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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | Bcl-2 degradation is an additional pro-apoptotic effect of polo-like kinase inhibition in cholangiocarcinoma cells显示文摘AIM To examine the influence on apoptotic mechanisms following inhibition of polo-like kinases as therapeuticallyapproach for cholangiocellular cancer treatment. METHODS As most cholangiocarcinomas are chemotherapyresistant due to mechanisms preventing tumor cell death, we investigated the effect of Cisplatin on cholangiocellular carcinoma(CCA) cell lines KMCH-1 and Mz-Ch-1. Polo-like kinases(PLK) are important regulators of the cell cycle and their inhibition is discussed as a potential therapy while PLK inhibition can regulate apoptotic mediators. Here, cells were treated with PLK inhibitor BI6727(Volasertib), Cisplatin, and in combination of both compounds. Cell viability was assessed by MTT; apoptosis was measured by DAPI staining and caspase-3/-7 assay. Western blot and q RT-PCR were used to measure expression levels of apoptosis-related molecules Bax and Bcl-2. RESULTS The cell viability in the CCA cell lines KMCH-1 and Mz-Ch-1 was reduced in all treatment conditions compared to vehicle-treated cells. Co-treatment with BI6727 and cisplatin could even enhance the cytotoxic effect of cisplatin single treatment. Thus, co-treatment of cisplatin with BI6727 could slightly enhance the cytotoxic effect of the cisplatin in both cell lines whereas there was evidence of increased apoptosis induction solely in Mz-Ch-1 as compared to KMCH-1. Moreover, PLK inhibition decreases protein levels of Bcl-2; an effect that can be reversed by the proteasomal degradation inhibitor MG-132. In contrast, protein levels of Bax were not found to be altered by PLK inhibition. These findings indicate that cytotoxic effects of Cisplatin in Mz-Ch-1 cells can be enhanced by co-treatment with BI6727.CONCLUSION In conclusion, BI6727 treatment can sensitize CCA cells to cisplatin-induced apoptosis with proteasomal Bcl-2 degradation as an additional pro-apoptotic effect. | Svenja Sydor Sami Jafoui Lena Wingerter Sandra Swoboda Joachim C Mertens Guido Gerken Ali Canbay Andreas Paul Christian D Fingas | 2017 | World Journal of Gastroenterology2017，23，22： | 5 |
| 3 | Single vs dual(en bloc) kidney transplants from donors ≤ 5 years of age: A single center experience显示文摘AIM: To compare outcomes between single and dual en bloc(EB) kidney transplants(KT) from small pediatric donors. METHODS: Monocentric nonprospective review of KTs from pediatric donors ≤ 5 years of age. Dual EB KT was defined as keeping both donor kidneys attached tothe inferior vena cava and aorta, which were then used as venous and arterial conduits for the subsequent transplant into a single recipient. Donor age was less useful than either donor weight or kidney size in decision-making for kidney utilization as kidneys from donors < 8 kg or kidneys < 6 cm in length were not transplanted. Post-transplant management strategies were standardized in all patients.RESULTS: From 2002-2015, 59 KTs were performed including 34 dual EB and 25 single KTs. Mean age of donors(17 mo vs 38 mo, P < 0.001), mean weight(11.0 kg vs 17.4 kg, P = 0.046) and male donors(50% vs 84%, P = 0.01) were lower in the dual EB compared to the single KT group, respectively. Mean cold ischemia time(21 h), kidney donor profile index(KDPI; 73% vs 62%) and levels of serum creatinine(SCr, 0.37 mg/d L vs 0.49 mg/d L, all P = NS) were comparable in the dual EB and single KT groups, respectively. Actuarial graft and patient survival rates at 5-years follow-up were comparable. There was one case of thrombosis resulting in graft loss in each group. Delayed graft function incidence(12% dual EB vs 20% single KT, P = NS) was slightly lower in dual EB KT recipients. Initial duration of hospital stay(mean 5.4 d vs 5.6 d) and the one-year incidences of acute rejection(6% vs 16%), operative complications(3% vs 4%), and major infection were comparable in the dual EB and single KT groups, respectively(all P = NS). Mean 12 mo SCr and abbreviated MDRD levels were 1.17 mg/d L vs 1.35 mg/d L and 72.5 m L/min per 1.73 m^2 vs 60.5 m L/min per 1.73 m^2(both P = NS) in the dual EB and single KT groups, respectively. CONCLUSION: By transplanting kidneys from young pediatric donors into adult recipients, one can effectively expand the limited donor pool and achieve excellent medium-term outcomes. | Yousef Al-Shraideh Umar Farooq Hany El-Hennawy Alan C Farney Amudha Palanisamy Jeffrey Rogers Giuseppe Orlando Muhammad Khan Amber Reeves-Daniel William Doares Scott Kaczmorski Michael D Gautreaux Samy S Iskandar Gloria Hairston Elizabeth Brim Margaret Mangus Robert J Stratta | 2016 | World Journal of Transplantation2016，6，1： | 3 |
| 4 | Hepatocellular carcinoma in Lebanon: Etiology and prognostic factors associated with short-term survival显示文摘瞄准:在黎巴嫩和早死亡预兆的预示的因素学习 HCC 的传染病学。方法:在一个五年的时期上诊断的 HCC 盒子的观察后续队研究被执行。Multivariate 分析被进行与肝意大利的程序(片断) 分数的癌症相比识别预示的因素。包括内在的肝疾病,病人的人口统计的特征,和孩子呸评估的肝疾病的严厉的病原学的多重变量得分被学习。肿瘤参数包括了小瘤,门静脉血栓的存在,和治疗形式的 HCC, alpha-fetoprotein 水平,数字和尺寸的诊断的时间。后续的死亡或损失被看作一个端点事件。结果:92 个病人(平均数 60.5 +/- 22.3 年) 被包括。内在的疾病的病原学分别地是在 67% , 20% ,和 23.5% 的肝炎 B, C,和酒精。在诊断的孩子呸班分别地是在 34.8% , 39.3% 和 25.8% 的 A, B,和 C。全面幸存分别地在 1, 2 和 3 年是 44.8% , 32.8% 和 17.6%( 吝啬的 F/U 40.2 +/- 23.5 瞬间) 。Multivariate 分析识别了早死亡的三个预言者(<
6 瞬间) :胆红素 >
3.2 mg/dL (P <
0.01 ) , HCC 作为肝疾病的第一个演讲(P = 0.035 ) ,并且肌酸酐 >
1 mg/dL (P = 0.017 ) 。一个分数由考克斯基于这些变量超过了片断分数比例的危险。巨鸟曲线显示了两个模型相等、中等精确。结论:HBV 是在黎巴嫩的 HCC 的领先的原因。早死亡的独立预言者是象疾病的第一表明的提高的胆红素,肌酸酐和 HCC。一个分数的未来的确认基于在预言短期的幸存的这些临床的参数被需要。 | César Yaghi Ala I Sharara Paul Rassam Rami Moucari Khalil Honein Joseph BouJaoude Rita Slim Roger Noun Heitham Abdul-Baki Mohamad Khalifeh Sami Ramia Raymond Sayegh | 2006 | World Journal of Gastroenterology2006，12，22： | 3 |
| 5 | Stability of aflatoxins B1 and ochrotoxin A in brewing显示文摘 | CHU F S CHANG C C SAMY H | 1975 | Applied Microbiology1975，19，3： | 1 |
| 6 | An improved model for predicting the dynamic behavior of adsorption systems显示文摘 | Sami S M Tribes C | 1996 | Applied Thermal Engineering1996，16，2： | 1 |
| 7 | Using a Grounded Theory Approach for Ex- ploring Software Product Management Challenges 显示文摘 | SAMI J DONALD C G | 2014 | Journal of Systems and Software2014，，95： | 1 |
| 8 | Effect of topical anti-inflammatory drugs on corneal and limbal wound healing显示文摘 | Barba KR Samy A Lai C | 2000 | J Cataract Refract Surg2000，26，6： | 1 |
| 9 | Immune enhancement in rainbow trout(Oncorhynchus mykiss)by potential probiotic bacteria(Lactobacillus rhamnosus) 显示文摘 | SAMI N ARTHUR C O GRAN B | 2003 | Fish & Shellfish Immunology2003，15，： | 1 |
| 10 | Numerical prediction of capillary tube behavior with pure and binary alternation refrigerants显示文摘 | TRIBES C | 1998 | Applied Thermal Engineering1998，18，6： | 1 |
| 11 | The investment opportunity set, director ownership, and corporate policies: evidence from an emerging market 显示文摘 | Simon S M Ho Kevin C K Heibatollah Sami | 2004 | Journal of Corporate Finance2004，，10： | 1 |
| 12 | Evaluation of the sap flow determined with a heat balance method to measure the transpiration of a sugarcane canopy显示文摘 | Rosanne Chabot Sami Bouarfa Daniel Zimmer Cédric Chaumont Sylvain Moreau | 2005 | Agricultural Water Management2005，，1： | 1 |
| 13 | Immunamodulatory activily of shikimic acid and quereitin in comparison with oseltamivir (Tamiflu)in an in vitro model 显示文摘 | Bertelli AA Mannari C Sami S | 2008 | J Med Virol2008，80，4： | 1 |
| 14 | Immune enhancement in rainbow trout by potential probiotic bacteria显示文摘 | Sami N Arthur C O Gran B | 2003 | Fish & Shellfish Immunology2003，15，： | 1 |
| 15 | Sugarcane transpiration with shallow water-table: Sap flow measurements and modeling 显示文摘 | ROSANNE C SAMI B DANIEL Z | 2002 | Agricultural Water Management2002，54，： | 1 |
| 16 | Adaptive control of a stewart platfor-based manipulator显示文摘 | Sami S Antrazi Zhou Zhen-lei | 1993 | J of Robotic Systems1993，10，5： | 1 |
| 17 | Numerical prediction of capillary tube behaviour and binary alternative refrigerants 显示文摘 | Sami S M Tribes C | 1998 | Applied Thermal Engineering1998，18，6： | 1 |
| 18 | Tumor Characteristics and Clinical Outcome of Elderly Women With Breast Cancer显示文摘 | SAMI G D RICHARD M E GARY M C | 2000 | Natl Cancer Inst2000，92，： | 1 |
| 19 | Analysis and Implementation of a 6 - DOF Stewart Platform - based Robotic Wrist显示文摘 | Charles C Nguyen Sami C Antrazi | 1991 | Computers & Electrical Engineering1991，17，： | 1 |
| 20 | Flexual Behaivior of OneWay Concrete Slabs Reinforced Plastic Reinforcement 显示文摘 | Michaluk C raig R Rizkalla Sami H | 1995 | ACI Structural Journal1995，，52： | 1 |
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