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| 1 | Sodium butyrate prevents radiation-induced cognitive impairment by restoring pCREB/BDNF expression显示文摘Sodium butyrate is a histone deacetylase inhibitor that affects various types of brain damages.To investigate the effects of sodium butyrate on hippocampal dysfunction that occurs after whole-brain irradiation in animal models and the effect of sodium butyrate on radiation exposure-induced cognitive impairments,adult C57BL/6 mice were intraperitoneally treated with 0.6 g/kg sodium butyrate before exposure to 10 Gy cranial irradiation.Cognitive impairment in adult C57BL/6 mice was evaluated via an object recognition test 30 days after irradiation.We also detected the expression levels of neurogenic cell markers(doublecortin)and phosphorylated cAMP response element binding protein/brain-derived neurotrophic factor.Radiation-exposed mice had decreased cognitive function and hippocampal doublecortin and phosphorylated cAMP response element binding protein/brain-derived neurotrophic factor expression.Sodium butyrate pretreatment reversed these changes.These findings suggest that sodium butyrate can improve radiation-induced cognitive dysfunction through inhibiting the decrease in hippocampal phosphorylated cAMP response element binding protein/brain-derived neurotrophic factor expression.The study procedures were approved by the Institutional Animal Care and Use Committee of Korea Institute of Radiological Medical Sciences(approval No.KIRAMS16-0002)on December 30,2016. | Hae June Lee Yeonghoon Son Minyoung Lee Changjong Moon Sung Ho Kim In Sik Shin Miyoung Yang Sangwoo Bae Joong Sun Kim | 2019 | Neural Regeneration Research2019，14，9： | 7 |
| 2 | T cell epitopes in SARS-CoV-2 proteins are substantially conserved in the Omicron variant显示文摘In November 2021,the Omicron variant(B.1.1.529)emerged and was designated a variant of concern(VOC)by the World Health Organization.Recently,Omicron was reported to extensively escape neutralizing antibodies elicited by COVID-19 vaccination or natural infection[1,2,3].However,whether Omicron evades the T cell immunity elicited by COVID-19 vaccination or natural infection remains to be elucidated.To address this issue,we analyzed the amino acid sequences of T cell epitopes identified from the original SARS-CoV-2 strain(Wuhan-Hu-1)in the Omicron variant(hCoV-19/South Africa/CERI-KRISP-K032284/2021). | Seong Jin Choi Dong-Uk Kim Ji Yun Noh Sangwoo Kim Su-Hyung Park Hye Won Jeong Eui-Cheol Shin | 2022 | Cellular & Molecular Immunology2022，19，3： | 5 |
| 3 | Conceptual design of the Kumgang laser: a high-power coherent beam combination laser using SC-SBS-PCMs towards a Dream laser显示文摘In this review paper, we introduce a self-phase controlled stimulated Brillouin scattering phase conjugate mirror(SCSBS-PCM) and the Kumgang laser. The SC-SBS-PCM was proposed and demonstrated its success at the academic low power level, ~100 mJ@10 Hz. The Kumgang laser is under development to verify whether the SC-SBS-PCM is operable at the k W level. It is a 4 kW beam combination laser combining four 1 k W beams using the SC-SBS-PCM. If the Kumgang laser functions successfully, it will be the most important step towards a Dream laser, a hypothetical laser with unlimited power and a high repetition rate. | Hong Jin Kong Sangwoo Park Seongwoo Cha Heekyung Ahn Hwihyeong Lee Jungsuk Oh Bong Ju Lee Soungwoong Choi Jom Sool Kim | 2015 | High Power Laser Science and Engineering2015，3，1： | 5 |
| 4 | Characterization of particulate matter from diesel passenger cars tested on chassis dynamometers显示文摘Emission characterization of particle number as well as particle mass from three diesel passenger cars equipped with diesel particulate filter(DPF), diesel oxidation catalyst(DOC)and exhaust gas recirculation(EGR) under the vehicle driving cycles and regulatory cycle.Total particle number emissions(PNEs) decreased gradually during speed-up of vehicle from 17.3 to 97.3 km/hr. As the average vehicle speed increases, the size-segregated peak of particle number concentration shifts to smaller size ranges of particles. The correlation analysis with various particulate components such as particle number concentration(PNC),ultrafine particle number concentration(UFPNC) and particulate matter(PM) mass was conducted to compare gaseous compounds(CO, CO_2, HC and NOx). The UFPNC and PM were not only emitted highly in Seoul during severe traffic jam conditions, but also have good correlation with hydrocarbons and NOxinfluencing high potential on secondary aerosol generation. The effect of the dilution temperature on total PNC under the New European Driving Cycle(NEDC), was slightly higher than the dilution ratio. In addition, the nuclei mode(DP: ≤ 13 nm) was confirmed to be more sensitive to the dilution temperature rather than other particle size ranges. Comparison with particle composition between vehicle speed cycles and regulatory cycle showed that sulfate was slightly increased at regulatory cycle, while other components were relatively similar. During cold start test, semivolatile nucleation particles were increased due to effect of cold environment. Research on particle formation dependent on dilution conditions of diesel passenger cars under the NEDC is important to verify impact on vehicular traffic and secondary aerosol formation in Seoul. | Sungwoon Jung Jaehyun Lim Sangil Kwon Sangwoo Jeon Jeongsoo Kim Jongtae Lee Sunmoon Kim | 2017 | Journal of Environmental Sciences2017，29，4： | 4 |
| 5 | A Lightweight Program Similarity Detection Model using XML and Levenshtein Distance显示文摘 | Seo-Young Noh Sangwoo Kim Cheonyoung Jung | 2006 | FECS2006，，： | 1 |
| 6 | Fabrication of practical deformable displays:advances and challenges显示文摘Display form factors such as size and shape have been conventionally determined in consideration of usability and portability.The recent trends requiring wearability and convergence of various smart devices demand innovations in display form factors to realize deformability and large screens.Expandable displays that are foldable,multi-foldable,slidable,or rollable have been commercialized or on the edge of product launches.Beyond such two-dimensional(2D)expansion of displays,efforts have been made to develop three dimensional(3D)free-form displays that can be stretched and crumpled for use in realistic tactile sensation,artificial skin for robots,and on-skin or implantable displays.This review article analyzes the current state of the 2D and 3D deformable displays and discusses the technological challenges to be achieved for industrial commercialization. | Dong Wook Kim Seong Won Kim Gyujeong Lee Jangyeol Yoon Sangwoo Kim Jong-Ho Hong Sung-Chan Jo Unyong Jeong | 2023 | Light(Science & Applications)2023，12，5： | 1 |
| 7 | mTOR inhibitors radiosensitize PTEN‐deficient non‐small‐cell lung cancer cells harboring an EGFR activating mutation by inducing autophagy显示文摘 | Eun Ju Kim Jae‐Hoon Jeong Sangwoo Bae Seongman Kang Cheol Hyeon Kim Young‐Bin Lim | 2013 | Biochem2013，，6： | 1 |
| 8 | Transgenic poplar trees expressing yeast cadmi- um factor 1 exhibit the characteristics necessary for the phytoremediation of mine tailing soil 显示文摘 | Donghwan Shim Sangwoo Kim Young-Im Choi Won-Yong Song etc | 2013 | Chemosphere2013，90，4： | 1 |
| 9 | A contribution of brown carbon aerosol to the aerosol light absorption and its radiative forcing in East Asia显示文摘 | Rokjin J. Park Minjoong J. Kim Jaein I. Jeong Daeok Youn Sangwoo Kim | 2010 | Atmospheric Environment2010，，11： | 1 |
| 10 | Three dimensional numerical simulation of injection molding filling of optical lens and multiscale geometry using finite element method显示文摘 | Kim Sangwoo Turng Lihsheng | 2006 | Polymer Engineering and Science2006，46，9： | 1 |
| 11 | Effects of high pressure processing on fatty acid composition and volatile compounds in Korean native black goat meat显示文摘 | Geunho Kang Soohyun Cho Pilnam Seong Beomyoung Park Sangwoo Kim Donghun Kim Youngjun Kim Sunmun Kang Kyoungmi Park | 2013 | Meat Science2013，，4： | 1 |
| 12 | Epitaxially grownLa-modified BiFeO3 magnetoferroelectric thin films 显示文摘 | LEE D KIM M G SANGWOO R JANG H M | 2005 | Appl PhysLett2005，86，222903： | 1 |
| 13 | Vision-based defect detection of scale-covered steel billet surfaces显示文摘 | YUN Jongpil Choi SungHoo Kim SangWoo | 2009 | Optical Engineering2009，48，03： | 1 |
| 14 | Influence of material properties on temperature and thermal stress of thermal barrier coating near a normal cooling hole显示文摘 | Kyung Min Kim Sangwoo Shin Dong Hyun Lee Hyung Hee Cho | 2011 | International Journal of Heat and Mass Transfer2011，，25： | 1 |
| 15 | New Block Cipher: ARIA显示文摘 | Kwon Daesung Kim Jaesung Sangwoo Park | 2003 | Information Security and Cryptology2003，8，10： | 1 |
| 16 | Clinical and genetic analysis of Ser341Pro MYOC variant in a Korean family with primary open angle glaucoma显示文摘AIM:To report the first discovery of Ser341Pro myocilin(MYOC)variant in Korea and analyze its clinical characteristics and genetic significance.METHODS:Ten family members from three generations participated in this study and received the thorough ophthalmologic examination.Focused exome sequencing on a proband was performed to confirm the target mutations(MYOC c.1021T>C)in the family members,and the direct sequencing was conducted.Variant was analyzed according to the American College of Medical Genetics and Genomics and the Association for Molecular Pathology(ACMG/AMP)guidelines.RESULTS:A nucleotide change from thymine to cytosine at c.1021T>C was found in eight family members.Three members diagnosed with primary open angle glaucoma(POAG)were characterized by severe clinical presentations,high intraocular pressure,and poor response to medical treatment(100%of the patient required filtering surgery).On variant analysis by ACMG/AMP guidelines,Ser341Pro is not found in normal population.Multiple computational predictive programs support a deleterious effect of Ser341Pro variant(PoIyPhen 2,SIFT,Mutation Taster).Ser341Pro could be involved in moderate(PM)and supporting(PP)criteria(PM1,PM2,PP2,PP3).Combiningthe criteria,Ser341Pro has a combination of 2 moderate(PM1+PM2)and 2 supporting(PP2+PP3)criteria,which is interpreted to'likely pathogenic'.CONCLUSION:The Ser341Pro variant is correlated with severe phenotype of POAG.There are similar clinical aspects to previous studies:autosomal dominant inheritance,incomplete penetrance(62.50%and 66.67%),and proportion of patients requiring trabeculectomy(100%in both study).According to ACMG/AMP guidelines and the previous basic researches,the Ser341Pro variant had a'strong evidence of pathogenicity(PS3)'and then it could be interpreted to“pathogenic(PS3,PM1,PM2,PP2,PP3)”.Additionally,Ser341Pro variant can be reported as'c.1021T>C(p.Ser341Pro)',likely pathogenic,POAG,autosomal dominant”according to guideline. | Sangwoo Moon Namhee Kim Jiwoong Lee | 2020 | International Journal of Ophthalmology(English edition)2020，13，11： | 0 |
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