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| 1 | Combined chemo-radiotherapy in locally advanced nasopharyngeal carcinomas显示文摘AIM:To provide efficacy and safety data about the combined use of radiotherapy and chemo-radiotherapy in nasopharyngeal carcinoma(NPC).METHODS:We reviewed data of 40 patients with locally advanced NPC treated with induction chemotherapy followed by concomitant chemo-radiotherapy(CCRT)(22/40 patients)or CCRT alone(18/40)from March 2006 to March 2012.Patients underwent fiberoscopy with biopsy of the primitive tumor,and computed tomography scan of head,neck,chest and abdomen with and without contrast.Cisplatin was used both as induction and as concomitant chemotherapy,while 3D conformal radiation therapy was delivered to the nasopharynx and relevant anatomic regions(total dose,70 Gy).The treatment was performed using 6 MV photons of the linear accelerator administered in 2 Gy daily fraction for five days weekly.This retrospective analysis was approved by the review boards of the participating institutions.Patients gave their consent to treatment and to anonymous analysis of clinical data.RESULTS:Thirty-three patients were males and 7 were females.Median follow-up time was 58 mo(range,1-92 mo).In the sub-group of twenty patients with a follow-up time longer than 36 mo,the 3-year survival and disease free survival rates were 85%and 75%,respectively.Overall response rate both in patients treated with induction chemotherapy followed by CCRT and in those treated with CCRT alone was 100%.Grade 3 neutropenia was the most frequent acute side-effect and it occurred in 20 patients.Grade 2 mucositis was seen in 29 patients,while grade 2 xerostomia was seen in 30 patients.Overall toxicity was manageable and it did not cause any significant treatment delay.In the whole sample population,long term toxicity included grade 2 xerostomia in 22 patients,grade 1 dysgeusia in 17 patients and grade 1 subcutaneous fibrosis in 30 patients.CONCLUSION:Both CCRT and induction chemotherapy followed by CCRT showed excellent activity in locally advanced NPC.The role of adjuvant chemotherapy remains to be defined. | Francesco Perri Giuseppina Della Vittoria Scarpati Carlo Buonerba Giuseppe Di Lorenzo Francesco Longo Paolo Muto Concetta Schiavone Fabio Sandomenico Francesco Caponigro | 2013 | World Journal of Clinical Oncology2013，4，2： | 22 |
| 2 | Low mechanical index contrast-enhanced sonographic findings of pyogenic hepatic abscesses显示文摘 | Catalano O Sandomenico F Raso MM | 2004 | AJR2004，182，： | 1 |
| 3 | Oxaliplatin Plus Dual Inhibition of Thymidilate Synthase During Preoperative Pelvic Radiotherapy for Locally Advanced Rectal Carcinoma: Long-Term Outcome显示文摘 | Antonio Avallone Paolo Delrio Biagio Pecori Fabiana Tatangelo Antonella Petrillo Nigel Scott Pietro Marone Luigi Aloi Claudia Sandomenico Secondo Lastoria Vincenzo Rosario Iaffaioli Dario Scala Giovanni Iodice Alfredo Budillon Pasquale Comella | 2011 | International Journal of Radiation Oncology, Biology, Physics2011，，3： | 1 |
| 4 | Aneurysma bone cyst:diagnostic role of computerized tomography and magnetic resonance显示文摘 | Sandomenico F Cappabianca S lovino M | | 0，，05： | 1 |
| 5 | Real-time, contrast-enhanced sonography: a new tool for detecting active bleeding显示文摘 | Gatalano O Sandomenico F Raso MM | 2005 | J Trauma2005，59，4： | 1 |
| 6 | Real-time,contrast-enhanced sonographic imaging in emergency radiology显示文摘 | Catalano O Lobianco R Sandomenico F | 2004 | Radiol Med (Torino)2004，108，56： | 1 |
| 7 | Cancer-se- lective targeting of the NF-KB survival pathway with GADD4513/MKK7 inhibitors 显示文摘 | Tomatore L Sandomenico A Raimondo D | 2014 | Cancer Cell2014，26，4： | 1 |
| 8 | Real-time,contrastenhanced sonographic imaging in emergency radiology显示文摘 | Catalano O Lobianco R Sandomenico F | 2004 | Radiol Med Torino2004，108，56： | 1 |
| 9 | Oxaliplatin Plus Dual Inhibition of Thymidilate Synthase During Preoperative Pelvic Radiotherapy for Locally Advanced Rectal Carcinoma: Long-Term Outcome显示文摘 | Antonio Avallone Paolo Delrio Biagio Pecori Fabiana Tatangelo Antonella Petrillo Nigel Scott Pietro Marone Luigi Aloi Claudia Sandomenico Secondo Lastoria Vincenzo Rosario Iaffaioli Dario Scala Giovanni Iodice Alfredo Budillon Pasquale Comella | 2011 | International Journal of Radiation Oncology Biology Physics2011，，3： | 1 |
| 10 | Con- trast-enhanced sonography of the kidney显示文摘 | Setola SV Catalano O Sandomenico F | 2007 | Abdom Imaging2007，32，： | 1 |
| 11 | Contrast enhanced sonography of the kidney显示文摘 | Setola SV Catalano 0 Sandomenico F etal | 2007 | Abdom lmaging2007，32，： | 1 |
| 12 | Acute flank pain: comparison of unenhanced helical CT and ultrasonography in detecting causes other than ureterolithiasis显示文摘 | Orlando Catalano Antonio Nunziata Fabio Sandomenico Alfredo Siani | 2002 | Emergency Radiology2002，，3： | 1 |
| 13 | Contrast-enhanced sonography of the kidney显示文摘 | Setola SV Catalano O Sandomenico F | 2007 | Abdom Imaging2007，32，1： | 1 |
| 14 | Low mechanical index contrast-enhanced sonographic findings of pyogenic hepatic abscess 显示文摘 | Catalano O Sandomenico F Raso MM | 2004 | A JR2004，182，2： | 1 |
| 15 | Low mechanical indexcontrast-enhanced sonographic findings ofpyogenie hepatic abscesses 显示文摘 | Catahno 0 Sandomenico F Raso MM | 2004 | Am J Roentgenol2004，182，2： | 1 |
| 16 | Bevaeizumab in non small cell lung cancer: development, current status and issues显示文摘 | Sandomenico C Costanzo R Carillio G | 2012 | Curr Med Chem2012，19，7： | 1 |
| 17 | Splenic trauma:evaluation with contrast-specific sonography and a second-generation contrast medium:preliminary experience显示文摘 | Lobianco R Sandomenico F | 2003 | J Ultrasound Med2003，22，5： | 1 |
| 18 | Low Mechanical Index Contrast-Enhanced Sonographic Findings of Pyogenic Hepatic Abscesses显示文摘 | CATALANO O SANDOMENICO F RASO M M | 2004 | AJR2004，182，2： | 1 |
| 19 | Contrast-enhanced sonography of the kidney显示文摘 | Setola SV Catalano O Sandomenico F | 2007 | Abdom Imaqing2007，32，1： | 1 |
| 20 | Capecitabine,alone and in combination,in the management of patients with colorectal cancer:a review of the evidence显示文摘 | Casaretti R Sandomenico C | 2008 | Drugs2008，68，7： | 1 |
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