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| 1 | challenges of advanced hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC) is an aggressive malignancy,resulting as the third cause of death by cancer each year. The management of patients with HCC is complex,as both the tumour stage and any underlying liver disease must be considered conjointly. Although surveillance by imaging,clinical and biochemical parameters is routinely performed,a lot of patients suffering from cirrhosis have an advanced stage HCC at the first diagnosis. Advanced stage HCC includes heterogeneous groups of patients with different clinical condition and radiological features and sorafenib is the only approved treatment according to Barcelona Clinic Liver Cancer. Since the introduction of sorafenib in clinical practice,several phase Ⅲ clinical trials have failed to demonstrate any superiority over sorafenib in the frontline setting. Locoregional therapies have also been tested as first line treatment,but their role in advanced HCC is still matter of debate. No single agent or combination therapies have been shown to impact outcomes after sorafenib failure. Therefore this review will focus on the range of experimental therapeutics for patients with advanced HCC and highlights the successes and failures of these treatments as well as areas for future development. Specifics such as dose limiting toxicity and safety profile in patients with liver dysfunction related to the underlying chronic liver disease should be considered when developing therapies in HCC. Finally,robust validated and reproducible surrogate end-points as well as predictive biomarkers should be defined in future randomized trials. | Stefano Colagrande Andrea L Inghilesi Sami Aburas Gian G Taliani Cosimo Nardi Fabio Marra | 2016 | World Journal of Gastroenterology2016，22，34： | 19 |
| 2 | Diabetes and renal tubular cell apoptosis显示文摘Apoptosis contributes to the development of diabetic nephropathy, but the mechanism by which high glucose induces apoptosis is not fully understood. Apoptosis of tubular epithelial cells is a major feature of diabetic kidney disease, and hyperglycemia triggers the generation of free radicals and oxidant stress in tubular cells. Hyperglycemia and high glucose in vitro also lead to apoptosis, a form of programmed cell death. High glucose similar to those seen with hyperglycemia in people with diabetes mellitus, lead to accelerated apoptosis, a form of programmed cell death characterized by cell shrinkage, chromatin condensation and DNA fragmentation, in variety of cell types, including renal proximal tubular epithelial cells. | Samy L Habib | 2013 | World Journal of Diabetes2013，4，2： | 9 |
| 3 | Preoperative embolization in the management of neck paragangliomas 显示文摘 | Tapani T Jukka L Sami L | 1997 | Laryngoscope1997，107，： | 1 |
| 4 | The effect of noncontact, low-intensity, low-frequency, therapeutic ultrasound on lower extremity chronic wound pain, A retrospective chart review 显示文摘 | GEHLING M L SAMIES J H | 2007 | Ostomy Wound Management2007，53，3： | 1 |
| 5 | Anterior deep bite malocclusion treated with connecticut intrusion arch: biomeehanical consideration 显示文摘 | Sana S Bansal A Sami L | 2014 | J Clin Diagn Res2014，8，5： | 1 |
| 6 | Effect of environmental temperature on rainbow trout (Oncorhynchus mykiss) innate immunity显示文摘 | Goran B Esa-Matti L | 2004 | Developmental and Comparative Immunology2004，28，： | 1 |
| 7 | Multiple Shear Key Connections for Preeast Shear Wall Panels显示文摘 | RIZKALLA Sami H SERRETTE Reynaud L HEUVEL J Scott | 1989 | PCI Journal1989，34，2： | 1 |
| 8 | Akutes H?moperitoneum bei einer spontanen Tumorruptur als Erstmanifestation eines hepatozellul?ren Karzinoms显示文摘 | A Abdel Samie G Otto L Theilmann | 2007 | Z Gastroenterol2007，，07： | 1 |
| 9 | Three-dimensional reconstructed magnetic resonance scans:Accuracy in identifying and defining knee meniscal tears显示文摘AIM To determine whether three-dimensional(3D) reconstruction from conventional magnetic resonance imaging(MRI) is able to accurately detect a meniscal tear, and define the configuration.METHODS Thirty-three patients' 3T MRI scan data were collected and sagittal uni-planar 3D reconstructions performed from the preoperative MRI. There were 24 meniscal tears in 24 patients, and nine controls. All patients had arthroscopic corroboration of MRI findings. Two independent observers prospectively reported on all 33 reconstructions. Meniscal tear presence or absence was noted, and tear configuration subsequently categorised as either radial, bucket-handle, parrot beak, horizontal or complex.RESULTS Identification of control menisci or meniscal tear presence was excellent(Accuracy: observer 1 = 90.9%; observer 2 = 81.8%). Of the tear configurations, bucket handle tears were accurately identified(Accuracy observer 1 and 2 = 80%). The remaining tear configurations were notaccurately discernable.CONCLUSION Uni-planar 3D reconstruction from 3T MRI knee scan sequences are useful in identifying normal menisci and menisci with bucket-handle tears. Advances in MRI sequencing and reconstruction software are awaited for accurate identification of the remaining meniscal tear configurations. | Neil Kruger Eugene Mc Nally Sami Al-Ali Raj Rout Jonathan L Rees Andrew J Price | 2016 | World Journal of Orthopedics2016，7，11： | 1 |
| 10 | Use of a novel ultrasonic surgical system for decompression of the facial nerve显示文摘 | SAMY R N KRISHNAMOORTHY K PENSAK M L | 2007 | Laryngoscope2007，117，5： | 1 |
| 11 | Infectious diarrhea:newpathogens and new challenges in developed and developing areas显示文摘 | STEINER T S SAMIE A GUERRANT R L | 2006 | Clin Infec Dis2006，43，： | 1 |
| 12 | Nitrogen removal from on-site treated anaerobic effluents using intermittently aerated moving bed biofilm reactors at low temperatures 显示文摘 | Sari L Sami L Lara V | 2006 | Water Research2006，40，8： | 1 |
| 13 | Acute haemopentoneum due to spontaneous tomeur repture as first manifestation of hepatocellular careinoma显示文摘 | Abdel Samie A Otto G Theilmann L | 2007 | Z Gastnoenterol2007，45，7： | 1 |
| 14 | Self-organizing maps as a relevance feedback technique in content-based image retrieval显示文摘 | Jarma L Markus K Sami L | 2001 | Pattern Analysis & Application2001，，4： | 1 |
| 15 | Monitoring ultrathin film photopoly- merization of tetra-alkylepoxyporphyrin by UV-Vis spectroscopy显示文摘 | Kalle L Linda S Alexander E Sami H Risto A Nikolai T Helge L | 2009 | Journal of Polymer Science Part A: Polymer Chemistry2009，47，22： | 1 |
| 16 | L&p&roscopic transcystic bile duct exploration:the treatment of first choice for common bile duct stones显示文摘 | Hanif F Ahmed Z Samie M A et &l | 2010 | Surgical endoscopy2010，24，7： | 1 |
| 17 | Radiographic anatomy of the infracochlear approach to the petrous apex for computer-assisted surgery显示文摘 | LEUNG R SAMY R N LEACH J L | 2010 | Otol Neurotol2010，31，3： | 1 |
| 18 | Microstructure dependent switching properties of VO2 thin films 显示文摘 | J'YRKI L SANTrU H SAMI S | 2008 | Sensors and Actuators: A2008，142，1： | 1 |
| 19 | A physiologic reduced oxygen protocol decrease the incident of threshold retinopathy of prematurity显示文摘 | Wight K W Sami D Thompson L | 2006 | Trans Am Ophthalmol Soc2006，11，104： | 1 |
| 20 | Self-Organizing Maps as a Relevance Feedback Technique in Content-Based Image Retrieval显示文摘 | Jarma L Markus K Sami L el at | 2001 | Pattern Analysis & Application2001，，4： | 1 |
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