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| 1 | Enhancer variants reveal a conserved transcription factor network governed by PU.1 during osteoclast differentiation显示文摘Genome-wide association studies(GWASs) have been instrumental in understanding complex phenotypic traits. However, they have rarely been used to understand lineage-specific pathways and functions that contribute to the trait. In this study, by integrating lineage-specific enhancers from mesenchymal and myeloid compartments with bone mineral density loci, we were able to segregate osteoblast-and osteoclast(OC)-specific functions. Specifically, in OCs, a PU.1-dependent transcription factor(TF)network was revealed. Deletion of PU.1 in OCs in mice resulted in severe osteopetrosis. Functional genomic analysis indicated PU.1 and MITF orchestrated a TF network essential for OC differentiation. Several of these TFs were regulated by cooperative binding of PU.1 with BRD4 to form superenhancers. Further, PU.1 is essential for conformational changes in the superenhancer region of Nfatc1. In summary, our study demonstrates that combining GWASs with genome-wide binding studies and model organisms could decipher lineage-specific pathways contributing to complex disease states. | Heather A.Carey Blake E.Hildreth III Jennifer A.Geisler Mara C.Nickel Jennifer Cabrera Sankha Ghosh Yue Jiang Jing Yan James Lee Sandeep Makam Nicholas A.Young Giancarlo R.Valiente Wael N.Jarjour Kun Huang Thomas J.Rosol Ramiro E.Toribio Julia F.Charles Michael C.Ostrowski Sudarshana M.Sharma | 2018 | Bone Research2018，6，1： | 4 |
| 2 | Func- tionalization of electrospun poly (caprolactone) fibers for pH- controlled delivery of doxorubicin hydrochloride 显示文摘 | Manisha Jassal Sukalyau Sengupta Sankha Bhnwmick | 2015 | Journal of biomaterials science-polymer edition2015，26，18： | 1 |
| 3 | A neural network based methodology for machining operations selection in computer-aided process planning for rotationally symmetrical parts显示文摘 | SANKHA D KALYAN G PAUL S | 2006 | Journal of Intelligent Manufacturing2006，17，： | 1 |
| 4 | A neural network based methodology for machining operations selection in Computer-Aided Process Planning for rotationally symmetrical parts显示文摘 | Sankha Deb Kalyan Ghosh S. Paul | 2006 | Journal of Intelligent Manufacturing2006，，5： | 1 |
| 5 | Nonlinear system identification of large-scale smart pavement systems显示文摘 | Yeesock Kim Rajib Mallick Sankha Bhowmick Bao-Liang Chen | 2012 | Expert Systems With Applications2012，，： | 1 |
| 6 | Optimisation of low temperature extraction of banana juice using commercial pectinase显示文摘 | Sorel Tchewonpi Sagu Emmanuel Jong Nso Sankha Karmakar Sirshendu De | 2014 | Food Chemistry2014，，： | 1 |
| 7 | Optimisation of lowtemperature extraction of banana juice usingcommercial pectinase 显示文摘 | Sorel Tchewonpi Sagu Emmanuel Jong Nso Sankha Karmakar | 2014 | Food Chemistry2014，151，15： | 1 |
| 8 | Transmission dynamics of depression in socially connected population: A nonlinear modeling study显示文摘Human emotions are considered to be contagious that can be transmitted from one person to another during social interactions.However,interaction with people having excessive negative emotions may make other people depressed.Taking this aspect into consideration,a SIR nonlinear model is formulated to investigate the transmission dynamics of depression in social connections.Through qualitative analysis of the model,critical value of depression is determined.Two equilibria,viz.depression free and depression state,are obtained and their stability behaviors are analyzed.The stability analysis reveals the fact that both the equilibria are locally and globally stable,depending on critical value of depression.The sensitivity analysis of crucial parameters of critical value of depression is performed to point out the key parameters that can drastically influence the propagation of depression.The results demonstrate the importance of counselling for depressed persons in order to suppress the growth of depression in social connections.The model calibration has been done for the annual depression cases of Zimbabwe.The results of our study show that individuals will catch major depression disorders more quickly once they get initially(primary)depressed.For this,counselling rate for primary depressed population should be increased. | Abhinav Tandon Arti Mishra Sankha Banerjee | 2021 | International Journal of Modeling, Simulation, and Scientific Computing2021，12，5： | 0 |
| 9 | Can hydroxychloroquine be used for COVID-19-induced arthritis? A debatable hypothesis显示文摘Hydroxychloroquine(HCQ)is a known disease-modifying antirheumatic drug for rheumatoid arthritis.It is also being used in viral arthritis on many occasions.HCQ is also being used to treat coronavirus disease 2019,but the results are not satisfactory.HCQ has been shown to have antiviral effects.In this context,we have a hypothesis that HCQ may be used as a treatment option in post-coronavirus disease 2019 arthritis. | Raktim Swarnakar Sankha Subhra Roy Shiv Lal Yadav | 2022 | World Journal of Experimental Medicine2022，12，6： | 0 |
| 10 | Modeling the impact of migrated population on human-to-human transmission of Ebola virus disease显示文摘A nonlinear SEIR mathematical model is developed to investigate the impact of migrated population,infected with Ebola virus,on human-to-human transmission of Ebola Virus Disease(EVD)in a disease-free area.In view of the dynamics of Ebola virus disease,here,the infected class is supposed to be divided into subclasses,viz.primary and secondary infected.The proposed model is analyzed qualitatively using the stability theory of differential equations and quantitatively using numerical simulation.The obtained results,qualitatively and quantitatively,suggest that migration and contact rates play an important role in controlling the spreading of disease.Critical values for migration and contact rates are evaluated and it is revealed that if these rates go beyond their critical values,it leads to delay in the stabilization of the system.It is also found that primary reproductive number increases with increase in migration rate.Besides this,the approximate time required to attain stability of the disease model system is also determined.The model analysis recommends quarantining the noninfected from the secondary infected in order to control the spreading out of disease. | Abhinav Tandon Sankha Banerjee | 2018 | International Journal of Modeling, Simulation, and Scientific Computing2018，9，1： | 0 |
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