|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Biomarkers in schizophrenia:A focus on blood based diagnostics and theranostics显示文摘Identifying biomarkers that can be used as diagnostics or predictors of treatment response(theranostics) in people with schizophrenia(Sz) will be an important step towards being able to provide personalized treatment. Findings from the studies in brain tissue have not yet been translated into biomarkers that are practical in clinical use because brain biopsies are not acceptable and neuroimaging techniques are expensive and the results are inconclusive. Thus, in recent years, there has been search for blood-based biomarkers for Sz as a valid alternative. Although there are some encouraging preliminary data to support the notion of peripheral biomarkers for Sz, it must be acknowledged that Sz is a complex and heterogeneous disorder which needs to be further dissected into subtype using biological based and clinical markers. The scope of this review is to critically examine published blood-based biomarker of Sz, focusing on possible uses for diagnosis, treatment response, or their relationship with schizophreniaassociated phenotype. We sorted the studies into six categories which include:(1) brain-derived neurotrophic factor;(2) inflammation and immune function;(3) neurochemistry;(4) oxidative stress response and metabolism;(5) epigenetics and micro RNA; and(6) transcriptome and proteome studies. This review also summarized the molecules which have been conclusively reported as potential blood-based biomarkers for Sz in different blood cell types. Finally, we further discusses the pitfall of current blood-based studies and suggest that a prediction model-based, Sz specific, bloodoriented study design as well as standardize blood collection conditions would be useful for Sz biomarker development. | Chi-Yu Lai Elizabeth Scarr Madhara Udawela Ian Everall Wei J Chen Brian Dean | 2016 | World Journal of Psychiatry2016，6，1： | 6 |
| 2 | Allosteric modulation of cholinergic system:Potential approach to treating cognitive deficits of schizophrenia显示文摘Schizophrenia is a psychiatric disorder affecting approximately 1% of the population worldwide and is characterised by the presence of positive and negative symptoms and cognitive deficits. Whilst current therapeutics ameliorate positive symptoms, they are largely ineffective in improving negative symptoms and cognitive deficits. The cholinergic neurotransmitter system heavily influences cognitive function and there is evidence that implicates disruption of the central cholinergic system in schizophrenia. Historically, targeting the cholinergic system has been impeded by poor selectivity leading to intolerable side effects warranting the need to develop more targeted therapeutic compounds. In this review we will summarise evidence supporting the roles of the cholinergic system, particularly the muscarinic M1 receptor, in the pathophysiology of schizophrenia and discuss the potential of a promising new class of candidate compounds, allosteric ligands, for addressing the difficulties involved in targeting this system. The body of evidence presented here highlights the dysfunction of the cholinergic system in schizophrenia and that targeting this system by taking advantage of allosteric ligands is having clinically meaningful effect on cognitive deficits. | Shaun Hopper Madhara Udawela Elizabeth Scarr Brian Dean | 2016 | World Journal of Pharmacology2016，5，1： | 3 |
| 3 | PDCD2 is a negative regulator of HCF-1 (C1)显示文摘 | Scarr RB Sharp PA | 2002 | Oncogene2002，21，34： | 1 |
| 4 | Lethal and sublethal effects of imidacloprid on nicotine-tolerant Myzus nicotianae and Myzus persicae显示文摘 | Divane G J Harling Z K Scarr A W | 1996 | Pestic Sci1996，48，1： | 1 |
| 5 | Development of a pamphlet: in troducing advance directives to hemodialysis patients and their fam- ilies显示文摘 | Tigert J Chaloner N Scarr B | 2005 | Cannt Journal2005，15，1： | 1 |
| 6 | Gene expression profiling in Brodmann's area 46 from subjects with schizophrenia显示文摘 | Dean B Keriakous D Scarr E | 2007 | Aust N Z J Psychiatry2007，41，4： | 1 |
| 7 | Lethal and sublethal effects of imidacloprid on nicotine-tolerant Myzus nicotianae and Myzus persicae 显示文摘 | Devine G J Harling Z K Scarr A W | 1996 | Pestic Sci1996，48，1： | 1 |
| 8 | The effect of estrogen on dopamine and serotonin receptor and transporter levels in the brain: An autoradiography study 显示文摘 | Chavez C Hollaus M Scarr E | 2010 | Brain Research2010，1321，19： | 1 |
| 9 | Regionally specific changes in levels of cortical S100 beta in bipolar 1 disorder but not schizophrenia 显示文摘 | Gray Land Scarr E | 2006 | Australian & New Zealand Journal of Psychiatr2006，40，3： | 1 |
| 10 | Product design for automated manufacture and assembly 显示文摘 | Scarr A J | 1986 | Annals of the CIRP1986，35，1： | 1 |
| 11 | Regionally specific changes in levels of cortical S100beta in bipolar 1 disorder but not schizophrenia显示文摘 | Dean B Gray L Scarr E | 2006 | Aust N Z J Psychiatry2006，40，3： | 1 |
| 12 | The determination of the volumetric accuracy of multi-axis machine显示文摘 | Love W J Scarr A J | 1973 | Annals of 14th MTDR1973，，： | 1 |
| 13 | Lethal and sublethal effects of imidacloprid on nicotine tolerant Myzus nicotianae and Myzus pericae显示文摘 | Devine G J Harling Z K Scarr A W | 1996 | Pstic Sci1996，48，： | 1 |
| 14 | Bayesiantexture segmentation of weed and crop images using re-versible jump Markov chain Monte Carlo methods 显示文摘 | DRYDEN I L SCARR M R TAYLOR C C | 2003 | Journal of the Royal Statistical Society Series C2003，52，1： | 1 |
| 15 | American Child Care Today显示文摘 | Sandra Scarr | 1998 | American Psychologist1998，，2： | 1 |
| 16 | On being a whistleblower:the Needleman case显示文摘 | Ernhart CB Scarr S Geneson DF | 1993 | Ethics Behav1993，3，1： | 1 |
| 17 | MC 1R variation and melanoma risk in relation to host/clinical and environmental factors in CDKN 2A positive and negative melanoma patients显示文摘 | Paola Ghiorzo Luigina Bonelli Lorenza Pastorino William Bruno Monica Barile Virginia Andreotti Sabina Nasti Linda Battistuzzi Marco Grosso Giovanna Bianchi‐Scarrà Paola Queirolo | 2012 | Exp Dermatol2012，，9： | 1 |
| 18 | Product design for automated manufacture and assembly显示文摘 | Scarr AJ | 1986 | Annals of the CIRP1986，35，1： | 1 |
| 19 | How people make their own environments: A theory of genotype-environment effects 显示文摘 | Scarr S McCartney K | 1983 | Child Develop- ment1983，，54： | 1 |
| 20 | Contribution of germline mutations in the BRCA and PALB2 genes to pancreatic cancer in Italy显示文摘 | P. Ghiorzo V. Pensotti G. Fornarini S. Sciallero L. Battistuzzi F. Belli L. Bonelli G. Borgonovo W. Bruno A. Gozza S. Gargiulo L. Mastracci S. Nasti G. Palmieri F. Papadia L. Pastorino A. Russo V. Savarino L. Varesco L. Bernard G. Bianchi Scarrà | 2012 | Familial Cancer2012，，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员