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| 1 | Bioactive polymeric scaffolds for tissue engineering显示文摘A variety of engineered scaffolds have been created for tissue engineering using polymers,ceramics and their composites.Biomimicry has been adopted for majority of the three-dimensional(3D)scaffold design both in terms of physicochemical properties,as well as bioactivity for superior tissue regeneration.Scaffolds fabricated via salt leaching,particle sintering,hydrogels and lithography have been successful in promoting cell growth in vitro and tissue regeneration in vivo.Scaffold systems derived from decellularization of whole organs or tissues has been popular due to their assured biocompatibility and bioactivity.Traditional scaffold fabrication techniques often failed to create intricate structures with greater resolution,not reproducible and involved multiple steps.The 3D printing technology overcome several limitations of the traditional techniques and made it easier to adopt several thermoplastics and hydrogels to create micro-nanostructured scaffolds and devices for tissue engineering and drug delivery.This review highlights scaffold fabrication methodologies with a focus on optimizing scaffold performance through the matrix pores,bioactivity and degradation rate to enable tissue regeneration.Review highlights few examples of bioactive scaffold mediated nerve,muscle,tendon/ligament and bone regeneration.Regardless of the efforts required for optimization,a shift in 3D scaffold uses from the laboratory into everyday life is expected in the near future as some of the methods discussed in this review become more streamlined. | Scott Stratton Namdev B.Shelke Kazunori Hoshino Swetha Rudraiah Sangamesh G.Kumbar | 2016 | Bioactive Materials2016，1，2： | 14 |
| 2 | Bioactive polymeric materials and electrical stimulation strategies for musculoskeletal tissue repair and regeneration显示文摘Electrical stimulation(ES)is predominantly used as a physical therapy modality to promote tissue healing and functional recovery.Research efforts in both laboratory and clinical settings have shown the beneficial effects of this technique for the repair and regeneration of damaged tissues,which include muscle,bone,skin,nerve,tendons,and ligaments.The collective findings of these studies suggest ES enhances cell proliferation,extracellular matrix(ECM)production,secretion of several cytokines,and vasculature development leading to better tissue regeneration in multiple tissues.However,there is still a gap in the clinical relevance for ES to better repair tissue interfaces,as ES applied clinically is ineffective on deeper tissue.The use of a conducting material can transmit the stimulation applied from skin electrodes to the desired tissue and lead to an increased function on the repair of that tissue.Ionically conductive(IC)polymeric scaffolds in conjunction with ES may provide solutions to utilize this approach effectively.Injectable IC formulations and their scaffolds may provide solutions for applying ES into difficult to reach tissue types to enable tissue repair and regeneration.A better understanding of ES-mediated cell differentiation and associated molecular mechanisms including the immune response will allow standardization of procedures applicable for the next generation of regenerative medicine.ES,along with the use of IC scaffolds is more than sufficient for use as a treatment option for single tissue healing and may fulfill a role in interfacing multiple tissue types during the repair process. | Bryan Ferrigno Rosalie Bordett Nithyadevi Duraisamy Joshua Moskow Michael R.Arul Swetha Rudraiah Syam P.Nukavarapu Anthony T.Vella Sangamesh G.Kumbar | 2020 | Bioactive Materials2020，5，3： | 8 |
| 3 | Review: Bioengineering approach for the repair and regeneration of peripheral nerve显示文摘Complex craniofacial surgeries of damaged tissues have several limitations,which present complications and challenges when trying to replicate facial function and structure.Traditional treatment techniques have shown suitable nerve function regeneration with various drawbacks.As technology continues to advance,new methods have been explored in order to regenerate damaged nerves in an effort to more efficiently and effectively regain original function and structure.This article will summarize recent bioengineering strategies involving biodegradable composite scaffolds,bioactive factors,and external stimuli alone or in combination to support peripheral nerve regeneration.Particular emphasis is made on the contributions of growth factors and electrical stimulation on the regenerative process. | Joshua Moskow Bryan Ferrigno Nikhil Mistry Devina Jaiswal Ketan Bulsara Swetha Rudraiah Sangamesh G.Kumbar | 2019 | Bioactive Materials2019，4，1： | 6 |
| 4 | Nanocomposites and bone regeneration显示文摘这张手稿用设计策略的织物集中于骨头修理 / 新生,并且加亮导致新奇 nanocomposite 系统的 nanobiotechnology 开发。大约 650 万破裂在美国每年发生,并且大约 550,000 个这些单个盒子要求了骨头接枝的申请。自然发生并且 allogenous 骨头最广泛地为骨头接枝被使用了基于的治疗;然而,象施主缺乏和感染的风险那样有重要问题。用合成、自然的 biomaterials 的选择被开发了,并且一些为要求骨头接枝的临床的应用程序是商业地可得到的。然而,设计很仔细模仿骨头织物在结构上,和罐头的理想的合成接枝仍然是大挑战在造骨细胞和祖先房间人口调制需要的功能。Nanobiomaterials,明确地, nanocomposites hydroxyapatite 创作了(哈) 或骨胶原极其正在答应接枝代用品。biocomposites 能被制作模仿本国的骨头织物的材料作文,并且另外,当使用 nano 时 -- 哈(减少的谷物尺寸) ,一个人模仿本国的骨头的结构的安排。骨头生物学和结构的好理解对骨头 mimicking 接枝代用品的开发批评。哈并且能进一步调制 regenerative/healing 的优秀 osteoconductive 性质处理跟随破裂损害的骨胶原展览。与另外的聚合 biomaterials 结合将增强因此做新奇 nano 的机械性质 -- 哈比得上人的骨头的基于的 composites。我们用 nanocomposites 在最近的研究上报导为部分骨头缺点的新生作为粒子和 nanofibers 被制作了。在 nanocomposites 的研究,在理想的未来发展加亮一个枢轴的角色整形外科植入设备,然而进一步的重要前进是必要的完成临床的使用。 | Roshan JAMES Meng DENG Cato T. LAURENCIN Sangamesh G. KUMBAR | 2011 | Frontiers of Materials Science2011，5，4： | 5 |
| 5 | Biopolymer-nanotube nerve guidance conduit drug delivery for peripheral nerve regeneration:In vivo structural and functional assessment显示文摘Peripheral nerve injuries account for roughly 3%of all trauma patients with over 900,000 repair procedures annually in the US.Of all extremity peripheral nerve injuries,51%require nerve repair with a transected gap.The current gold-standard treatment for peripheral nerve injuries,autograft repair,has several shortcomings.Engineered constructs are currently only suitable for short gaps or small diameter nerves.Here,we investigate novel nerve guidance conduits with aligned microchannel porosity that deliver sustained-release of neurogenic 4-aminopyridine(4-AP)for peripheral nerve regeneration in a critical-size(15 mm)rat sciatic nerve transection model.The results of functional walking track analysis,morphometric evaluations of myelin development,and histological assessments of various markers confirmed the equivalency of our drug-conduit with autograft controls.Repaired nerves showed formation of thick myelin,presence of S100 and neurofilament markers,and promising functional recovery.The conduit’s aligned microchannel architecture may play a vital role in physically guiding axons for distal target reinnervation,while the sustained release of 4-AP may increase nerve conduction,and in turn synaptic neurotransmitter release and upregulation of critical Schwann cell neurotrophic factors.Overall,our nerve construct design facilitates efficient and efficacious peripheral nerve regeneration via a drug delivery system that is feasible for clinical applications. | Ohan S.Manoukian Swetha Rudraiah Michael R.Arul Jenna M.Bartley Jiana T.Baker Xiaojun Yu Sangamesh G.Kumbar | 2021 | Bioactive Materials2021，6，9： | 2 |
| 6 | Performance study of jute-epoxy composites/sandwiches under normal ballistic impact显示文摘This study is undertaken to explore the use of natural fiber Jute-epoxy(JE),Jute-epoxy-rubber(JRE)sandwich composite for ballistic energy absorption.Energy absorbed and residual velocities for these composites are evaluated analytically and through Finite Element Analysis(FEA).FE analysis of JE plates is carried out for different thicknesses(3,5,10 and 15 mm).JE plates and JRE sandwiches having the same thickness(15 mm) are fabricated and tested to measure residual velocity and energy absorbed.The analytical results are found to agree well with the results of FE analysis with a maximum error of 9%.The study on JE composite plate reveals that thickness influences the energy absorption.Experimental and FE analysis study showed that JRE sandwiches have better energy absorption than JE plates.Energy absorption of a JRE sandwich is about 71% greater than JE plates.Damages obtained from FEA and testing are in good agreement,SEM analysis confirms composites failed by fiber rupture and fragmentation. | Sangamesh Rajole K.S.Ravishankar S.M.Kulkarni | 2020 | Defence Technology(防务技术)2020，16，4： | 2 |
| 7 | 利用神经网络模型预测球团矿的冷压强度(英文)显示文摘建立了一个神经网络模型来预测球团矿的冷压强度,该网络模型采用三层前向BP神经网络,网络结构为12-12-1,12个输入变量分别为给料率、料层高度、焙烧温度、干透点温度、COREX煤气单耗、膨润土的添加量、生球水分、生球碳含量以及成品球的FeO、MgO、Al2O3含量和碱度;隐层含有12个神经元;输出为成品球团冷压强度;神经元激活函数选择双曲正切函数;神经网络学习算法使用的是带惯量项的误差反向传播学习算法(BP学习算法)。选取353组数据来训练和测试神经网络,其中247组数据用于训练网络,其余数据用于测试网络。测试结果表明,该网络的预测结果与实际结果的误差在3%以内,同时通过敏感性分析得出以下结论:①膨润土添加量、生球碳含量以及成品球的FeO、MgO、Al2O3含量和碱度对球团矿的冷压强度有重要影响;②增加膨润土添加量、成品球碱度、MgO含量、焙烧温度、干透点温度、COREX煤气单耗有助于改善球团矿的冷压强度;③增加FeO含量、生球碳含量、Al2O3含量、料层高度、给料率将使球团矿的冷压强度迅速下降;④增加生球水分会降低冷压强度;⑤提高球团矿冷压强度的参数设置(膨润土的添加量:0.86%~0.92%;wFeO<0.5%;生球碳含量:1.00%~1.10%;MgO含量:0.39%~0.44%);⑥在0.3~0.7范围内增加碱度不能显著改善球团矿的冷压强度。 | T Umadevi Naveen F Lobo Sangamesh Desai Manjunath Prabhu 黄可为 | 2012 | 世界钢铁2012，12，4： | 2 |
| 8 | Miscibility and in vitro osteocompatibility of biodegradable blends of poly[(ethyl alanato) ( p -phenyl phenoxy) phosphazene] and poly(lactic acid-glycolic acid)显示文摘 | Meng Deng Lakshmi S. Nair Syam P. Nukavarapu Sangamesh G. Kumbar Tao Jiang Nicholas R. Krogman Anurima Singh Harry R. Allcock Cato T. Laurencin | 2007 | Biomaterials2007，，3： | 1 |
| 9 | Formulation and in-vitro evaluation of novel starch-based tableted microspheres for controlled release of ampicilhn显示文摘 | Raghavendra C M Sangamesh A P Namdev B S | 2008 | Carbohydrate Polymers2008，71，1： | 1 |
| 10 | Preparation and characterization of interpenetrating network beads ofpoly (vinylalcohol)-grafted-poly (acrylamide) with sodium alginate and their eontroUed release characteristics for eypermethrin pesticide显示文摘 | Sangamesh G K Tejraj M A | 2002 | J Appl Polym Sci2002，84，3： | 1 |
| 11 | Additive manufacturing of biodegradable porous orthopaedic screw显示文摘Advent of additive manufacturing in biomedical field has nurtured fabrication of complex,customizable and reproducible orthopaedic implants.Layer-by-layer deposition of biodegradable polymer employed in development of porous orthopaedic screws promises gradual dissolution and complete metabolic resorption thereby overcoming the limitations of conventional metallic screws.In the present study,screws with different pore sizes(916×918μm to 254×146μm)were 3D printed at 200μm layer height by varying printing parameters such as print speed,fill density and travel speed to augment the bone ingrowth.Micro-CT analysis and scanning electron micrographs of screws with 45%fill density confirmed porous interconnections(40.1%)and optimal pore size(259×207×200μm)without compromising the mechanical strength(24.58±1.36 MPa).Due to the open pore structure,the 3D printed screws showed increased weight gain due to the deposition of calcium when incubated in simulated body fluid.Osteoblast-like cells attached on screw and infiltrated into the pores over 14 days of in vitro culture.Further,the screws also supported greater human mesenchymal stem cell adhesion,proliferation and mineralized matrix synthesis over a period of 21 days in vitro culture as compared to non-porous screws.These porous screws showed significantly increased vascularization in a rat subcutaneous implantation as compared to control screws.Porous screws produced by additive manufacturing may promote better osteointegration due to enhanced mineralization and vascularization. | Ramya Dhandapani Priya Dharshini Krishnan Allen Zennifer Vishal Kannan Amrutha Manigandan Michael R.Arul Devina Jaiswal Anuradha Subramanian Sangamesh Gurappa Kumbar Swaminathan Sethuraman | 2020 | Bioactive Materials2020，5，3： | 1 |
| 12 | Biologically Active Chitosan Systems for tissue engineering and regenerative medicine显示文摘 | Tao Jiang Sangamesh GK Lakshmi SN | 2008 | Current Topics in Medicinal Chemistry2008，8，： | 1 |
| 13 | Evaluation of acrylamide-grafted-xanthan gum copolymer matrix tablets for oral controlled delivery of antihypertensive drugs 显示文摘 | Raghavendra C M Sangamesh A P | 2007 | Carbohydrate Polymers2007，69，1： | 1 |
| 14 | Novel hydrogel microspheres of chitosan and pluronic F-127 for controlled release of 5-fluorouracil显示文摘 | Ajit P. Rokhade Namdev B. Shelke Sangamesh A. Patil Tejraj M. Aminabhavi | 2007 | Journal of Microencapsulation2007，，： | 1 |
| 15 | Preparation and characterization of interpenetrating network beads of poly(vinyl alcohol)-grafted poly(acrylamide) with sodium alginate and their controlled release characteristics for cypermethrin pesticide显示文摘 | SANGAMESH G KUMBAR TEJRAJ M | 2002 | Journal of Applied Polymer Science2002，84，： | 1 |
| 16 | Amorphous silica fiber matrix biomaterials:An analysis of material synthesis and characterization for tissue engineering显示文摘Silica biomaterials including Bioglass offer great biocompatibility and bioactivity but fail to provide pore and degradation features needed for tissue engineering.Herein we report on the synthesis and characterization of novel amorphous silica fiber matrices to overcome these limitations.Amorphous silica fibers were fused by sintering to produce porous matrices.The effects of sacrificial polymer additives such as polyvinyl alcohol(PVA)and cellulose fibers(CF)on the sintering process were also studied.The resulting matrices formed between sintering temperatures of 1,350-1,550◦C retained their fiber structures.The matrices presented pores in the range of 50-200μm while higher sintering temperatures resulted in increased pore diameter.PVA addition to silica significantly reduced the pore diameter and porosity compared with silica matrices with or without the addition of CF.The PVA additive morphologically appeared to fuse the silica fibers to a greater extent and resulted in significantly higher compressive modulus and strength than the rest of the matrices synthesized.These matrices lost roughly 30%of their original mass in an in vitro degradation study over 40 weeks.All matrices absorbed 500 wt%of water and did not change in their overall morphology,size,or shape with hydration.These fiber matrices supported human mesenchymal stem cell adhesion,proliferation,and mineralized matrix production.Amorphous silica fiber biomaterials/matrices reported here are biodegradable and porous and closely resemble the native extracellular matrix structure and water absorption capacity.Extending the methodology reported here to alter matrix properties may lead to a variety of tissue engineering,implant,and drug delivery applications. | Hyun S.Kim Sangamesh G.Kumbar Syam P.Nukavarapu | 2023 | Bioactive Materials2023，，1： | 1 |
| 17 | Synthesis and characterization of modified chitosan mlcrospheres: effect of the grafting ratio on the controlled release of nifedipine through microspheres显示文摘 | SANGAMESH G K TEJRAJ M A | 2003 | Journal of Applied Polymer Science2003，，： | 1 |
| 18 | Preparation and characterization of interpenetrating network beads of poly (vinyl alcohol)-grafted-poly (acrylamede) with sodium alginate and their cotrolled release characteristics for cypermethrin pesticide显示文摘 | Sangamesh G K Tejraj M A | 2002 | J Applied Polymer Science2002，84，3： | 1 |
| 19 | Synthesis and characterization of polyacrylamide-grafted sodium algiate copolymeric membranes and their use in pervaporatio separation of water ad tetrahydrofuran mixtures显示文摘 | Mahaveer D K Sangamesh G K Tejraj M A | 2002 | J Applied Polymer Science2002，86，2： | 1 |
| 20 | Evaluation of acrylamide-grafted-xanthan gum copolymer matrix tablets for oral controlled delivery of antihypertensive drugs显示文摘 | Raghavendra C M Sangamesh A P Tejraj M A | 2007 | Carbohydrate Polymers2007，69，1： | 1 |
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