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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | Miniature gastrointestinal endoscopy: Now and the future显示文摘Since its original application,gastrointestinal(GI)endoscopy has undergone many innovative transformations aimed at expanding the scope,safety,accuracy,acceptability and cost-effectiveness of this area of clinical practice.One method of achieving this has been to reduce the caliber of endoscopic devices.We propose the collective term“Miniature GI Endoscopy”.In this Opinion Review,the innovations in this field are explored and discussed.The progress and clinical use of the three main areas of miniature GI endoscopy(ultrathin endoscopy,wireless endoscopy and scanning fiber endoscopy)are described.The opportunities presented by these technologies are set out in a clinical context,as are their current limitations.Many of the positive aspects of miniature endoscopy are clear,in that smaller devices provide access to potentially all of the alimentary canal,while conferring high patient acceptability.This must be balanced with the costs of new technologies and recognition of device specific challenges.Perspectives on future application are also considered and the efforts being made to bring new innovations to a clinical platform are outlined.Current devices demonstrate that miniature GI endoscopy has a valuable place in investigation of symptoms,therapeutic intervention and screening.Newer technologies give promise that the potential for enhancing the investigation and management of GI complaints is significant. | John J McGoran Mark E McAlindon Prasad G Iyer Eric J Seibel Rehan Haidry Laurence B Lovat Sarmed S Sami | 2019 | World Journal of Gastroenterology2019，25，30： | 4 |
| 3 | Single vs dual(en bloc) kidney transplants from donors ≤ 5 years of age: A single center experience显示文摘AIM: To compare outcomes between single and dual en bloc(EB) kidney transplants(KT) from small pediatric donors. METHODS: Monocentric nonprospective review of KTs from pediatric donors ≤ 5 years of age. Dual EB KT was defined as keeping both donor kidneys attached tothe inferior vena cava and aorta, which were then used as venous and arterial conduits for the subsequent transplant into a single recipient. Donor age was less useful than either donor weight or kidney size in decision-making for kidney utilization as kidneys from donors < 8 kg or kidneys < 6 cm in length were not transplanted. Post-transplant management strategies were standardized in all patients.RESULTS: From 2002-2015, 59 KTs were performed including 34 dual EB and 25 single KTs. Mean age of donors(17 mo vs 38 mo, P < 0.001), mean weight(11.0 kg vs 17.4 kg, P = 0.046) and male donors(50% vs 84%, P = 0.01) were lower in the dual EB compared to the single KT group, respectively. Mean cold ischemia time(21 h), kidney donor profile index(KDPI; 73% vs 62%) and levels of serum creatinine(SCr, 0.37 mg/d L vs 0.49 mg/d L, all P = NS) were comparable in the dual EB and single KT groups, respectively. Actuarial graft and patient survival rates at 5-years follow-up were comparable. There was one case of thrombosis resulting in graft loss in each group. Delayed graft function incidence(12% dual EB vs 20% single KT, P = NS) was slightly lower in dual EB KT recipients. Initial duration of hospital stay(mean 5.4 d vs 5.6 d) and the one-year incidences of acute rejection(6% vs 16%), operative complications(3% vs 4%), and major infection were comparable in the dual EB and single KT groups, respectively(all P = NS). Mean 12 mo SCr and abbreviated MDRD levels were 1.17 mg/d L vs 1.35 mg/d L and 72.5 m L/min per 1.73 m^2 vs 60.5 m L/min per 1.73 m^2(both P = NS) in the dual EB and single KT groups, respectively. CONCLUSION: By transplanting kidneys from young pediatric donors into adult recipients, one can effectively expand the limited donor pool and achieve excellent medium-term outcomes. | Yousef Al-Shraideh Umar Farooq Hany El-Hennawy Alan C Farney Amudha Palanisamy Jeffrey Rogers Giuseppe Orlando Muhammad Khan Amber Reeves-Daniel William Doares Scott Kaczmorski Michael D Gautreaux Samy S Iskandar Gloria Hairston Elizabeth Brim Margaret Mangus Robert J Stratta | 2016 | World Journal of Transplantation2016，6，1： | 3 |
| 4 | Forced convective condensation and boiling of temary non-azeotropic refrigerant mixtures inside water/refrigerant enhanced surface tubing显示文摘 | TULEI P J SONG B | 1994 | Int J Ene Res1994，，： | 1 |
| 5 | What is needed of a taehyon if it is to be the dark energy? 显示文摘 | Copeland E J Garousi M R Sami M | 2005 | Phys Rev D2005，71，04： | 1 |
| 6 | The effect of noncontact, low-intensity, low-frequency, therapeutic ultrasound on lower extremity chronic wound pain, A retrospective chart review 显示文摘 | GEHLING M L SAMIES J H | 2007 | Ostomy Wound Management2007，53，3： | 1 |
| 7 | Synthesis and rheological properties of an associative star polymer in aqueous solutions显示文摘 | Sami Hietala Pekka Mononen Satu Strandman Paula J?rvi Mika Torkkeli Katja Jankova S?ren Hvilsted Heikki Tenhu | 2007 | Polymer2007，，14： | 1 |
| 8 | Capillarity in microfluidic channels with hydrophilic and hydrophobic walls显示文摘 | VILLE J SAMI F | 2008 | Microfluidics Nanofluidics2008，5，4： | 1 |
| 9 | A multi -criteria approach to contractor selection 显示文摘 | IBRAHIM M M MIKE J R SAMI M F | 2002 | Engi- neering Construction and Architectural Management2002，9，1： | 1 |
| 10 | Discovery of novel antituber- cular 1,5 - dimethyl - 2 - phenyl - 4 - ( methylamino) - 1, 2 - dihydro - 3h - pyrazol- 3- one analogues显示文摘 | Ahsan M J Samy JG Jain CB | 2012 | Bioorg Med Chem Lett2012，22，2： | 1 |
| 11 | A new design for an air source heat pump using a ternary mixture for cold climates显示文摘 | Sami S M Tulej P J | 2001 | Heat Recovery Systems & Chp2001，15，6： | 1 |
| 12 | Delayless recursive differentiator with efficient noise attenuation for motion control applications显示文摘 | Sami Valiviita Ovaska Seppo J | 1998 | IECON Proceedings (Industrial Electronics Conference)1998，，3： | 1 |
| 13 | Using a Grounded Theory Approach for Ex- ploring Software Product Management Challenges 显示文摘 | SAMI J DONALD C G | 2014 | Journal of Systems and Software2014，，95： | 1 |
| 14 | Rectification of the background potassium current : a determinant of rotor dynamics in ventricular fibrillation 显示文摘 | SAMIE F H BERENFELD O ANUMONWO J | 2001 | Circ Res2001，89，12： | 1 |
| 15 | Transparent silica gel-PMMA composites显示文摘 | Pope E J A A Sami M Mackenzie J D | 1989 | J Mater Res1989，，4： | 1 |
| 16 | Dynamics of Dark Energy显示文摘 | Copeland J E Sami M Tsujikawa S | | 0，，11： | 1 |
| 17 | Multiple Shear Key Connections for Preeast Shear Wall Panels显示文摘 | RIZKALLA Sami H SERRETTE Reynaud L HEUVEL J Scott | 1989 | PCI Journal1989，34，2： | 1 |
| 18 | Separation of fluorescein isoth iocyanate-labeled amines by microchip electrophoresis in uncoated and polyvinyl alcohol-coated glass chips using water and dimethyl sulfoxide as solvents of background electrolyte显示文摘 | Sami J O Varjo S J O Ludwig M Belder D.Riekkola M.L | | 0，，： | 1 |
| 19 | Three-dimensional reconstructed magnetic resonance scans:Accuracy in identifying and defining knee meniscal tears显示文摘AIM To determine whether three-dimensional(3D) reconstruction from conventional magnetic resonance imaging(MRI) is able to accurately detect a meniscal tear, and define the configuration.METHODS Thirty-three patients' 3T MRI scan data were collected and sagittal uni-planar 3D reconstructions performed from the preoperative MRI. There were 24 meniscal tears in 24 patients, and nine controls. All patients had arthroscopic corroboration of MRI findings. Two independent observers prospectively reported on all 33 reconstructions. Meniscal tear presence or absence was noted, and tear configuration subsequently categorised as either radial, bucket-handle, parrot beak, horizontal or complex.RESULTS Identification of control menisci or meniscal tear presence was excellent(Accuracy: observer 1 = 90.9%; observer 2 = 81.8%). Of the tear configurations, bucket handle tears were accurately identified(Accuracy observer 1 and 2 = 80%). The remaining tear configurations were notaccurately discernable.CONCLUSION Uni-planar 3D reconstruction from 3T MRI knee scan sequences are useful in identifying normal menisci and menisci with bucket-handle tears. Advances in MRI sequencing and reconstruction software are awaited for accurate identification of the remaining meniscal tear configurations. | Neil Kruger Eugene Mc Nally Sami Al-Ali Raj Rout Jonathan L Rees Andrew J Price | 2016 | World Journal of Orthopedics2016，7，11： | 1 |
| 20 | Study of Viscosity and Thermal Conductivity Effects on Condensation Characteristics of Some New Alternative Refrigerant Mixtures显示文摘 | SAMI S M COMEAU J D | 2003 | Energy Research2003，27，2： | 1 |
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