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| 1 | Features of extrahepatic metastasis after radiofrequency ablation for hepatocellular carcinoma显示文摘BACKGROUND Extrahepatic metastasis(EHM)of hepatocellular carcinoma(HCC)is associated with poor outcomes.However,the clinical features and risk factors of EHM of HCC after radiofrequency ablation(RFA)remain unclear.AIM To elucidate the characteristics and risk factors of EHM after RFA for HCC.METHODS From January 2008 to December 2017,we retrospectively enrolled 661 patients who underwent RFA as first-line treatment for HCC at 2 tertiary hospitals.The inclusion criteria were age≥18 years,a diagnosis of HCC,and treatment-naivety.Abdominal computed tomography(CT)or magnetic resonance imaging(MRI)and alpha-fetoprotein measurements were routinely performed at 1 mo after RFA and followed-up at intervals of 3-6 mo.Univariate analyses were performed using the chi-squared test or Student’s t-test,and univariate and multivariate analyses were performed via logistic regression,as appropriate.RESULTS EHM was diagnosed in 44 patients(6.7%)during a median follow-up period of 1204 days.The 10-year cumulative rate of HCC recurrence and EHM was 92.7%and 33.7%,respectively.Initial recurrence was most often intrahepatic,and the rate of extrahepatic recurrence at initial recurrence was only 1.2%.The median time to the diagnosis of EHM was 2.68 years,and 68.2%of patients developed EHM within 2 years of the first recurrence,regardless of recurrence-free survival and 75.0%of patients developed EHM within 5 years after first recurrence.EHM was mostly diagnosed via abdominal CT/MRI in 33(75.0%)and 38 of 44 patients(86.4%)with EHM had either positive abdominal CT scan results or serum AFP level elevation.In multivariate analysis,recurrence-free survival<2 years,ablation zone/tumor size<2,and alpha-fetoprotein level>400 IU/mL were associated with a high EHM risk.CONCLUSION EHM occurs following multiple intrahepatic recurrences after RFA and combined contrast-enhanced abdominal CT and serum AFP were useful for surveillance.Patients especially with high-risk factors require close follow-up for EHM. | Jae H Yoon Young J Goo Chae-Jun Lim Sung K Choi Sung B Cho Sang S Shin Chung H Jun | 2020 | World Journal of Gastroenterology2020，26，32： | 3 |
| 2 | Influences of Bentonite on conductivity of composite solid alkaline polymer electrolyte PVA- Bentonite-KOH-H2O显示文摘 | Sang S B Zhang J F Wu Q M | 2007 | Electrochim Acta2007，52，25： | 1 |
| 3 | Predictors of tuberculin reactivity among prospective Vietnamese migrants: the effect of smoking显示文摘 | Plant AJ Watkins RE Gushulak B O'Rourke T Jones W Streeton J Sang D | 2002 | Epidemiol Infect2002，128，1： | 1 |
| 4 | 显示文摘 | Wang L J Sang W B Shi W M | 2000 | Nucl Instrum Methods Phys Res Sect A2000，448，3： | 1 |
| 5 | Preparation and application of organo- minerals as sorbents of phenol, benzene and toluene显示文摘 | SANG M K JOE B D | 2001 | Ap- plied Clay Science2001，，18： | 1 |
| 6 | Catalytic reforming of methane with CO2 over metal foam based monolithic catalysts显示文摘 | SANG L X SUN B TAN H Y | 2012 | International Journal ofHydrogen Energy2012，37，13： | 1 |
| 7 | Inhibitory effects of gossypol on corticosteroid 11-hydroxysteroid dehydrogenase from guinea pig kidney:a possible mechanism for causing hypokalemia 显示文摘 | SANG G W LORENZO B REIDENBERG M | 1991 | J Steroid Biochem Mol Biol1991，39，1： | 1 |
| 8 | Phylogeny of rice genomes with emphasis on origins of allotetraploid species 显示文摘 | Ge S Sang T Lu B R | 1999 | PNAS1999，96，14： | 1 |
| 9 | Speckle Suppression in Dig- ital Holographic Imaging with Random Phases and Differ- ent Wavelengths显示文摘 | LENG J SANG X YAN B | 2014 | Optical Engineering2014，53，03： | 1 |
| 10 | The removal of nitrogen using an autotrophic hybrid hollow-fiber membrane biofilm reactor显示文摘 | SHIN J SANG B CHUNG Y | 2005 | Desalination2005，183，13： | 1 |
| 11 | Phylogeny of rice genomes with emphasis on origins of allotetraploid species 显示文摘 | GE S SANG T LU B R | 1999 | Proc Natl Acad Sci USA1999，96，14： | 1 |
| 12 | Lithium insertion into the raw multi-walled carbon nanotubes pre-doped with lithium--an electrochemical impedance study 显示文摘 | YANG Z H SANG S B HUANG K L | 2004 | Diamond and Related Ma- terials2004，13，： | 1 |
| 13 | Toxicological mechanisms of nanosized titanium dioxide-induced spleen injury in mice after repeated peroral application显示文摘 | Sang X Li B Ze Y | 2013 | J Agric Food Chem2013，61，23： | 1 |
| 14 | Synergy Effect of Naphthenic Acid Corrosion and Sulfur Corrosion in Crude Oil Distillation Unit显示文摘 | HUANG B S YIN W F SANG D H | 2012 | Applied Surface Science2012，259，： | 1 |
| 15 | Speciation of chromium in water samples with cloud point extraction separation and preconcentration and determination by graphite furnace atomic absorption spectrometry显示文摘 | Liang P Sang H B | 2008 | Journal of Hazardous Materials2008，154，： | 1 |
| 16 | Speckle Noise Reduction in Digital Holography with Spatial Light Modulalor And Nonlocal Means Algorithm 显示文摘 | LENG J SANG X YAN B | 2014 | Chinese Optics Letters2014，12，04： | 1 |
| 17 | Optimization of Pd content in ZnO microstructures for high-performance gas detection显示文摘 | HU J GAO F Q SANG S B | 2015 | Journal of Materials Science2015，50，4： | 1 |
| 18 | Porcine liver-expressed antimicrobial peptides, hepcidin and LEAP-2: cloning and induction by bacterial infection 显示文摘 | SANG Y RAMANATHAN B MINTON J E | 2006 | Dev Comp Immun2006，30，： | 1 |
| 19 | The removal of nitrogen using an autotrophic hybrid hollow-fiber membrane biofilm reactor 显示文摘 | Shin J H Sang B I Chung Y C | 2005 | Desalination2005，183，123： | 1 |
| 20 | Virtual target differential game midcourse guidance law for hypersonic cruise missile based on neural network显示文摘 | Sang B H Jiang C S | 2008 | Transactions of Nanjing University of Aeronautics & Astronautic2008，25，2： | 1 |
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