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| 1 | Heat shock protein 90 inhibition by 17-DMAG lessens disease in the MRL/Ipr mouse model of systemic lupus erythematosus显示文摘热吃惊蛋白质 90 的提高的表示(HSP90 ) 在全身的豺狼座 erythematosus (SLE ) 的肾和浆液被发现了病人和 MRL/Mp-Fas lpr /Fas lpr (MRL/lpr ) 自体免疫的老鼠。如果 HSP90 的抑制将在 MRL/lpr 老鼠减少疾病,我们调查了。在在 vivo 的 vitro,有在 IL-6 的有免疫力刺激的显示出的减少的表示以前的 HSP90 禁止者 Geldanamycin 的 mesangial 房间的预告的处理, IL-12 和号码,我们发现当与 C57BL/6 相比鼠标和 MRL/lpr 鼠标与 HSP90 禁止者 17-DMAG 对待时, HSP90 表示在 MRL/lpr 肾被提高。与 17-DMAG 对待的 MRL/lpr 老鼠显示出减少的 proteinuria 并且减少了浆液 anti-dsDNA 抗体生产。Glomerulonephritis 和 glomerular IgG 和 C3 没被 17-DMAG 的管理显著地在 MRL/lpr 影响。17-DMAG 增加了 CD8 + T 房间,减少的双 negative T 房间,减少 CD4/CD8 比率和减少的小囊的 B 房间。这些研究建议 HSP90 可以在调整 T 房间区别和激活起一个作用并且 HSP90 抑制可以在豺狼座减少发炎。 | Samuel K Shimp III Cristen B Chafin Nicole L Regna Sarah E Hammond Molly A Read David L Caudell Marissa Nichole Rylander Christopher M Reilly | 2012 | Cellular & Molecular Immunology2012，9，3： | 3 |
| 2 | Biomechanics of posterior shoulder instability-current knowledge and literature review显示文摘Posterior instability of the shoulder is a rare condition and represents about 10% of shoulder instability. It has become more frequently recognized in the last year,even though it is more difficult to diagnose than anterior shoulder instability. As this form of shoulder pathology is somewhat rare,biomechanical knowledge is limited. The purpose of our study was to perform an extensive literature search,including PubMed and Medline,and to give an overview of the current knowledge on the biomechanics of posterior shoulder instability. The Pub Med/Medline databases were utilized,and all articles related to posterior shoulder instability and biomechanics were included to form a comprehensive compilation of current knowledge. A total of 93 articles were deemed relevant according to our inclusion and exclusion criteria. As expected with any newly acknowledged pathology,biomechanical studies on posterior shoulder instability remain limited in the literature. Current biomechanical models are performed in a static manner,which limits their translation for explaining a dynamic pathology. Newer models should incorporate dynamic stabiliza-tion of both the rotator cuff and scapulothoracic joint. There is a current lack of knowledge with regards to the pathomechanism of posterior shoulder instability,with no consensus on appropriate treatment regimens. Further investigation is therefore required at both basic science and clinical levels. | Henrik Constantin B?cker Samuel E Galle Mauro Maniglio Melvin Paul Rosenwasser | 2018 | World Journal of Orthopedics2018，9，11： | 2 |
| 3 | Chemical factors for chemical-mechanical and electrochemical mechanical planarization of silver examined using potentiodynamic and impedance measurements 显示文摘 | SAMUEL B E JENNIFER L H MARIA A D | 2005 | Materials Chemistry and Physics2005，89，23： | 1 |
| 4 | Biosynthesis of reovirus-specified polypeptides:identification of regions of the bicistronic reovirs S1 mRNA that affect the efficiency of translation in animal cells显示文摘 | Belli B A Samuel C E | 1993 | Virology1993，193，： | 1 |
| 5 | Trehalose and Sucrose Protect both Membranes and Proteins in Intact Bacteria during Drying 显示文摘 | SAMUEL B L ISRAELII E BRUCE L | 1995 | Applied and Environmental Microbiology1995，61，10： | 1 |
| 6 | Subduction components and the generation of arc-like melts in the Zambales ophiolite,Philippines:Pb,Sr and Nd isotopic constraints显示文摘 | John E Samuel B M Cynthia A E | | 0，，： | 1 |
| 7 | Mutations in filamin 1 Prevent Migration of Cerebral Cortical Neurons in Human Periventricular Heterotopia显示文摘 | Jeremy W Fox Edward D Lamperti Yaman Z Ek?io?lu Susan E Hong Yuanyi Feng Donna A Graham Ingrid E Scheffer William B Dobyns Betsy A Hirsch Rodney A Radtke Samuel F Berkovic Peter R Huttenlocher Christopher A Walsh | 1998 | Neuron1998，，6： | 1 |
| 8 | A polymer-free fluid for fracturin g applications显示文摘 | Card R j Nelson E B | 1999 | Soc Petrol Engrs Drilling & Completion1999，14，4： | 1 |
| 9 | Vaccination with genetically modified Shiga-like toxinⅡe prevents edema disease in swine 显示文摘 | Bosworth B T Samuel J E Moon H W | 1996 | Infect Immun1996，64，1： | 1 |
| 10 | Polymer-free fluid for fracturing applications显示文摘 | Samuel M M Card R J Nelson E B | 1999 | Soc Petrol Engrs Drilling Completion1999，14，4： | 1 |
| 11 | A polymer-free fluid for fracturing applications显示文摘 | Samuel M Card R J Nelson E B | 1999 | SPE Drilling & Completion1999，14，4： | 1 |
| 12 | Inter-relation between true stress at the onset of necking and true uniform strain in steels-A manifestation of onset to plastic instability显示文摘 | Samuel I E Choudhary B K Bhanu Sankara Rao K | 2008 | Materials Science and Engineering A2008，480，： | 1 |
| 13 | Molecular bio-markers for breast cancer prognosis:coexpression of C-erbB-2 and p53显示文摘 | Samuel W B William E G Crowe D R | 2001 | Ann Surg2001，233，5： | 1 |
| 14 | 查看详情显示文摘 | Namdas E B Ruseckas A Samuel D W | | 0，，： | 1 |
| 15 | Polymer - free fluid for fracturing applications 显示文摘 | Samuel M M Card R J Nelson E B | 1999 | Society petroleum Engineers Drilling Completion1999，14，4： | 1 |
| 16 | An oil spill trajectory analysis model with a variable wind deflection angle 显示文摘 | SAMUELS W B HUANG N E AMSTUTZ D E | 1982 | Ocean Engineering1982，9，： | 1 |
| 17 | A poly- mer-free fluid for fracturing applications显示文摘 | SAMUEL M M CARD R J NELSON E B et ai | 1999 | SPE Drilling Completion1999，14，4： | 1 |
| 18 | Polymer-free fluid for fracturing applications显示文摘 | Samuel M Card R J Nelson E B | 1999 | SPE Drilling & Completion1999，14，4： | 1 |
| 19 | Polymer-free fluid for hydraulic fracturing显示文摘 | Samuel M Card R J Nelson E B | 1997 | SPE 386221997，，： | 1 |
| 20 | How to recognize lasing显示文摘 | Samuel I D W Namdas E B Turnbull G A | 2009 | Nature Photonics2009，3，10： | 1 |
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