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| 1 | Acute-on-Chronic Liver Failure Is a Distinct Syndrome That Develops in Patients With Acute Decompensation of Cirrhosis显示文摘 | Richard Moreau Rajiv Jalan Pere Gines Marco Pavesi Paolo Angeli Juan Cordoba Francois Durand Thierry Gustot Faouzi Saliba Marco Domenicali Alexander Gerbes Julia Wendon Carlo Alessandria Wim Laleman Stefan Zeuzem Jonel Trebicka Mauro Bernardi Vicente Arro | 2013 | Gastroenterology2013，，7： | 12 |
| 2 | Salicylic acid binds NPR3 and NPR4 to regulate NPRl-dependent defense responses显示文摘 | Magali Moreau Miaoying Tian Daniel F Klessig | 2012 | Cell Research2012，22，12： | 10 |
| 3 | 慢加急性肝衰竭进展显示文摘2017年3月Gut发表了Hernaez等的综述《慢加急性肝衰竭进展》[Hernaez R,solaE,MoreauR,eta1.Acute—on—chronicliver failure:anupdate.Gut.2017.66:541—553]。慢加急性肝功能衰竭(acute—on—chronicliver failure,ACLF)是一种发生在有基础慢性肝病或者代偿期肝硬化患者中的,以由不同类型的损害导致的急性的严重肝功能异常为特征的综合征,短期病死率高,预后与急性肝衰竭相似。目前有很多不同的定义标准,2009年亚太肝病研究协会(APASL)提出了ACLF的第1版共识,2014年进行了更新。 | 姚勤伟 欧阳颖 孟庆华 Hernaez R Solà E Moreau R | 2017 | 北京医学2017，39，9： | 6 |
| 4 | 选择性CD_(34)^+细胞和非选择性自体外周血干细胞移植治疗多发性骨髓瘤的比较研究显示文摘目的 明确选择性CD3 4+ 细胞自体外周血干细胞移植 (APBSCT)治疗多发性骨髓瘤 (MM)的临床效果。方法 对 2 1例接受CD3 4+ 细胞APBSCT治疗的MM患者 (选择组 )和另外 2 1例接受非选择性APBSCT的MM患者 (对照组 )的造血恢复时间、有效率、生存率、移植相关不良反应、移植费用进行比较。两组病例在年龄、初诊时血清 β2 微球蛋白水平和移植时疾病状态均具有可比性 ,诱导治疗及预处理方案基本相同。结果 与对照组相比 ,选择组患者回输的CD3 4+ 细胞数显著偏低 [对照组和选择组分别为 9.4(1.1~ 15 .0 )× 10 6/kg和 2 .2 (0 .5~ 14.3)× 10 6/kg](P <0 .0 0 1) ,中性粒细胞恢复至≥ 0 .5× 10 9/L和血小板恢复至≥ 2 0× 10 9/L的中位时间 ,在选择组分别为 10d和 9d ,对照组分别为 9.5d(P=0 .35 7)和 4.5d(P =0 .0 0 5 )。两组的治疗有效率相似 (选择组 85 .7% ,对照组 90 .4% ) ,3年无病生存率 (选择组和对照组分别为 32 %和 39% )和总生存率 (选择组和对照组分别为 85 %和 79% )两组相比差异无显著性 ,而且使用非选择性APBSCT可明显降低移植费用。结论 选择性CD3 4+ 细胞APBSCT与非选择性APBSCT相比 ,并不能改善MM的临床治疗结果 ,而且移植费用更大。 | 唐晓文 N Morineau N Milpied P Moreau R Bataille JL Harousseau | 2001 | 中华血液学杂志2001，22，7： | 5 |
| 5 | The management of ascites in cirrhosis: Report on the consensus conference of the International Ascites Club显示文摘 | Kevin P. Moore Florence Wong Pere Gines Mauro Bernardi Andreas Ochs Francesco Salerno Paolo Angeli Michael Porayko Richard Moreau Guadelupe Garcia-Tsao Wladimiro Jimenez Ramon Planas Vicente Arroyo | 2003 | Hepatology2003，，1： | 4 |
| 6 | Role of nonalcoholic fatty liver disease as risk factor for drug-induced hepatotoxicity显示文摘Background:Obesity is often associated with nonalcoholic fatty liver disease(NAFLD),which refers to a large spectrum of hepatic lesions including fatty liver,nonalcoholic steatohepatitis(NASH)and cirrhosis.Different investigations showed or suggested that obesity and NAFLD are able to increase the risk of hepatotoxicity of different drugs.Some of these drugs could induce more frequently an acute hepatitis in obese individuals whereas others could worsen pre-existing NAFLD.Aim:The main objective of the present review was to collect the available information regarding the role of NAFLD as risk factor for drug-induced hepatotoxicity.For this purpose,we performed a data-mining analysis using different queries including drug-induced liver injury(or DILI),drug-induced hepatotoxicity,fatty liver,nonalcoholic fatty liver disease(or NAFLD),steatosis and obesity.The main data from the collected articles are reported in this review and when available,some pathophysiological hypotheses are put forward.Relevance for patients:Drugs that could pose a potential risk in obese patients include compounds belonging to different pharmacological classes such as acetaminophen,halothane,methotrexate,rosiglitazone,stavudine and tamoxifen.For some of these drugs,experimental investigations in obese rodents confirmed the clinical observations and unveiled different pathophysiological mechanisms which could explain why these pharmaceuticals are particularly hepatotoxic in obesity and NAFLD.Other drugs such as pentoxifylline,phenobarbital and omeprazole might also pose a risk but more investigations are required to determine whether this risk is significant or not.Because obese people often take several drugs for the treatment of different obesity-related diseases such as type 2 diabetes,hyperlipidemia and coronary heart disease,it is urgent to identify the main pharmaceuticals that can cause acute hepatitis on a fatty liver background or induce NAFLD worsening. | Julie Massart Karima Begriche Caroline Moreau Bernard Fromenty | 2017 | Journal of Clinical & Translational Research2017，3，1： | 4 |
| 7 | Identification of Ca2+ signaling components in neural stem/progenitor cells during differentiation into neurons and glia in intact and dissociated zebrafish neurospheres显示文摘The development of the CNS in vertebrate embryos involves the generation of different sub-types of neurons and glia in a complex but highly-ordered spatio-temporal manner. Zebrafish are commonly used for exploring the development, plasticity and regeneration of the CNS, and the recent development of reliable protocols for isolating and culturing neural stem/progenitor cells(NSCs/NPCs) from the brain of adult fish now enables the exploration of mechanisms underlying the induction/specification/differentiation of these cells. Here, we refined a protocol to generate proliferating and differentiating neurospheres from the entire brain of adult zebrafish. We demonstrated via RT-qPCR that some isoforms of ip3 r, ryr and stim are upregulated/downregulated significantly in differentiating neurospheres, and via immunolabelling that 1,4,5-inositol trisphosphate receptor(IP3 R) type-1 and ryanodine receptor(RyR) type-2 are differentially expressed in cells with neuron-or radial glial-like properties. Furthermore, ATP but not caffeine(IP3 R and RyR agonists, respectively), induced the generation of Ca^(2+) transients in cells exhibiting neuron-or glial-like morphology. These results indicate the differential expression of components of the Ca^(2+) -signaling toolkit in proliferating and differentiating cells. Thus, given the complexity of the intact vertebrate brain, neurospheres might be a useful system for exploring neurodegenerative disease diagnosis protocols and drug development using Ca^(2+) signaling as a read-out. | Man Kit Tse Ting Shing Hung Ching Man Chan Tiffany Wong Mike Dorothea Catherine Leclerc Marc Moreau Andrew L.Miller Sarah E.Webb | 2018 | Science China(Life Sciences)2018，61，11： | 4 |
| 8 | Acute-on chronic liver failure显示文摘 | Rajiv Jalan Pere Gines Jody C Olson Rajeshwar P Mookerjee Richard Moreau Guadalupe Garcia-Tsao Vicente Arroyo Patrick S Kamath | 2012 | Journal of Hepatology2012，，6： | 4 |
| 9 | 橡胶树树皮坏死的症状、病因和流行规律的研究显示文摘引起橡胶树停止排胶主要有两种不同症状:(1)割面干涸(TPD),一种过度采胶引起的可恢复性生理反应;(2)树皮坏死(BN),一种从芽接部位韧皮部扩展的不可恢复的病症。目前树皮坏死在世界各国橡胶种植园都有发生,其危害程度取决于种植品种、树龄和种植地点。通过对大量种植园的调查,目前澄清了橡胶树树皮综合病症多态的各种争议。虽然对以前和近来的病原分析还不能下定论,但环境因素确实与树皮坏死有关。对一些开割树位的流行规律研究表明,早期病树发生的位置不是随机的,其主要发生在靠近沼泽、胶园道路、边行、原推土机过道、树桩残余地和斜坡缓冲地等区域。树皮坏死的发生与土壤的化学因素没有显著的相关性,但是土壤物理测定(如土壤紧实度)表明,树皮坏死树较差的根系与土壤较高的紧实度有关。此外,在砧木与芽片接合处首先观察到树皮坏死的早期症状。用PMS压力计测定的大量生理生态学对照数据表明,树皮坏死树内有水分胁迫。这些结果意味着患病树树干同其根系的维管联系处于非理想状态。因此,同土壤紧实度相关的土壤有效水分的减少、不能满足旱季水分需求的脆弱根系、被扰乱的树液流动和土壤水分循环等因素的共同作用,被认为是在芽接区产生树皮坏死的主要外部诱因,坏死随后向上扩展到割面。此外,细胞及分子生物学研究表明,橡胶树内在失调是导致树皮坏死迅速扩展的原因。在这些胁迫的作用下,胶树芽接部位的细胞破裂,释放出极具扩散性的高浓度氰化物。这种韧皮部内氰化物的产生和分解作用的不平衡将毒害邻近细胞。多学科的交叉研究为多因素胁迫诱导的这种生理病害提出了一个新的、完整的模型。 | D. Nandris R. Moreau F. Pellegrin H. Chrestin 和丽岗 | 2006 | 热带农业科技2006，29，1： | 4 |
| 10 | 第四纪红粘土发育的红壤在施用石灰和石膏后元素的淋溶特征显示文摘本文利用模拟土柱试验研究了施用石灰和石膏对第四纪红粘土发育的红壤中元素淋溶过程的影响。结果表明,施用石灰后10cm土层中除Ca2+以外的阳离子元素的淋失量减少,而SO2-4;一和HCO-3的淋失量增加;施用石膏后10cm土层中所有阳离子元素、特别是Al3+的淋失量增加。红壤中Ca2+的淋失以自由态为主,施用石膏后与SO2-4结合的比例增加。不同处理中 30cm土层处铝的淋失以自由态为主; 10cm土层处铝的淋失在石灰处理中以羟基铝为主,在石膏处理中初期与SO2-4结合的比例增加,后期主要以自由态淋失。除了施用石灰的表层红壤溶液中羟基铝比例增加外,在所有的亚表层红壤溶液中以及施用石膏的表层红壤溶液中与SO2-4结合的铝比例增加。 | 孙波 Moreau,R | 2000 | 土壤学报2000，37，1： | 3 |
| 11 | TRPC3 is required for the survival, pluripotency and neural differentiation of mouse embryonic stem cells(mESCs)显示文摘Transient receptor potential canonical subfamily member 3(TRPC3) is known to be important for neural development and the formation of neuronal networks. Here, we investigated the role of TRPC3 in undifferentiated mouse embryonic stem cells(mESCs) and during the differentiation of mESCs into neurons. CRISPR/Cas9-mediated knockout(KO) of TRPC3 induced apoptosis and the disruption of mitochondrial membrane potential both in undifferentiated mESCs and in those undergoing neural differentiation. In addition, TRPC3 KO impaired the pluripotency of mESCs. TRPC3 KO also dramatically repressed the neural differentiation of mESCs by inhibiting the expression of markers for neural progenitors, neurons, astrocytes and oligodendrocytes.Taken together, our new data demonstrate an important function of TRPC3 with regards to the survival, pluripotency and neural differentiation of mESCs. | Helen Baixia Hao Sarah E. Webb Jianbo Yue Marc Moreau Catherine Leclerc Andrew L. Miller | 2018 | Science China(Life Sciences)2018，61，3： | 3 |
| 12 | Association Between Diabetes and Stroke Subtype on Survival and Functional Outcome 3 Months After Stroke: Data From the European BIOMED Stroke Project显示文摘 | Salah-Eddine Megherbi Chantal Milan Dominique Minier Grégory Couvreur Guy-Victor Osseby Kate Tilling Antonio Di Carlo Domenico Inzitari Charles D.A. Wolfe Thibault Moreau Maurice Giroud | 2003 | Stroke: Journal of the American Heart Association2003，，3： | 3 |
| 13 | Molecular phylogeny of Trametes and related genera,and description of a new genus Leiotrametes显示文摘A phylogenetic analysis of Trametes and related taxa is proposed,based on a wide sampling of temperate and tropical species.Concatenate sequences of ribosomal DNA(ITS1-5.8S-ITS2)and RPB2 gene from mycelia cultures were analyzed by Maximum Likelihood and Bayesian methods,whilst morphological features were documented from the corresponding herbarium vouchers.Congruent results were obtained from analyses of ribosomal LSU sequences downloaded from Genbank.The Bayesian analysis of ITS+RPB2 sequences gave the best resolution for the phylogenetic reconstructions and revealed the existence of three main lineages in the Trametes-clade:1)a monospecific lineage represented by Artolenzites elegans 2)a lineage including the genus Pycnoporus in its traditional sense and several species usually classified in the genus Trametes(T.cingulata,T.lactinea,T.ljubarskyi,T.menziesii)&3)a lineage corresponding to the core genus Trametes,including type species of Trametes,Coriolopsis and Lenzites.The presence of a pseudostipe,aspect and structure of the abhymenial surface,colour change with 5%aqueous solutions of potassium hydroxide and topography of pigments on skeletal hyphae gave relevant morphological support to these clades.When the structure of the hymenial surface,presence of a black line below the tomentum and color of context(except for genus Pycnoporus)usually used in traditional polypore-classifications did not reveal any phylogenetic significance.A partial systematic arrangement of the Trametes clade is proposed,with the introduction of a new genus:Leiotrametes Welti&Courtec.gen.nov..Two new combinations:Leiotrametes lactinea(Berk.)Welti&Courtec.comb.nov.and L.menziesii(Berk.)Welti&Courtec.comb.nov.are proposed. | Stéphane Welti Pierre-Arthur Moreau Anne Favel Régis Courtecuisse Mireille Haon David Navarro Sabine Taussac Laurence Lesage-Meessen | 2012 | Fungal Diversity2012，，4： | 3 |
| 14 | Investigation of thermoelectric magnetic convection and its effect on solidification structure during directional solidification under a low axial magnetic field显示文摘 | Xi Li Annie Gagnoud Zhongming Ren Yves Fautrelle Rene Moreau | 2009 | Acta Materialia2009，，7： | 3 |
| 15 | Modification of interdendritic convection in directional solidification by a uniform magnetic field显示文摘 | P. Lehmann R. Moreau D. Camel R. Bolcato | 1998 | Acta Materialia1998，，11： | 3 |
| 16 | A LIM Domain Protein from Tobacco Involved in Actin-Bundling and Histone Gene Transcription显示文摘从植物(秘鲁利玛机场之代号) 的二秘鲁利玛机场之代号包含域的蛋白质典型地展出双 cytoplasmicnuclear 分布,建议除了他们在肌动朊细胞骨架组织的以前描述的角色,他们参予原子过程。用针对识别绑种 histone 基因倡导者的因素的一幅西南的基于污点的屏幕,我们孤立包含烟草秘鲁利玛机场之代号蛋白质 WLIM2 (NtWLIM2 ) 的积极克隆 cDNA。用两块草地荧光灯蛋白质(GFP ) 基于熔化、基于免疫学的策略,我们提供 NtWLIM2 本地化到肌动朊细胞骨架,原子核,和核的清楚的证据。有趣地,由 latrunculin B 的肌动朊细胞骨架的混乱显著地增加 NtWLIM2 原子部分,指出可能的新奇 cytoskeletalnuclear 串音。生物化学并且电子显微镜学实验揭示 NtWLIM2 的能力直接把后者绑在肌动朊细丝并且到交叉连接进厚肌动朊捆。NtWLIM2 明确地绑在 Arabidopsis histone H4A748 基因倡导者的保存 octameric cis 元素(10 月) 并且这绑定大部分依靠两个秘鲁利玛机场之代号领域的 Electrophoretic 活动性移动试金表演。重要地,在 Arabidopsis 和烟草原物进行的基于记者的实验证实 NtWLIM2 的能力绑在并且在实时房间激活 H4A748 基因倡导者。表示研究在烟草 BY-2 房间增长和房间周期前进期间显示 NtWLIM2 mRNA 和 NtWLIM2 蛋白质的组成的存在,建议在基础 histone 基因表示的激活的 NtWLIM2 的一个角色。有趣地,两个都生活房间并且在 vitro 数据支持 NtWLIM2 di/oligomerization。我们建议 NtWLIM2 作为稳定肌动朊的蛋白质工作,它在改变的细胞骨架之上,梭到原子核以便修改基因表示。 | Danièle Moes Sabrina Gatti CEline Hoffmann Monika Dieterle Flora Moreau Katrin Neumann Marc Schumacher Marc Diederich Erwin Grill Wen-Hui Shen André Steinmetz Cldment Thomas | 2013 | Molecular Plant2013，6，2： | 2 |
| 17 | PNPLA3 rs738409, hepatocellular carcinoma occurrence and risk model prediction in patients with cirrhosis显示文摘 | Erwan Guyot Angela Sutton Pierre Rufat Christelle Laguillier Abdellah Mansouri Richard Moreau Nathalie Ganne-Carrié Michel Beaugrand Nathalie Charnaux Jean-Claude Trinchet Pierre Nahon | 2012 | Journal of Hepatology2012，，： | 2 |
| 18 | Ciclosporin versus infliximab in patients with severe ulcerative colitis refractory to intravenous steroids: a parallel, open-label randomised controlled trial显示文摘 | David Laharie Arnaud Bourreille Julien Branche Matthieu Allez Yoram Bouhnik Jerome Filippi Frank Zerbib Guillaume Savoye Maria Nachury Jacques Moreau Jean-Charles Delchier Jacques Cosnes Elena Ricart Olivier Dewit Antonio Lopez-Sanroman Jean-Louis Dupas F | 2012 | The Lancet2012，，9857： | 2 |
| 19 | 吲哚菁绿静脉注射近红外荧光成像在头颈癌患者颈清术中的应用:一项可行性研究显示文摘吲哚菁绿(ICG)静脉注射后行颈清术尚未见研究报道。该文旨在研究颈清术中ICG在淋巴结的分布情况。11例需要接受颈淋巴清扫术的患者纳入研究。在麻醉诱导期间行ICG静脉注射。手术前、后进行荧光成像。病理科医师进行任意单位(AUs)免疫荧光检测。评估手段包括混合线性模型和广义评估方程式(GEEs)。 | Digonnet A van Kerckhove S Moreau M 张凌 | 2016 | 中国口腔颌面外科杂志2016，14，1： | 2 |
| 20 | Acute-on-Chronic Liver Failure: Recent Concepts显示文摘 | Richard Moreau Rajiv Jalan Vicente Arroyo | 2014 | Journal of Clinical and Experimental Hepatology2014，，： | 2 |
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