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| 1 | Mesenchymal stem cell treatment improves outcome of COVID-19 patients via multiple immunomodulatory mechanisms显示文摘The infusion of coronavirus disease 2019(COVID-19)patients with mesenchymal stem cells(MSCs)potentially improves clinical symptoms,but the underlying mechanism remains unclear.We conducted a randomized,single-blind,placebo-controlled(29 patients/group)phase II clinical trial to validate previous findings and explore the potential mechanisms.Patients treated with umbilical cord-derived MSCs exhibited a shorter hospital stay(P=0.0198)and less time required for symptoms remission(P=0.0194)than those who received placebo.Based on chest images,both severe and critical patients treated with MSCs showed improvement by day 7(P=0.0099)and day 21(P=0.0084).MSC-treated patients had fewer adverse events.MSC infusion reduced the levels of C-reactive protein,proinflammatory cytokines,and neutrophil extracellular traps(NETs)and promoted the maintenance of SARS-CoV-2-specific antibodies.To explore how MSCs modulate the immune system,we employed single-cell RNA sequencing analysis on peripheral blood.Our analysis identified a novel subpopulation of VNN2+hematopoietic stem/progenitorlike(HSPC-like)cells expressing CSF3R and PTPRE that were mobilized following MSC infusion.Genes encoding chemotaxis factors—CX3CR1 and L-selectin—were upregulated in various immune cells.MSC treatment also regulated B cell subsets and increased the expression of costimulatory CD28 in T cells in vivo and in vitro.In addition,an in vivo mouse study confirmed that MSCs suppressed NET release and reduced venous thrombosis by upregulating kindlin-3 signaling.Together,our results underscore the role of MSCs in improving COVID-19 patient outcomes via maintenance of immune homeostasis. | Rongjia Zhu Tingdong Yan Yingmei Feng Yan Liu Hongcui Cao Gongxin Peng Yanlei Yang Zhen Xu Jingqi Liu Wei Hou Xiaoyue Wang Zhe Li Luchan Deng Shihua Wang Jing Li Qin Han Hongling Li Guangliang Shan Yinghao Cao Xingyan An Jianshe Yan Zhonghui Zhang Huafei Li Xuebin Qu Jiaqi Zhu Shumin Zhou Jiao Wang Fengchun Zhang Jinming Gao Ronghua Jin Dayong Xu Yan-Qing Ma Tao Huang Shuang Peng Zhi Zheng Ilia Stambler Eric Gilson Lee Wei Lim Alexey Moskalev Antonio Cano Sasanka Chakrabarti Brun Ulfhake Huanxing Su Haoying Xu Sihuan Xu Feng Wei Holly MBrown-Borg Kyung-Jin Min Georgina Ellison-Hughes Calogero Caruso Kunlin Jin Robert Chunhua Zhao | 2021 | Cell Research2021，31，12： | 5 |
| 2 | Microstructure,mechanical response and fractography of AZ91E/Al_(2)O_(3)_(p) nano composite fabricated by semi solid stir casting method显示文摘The present study confers to the fabrication and its characterization of magnesium alloy(AZ91E)based nano composites with nano Al_(2)O_(3) particulate reinforcements.A novel Semi Solid stir casting technique was adopted for the fabrication of the composite.An average particle size of 50 nm was used as reinforcement to disperse in matrix.The effects of change in weight fraction of reinforcements on the distribution of particles,particle–matrix interfacial reactions,physical as well as mechanical properties were reported.The SEM and EDS analysis has shown the uniform distribution of particles in the composite along with the presence of elements.The mechanical properties of reinforced and unreinforced composite were evaluated and presented.Fractography of tensile specimens was also discussed. | Sameer Kumar D Suman K.N.S Tara Sasanka C Ravindra K Palash Poddar | 2017 | Journal of Magnesium and Alloys2017，5，1： | 4 |
| 3 | Synthesis and magnetic properties of Mn doped ZnO nanowires 显示文摘 | Sasanka Deka Joy P A | 2007 | Solid State Communications2007，142，12： | 1 |
| 4 | Highly selective and sensitive fluorescence reporter fou toxic Hg (Ⅱ) ion by a synthetic symmetrical azine derevative显示文摘 | Sasanka D Bijan K Sankar J | | 0，，： | 1 |
| 5 | AnEconomic Evaluation of Health- PromotiveBuilt Environment Changes显示文摘 | Guo Jessica Y Gandavarapu Sasanka | 2010 | PreventiveMedicine2010，50，1： | 1 |
| 6 | Synthesis and magnetic properties of Mn doped ZnO nanowires显示文摘 | SASANKA D JOY P A | | 0，，04： | 1 |
| 7 | Optimized species growth in epoxy polymerization with real-coded NSGA-II 显示文摘 | Saptarshi Majumdar Kishalay Mitra Sasanka Raha | 2005 | Polymer (S0032-3861)2005，46，11： | 1 |
| 8 | Two‐Dimensional Tetrathiafulvalene Covalent Organic Frameworks: Towards Latticed Conductive Organic Salts显示文摘 | Shangbin Jin Tsuneaki Sakurai Tim Kowalczyk Sasanka Dalapati Fei Xu Hao Wei Xiong Chen Jia Gao Shu Seki Stephan Irle Donglin Jiang | 2014 | Chem. Eur. J2014，，45： | 1 |
| 9 | Unusual case of nephrocutaneous fistula--Our experience显示文摘A rare case of nephrococutaneous fistula due to spontaneous expulsion of renal calculi is described.A 45-year-old man presented with urinary leakage from an ulcer over the left lumbar region for the last 3 months after a history of spontaneous expulsion of stones from this area.Ultrasonography abdomen revealed a small contracted kidney with multiple calculi in the kidney and renal pelvis,sinus tract from the lower pole of the left kidney with a ruptured calyceal calculus in the sinus tract.CT urography revealed a non excreting left kidney with multiple renal calculi,with hyperdense collection in the renal parenchyma extending to the subcutaneous tissue and left lung suggesting a xenthogranulomatous pyelonephritis(XGP).We performed a left-sided simple nephrectomy with excision of the fistulous tract.Histopathological examination revealed XGP.There have been a few case reports of XGP forming nephrocutaneous fistula in the back. | Rajeev Thekumpadam Puthenveetil Debajit Baishya Sasanka Barua Debanga Sarma | 2016 | Asian Journal of Urology2016，3，1： | 0 |
| 10 | Implication of ultrasound bladder parameters on treatment response in patients with benign prostatic hyperplasia under medical management显示文摘Objective:The prevalence of benign prostatic hyperplasia(BPH)rapidly increases after the 4th decade of life.The combination of tamsulosin and dutasteride is a well established therapy for BPH of40 g.Non-invasive urodynamic parameters can predict the outcome of medical therapy in patients with BPH.We aimed to correlate these parameters with treatment responses in BPH patients under medical management.Methods:A prospective study was conducted in the Department of Urology in our hospital from May 2014 to April 2015.A total of 100 patients with BPH40 g who fulfilled our inclusion criteria were included.Treatment responses were determined by the International Prostate Symptom Score(IPSS)and uroflowmetry.Transabdominal ultrasonography with Doppler was performed to measure prostate volume,intravesical prostatic protrusion(IPP),detrusor wall thickness(DWT),the prostatic capsular artery resistive index(RI)and prostatic urethral angle(PUA)before and 3 months after combination therapy of tamsulosin and dutasteride.Treatment responses were correlated with non-invasive urodynamic parameters.Results:The IPSS,uroflow,age,prostate volume,RI,IPP,DWT and PUA were correlated before and after treatment.Of the 100 patients,70(70%)showed significant improvement and 30(30%)showed no improvement with therapy.Conclusion:Ultrasound bladder parameters are useful tools for measuring the treatment response in BPH patients.Our study shows that RI and DWT significantly correlate with the treatment response in BPH patients.More importantly,pretreatment values of increased IPP and PUA determines the non-improvement of symptoms in BPH patients.Our study suggests the importance of transabdominal ultrasonography(KUBeP)with Doppler for evaluating treatment responses to medical management. | Rajeev Thekumpadam Puthenveetil Debajit Baishya Sasanka Barua Debanga Sarma | 2015 | Asian Journal of Urology2015，2，4： | 0 |
| 11 | Coarse-Grained Langevin Approximations and Spatiotemporal Acceleration for Kinetic Monte Carlo Simulations of Diffusion of Interacting Particles显示文摘Kinetic Monte Carlo methods provide a powerful computational tool for the simulation of microscopic processes such as the diffusion of interacting particles on a surface,at a detailed atomistic level. However such algorithms are typically computationally expensive and are restricted to fairly small spatiotemporal scales. One approach towards overcoming this problem was the development of coarse-grained Monte Carlo algorithms. In recent literature,these methods were shown to be capable of efficiently describing much larger length scales while still incorporating information on microscopic interactions and fluctuations. In this paper,a coarse-grained Langevin system of stochastic differential equations as approximations of diffusion of interacting particles is derived,based on these earlier coarse-grained models. The authors demonstrate the asymptotic equivalence of transient and long time behavior of the Langevin approximation and the underlying microscopic process,using asymptotics methods such as large deviations for interacting particles systems,and furthermore,present corresponding numerical simulations,comparing statistical quantities like mean paths,auto correlations and power spectra of the microscopic and the approximating Langevin processes. Finally,it is shown that the Langevin approximations presented here are much more computationally efficient than conventional Kinetic Monte Carlo methods,since in addition to the reduction in the number of spatial degrees of freedom in coarse-grained Monte Carlo methods,the Langevin system of stochastic differential equations allows for multiple particle moves in a single timestep. | Sasanka ARE Markos A. KATSOULAKIS Anders SZEPESSY | 2009 | Chinese Annals of Mathematics,Series B2009，30，6： | 0 |
| 12 | Giant adrenal tumor presenting as Cushing’s syndrome and pheochromocytoma:A case report显示文摘We report a case of a 35-year-old lady who presented with Cushingoid features and associated raised urinary metanephrine.The patient underwent open adrenelectomy.Histopathological examination revealed adreno-cortical carcinoma with microscopic lymphovascular invasion.Postoperative period was uneventful and is on follow-up for the last one year and is doing well. | Puskal Kumar Bagchi Somor Jyoti Bora Sasanka Kumar Barua Rajeev Thekumpadam Puthenveetil | 2015 | Asian Journal of Urology2015，2，3： | 0 |
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