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| 1 | Coexpression of CD163 and CD141 identifies human circulating IL-10-producing dendritic cells (DC-10)显示文摘Tolerogenic dendritic cells(DCs)are key players in maintaining immunological homeostasis,dampening immune responses,and promoting tolerance.DC-10,a tolerogenic population of human IL-10-producing DCs characterized by the expression of HLA-G and ILT4,play a pivotal role in promoting tolerance via T regulatory type 1(Tr1)cells.Thus far,the absence of markers that uniquely identify DC-10 has limited in vivo studies.By in vitro gene expression profiling of differentiated human DCs,we identified CD141 and CD163 as surface markers for DC-10.The coexpression of CD141 and CD163 in combination with CD14 and CD16 enables the ex vivo isolation of DC-10 from the peripheral blood.CD14+CD16+CD141+CD163+cells isolated from the peripheral blood of healthy subjects(ex vivo DC-10)produced spontaneously and upon activation of IL-10 and limited levels of IL-12.Moreover,in vitro stimulation of allogeneic naive CD4+T cells with ex vivo DC-10 induced the differentiation of alloantigen-specific CD49b+LAG-3+Tr1 cells.Finally,ex vivo DC-10 and in vitro generated DC-10 exhibited a similar transcriptional profile,which are characterized by an anti-inflammatory and pro-tolerogenic signature.These results provide new insights into the phenotype and molecular signature of DC-10 and highlight the tolerogenic properties of circulating DC-10.These findings open the opportunity to track DC-10 in vivo and to define their role in physiological and pathological settings. | Michela Comi Daniele Avancini Francesca Santoni de Sio Matteo Villa Molly Javier Uyeda Matteo Floris Daniela Tomasoni Alessandro Bulfone Maria Grazia Roncarolo Silvia Gregori | 2020 | Cellular & Molecular Immunology2020，17，1： | 4 |
| 2 | Effect of minor amounts of β-calcium pyrophosphate and hydroxyapatite on the physico-chemical properties and osteoclastic resorption of β-tricalcium phosphate cylinders显示文摘β-Tricalcium Phosphate(β-TCP),one of the most used bone graft substitutes,may contain up to 5 wt%foreign phase according to standards.Typical foreign phases includeβ-calcium pyrophosphate(β-CPP)and hydroxyapatite(HA).Currently,the effect of small amounts of impurities on β-TCP resorption is unknown.This is surprising since pyrophosphate is a very potent osteoclast inhibitor.The main aim of this study was to assess the effect of small β-CPP fractions(<1 wt%)on the in vitro osteoclastic resorption of β-TCP.A minor aim was to examine the effect of β-CPP and HA impurities on the physico-chemical properties of β-TCP powders and sintered cylinders.Twenty-six batches of β-TCP powder were produced with a Ca/P molar ratio varying between 1.440 and 1.550.Fifteen were further processed to obtain dense and polished β-TCP cylinders.Finally,six of them,with a Ca/P molar ratio varying between 1.496(1 wt% β-CPP)and 1.502(1 wt% HA),were incubated in the presence of osteoclasts.Resorption was quantified by white-light interferometry.Osteoclastic resorption was significantly inhibited by β-CPP fraction in a linear manner.The presence of 1% β-CPP reduced β-TCP resorption by 40%,which underlines the importance of controllingβ-CPP content when assessing β-TCP biological performance. | B.Le Gars Santoni L.Niggli S.Dolder O.Loeffel G.A.Sblendorio R.Heuberger | 2022 | Bioactive Materials2022，7，4： | 3 |
| 3 | Altering macrophage polarization in the tumor environment: the role of response gene to complement 32显示文摘 | Matteo Santoni Stefano Cascinu Charles D Mills | 2015 | Cellular & Molecular Immunology2015，12，6： | 2 |
| 4 | Risk of gastrointestinal events with sorafenib, sunitinib and pazopanib in patients with solid tumors: A systematic review and meta‐analysis of clinical trials显示文摘 | Matteo Santoni Alessandro Conti Ugo De Giorgi Roberto Iacovelli Francesco Pantano Luciano Burattini Giovanni Muzzonigro Rossana Berardi Daniele Santini Stefano Cascinu | 2014 | Int. J. Cancer2014，，： | 2 |
| 5 | Malpractice in Radiology: What Should You Worry About?显示文摘 | Alessandro Cannavale Mariangela Santoni Paola Mancarella Roberto Passariello Paolo Arbarello Ali Guermazi | 2013 | Radiology Research and Practice2013，，： | 1 |
| 6 | Toll like receptors and pancreatic diseases:From a pathogenetic mechanism to a therapeutic target显示文摘 | Santoni M Andrikou K Sotte V | 2015 | Cancer Treat Rev2015，41，7： | 1 |
| 7 | CXC and CC Chemokines as Angiogenic Modulators in Nonhaematological Tumors显示文摘 | Matteo Santoni Sergio Bracarda Massimo Nabissi Francesco Massari Alessandro Conti Emilio Bria Giampaolo Tortora Giorgio Santoni Stefano Cascinu Yi-Fang Ping | 2014 | BioMed Research International2014，，： | 1 |
| 8 | Anticandidal immunity and vaginitis : novel opportunities for immune intervention 显示文摘 | CASSONE A DE BERNARDIS F SANTONI G | 2007 | Infect Immun2007，75，10： | 1 |
| 9 | Can domestic unions gain from offshoring?显示文摘 | Giuseppe Bognetti Michele Santoni | 2010 | Journal of Economics2010，，1： | 1 |
| 10 | Intel virtualization Technology: Hardware support for efficient processor virtualization 显示文摘 | Neiger G Santoni A Leung F | 2006 | Intel Technology Journal2006，10，3： | 1 |
| 11 | Use of two-dimensional protein-pattern analysis for the characterization of Arabidopsis thaliana mutants显示文摘 | Santoni V Bellini C Caboche M | 1994 | Planta1994，192，： | 1 |
| 12 | The LAP family:a phylogenetic point of view显示文摘 | Santoni MJ Pontarotti P Birnbaum D | 2002 | Trends Genet2002，18，： | 1 |
| 13 | Stock Prices Volatility: Some Evi- dence from an ARCH Model显示文摘 | Baldanf B Santoni G J | 1991 | Journal of Futures Mar- kets1991，，2： | 1 |
| 14 | Role of a single aquaporin isoform in root water uptake显示文摘 | JAVOT H LAUVERGEAT V SANTONI V | 2003 | The Plant Cell2003，15，2： | 1 |
| 15 | Domestication history in the Medicago sativa species com- plex: inferences from nuclear sequence polymorphism显示文摘 | Muller M H Poncet C Prosperi J M Santoni S Ronfort J | 2006 | Molecular Ecology2006，15，15： | 1 |
| 16 | Toll like receptors and pancre- atic diseases: From a pathogenetic mechanism to a therapeutic tar- get显示文摘 | Santoni M Andrikou K Sotte V | 2015 | Cancer Treat Rev2015，41，7： | 1 |
| 17 | Cyclins of phases G1,S and G2/M are overexpressed in aneuploid mammary carcinomas显示文摘 | Collecchi P Santoni T Gnesi E | 2000 | Cytometry2000，42，4： | 1 |
| 18 | Usefulness of SPECT/CT with a hybrid camera for the functional anatomical mapping of primary brain tumors by 99Tcm-tetrofosmin显示文摘 | Filippi L Schillaci O Santoni R | 2006 | Cancer Biother Radiopharm2006，21，1： | 1 |
| 19 | Use of two-dimensional protein-pattern analysis for the characterization of Arabidopsis thaliana mutants显示文摘 | Veronique Santoni Catherine Bellini Michel Caboche | 1994 | Planta1994，192，： | 1 |
| 20 | Validationstudy of a two-dimensional model of fire spread across a fuel bed显示文摘 | MORANDINI F SANTONI P A BAJACQUES H | 2000 | Combustion Science and Technology2000，157，1： | 1 |
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