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| 1 | NAC Transcription Factor ORE1 and Senescence- Induced BIFUNCTIONAL NUCLEASE1 (BFN1) Constitute a Regulatory Cascade in Arabidopsis显示文摘老朽是包含很多抄写因素的行动的一个高度调整的过程。NAC 抄写因素 ORE1 (ANAC092 ) 最近被显示了在断然在 Arabidopsis thaliana 控制老朽起一个关键作用;然而,它通过施加它的分子的功能的直接目标基因都没以前被识别。这里,我们报导那 BIFUNCTIONAL NUCLEASE1 (BFN1 ) ,著名提高老朽的基因,被 ORE1 直接调整。我们已经检测了 BFN1 的提高的表示在在 estradiol 可诱导的 ORE1 overexpression 线的 ORE1 的正式就职以后的 2 h 和在有 35S:ORE1 的 Arabidopsis 叶肉房间原物的 transfection 以后的 6 h 构造。当在衰老的叶子和成熟的花机关的截去地区的 BFN1 表示在 ore1 异种背景是几乎不在的时, ORE1 和 BFN1 表示模式大部分重叠,由 promoterreporter 显示出基因(GUS ) 熔化。在 vitro 绑定地点试金揭示了一个由两部组成的 ORE1 有约束力的地点,类似于 ORS1 的, ORE1 的 paralog。一个由两部组成的 ORE1 有约束力的地点在 BFN1 倡导者被识别;变异在全身的 BFN1 倡导者的上下文以内的 cis 元素急速地减少了调停 ORE1 的 transactivation 能力在短暂地 transfected Arabidopsis 叶肉房间原物。而且,染色质 immunoprecipitation (薄片) 在 ORE1 有约束力的 vivo 示威到 BFN1 倡导者。我们也在 vivo 表明 ORE1 的绑定到二另外的联系老朽的基因的倡导者,也就是 SAG29/SWEET15 和 SINA1,在老朽期间支持 ORE1 的中央角色。 | Lilian R Matallana-Ramirez Mamoona Rauf Sarit Farage-Barhom Hakan Dortay Gang-Ping Xue Wolfgang Droge-Laser Amnon Lers Salma Balazadeh Bernd Mueller-Roeber | 2013 | Molecular Plant2013，6，5： | 8 |
| 2 | Dynamic chromatin states in human ES cells reveal potential regulatory sequences and genes involved in pluripotency显示文摘Pluripotency,一个细胞的能力区分并且产生所有胚胎的系,定义象胚胎的茎(ES ) 那样的哺乳动物的细胞类型的一个小数字细胞。当它通常被保持了时,那 pluripotency 是 transcriptional 的产品激活并且维持关键干细胞基因的表达式的规章的网络,积累的证据在建立并且保卫 ES 房间的 pluripotency 为 epigenetic 进程正在指向一个关键角色,象维持区分的房间类型的身份一样。以便更好在 pluripotency 理解 epigenetic 机制的角色,我们检验了在经历区别进一个 mesendodermal 系的人的 ES 房间(hESCs ) 染色体宽的染色质修正的动力学。我们发现在倡导者的染色质修正在区别期间仍然保持大部分不变,除了在在在 H3K27 的 acetylation 和 methylation 之间的一个动态开关标记在基因表示的激活和 silencing 之间的转变的倡导者的一个小数字,建议在在大多数差别上的房间命运承诺的一个层次表示了基因。我们也在 50 000 潜在的 enhancers 上印射,并且在染色质修正,特别 H3K4me1 和 H3K27ac 观察了大得多的动力学,它与他们的潜在的目标基因的表示相关。这些 enhancers 的进一步的分析揭示了 pluripotency 和可以在 hESCs 授与发展胜任的一个平衡状态的一口染色质签名陈述语气的潜在地关键的 transcriptional 管理者。我们的结果提供在定义 enhancers 和 pluripotency 支持染色质修正的角色的新证据。 | R David Hawkins Gary C Hon Chuhu Yang Jessica E Antosiewicz-Bourget Leonard K Lee Que-Minh Ngo Sarit Klugman Keith A Ching Lee E Edsall Zhen Ye Samantha Kuan Pengzhi Yu Hui Liu Xinmin Zhang Roland D Green Victor V Lobanenkov Ron Stewart James A Thomson Bing Ren | 2011 | Cell Research2011，21，10： | 6 |
| 3 | 在稍尖的巨大的肺的栓塞的机械故障和 thrombolysis : 未来的试用显示文摘 AIM: To assess role of combined modality of mechanical fragmentation and intralesional thrombolysis in patients with massive pulmonary embolism presenting subacutely. METHODS: Eight of 70 patients presenting in tertiary care centre of North India with massive pulmonary embolism within 4 years had subacute presentation (symptom onset more than 2 wk). These patients were subjected to pulmonary angiography with intention to treat basis via mechanical breakdown and intra lesional thrombolysis. Mechanical breakdown of embolus was accomplished with 5-F multipurpose catheter to reestablish flow, followed by intralesional infusion of urokinase (4400 IU/kg over 10 min followed by 4400 IU/kg per hour over 24 h). RESULTS: Eight patients, mean age 47.77±12.20 years presented with subacute pulmonary embolism (mean duration of symptoms 2.4 wk). At presentation, mean heart rate, shock index, miller score and mean pulmonary pressures were 101.5±15.2/min, 0.995±0.156, 23.87±3.76 and 37.62±6.67 mmHg which reduced to 91.5±12.2/min (P=0.0325), 0.789±0.139 (P=0.0019), 5.87±1.73 (P=0.0000004) and 27.75±8.66 mmHg (P=0.0003) post procedurally. Mean BP improved from 80.00±3.09 mmHg to 90.58±9.13 mmHg (P=0.0100) post procedurally. Minor complications in the form of local hematoma-minor hematoma in 1 (12.5%), and pseudoaneurysm (due to femoral artery puncture) in 1 (12.5 %) patient were seen. At 30 d and 6 mo follow up survival rate was 100% and all the patients were asymptomatic and in New York Heart Association class 1. CONCLUSION: Combined modality of mechanical fragmentation and intralesional thrombolysis appears to be a promising alternative to high risk surgical procedures in patients with subacute massive pulmonary embolism. | Bishav Mohan Shibba Takkar Chhabra Naved Aslam Gurpreet Singh Wander Naresh Kumar Sood Sumati Verma Anil Kumar Mehra Sarit Sharma | 2013 | World Journal of Cardiology2013，5，5： | 5 |
| 4 | Localization of the Arabidopsis Senescence- and Cell Death-Associated BFN1 Nuclease: From the ER to Fragmented Nuclei显示文摘植物联系老朽或联系 PCD 的核酸酶从不同有机体与核酸酶分享重要相同。然而,他们的功能的知识是有限的。Arabidopsis 联系老朽、联系 PCD 的核酸酶 BFN1 的细胞内部的本地化被调查。在短暂地转变的烟草原物的 BFN1GFP 本地化的分析表明在细丝状的结构的起始的本地化在整个细胞质传播了,它然后在原物开始衰老的原子核附近聚类。这些细丝状的结构作为具有被识别嗯起源。在 BFN1GFP 转基因的 Arabidopsis 植物, BFN1GFP 的类似的本地化在年轻叶子被观察,也就是说,在细丝状的结构,那仅仅在开始衰老在原子核附近重新组织房间。在迟了的老朽, BFN1GFP 与在包膜的泡的碎裂的原子核是局部性的。BFN1 的要求的功能作为 nucleic,在老朽和 PCD 的酸降级的酶被它的本地化模式支持。我们的结果建议在老朽和 PCD 的 nucleic 酸降级处理的调停的奉献分隔空间的存在。 | Sarit Farage-Barhom Shaul Burd Lilian Sonego Ana Mett Eduard Belausov David Gidoni Amnon Lers | 2011 | Molecular Plant2011，4，6： | 5 |
| 5 | English vocabulary learning strategies of Miao students in senior high school in China——Apilot study显示文摘 | PENG Si-xiang Sarit Srikhao | 2009 | US-China Foreign Language2009，7，12： | 2 |
| 6 | Translocation (12;14) and other chromosome abnormalities in squamous cell carcinoma of the tongue显示文摘 | Esther Manor Sarit Tetro Lipa Bodner | 2010 | European Archives of Oto-Rhino-Laryngology2010，，8： | 1 |
| 7 | Pre-exposure Prophylaxis State of the Science: Empirical Analogies for Research and Implementation显示文摘 | Sarit A. Golub Don Operario Pamina M. Gorbach | 2010 | Current HIV / AIDS Reports2010，，4： | 1 |
| 8 | Negotiation and cooperation in mulfi-ageat en- vironments 显示文摘 | Sarit Kraus | 1997 | Artificial Intelligence1997，，： | 1 |
| 9 | Effect of particle size on the convective heat transfer in nanofluid in the developing regi-on显示文摘 | ANOOP K B SUNDARARAJAN T SARIT K D | 2009 | International Journal of Heat and Mass Transfer2009，52，910： | 1 |
| 10 | Pool boilingof nano-fluids on horizontal narrow tubes显示文摘 | Das Sarit K Putra Nandy Roetze Wilfried | 2003 | International Journal of Multiphase Flow2003，29，： | 1 |
| 11 | Herentiol vegnlation and function of the Fas/FasL Ligand system in human trophoblast cells显示文摘 | Sarit Aschkenazi Shawn Straszowski Di | 2002 | Boil Reprod2002，66，： | 1 |
| 12 | Algorithms of distributed task allocation for cooperative agents 显示文摘 | SARIT K TATJANA P | 2000 | Theoretical Computer Science2000，242，： | 1 |
| 13 | Method for task allocation via agent coalition formation 显示文摘 | Shehory Onn Kraus Sarit | 1998 | Artificial Intelligence1998，101，： | 1 |
| 14 | Differential regul- ation and function of the Fas/Fas ligand system in human trophoblast cells 显示文摘 | Sarit Aschkenazi Shawn Straszewski | 2002 | Boil Reprod2002，66，： | 1 |
| 15 | Immunological detection of proteins similar to bacterial proteases in higher plant chloroplasts显示文摘 | Oren O Sarit T Oded Y | 1996 | FEBS1996，236，： | 1 |
| 16 | Proteasome inhibitors sensitize glioma cells and glioma stem cells to TRAIL-induced apoptosis by PKCε-dependent downregulation of AKT and XIAP expressions显示文摘 | Sarit Kahana Susan Finniss Simona Cazacu Cunli Xiang Hae-Kyung Lee Shlomit Brodie Ronald S. Goldstein Vered Roitman Shimon Slavin Tom Mikkelsen Chaya Brodie | 2011 | Cellular Signalling2011，，8： | 1 |
| 17 | Multiagent negotiation under time constrain显示文摘 | Sarit Kraus | 1995 | Artificial Intelligence1995，75，6： | 1 |
| 18 | Methods for task allocation via agent coalition formation 显示文摘 | Onn Shehory Sarit Kraus | 1998 | Artificial Intelligence1998，101，1998： | 1 |
| 19 | Sleep disturbances are associated with reduced school achievements in first-grade pupils显示文摘 | Sarit R Iris A Suheir S | 2009 | Development Neuropsychology2009，34，5： | 1 |
| 20 | Negotiation and Cooperation in Mulfi-ageat Environments 显示文摘 | Sarit Kraus | 1997 | Artificial Intelligence1997，，： | 1 |
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