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| 1 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 2 | <ce:link locator='fx1'/> <ce:link locator='fx2'/> Insulin Resistance in Chronic Hepatitis C: Association With Genotypes 1 and 4, Serum HCV RNA Level, and Liver Fibrosis显示文摘 | Rami Moucari Tarik Asselah Dominique Cazals–Hatem Hélène Voitot Nathalie Boyer Marie–Pierre Ripault Rodolphe Sobesky Michèle Martinot–Peignoux Sarah Maylin Marie–Hélène Nicolas–Chanoine Valérie Paradis Michel Vidaud Dominique Valla Pierre Bedossa Patrick | 2008 | Gastroenterology2008，，2： | 2 |
| 3 | Cordierite glass-ceramics for multiplayer ceramic packaging显示文摘 | SARAH H K ANANDA H K HERRON L Wynn | 1993 | Am Ceram Soc Bull1993，72，1： | 1 |
| 4 | Neuroprotective signaling pathways are modulated by adenosine in the anoxia tolerant turtle显示文摘 | GAURI H N HOWARD M P SARAH L M | 2011 | J Cereb Blood Flow Metab2011，31，2： | 1 |
| 5 | Elevated carbon dioxide ahers impacts of precipitation pulses on ecosystem photosynthesis and res- piration in a semi-arid grassland 显示文摘 | Sarah B Jana L H Elise P | 2009 | Oecologia2009，162，3： | 1 |
| 6 | Mitigation of Urban Heat Islands: Materials, Utility Programs, Updates显示文摘 | Rosenfeld Arthur H Hashem Akbari Sarah Bretz Beth L Fishman Dan M Kurn David J Sailor Haider Taha | 1995 | Energy and Buildings1995，22，： | 1 |
| 7 | <ce:link locator='fx1'/> <ce:link locator='fx2'/> Insulin Resistance in Chronic Hepatitis C: Association With Genotypes 1 and 4, Serum HCV RNA Level, and Liver Fibrosis显示文摘 | Rami Moucari Tarik Asselah Dominique Cazals–Hatem Hélène Voitot Nathalie Boyer Marie–Pierre Ripault Rodolphe Sobesky Michèle Martinot–Peignoux Sarah Maylin Marie–Hélène Nicolas–Chanoine Valérie Paradis Michel Vidaud Dominique Valla Pierre Bedossa Patrick | 2008 | Gastroenterology2008，，2： | 1 |
| 8 | Bone marrow is a reservoir for CD4+ CD25+ regulatory T cells that traffic through CXCL12/CXCR4 signals显示文摘 | Zou L Barnett B Sarah H | 2004 | Cancer Res2004，64，22： | 1 |
| 9 | Comparative X-ray and27AlNMR spectroscopic studies of the speciation of aluminum in aqueous systems:Al(Ⅲ)Complexes of N(CH2CO2H)2(CH2CH2OH)显示文摘 | Sarah L H Peter A J Ian D J | 1995 | Journal of Inorgranic Biochemistry1995，59，4： | 1 |
| 10 | Cordierite glass-ceramics for multilayer ceramic packaging显示文摘 | SARAH H K ANANDA H K HERRON L W | 1993 | Am Ceram Soc Bull1993，72，1： | 1 |
| 11 | Pharmacology of insect GABA receptors显示文摘 | DAVID B S SARAH C R L JAMES F H W | 1991 | Neurochemical Research1991，16，3： | 1 |
| 12 | Distinct mac-rophage phe-notypes contribute to kidney injury and repair 显示文摘 | Sik L Sarah H Hitoshi N | 2011 | J AmSoc Nephrol2011，22，2： | 1 |
| 13 | Disparities in Breast Cancer Survival Among Asian Women by Ethnicity and Immigrant Status: A Population-Based Study显示文摘 | Gomez Scarlett Lin Clarke Christina A Shema Sarah J Chang Ellen T Keegan Theresa H M Glaser Sally L | 2010 | American Journal of Public Health2010，，5： | 1 |
| 14 | Prevention of LPS-induced a-cute lung injury in mice by mesenchymal stem cells overexpressingangiopoietin显示文摘 | Shirley H Sarah D Carter L | 2007 | PloS Med2007，9，4： | 1 |
| 15 | Sentinel lymph node biopsy for patients with early-stage breast cancer: Ameri- can society of clinical oncology clinical practice guideline update显示文摘 | Gary H L Sarah T Stephen BE | 2014 | J Clin Oncol2014，32，13： | 1 |
| 16 | Insulin Resistance in Chronic Hepatitis C: Association With Genotypes 1 and 4, Serum HCV RNA Level, and Liver Fibrosis显示文摘 | Rami Moucari Tarik Asselah Dominique Cazals–Hatem Hélène Voitot Nathalie Boyer Marie–Pierre Ripault Rodolphe Sobesky Michèle Martinot–Peignoux Sarah Maylin Marie–Hélène Nicolas–Chanoine Valérie Paradis Michel Vidaud Dominique Valla Pierre Bedossa Patrick | 2008 | Gastroenterology2008，，2： | 1 |
| 17 | Glycosyl disulfidesz Novel glycosylating reagents with flexible aglycon alteration显示文摘 | Elizabeth J G Sarah J W Alison L H etal | 2005 | The Journal of Organic Chemistry2005，70，24： | 1 |
| 18 | Phylogenetic analysis of geographically diverse Radopholus similis via rDNA sequence reveals a monomorphic motif显示文摘 | KAPLAN D T THOMAS W K FRISSE L M SARAH J L STANTON J M SPEIJER P R MARIN D H AND OPPERMAN C H | | 0，，： | 1 |
| 19 | Optimal fixation of acute scaphoid fi'actm~s : finite element analysis显示文摘 | Shai L Sarah H Meir L | 2010 | J Hand Surg Am2010，35，8： | 1 |
| 20 | Soundscape Ecology: The Science of Sound in the Landscape显示文摘 | Pijanowski Bryan C Villanueva-Rivera Luis J Dumyahn Sarah L Farina Almo Krause Bernie L Napoletano Brian M Gage Stuart H Pieretti Nadia | 2011 | Bioscience2011，，3： | 1 |
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