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| 1 | Molecular insights into the heterogeneity of telomere reprogramming in induced pluripotent stem cells显示文摘有各种各样的长度的 telomeres 的返老还童在导致的 pluripotent 干细胞(iPSCs ) 被发现了。telomere 长度规定的机制在 iPSCs 的正式就职和增长期间留下逃犯。我们证明 telomere 动力学在 reprogramming 和经过期间在鼠标 iPSCs 是可变的,并且建议这些差别多半源于多重潜在的因素,包括包括外长的 reprogramming 因素的表示的 telomerase 机械, telomerase 独立的机制和同种细胞的影响。用一个基因模型 telomerase 缺乏(为 iPSCs 的推导和段落的 Terc −/− 和 Terc +/−) 房间,我们发现 telomerase 在 iPSCs 的 reprogramming 和自强起一个关键作用。进一步,当由再结合的延伸和维护的其他的小径也被要求时, telomeres 的 telomerase 维护为真 pluripotency 的正式就职是必要的,然而并非足够。一起, telomere 生物学的几个方面可以在 iPSCs 说明可变 telomere 动力学。尤其是,采用在 iPSC reprogramming 期间维持 telomeres 的机制很类似于胚胎的干细胞的那些。这些调查结果可以也联系到这些机制能为在由体的房间的原子 reprogramming 以后的 telomere 异质负责的克隆的地原子转移。 | Fang Wang Yu Yin Xiaoying Ye Kai Liu Haiying Zhu Lingling Wang Maria Chiourea Maja Okuka Guangzhen Ji Jiameng Dan Bingfeng Zuo Minshu Li Qian Zhang Na Liu Lingyi Chen Xinghua Pan Sarantis Gagos David L Keefe Lin Liu | 2012 | Cell Research2012，22，4： | 7 |
| 2 | Polycystic ovary syndrome and type 2 diabetes mellitus:A state-ofthe-art review显示文摘Polycystic ovary syndrome(PCOS)often coexists with a wide spectrum of dysglycemic conditions,ranging from impaired glucose tolerance to type 2 diabetes mellitus(T2D),which occur to a greater extent compared to healthy body mass index-matched women.This concurrence of disorders is mainly attributed to common pathogenetic pathways linking the two entities,such as insulin resistance.However,due to methodological flaws in the available studies and the multifaceted nature of the syndrome,there has been substantial controversy as to the exact association between T2D and PCOS which has not yet been elucidated.The aim of this review is to present the best available evidence regarding the epidemiology of dysglycemia in PCOS,the unique pathophysiological mechanisms underlying the progression of dysglycemia,the most appropriate methods for assessing glycemic status and the risk factors for T2D development in this population,as well as T2D risk after transition to menopause.Proposals for application of a holistic approach to enable optimal management of T2D risk in PCOS are also provided.Specifically,adoption of a healthy lifestyle with adherence to improved dietary patterns,such the Mediterranean diet,avoidance of consumption of endocrine-disrupting foods and beverages,regular exercise,and the effect of certain medications,such as metformin and glucagon-like peptide 1 receptor agonists,are discussed.Furthermore,the maintenance of a healthy weight is highlighted as a key factor in achievement of a significant reduction of T2D risk in women with PCOS. | Sarantis Livadas Panagiotis Anagnostis Julia K Bosdou Dimitra Bantouna Rodis Paparodis | 2022 | World Journal of Diabetes2022，13，1： | 4 |
| 3 | Pancreatic ductal adenocarcinoma: Treatment hurdles, tumor microenvironment and immunotherapy显示文摘Pancreatic ductal adenocarcinoma(PDAC)is one of the most lethal diseases,with an average 5-year survival rate of less than 10%.Unfortunately,the majority of patients have unresectable,locally advanced,or metastatic disease at the time of diagnosis.Moreover,traditional treatments such as chemotherapy,surgery,and radiation have not been shown to significantly improve survival.Recently,there has been a swift increase in cancer treatments that incorporate immunotherapybased strategies to target all the stepwise events required for tumor initiation and progression.The results in melanoma,non-small-cell lung cancer and renal cell carcinoma are very encouraging.Unfortunately,the application of checkpoint inhibitors,including anti-CTLA4,anti-PD-1,and anti-PD-L1 antibodies,in pancreatic cancer has been disappointing.Many studies have revealed that the PDAC microenvironment supports tumor growth,promotes metastasis and consists of a physical barrier to drug delivery.Combination therapies hold great promise for enhancing immune responses to achieve a better therapeutic effect.In this review,we provide an outline of why pancreatic cancer is so lethal and of the treatment hurdles that exist.Particular emphasis is given to the role of the tumor microenvironment,and some of the latest and most promising studies on immunotherapy in PDAC are also presented. | Panagiotis Sarantis Evangelos Koustas Adriana Papadimitropoulou Athanasios G Papavassiliou Michalis V Karamouzis | 2020 | World Journal of Gastrointestinal Oncology2020，12，2： | 4 |
| 4 | Upgraded role of autophagy in colorectal carcinomas显示文摘Autophagy is a basic catabolic process closely asso-ciated with degradation of cellular components. The role of autophagy in colorectal cancer(CRC) remains controversial. The mechanism of autophagy has been identified as protecting mechanism against tumorige-nesis by isolation of damaged organelles or as cytopro-tective provides energy in hypoxic regions of CRC tumors. Mutations in proto-oncogenes, such as RAS and BRAF, have been associated with autophagy initiation through signaling pathways of BRAF/MEK/ERK and PI3 K/AKT/m TOR. A combination therapy of chemotherapeutic agents and autophagy inhibitors such as hydroxychloroquine or immunotherapy might represent a major step that could be evaluated as a putative novel therapeutic strategy in CRC patients. | Evangelos Koustas Panagiotis Sarantis Athanassios G Papavassiliou Michalis V Karamouzis | 2018 | World Journal of Gastrointestinal Oncology2018，10，11： | 3 |
| 5 | Energy consumption and economic growth: assessing the evidence from Greece显示文摘 | George Hondroyiannis Sarantis Lolos Evangelia Papapetrou | 2002 | Energy Economics2002，，4： | 2 |
| 6 | 查看详情显示文摘 | Saranti A Koutselas I Karakassides M A | | 0，，： | 1 |
| 7 | Energy consumption and economic growth: assessing the evidence from Greece显示文摘 | George Hondroyiannis Sarantis Lolos Evangelia Papapetrou | 2002 | Energy Economics2002，，24： | 1 |
| 8 | Modeling non-linearities in real effective exchange rates显示文摘 | Nicholas Sarantis | 1999 | Journal of International Money and Finance1999，，1： | 1 |
| 9 | Energy Con-sumption and Economic Growth:Assessing the Evidence from Greece显示文摘 | GEORGE H SARANTIS L EVANGELIA P | 2002 | Energy Economics2002，24，4： | 1 |
| 10 | Bioactive glasses in the system CaOB2O3-P2O5:preparation,structural study and in vitro evaluation显示文摘 | Saranti A Koutselas I 1 Karakassides M A | 2006 | Journal of Non-Crystalline Solids2006，352，： | 1 |
| 11 | Energy Consumption and Economic Growth:Assessing the Evidence from Greece显示文摘 | SARANTIS Lolos EVANGELIA Papapetrou | 2002 | Energy Economics2002，24，： | 1 |
| 12 | Nonlinearities, cyclical behavior and predictability in stock markets: international evidence 显示文摘 | Sarantis | 2001 | International Journal of Forecasting2001，，： | 1 |
| 13 | The specific innate immune receptor CEACAM3 triggers neutrophil bactericidal activities via a Syk kinase-dependent pathway 显示文摘 | SARANTIS H GRAY-OWEN SD | 2007 | Cell Microbiol2007，9，9： | 1 |
| 14 | An Efficient RSVP-mobile IP Interworking Scheme 显示文摘 | Sarantis P | 2003 | Mobile Networks and Applications2003，8，3： | 1 |
| 15 | Assessing Competitive Conditions in the Greek Banking System 显示文摘 | Hondroyiannis George Lolos Sarantis Papapetrou Evangelia | 1999 | Journal of International Financial Markets1999，，4： | 1 |
| 16 | Expression and translocation of fluorescent-tagged p21-activated kinase-binding domain and PH domain of protein kinase B during murine neutrophil chemotaxis显示文摘 | Magalhaes MA Zhu F Sarantis H | 2007 | J Leukoc Biol2007，82，： | 1 |
| 17 | Liquidity Constraints, Precautionary Saving and Aggregate Consump- tion : An International Comparison 显示文摘 | Sarantis N Stewart C | 2003 | Econom- ic Modeling2003，20，6： | 1 |
| 18 | Energy Consumption and Economic Growth:Assessing the Evidence from Greece显示文摘 | George H Sarantis L Evangelia P | 2002 | Energy Economics2002，，24： | 1 |
| 19 | Physiological and pathological operation of glutamate transporters显示文摘 | Billups B Rossi D Oshima T Warr O Takahashi M Sarantis M Szatkowski M Attwell D | | 0，，： | 1 |
| 20 | An Efficient RSVP-Mobile IP Interworking Scheme 显示文摘 | P Sarantis | 2003 | Mobile Networks and Applications2003，8，3： | 1 |
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