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| 1 | Osteoclasts are not a source of SLIT3显示文摘The axon guidance cue SLIT3 was identified as an osteoanabolic agent in two recent reports. However, these reports conflict in their nomination of osteoblasts versus osteoclasts as the key producers of skeletal SLIT3 and additionally offer conflicting data on the effects of SLIT3 on osteoclastogenesis. Here, aiming to address this discrepancy, we found no observable SLIT3 expression during human or mouse osteoclastogenesis and the only modest SLIT3-mediated effects on osteoclast differentiation. Conditional deletion of SLIT3 in cathepsin K(CTSK)-positive cells, including osteoclasts, had no effect on the number of osteoclast progenitors, in vitro osteoclast differentiation, overall bone mass, or bone resorption/formation parameters. Similar results were observed with the deletion of SLIT3 in Lys M-positive cells, including osteoclast lineage cells. Consistent with this finding, bone marrow chimeras made from Slit3-/-donors that lacked SLIT3 expression at all stages of osteoclast development displayed normal bone mass relative to controls. Taken in context, multiple lines of evidence were unable to identify the physiologic function of osteoclast-derived SLIT3,indicating that osteoblasts are the major source of skeletal SLIT3. | Na Li Kazuki Inoue Jun Sun Yingzhen Niu Sarfaraz Lalani Alisha Yallowitz Xu Yang Chao Zhang Rong Shen Baohong Zhao Ren Xu Matthew B.Greenblatt | 2020 | Bone Research2020，8，2： | 4 |
| 2 | An investigation of eye lens complication for gamma knife radiosurgery of trigeminal neuralgia显示文摘 | Ma L Chin L Sarfaraz M | 2000 | Annual Internal Conference of the IEEE Engineering in Medicine and Biology-Proceedings2000，，4： | 1 |
| 3 | An evaluation of the effects of irradiated sodium alginate on the growth,physiological activities and essential oil production of fennel(Foeniculum vulgare Mill)显示文摘 | Sarfaraz A Naeem M Nasir S Idrees M Aftab T Hashmi N. | | 0，，： | 1 |
| 4 | Decision making on business issues with foresight perspective; an application of new hybrid MCDM model in shopping mall locating显示文摘 | Sarfaraz Hashemkhani Zolfani Mohammad Hasan Aghdaie Arman Derakhti Edmundas Kazimieras Zavadskas Mohammad Hossein Morshed Varzandeh | 2013 | Expert Systems With Applications2013，，17： | 1 |
| 5 | Optimiza- tion of phosphate coating properties on steel sheet for su- perior paint performance 显示文摘 | Nitu Rani Arun K Singh Sarfaraz Alam | 2012 | Journal of Coatings Tech- nology and Research2012，9，5： | 1 |
| 6 | Application of a spectroscopic method to estimate the olive oil oxidative status 显示文摘 | Sarfaraz A M Alessandra B Lorenzo C | 2010 | European Journal of Lipid Science and Technolo- gy2010，112，12： | 1 |
| 7 | Cannabinoid receptor as a novel target for the treatment of prostate cancer显示文摘 | SARFARAZ S AFAQ F ADHAMI V M | 2005 | Canc Res2005，65，5： | 1 |
| 8 | ACE2: Angiotensin II/Angiotensin-(1–7) Balance in Cardiac and Renal Injury显示文摘 | Jasmina Varagic Sarfaraz Ahmad Sayaka Nagata Carlos M. Ferrario | 2014 | Current Hypertension Reports2014，，3： | 1 |
| 9 | Delphinidin inhibits cell proliferation and invasion via modulation of Met receptor phosphorylation显示文摘 | Syed DN Afaq F Sarfaraz S | | 0，，01： | 1 |
| 10 | CFD applications in various heat exchangers design: A review显示文摘 | Muhammad Mahmood Aslam Bhutta Nasir Hayat Muhammad Hassan Bashir Ahmer Rais Khan Kanwar Naveed Ahmad Sarfaraz Khan | 2011 | Applied Thermal Engineering2011，，： | 1 |
| 11 | An investigation of eye lens dose for gamma knife treatments of trigeminal neuralgia 显示文摘 | Chin L Sarfaraz M | 2000 | J Appl Clin Med Phys2000，1，4： | 1 |
| 12 | Bhattacharyya coefficient in correlation of gray-scale objects 显示文摘 | Khalid M S Ilyas M U Sarfaraz M S | 2006 | Journal of Multimedia2006，1，1： | 1 |
| 13 | Mo- nitoring strain gradients in adhesive composite joints by embedded fiber Bragg grating sensors 显示文摘 | CANAL L P SARFARAZ R VIOLAKIS G | 2014 | Composite Structures2014，11，2： | 1 |
| 14 | Preparation and Characterization of NiO Nanoparticles by Chemical Precipitation Method 显示文摘 | Khoshhesab Z M Sarfaraz M | 2010 | Synth React Inorg Met-Org Chem2010，40，： | 1 |
| 15 | Molecular handling of cadmium in transporting epithelia显示文摘 | Zalups Sarfaraz Ahmad | 2003 | Toxicology and Applied Pharmacology2003，186，： | 1 |
| 16 | Delphinidin inhibits cell prolifera- tion and invasion via modulation of Met receptor phosphorylation 显示文摘 | Syed DN Afaq F Sarfaraz S | 2008 | Toxicol Appl Pharmacol2008，231，1： | 1 |
| 17 | Cannabinoid receptor as a novel target for the treatment of prostate cancer显示文摘 | Sarfaraz S Afaq F Adhami VM | 2005 | Cancer Res2005，65，5： | 1 |
| 18 | Clinical implementation of intensity-modulated arc therapy显示文摘 | C.X Yu X.A Li L Ma D Shepard M Sarfaraz T Holmes M Suntharalingam C.M Mansfield | 2000 | International Journal of Radiation Oncology, Biology, Physics2000，，： | 1 |
| 19 | Delphinidin inhibits cell proliferation and invasion via modulation of Met receptor phosphorylation显示文摘 | Syed DN Afaq F Sarfaraz S | 2008 | Toxicol Appl Pharmacol2008，231，1： | 1 |
| 20 | Degradation of phenol and phenolic compounds by a defined denitrifying bacterial culture 显示文摘 | Thomas S Sarfaraz S Mishra L C | 2002 | World J Microb Biot2002，18，1： | 1 |
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