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| 1 | Comparison of four proton pump inhibitors for the short-term treatment of esophagitis in elderly patients显示文摘AIM: To compare efficacy and tolerability of four proton pump inhibitors (PPIs) commonly used in the short-term therapy of esophagitis in elderly patients.METHODS: A total of 320 patients over 65 years with endoscopically diagnosed esophagitis were randomly assigned to one of the following treatments for 8 wk: (1) omeprazole 20 mg/d; (2) lansoprazole 30 mg/d; (3) pantoprazole 40 mg/d, or (4) rabeprazole 20 mg/d. Major symptoms, compliance, and adverse events were recorded. After 8 wk, endoscopy and clinical evaluation were repeated.RESULTS: Per protocol and intention to treat healing rates of esophagitis were: omeprazole = 81.0% and 75.0%, lansoprazole = 90.7% (P = 0.143 vs omeprazole) and 85.0%, pantoprazole = 93.5% (P = 0.04 vs omeprazole) and 90.0% (P = 0.02 vs omeprazole), rabeprazole = 94.6% (P = 0.02 vs omeprazole) and 88.8% (P = 0.04 vs omeprazole). Dividing patients according to the grades of esophagitis, omeprazole was significantly less effective than the three other PPIs in healing grade 1 esophagitis (healing rates: 81.8% vs 100%, 100% and 100%, respectively, P = 0.012). Pantoprazole and rabeprazole (100%) were more effective vs omeprazole (89.6%, P = 0.0001)and lansoprazole (82.4%, P = 0.0001) in decreasing heartburn. Pantoprazole and rabeprazole (92.2% and 90.1%, respectively) were also more effective vs lansoprazole (75.0%, P < 0.05) in decreasing acid regurgitation. Finally, pantoprazole and rabeprazole (95.2% and 100%) were also more effective vs lansoprazole (82.6%, P < 0.05) in decreasing epigastric pain.CONCLUSION: In elderly patients, pantoprazole and rabeprazole were significantly more effective than omeprazole in healing esophagitis and than omeprazole or lansoprazole in improving symptoms. H pylori infection did not influence the healing rates of esophagitis after a short-term treatment with PPI. | Alberto Pilotto Marilisa Franceschi Gioacchino Leandro Carlo Scarcelli Luigi Piero D'Ambrosio Francesco Paris Vito Annese Davide Seripa Angelo Andriulli Francesco Di Mario | 2007 | World Journal of Gastroenterology2007，13，33： | 5 |
| 2 | Intermittent gastric outlet obstruction due to a gallstone migrated through a cholecysto-gastric fistula:A new variant of “Bouveret’s syndrome”显示文摘Bouveret's syndrome, defined as gastric outlet obstruction due to a large gallstone, is still one of the most dramatic biliary gallstone complications. Although new radiological and endoscopic techniques have made pre-surgical diagnosis possible in most cases and the death rate has dropped dramatically, 'one-stage surgery' (biliary surgery carried out at the same time as the removal of the gut obstruction) should be still considered as the gold standard for the treatment of gallstone ileus.In this case, partial gastric outlet obstruction resulted in an atypical and insidious clinical presentation that allowed us to perform the conventional one-stage laparatomic procedure that completely solved the problem, thus avoiding any further complications. | Dimitry Arioli Ivo Venturini Michele Masetti Elisa Romagnoli Antonella Scarcelli Pietro Ballesini Athos Borghi Alessandro Barberini Vincenzo Spina Mario De Santis Fabrizio Di Benedetto Giorgio Enrico Gerunda Maria Luisa Zeneroli | 2008 | World Journal of Gastroenterology2008，14，1： | 2 |
| 3 | New insights into the brain involvement in patients with Crohn’s disease: a voxel‐based morphometry study显示文摘 | A. Agostini F. Benuzzi N. Filippini A. Bertani A. Scarcelli V. Farinelli C. Marchetta C. Calabrese F. Rizzello P. Gionchetti M. Ercolani M. Campieri P. Nichelli | 2012 | Neurogastroenterology & Motility2012，，2： | 2 |
| 4 | Endogenous sex hor- mones affect the mutagen-induced chromosome damage by al- tering a caffernine-sensitive checkpoint显示文摘 | CocchiL Scarcelli V Puliti A | 2005 | Murat Res2005，570，4： | 1 |
| 5 | Yanhua Shih Can Two-Photon Correlation of Chaotic Light Be Considered as Correlation of Intensity Fluctuations? 显示文摘 | GIULIANO SCARCELLI VINCENZO BERARDI | 2006 | Phys Rev Lett2006，96，06： | 1 |
| 6 | Scarcelli, Berardi, and Shih Reply 显示文摘 | SCARCELLI G BERARDI V SHIH Y H | 2007 | Phys Rev Lett2007，98，03： | 1 |
| 7 | Genotoxic hazard of pollutants in cetaceans : DNA damage and repair evaluated in the bottlenose dolphin( Tursiops truncatus ) by the Comet Assay显示文摘 | TADDEI F SCARCELLI V FRENZILLI G | 2001 | Mar Pollut Bull2001，42，4： | 1 |
| 8 | Genotoxic hazard of pollutants in cetaceans: DNA damage and repair evaluated in the bottlenose dolphin(Tursiops truncatus) by the Comet Assay显示文摘 | Taddei F Scarcelli V Frenzilli G | 2001 | Mar Pollut Bull2001，42，4： | 1 |
| 9 | DNA integrity and total oxyradical scavenging capacity in the Mediterranean mussel, Mytilus galloprovincialis: a field study in a highly eutrophicated coastal lagoon显示文摘 | Frenzilli G Nigro M Scarcelli V | 2001 | Aquat Toxicol2001，53，： | 1 |
| 10 | Stimulation of hippocampal neurogenesis by transcranial focused ultrasound and microbubbles in adult mice显示文摘 | Scarcelli T Jordao JF O'Reilly MA | 2014 | Brain Stimul2014，7，2： | 1 |
| 11 | Brillouin optical microscopy for corneal biomechanics显示文摘 | Scarcelli G Pineda R Yun SH | 2012 | Invest Ophthalmol Vis Sci2012，53，1： | 1 |
| 12 | Segregation patterns of isozyme loci and microsatellite markers show the diploidy of African yam Dioscorea rotundata (2n=40)显示文摘 | Nora Scarcelli Ogoubi Da?nou Clément Agbangla Serge Tostain Jean-Louis Pham | 2005 | Theoretical and Applied Genetics2005，，2： | 1 |
| 13 | Effects of algal extracts (Polysiphonia fucoides) on rainbow trout (Oncorhynchus mykiss):a biomarker approach显示文摘 | DEL BARGA G FRENZILLI V SCARCELLI M | 2006 | Marine Environmental Research2006，62，1： | 1 |
| 14 | Two-photon in- terference with thermal light显示文摘 | Scarcelli G Valencia A Shih Y | 2004 | Europhysics Let- ters2004，68，5： | 1 |
| 15 | Brillouin microscopy of collagen crosslinking: noncontact depth-dependent analysis of corneal elastic modulus显示文摘 | Scarcelli G Kling S Quijano E | 2013 | Invest Ophthalmol Vis Sci2013，54，2： | 1 |
| 16 | Can two-photon correlation of chaotic light be considered as correlation of intensity fluctuations显示文摘 | G Scarcelli V Berardi Y Shih | 2006 | Phys Rev Lett2006，96，06： | 1 |
| 17 | Genotoxic potential of TiO2 on bottlenose dolphin leukocytes 显示文摘 | Bernardeschi M Guidi P Scarcelli V Frenzilli G Nigro M | 2010 | Anal Bioanal Chem2010，396，： | 1 |
| 18 | Detection of Brucella DNA from aborted bovine foetuses by polymerase chain reaction显示文摘 | Cortez A Scarcelli E Soares R M | 2001 | Aust Vet J2001，79，： | 1 |
| 19 | Non-steroidal anti-inflammatory drug use in the elderly显示文摘 | Alberto Pilotto Daniele Sancarlo Filomena Addante Carlo Scarcelli Marilisa Franceschi | 2009 | Surgical Oncology2009，，3： | 1 |
| 20 | Prevalence,clinical features andavoidability of adverse drug reactions as cause of admission to a geriatricunit:a prospective study of 1756 patients显示文摘 | Franceschi M Scarcelli C Niro V | 2008 | Drug Saf2008，31，6： | 1 |
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