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| 1 | 大于90°的重度脊柱侧凸患者的单纯后路椎弓根螺钉内固定治疗显示文摘研究设计回顾性比较研究。目的评估单纯后路椎弓根螺钉内固定治疗侧凸角度>90°的重度脊柱畸形的疗效和安全性。研究背景对于侧凸角度>90°的重度脊柱畸形的标准手术方式仍存争议,传统术式包括围手术期牵引辅助和分期前后路联合手术。方法回顾性分析由同一术者采取单纯后路椎弓根螺钉内固定治疗的40例侧凸角度>90°的重度脊柱畸形患者资料,侧凸角度平均为111.4°(91~175)°,平均随访31(6~60)个月。其中特发性脊柱侧凸27例,先天性9例,神经肌肉型3例,症状性1例。40例中,25例行多节段Ponte截骨术联合后路椎弓根螺钉内固定术,另15例则行全脊椎切除联合后路椎弓根螺钉内固定术。分析影像学结果和并发症发生率。结果影像学结果表明,单纯后路椎弓根螺钉矫形术可使主弯平均矫正率术后8周达49%,而末次随访时为47%(P<0.001)。总畸形角度(主弯Cobb’s角+最大后凸角)术前平均为160°,而术后8周和末次随访时,平均矫正率分别为50%和48%(P<0.001)。有7例(18%)术中运动诱发电位(motorevokedpotential,MEP)消失,而4例(10%)术后出现暂时性脊髓神经损伤。1例术后并发伤口感染。另1例术后2年随访时发现内植物断裂,予以观察随访。结论单纯后路椎弓根螺钉内固定可有效治疗角度>90°的重度脊柱侧凸,其可避免前路手术或围手术期牵引,达到理想的矫形效果,且无严重并发症。 | Kola Jegede Yongjung J.Kim Zaomin Zheng Gene Cheh Samuel Cho Sally Pak | 2014 | 中国骨与关节杂志2014,3,12: | 2 |
| 2 | A novel nonsense mutation of GPR143 gene in a Korean kindred with X-linked congenital nystagmus显示文摘Dear Editor,I am Dr.Ungsoo Samuel Kim.from Kim's Eye Hospital,Konyang University,Seoul,Korea.I write to present a novel mutation of GPR143 in Korean patients with X-linked congenital nystagmus by using exome sequencing.Congenital nystagmus is an inherited ocular disorder that can occur as an X-linked condition.Three genetic loci have been identified for X-linked congenital nystagmus(XLCN): | Ungsoo Samuel Kim Eunhae Cho Hyon J.Kim | 2016 | International Journal of Ophthalmology(English edition)2016,9,9: | 2 |
| 3 | Diagnosis and Management of Partial Small Bowel Obstruction after Laparoscopic Antecolic Antegastric Roux-en-Y Gastric Bypass for Morbid Obesity显示文摘 | Minyoung Cho Lester Carrodeguas David Pinto Charles Lascano Flavia Soto Oliver Whipple Richard Gordon Conrad Simpfendorfer John Paul Gonzalvo Samuel Szomstein Raul J. Rosenthal | 2006 | Journal of the American College of Surgeons2006,,2: | 1 |
| 4 | Assessing the economic value of a world heritage site and willingness-to-pay determinants:A case of Changdeok Palace显示文摘 | Samuel Seongseop Kim Kevin K F Wong Min Cho | 2007 | Tourism Management2007,28,: | 1 |
| 5 | Determinants of Regional Investment Decisions in China: An Econometric Model of Tax Incentive Policy显示文摘 | Samuel Tung Stella Cho | 2001 | Review of Quantitative Finance and Accounting2001,,2: | 1 |
| 6 | The Impact of Tax Incentives on Foreign Direct Investment in China显示文摘 | Samuel Tung Stella Cho | 2000 | Journal of Inter- national Accounting Auditing and Taxation2000,,9: | 1 |
| 7 | Determinants of Regional Investment Decisions in China:An Econometric Model of Tax Incentive Policy显示文摘 | Samuel Tung Stella Cho | 2001 | Review of Quantitative Finance and Accounting2001,,17: | 1 |
| 8 | Assessing the economic value of a world heritage site and willingness-to-pay determinants: A case of Changdeok Palace显示文摘 | Samuel Seongseop Kim Kevin K F Wong and Min Cho | 2007 | Tourism Management2007,28,2: | 1 |
| 9 | Assessing the Economic Value of a World Heritage Site and Willingness - to - pay Determinants: A Case of Changdcok Palace显示文摘 | Samuel Seoagseop Kim Kevin K F Wong Min Cho | 2007 | Tourism Management2007,,28: | 1 |
| 10 | Assessing the economic value of a world heritage site and willingness -to-pay determi- nants: A case of Changdeok Palace 显示文摘 | Samuel Kim Kevin Wong Min Cho | 2007 | Tourism Management2007,28,: | 1 |
| 11 | Randomized comparison of quinine-clindamycin versus artesunate in the treatment of falciparum malaria in pregnancy 显示文摘 | McGready R Cho T Samuel A | 2001 | Trans R Soc Trop Med Hyg2001,95,: | 1 |
| 12 | A three-layer model for cuttings transport with coiled tubing horizontal drilling显示文摘 | Hyun Cho Subhash N S Samuel O O | 2000 | SPE632692000,,: | 1 |
| 13 | Effect of sleeve gastrectomy on type 2 diabetes as an alternative treatment modality to Roux-en-Y gastric bypass: systemic review and meta-analysis显示文摘 | Jun-Min Cho Hyun Jung Kim Emanuele Lo Menzo Sungsoo Park Samuel Szomstein Raul J. Rosenthal | 2015 | Surgery for Obesity and Related Diseases2015,,: | 1 |
| 14 | The Impact of Tax Incentives on Foreign Direct Investment in China显示文摘 | Samuel Tung Stella Cho | 2000 | Journal of International Accounting Auditing & Taxation2000,9,2: | 1 |
| 15 | Determinants of Regional Investment Decisions in China: An Econometric Model of Tax Incentive Policy显示文摘 | Tung Samuel and Stella Cho | 2001 | Review of Quantitative Finance and Accounting2001,,17: | 1 |
| 16 | 建筑的“青葱”岁月 韩国某服饰店显示文摘Mass Studies是由韩国设计师Minsuk Cho2003年在首尔成立的韩国本土建筑设计事务所。成立至今,他们的作品已经遍及世界各地,成为韩国最红的建筑事务所。Minsuk Cho毕业于韩国延世大学(Yonsei University)建筑工程系,在哥伦比亚大学获得硕士学位。在回国成立自己的设计事务所之前,Minsuk Cho先在纽约的两个设计公司Kolatan/Macdonald studio和Polshekand Partners中任职。 | Minsuk Cho Samuele Martelli 许科 | 2008 | 室内设计与装修2008,,7: | 0 |
| 17 | Impact of palliative therapies in metastatic esophageal cancer patients not receiving chemotherapy显示文摘BACKGROUND Palliative therapy has been associated with improved overall survival(OS)in several tumor types.Not all patients with metastatic esophageal cancer receive palliative chemotherapy,and the roles of other palliative therapies in these patients are limited.AIM To investigate the impact of other palliative therapies in patients with metastatic esophageal cancer not receiving chemotherapy.METHODS The National Cancer Database was used to identify patients between 2004-2015.Patients with M1 disease who declined chemotherapy and had known palliative therapy status[palliative therapies were defined as surgery,radiotherapy(RT),pain management,or any combination thereof]were included.Cases with unknown chemotherapy,RT,or nonprimary surgery status were excluded.Kaplan-Meier estimates of OS were calculated.Cox proportional hazards regression models were employed to examine factors influencing survival.RESULTS Among 140234 esophageal cancer cases,we identified 1493 patients who did not receive chemotherapy and had complete data.Median age was 70 years,most(66.3%)had a Charlson Comorbidity Index(CCI)of 0,and 37.1%were treated at an academic center.The majority(72.7%)did not receive other palliative therapies.On both univariate and multivariable analyses,there was no difference in OS between those receiving other palliative therapy(median 2.83 mo,95%CI:2.53-3.12)vs no palliative therapy(2.37 no,95%CI:2.2-2.56;multivariable P=0.290).On univariate,but not multivariable analysis,treatment at an academic center was predictive of improved OS[Hazard ratio(HR)0.90,95%CI:0.80-1.00;P=0.047].On multivariable analysis,female sex(HR 0.81,95%CI:0.71-0.92)and non-black,other race compared to white race(HR 0.72,95%CI:0.56-0.93)were associated with reduced mortality,while South geographic region relative to West region(HR 1.23,95%CI:1.04-1.46)and CCI of 1 relative to CCI of 0(HR 1.17,95%CI:1.03-1.32)were associated with increased mortality.Higher histologic grade and T-stage were also associated with worse OS(P<0.05).CONCLUSION Palliative therapies other than chemotherapy conferred a numerically higher,but not statistically significant difference in OS among patients with metastatic esophageal cancer not receiving chemotherapy.Quality of life metrics,inpatient status,and subgroup analyses are important for examining the role of palliative therapies other than chemotherapy in metastatic esophageal cancer and future studies are warranted. | Sungjin Kim Timothy P DiPeri Michelle Guan Veronica R Placencio-Hickok Haesoo Kim Jar-Yee Liu Andrew Hendifar Samuel J Klempner Ryan Nipp Alexandra Gangi Miguel Burch Kevin Waters May Cho Joseph Chao Katelyn Atkins Mitchell Kamrava Richard Tuli Jun Gong | 2020 | World Journal of Gastrointestinal Surgery2020,12,9: | 0 |
| 18 | The combined role of MRI prostate and prostate health index in improving detection of significant prostate cancer in a screening population of Chinese men显示文摘Using prostate-specific antigen(PSA)for prostate cancer(PCa)screening led to overinvestigation and overdiagnosis of indolent PCa.We aimed to investigate the value of prostate health index(PHI)and magnetic resonance imaging(MRI)prostate in an Asian PCa screening program.Men aged 50–75 years were prospectively recruited from a community-based PSA screening program.Men with PSA 4.0–10.0 ng ml^(−1) had PHI result analyzed.MRI prostate was offered to men with PSA 4.0–50.0 ng ml−1.A systematic prostate biopsy was offered to men with PSA 4.0–9.9 ng ml^(−1) and PHI≥35,or PSA 10.0–50.0 ng ml^(−1).Additional targeted prostate biopsy was offered if they had PI-RADS score≥3.Clinically significant PCa(csPCa)was defined as the International Society of Urological Pathology(ISUP)grade group(GG)≥2 or ISUP GG 1 with involvement of≥30%of total systematic cores.In total,12.8%(196/1536)men had PSA≥4.0 ng ml^(−1).Among 194 men with PSA 4.0–50.0 ng ml^(−1),187(96.4%)received MRI prostate.Among them,28.3%(53/187)had PI-RADS≥3 lesions.Moreover,7.0%(107/1536)men were indicated for biopsy and 94.4%(101/107)men received biopsy.Among the men received biopsy,PCa,ISUP GG≥2 PCa,and csPCa was diagnosed in 42(41.6%),24(23.8%),and 34(33.7%)men,respectively.Compared with PSA/PHI pathway in men with PSA 4.0–50.0 ng ml^(−1),additional MRI increased diagnoses of PCa,ISUP GG≥2 PCa,and csPCa by 21.2%(from 33 to 40),22.2%(from 18 to 22),and 18.5%(from 27 to 32),respectively.The benefit of additional MRI was only observed in PSA 4.0–10.0 ng ml^(−1),and the number of MRI needed to diagnose one additional ISUP GG≥2 PCa was 20 in PHI≥35 and 94 in PHI<35.Among them,45.4%(89/196)men with PSA≥4.0 ng ml^(−1) avoided unnecessary biopsy with the use of PHI and MRI.A screening algorithm with PSA,PHI,and MRI could effectively diagnose csPCa while reducing unnecessary biopsies.The benefit of MRI prostate was mainly observed in PSA 4.0–9.9 ng ml^(−1) and PHI≥35 group.PHI was an important risk stratification step for PCa screening. | Peter KF Chiu Thomas YT Lam Chi-Fai Ng Jeremy YC Teoh Carmen CM Cho Hiu-Yee Hung Cindy Hong Monique J Roobol Winnie CW Chu Samuel YS Wong Joseph JY Sung | 2023 | Asian Journal of Andrology2023,25,6: | 0 |
| 19 | Chemotherapy predictors and a time-dependent chemotherapy effect in metastatic esophageal cancer显示文摘BACKGROUND Chemotherapy has long been shown to confer a survival benefit in patients with metastatic esophageal cancer.However,not all patients with metastatic disease receive chemotherapy.AIM To evaluate a large cancer database of metastatic esophageal cancer cases to identify predictors of receipt to chemotherapy and survival.METHODS We interrogated the National Cancer Database(NCDB)between 2004-2015 and included patients with M1 disease who had received or did not receive chemotherapy.A logistic regression model was used to examine the associations between chemotherapy and potential confounders and a Cox proportional hazards model was employed to examine the effect of chemotherapy on overall survival(OS).Propensity score analyses were further performed to balance measurable confounders between patients treated with and without chemotherapy.RESULTS A total of 29182 patients met criteria for inclusion in this analysis,with 21911(75%)receiving chemotherapy and 7271(25%)not receiving chemotherapy.The median follow-up was 69.45 mo.The median OS for patients receiving chemotherapy was 9.53 mo(9.33-9.72)vs 2.43 mo(2.27-2.60)with no chemotherapy.Year of diagnosis 2010-2014[odds ratio(OR):1.29,95%confidence interval(CI):1.17-1.43,P value<0.001],median income>$46000(OR:1.49,95%CI:1.27-1.75,P value<0.001),and node-positivity(OR:1.35,95%CI:1.20-1.52,P<0.001)were independent predictors of receiving chemotherapy,while female gender(OR:0.86,95%CI:0.76-0.98,P=0.019),black race(OR:0.76,95%CI:0.67-0.93,P=0.005),uninsured status(OR:0.41,95%CI:0.33-0.52,P<0.001),and high Charlson Comorbidity Index(CCI)(OR for CCI≥2:0.61,95%CI:0.50-0.74,P<0.001)predicted for lower odds of receiving chemotherapy.Modeling the effect of chemotherapy on OS using a time-dependent coefficient showed that chemotherapy was associated with improved OS up to 10 mo,after which there is no significant effect on OS.Moreover,uninsured status[hazard ratio(HR):1.20,95%CI:1.09-1.31,P<0.001],being from the geographic Midwest(HR:1.07,95%CI:1.01-1.14,P=0.032),high CCI(HR for CCI≥2:1.16,95%CI:1.07-1.26,P<0.001),and higher tumor grade(HR for grade 3 vs grade 1:1.28,95%CI:1.14-1.44,P<0.001)and higher T stage(HR for T1 vs T4:0.89,95%CI:0.84-0.95,P<0.001)were independent predictors of worse OS on multivariable analyses.CONCLUSION In this large,retrospective NCDB analysis,we identified several socioeconomic and clinicopathologic predictors for receiving chemotherapy and OS in patients with metastatic esophageal cancer.The benefit of chemotherapy on OS is timedependent and favors early initiation.Focused outreach in lower income and underinsured patients is critical as receipt of chemotherapy is associated with improved OS. | Lauren Midthun Sungjin Kim Andrew Hendifar Arsen Osipov Samuel J Klempner Joseph Chao May Cho Michelle Guan Veronica R Placencio-Hickok Alexandra Gangi Miguel Burch De-Chen Lin Kevin Waters Katelyn Atkins Mitchell Kamrava Jun Gong | 2022 | World Journal of Gastrointestinal Oncology2022,14,2: | 0 |