:A pictorial essay显示文摘Visceral artery aneurysms(VAAs) include aneurysms of the splanchnic circulation and those of the renal artery.Their diagnosis is clinically important because of the associated high mortality and potential complications.Splenic,superior mesenteric,gastroduodenal,hepatic and renal arteries are some of the common arteries affected by VAAs.Though surgical resection and anastomosis still remains the treatment of choice in some of the cases,especially cases involving the proximal arteries,increasingly endovascular treatment is being used for more distal vessels.We present a pictorial review of various intra-abdominal VAAs and their endovascular management. | Manisha Jana Shivanand Gamanagatti Amar Mukund Sujoy Paul Pankaj Gupta Pramod Garg Tushar K Chattopadhyay Peush Sahni | 2011 | World Journal of Radiology2011，3，7： | 5 |
| 5 | Plasma cathepsin L:A prognostic marker for pancreatic cancer显示文摘AIM:To assess the prognostic significance of cathepsin L,a cysteine protease that degrades the peri-tumoral tissue,in patients with pancreatic cancer.METHODS:Plasma samples from 127 pancreatic cancer patients were analyzed for cathepsin L levels by ELISA.Out of these patients,25 underwent surgeryand their paraffin-embedded tissue was analyzed for cathepsin L expression by immunohistochemistry.Survival of patients and clinicopathological parameters was correlated with cathepsin L expression in plasma and tissue using appropriate statistical analysis.RESULTS:The mean(±SD)cathepsin L in plasma samples of pancreatic cancer patients was 5.98±2.5ng/m L that was significantly higher compared to the levels in healthy controls(3.83±0.45)or chronic pancreatitis patients(3.97±1.06).Using ROC curve,a cut-off level of 5.0 ng/m L was decided for survival analysis.Elevated plasma levels of cathepsin L were found to be associated with poor prognosis(P=0.01)in multivariate analysis.The plasma levels of the protease decreased after surgery.Though no significant correlation was seen between plasma and tissue expression of this protease,a trend did emerge that high cathepsin L expression in tissue correlated with its high levels in plasma.CONCLUSION:Cathepsin L levels in plasma of pancreatic cancer patients may be used as a potential prognostic marker for the disease. | Nidhi Singh Prasenjit Das Surabhi Gupta Vikas Sachdev Siddhartha Srivasatava Siddhartha Datta Gupta Ravindra Mohan Pandey Peush Sahni Shyam S Chauhan Anoop Saraya | 2014 | World Journal of Gastroenterology2014，20，46： | 2 |
| 6 | Prognostic Significance of Extracellular Matrix Degrading Enzymes—Cathepsin L and Matrix Metalloproteases-2 [MMP-2] in Human Pancreatic Cancer显示文摘 | Nidhi Singh Prasenjit Das Siddhartha Datta Gupta Peush Sahni R. M. Pandey Surabhi Gupta Shyam S. Chauhan Anoop Saraya | 2013 | Cancer Investigation2013，，7： | 2 |
| 7 | 临床试验数据共享声明国际医学期刊编辑委员会统一要求显示文摘国际医学期刊编辑委员会(ICMJE)认为,由于临床试验参与者处于研究风险之中,我们有伦理义务来负责任地共享干预性临床试验产生的原始数据。2016年1月,ICMJE发表了1项关于临床试验数据共享的提案,旨在帮助创造共享去标识个体患者数据的常态化环境。迄今,应我们的反馈要求,ICMJE收到了很多来自个人和团体的意见。 | Darren B Taichman Peush Sahni Larry Peiperl Christine Laine Astrid James Sung-Tae Hong Abraham Haileamlak Laragh Gollogly Fiona Godlee Frank A Frizelle Fernando Florenzano Jeffrey M Drazen Howard Bauchner Christopher Baethge Deutsches Arzteblatt Joyce Backus 季媛媛 | 2017 | 英国医学杂志中文版2017，20，7： | 2 |
| 8 | Molecular functions of the iron-regulated metastasis suppressor, NDRG1, and its potential as a molecular target for cancer therapy显示文摘 | Bernard A. Fang ?aklina Kova?evi? Kyung Chan Park Danuta S. Kalinowski Patric J. Jansson Darius J.R. Lane Sumit Sahni Des R. Richardson | 2014 | BBA - Reviews on Cancer2014，，1： | 2 |
| 9 | 临床试验数据共享声明显示文摘国际医学期刊编辑委员会(ICMJE)认为,由于临床试验参与者处于研究风险之中,我们有伦理义务来负责任地共享干预性临床试验产生的原始数据。2016年1月,ICMJE发表了一项关于临床试验数据共享的提案,旨在帮助创造共享去标识个体患者数据的常态化环境。 | Darren B Taichman Peush Sahni Anja Pinborg Larry Peiperl Christine Laine Astrid James Sung-Tae Hong Abraham Haileamlak Laragh Gollogly Fiona Godlee Frank A Frizelle Fernando Florenzano Jeffrey M Drazen Howard Bauchner Christopher Baethge Joyce Backus 季媛媛 | 2017 | 中国医院院长2017，13，16： | 2 |
| 10 | Efficient construction of multibit tries for IP lookup显示文摘 | Sahni S Kun Suk Kim | 2003 | IEEE/ACM Transactions on Networking2003，11，4： | 2 |
| 11 | Dentition ofSivaladapis nagrii (Adapidae) from the late Miocene of India显示文摘 | Philip D. Gingerich Ashok Sahni | | International Journal of Primatology0，，1： | 2 |
| 12 | PARALLEL ADAPTIVE SIMULATION OF A PLUNGING LIQUID JET显示文摘This paper is concerned with three-dimensional numerical simulation of a plunging liquid jet.The transient processes of forming an air cavity around the jet,capturing an initially large air bubble,and the break-up of this large toroidal-shaped bubble into smaller bubbles were analyzed.A stabilized finite element method(FEM)was employed under parallel numerical simulations based on adaptive,unstructured grid and coupled with a level-set method to track the interface between air and liquid.These simulations show that the inertia of the liquid jet initially depresses the pool's surface,forming an annular air cavity which surrounds the liquid jet.A toroidal liquid eddy which is subsequently formed in the liquid pool results in air cavity collapse,and in turn entrains air into the liquid pool from the unstable annular air gap region around the liquid jet. | Azat Yu.Galimov Onkar Sahni Richard T.Lahey Jr. Mark S.Shephard Donald A.Drew Kenneth E.Jansen | 2010 | Acta Mathematica Scientia2010，30，2： | 2 |
| 13 | TRPM7 ion channels are required for sustained phosphoinositide 3-kinase signaling in lymphocytes显示文摘 | Sahni J Scharenberg AM | 2008 | Cell Metabolism2008，8，1： | 1 |
| 14 | Statefinder—A new geometrical diagnostic of dark energy显示文摘 | V. Sahni T. D. Saini A. A. Starobinsky U. Alam | 2003 | Journal of Experimental and Theoretical Physics Letters2003，，5： | 1 |
| 15 | GPU - to - GPU and host - to - host mul- tipattern string matching on a GPU 显示文摘 | ZHA X SAHNI S | 2013 | IEEE Transactions on Computers2013，62，6： | 1 |
| 16 | Early multifocal electroretinogram findings during intravitreal ranibizumab treatment for neovascular age-related macular degeneration显示文摘 | Campa C Hagan R Sahni J N | 2011 | Invest Ophthalmol Vis Sci2011，52，6： | 1 |
| 17 | P- complete approximation problems 显示文摘 | Sahni S Gonzalez T | 1976 | Journal of the Association of computing Machinery1976，23，： | 1 |
| 18 | Use of percutaneous transpedicular external fixation pins to measure intervertebral motion显示文摘 | Sahni IK Hipp JA Kirking BC | 1999 | Spine (Phila Pa 1976)1999，24，18： | 1 |
| 19 | Special issue on general-purpose processing using graphics processing units显示文摘 | GOTTLIED A HWANG K SAHNI S | 2008 | Journal of Parallel and Distributed Computing2008，68，10： | 1 |
| 20 | Is there Supernova Evidence for Dark Energy Metamorphosis? 显示文摘 | ALAM U SAHNI V SAINI T D | 2004 | Mon Not Roy Astron Soc2004，354，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员