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| 1 | Examining the whole bowel, double balloon enteroscopy: Indications, diagnostic yield and complications显示文摘Double balloon enteroscopy(DBE) is an advanced type of endoscopic procedure which brings the advantage of reaching the whole small bowel using anterograde or the retrograde route. This procedure is both diagnostic and interventional for a variety of small intestinal diseases, such as vascular lesions, tumors, polyps and involvement of inflammatory bowel diseases.Main indication is the diagnosis and treatment of mid-gastrointestinal bleeding according to the recent published data all over the world. The complication rates seem to be higher than conventional procedures but growing experience is lowering them and improving the procedure to be safe and well tolerated. This review is about the technique, indications, diagnostic importance and complications of DBE according to the literature growing since 2001. | Fatih Saygili Saba Mukaddes Saygili Erkin Oztas | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，3： | 9 |
| 2 | Effectiveness of Saccharomyces boulardii in a rat model of colitis显示文摘AIM:To investigate the effects of Saccharomyces boulardii(S.boulardii) in an experimental rat model of trinitrobenzene sulfonic acid(TNBS)-induced colitis.METHODS:Thirty-two Wistar albino female rats were categorized into five groups.On the first day of the study,50 mg TNBS was administered via a rectal catheter in order to induce colitis in all rats,except those in the control group.For 14 d,the rats were fed a standard diet,without the administration of any additional supplements to either the control or TNBS groups,in addition to 1 mg/kg per day S.boulardii to the S.boulardii group,1 mg/kg per day methyl prednisolone(MP) to the MP group.The animals in the S.boulardii + MP group were coadministered these doses of S.boulardii and MP.During the study,weight loss,stool consistency,and the presence of obvious blood in the stool were evaluated,and the disease activity index(DAI) for colitis was recorded.The intestines were examined and colitis was macro-and microscopically scored.The serum and tissue levels of tumor necrosis factor-α(TNF-α) and nitric oxide(NO) were determined,and fungemia was evaluated in the blood samples.RESULTS:The mean DAI scores for the MP and S.boulardii + MP groups was significantly lower than the TNBS group(3.69 ± 0.61 vs 4.46 ± 0.34,P = 0.018 and 3.77 ± 0.73 vs 4.46 ± 0.34,P = 0.025,respectively).While no significant differences between the TNBS and the S.boulardii or MP groups could be determined in terms of serum NO levels,the level of serum NO in the S.boulardii + MP group was significantly higher than in the TNBS and S.boulardii groups(8.12 ± 4.25 μmol/L vs 3.18 ± 1.19 μmol/L,P = 0.013;8.12 ± 4.25 μmol/L vs 3.47 ± 1.66 μmol/L,P = 0.012,respectively).The tissue NO levels in the S.boulardii,MP and S.boulardii + MP groups were significantly lower than the TNBS group(16.62 ± 2.27 μmol/L vs 29.72 ± 6.10 μmol/L,P = 0.002;14.66 ± 5.18 μmol/Lvs 29.72 ± 6.10 μmol/L,P = 0.003;11.95 ± 2.34 μmol/Lvs 29.72 ± 6.10 μmol/L,P = 0.002,respectively).The tissue NO levels in the S.boulardii,MP and S.boulardii + MP groups were similar.The mean serum and tissue TNF-α levels were determined to be 12.97 ± 18.90 pg/mL and 21.75 ± 15.04 pg/mL in the control group,18.25 ± 15.44 pg/mL and 25.27 ± 11.95 pg/mL in the TNBS group,20.59 ± 16.15 pg/mL and 24.39 ± 13.06 pg/mL in the S.boulardii group,9.05 ± 5.13 pg/mL and 24.46 ± 10.85 pg/mL in the MP group,and 13.95 ± 10.17 pg/mL and 24.26 ± 10.37 pg/mL in the S.boulardii + MP group.Significant differences in terms of the levels of serum and tissue TNF-α and the macroscopic and microscopic scores were not found between the groups.S.boulardii fungemia was not observed in any of the rats.However,Candida fungemia was detected in one rat(14%) in the TNBS group,two rats(28%) in the S.boulardii group,three rats(50%) in the MP group,and three rats(42%) in S.boulardii + MP group.CONCLUSION:S.boulardii does not demonstrate considerable effects on the DAI,pathological scores,or cytokine levels but does decrease the tissue NO levels. | Mujde Soyturk Saba Mukaddes Saygili Huseyin Baskin Ozgul Sagol Osman Yilmaz Fatih Saygili Hale Akpinar | 2012 | World Journal of Gastroenterology2012，18，44： | 6 |
| 3 | Value of computed tomography and magnetic resonance imaging for assessing severity of liver cirrhosis secondary to viral hepatitis显示文摘 | O. Barutcu Saygili N.C. Tarhan T. Yildirim E. Serin B. Ozer A.M. Agildere | 2004 | European Journal of Radiology2004，，3： | 3 |
| 4 | Can serum CA125 levels predict the optimal primary cytoreduction in patients with advanced ovarian carcinoma?显示文摘 | Saygili U Guclu S Uslu T | 2002 | Gynecol Oncol2002，86，1： | 1 |
| 5 | Can serum CA-125 levels predict the optimal primary cytoreduction in patients with advanced ovarian carcinoma显示文摘 | Saygili U Gudu S Uslu T | 2002 | Gynecol Oncol2002，86，1： | 1 |
| 6 | Human anterior lens capsule as carrier matrix forcultivated human comeal endothelial cells显示文摘 | Yoeruek E Saygili O Spitzer MS Tatar O Bartz-Schmidt KU Szurman P | 2009 | Cornea2009，28，41： | 1 |
| 7 | Regression of endometrial explants in rats treated with the cyclooxygenase-2 inhibitor rofewxib显示文摘 | Dogan E Saygili U Posaci C | 2004 | Fertil Steril2004，82，3： | 1 |
| 8 | Serum, pleural effusion, and ascites CA125 levels in ovarian cancer and nonovarian benign and malignant diseases: a comparative study显示文摘 | Topalak O Saygili U Soyturk M | 2002 | Gynecol Oncol2002，85，： | 1 |
| 9 | Autoimmune thyroid disease in pregnancy and the postpartum period:relationship to spontaneous abortion显示文摘 | BAGIS T GOKCEL A SAYGILI E S | 2001 | Thyroid:Official Journal of the American Thyroid Association2001，11，11： | 1 |
| 10 | Empirical predictive models for earthquake-induced sliding displacements of slopes 显示文摘 | SAYGILI G RATHJE E M | 2008 | Journal of Geotechnical and Geoenvironmental Engineering2008，134，6： | 1 |
| 11 | Regression of endometrial explants in rats treated with the cyclooxygenase-2 inhibitor rofecoxib显示文摘 | Dogan E Saygili U Posaci C | 2004 | Fertil Steril2004，82，3： | 1 |
| 12 | Double uterus with a double cervix and longitudinal vaginal septum显示文摘 | Saygili YES Erman AM Bayar D | | 0，，10： | 1 |
| 13 | Human anterior lens capsule as carrier matrix for cultivated human corneal endothelial cells显示文摘 | Yoeruek E Saygili O Spitzer MS | | 0，，： | 1 |
| 14 | Aucte renal failure and mortality after open-heart surgery in infants 显示文摘 | Baskin E Saygili A Harmanci K | 2005 | Renal Failure2005，27，5： | 1 |
| 15 | Losartanprevents stretch-induced electrical remodeling incultured atrial neonatal myocytes显示文摘 | Saygili E Rana OR Saygili E | 2007 | Am J Physiol Heart Circ Physiol2007，292，8： | 1 |
| 16 | Regulation of nerve growth factor in the heart:the role of the calcineurin-NFAT pathway显示文摘 | Rana O R Saygili E Meyer C | 2009 | J Mol Cell Cardiol2009，46，4： | 1 |
| 17 | Abdominopelvic tuberculosis simulating disseminated ovarian carcinoma with elevated CA-125 level:report of two cases显示文摘 | Barutcu O Erel HE Saygili E | 2002 | Abdom Imaging2002，27，4： | 1 |
| 18 | TSH influences serum leptin levels independent of thyroid hormones in hypothyroid and hyperthyroid patients显示文摘 | Oge A Bayraktar F Saygili F | 2005 | Endocr J2005，52，2： | 1 |
| 19 | Functionalised organosulfur donor molecules;Synthesis of racemic hydroxymethyl-,alkoxymerthyl-and dialkoxymethyl -bis (ethylenedithio) tetrathiafulvalenes显示文摘 | Nezire Saygili R James Brown Peter Day | 2001 | Tetrahedron2001，57，： | 1 |
| 20 | I-Iistopathologic correlation of dilatation and curettage and hysterectomy specimens in patients with postmenopausal bleeding显示文摘 | Saygili H | 2006 | Eur J Gynaecol Oncol2006，27，2： | 1 |
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