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| 1 | Biotribology of artificial hip joints显示文摘Hip arthroplasty can be considered one of the major successes of orthopedic surgery, with more than 350000 replacements performed every year in the United States with a constantly increasing rate. The main limitations to the lifespan of these devices are due to tribological aspects, in particular the wear of mating surfaces, which implies a loss of matter and modification of surface geometry. However, wear is a complex phenomenon, also involving lubrication and friction. The present paper deals with the tribological performance of hip implants and is organized in to three main sections. Firstly, the basic elements of tribology are presented, from contact mechanics of ball-in-socket joints to ultra high molecular weight polyethylene wear laws. Some fundamental equations are also reported, with the aim of providingthe reader with some simple tools for tribological investigations. In the second section, the focus moves to artificial hip joints, defining materials and geometrical properties and discussing their friction, lubrication and wear characteristics. In particular, the features of different couplings, from metal-on-plastic to metal-on-metal and ceramic-on-ceramic, are discussed as well as the role of the head radius and clearance. How friction, lubrication and wear are interconnected and most of all how they are specific for each loading and kinematic condition is highlighted. Thus, the significant differences in patients and their lifestyles account for the high dispersion of clinical data. Furthermore, such consideration has raised a new discussion on the most suitable in vitro tests for hip implants as simplified gait cycles can be too far from effective implant working conditions. In the third section, the trends of hip implants in the years from 2003 to 2012 provided by the National Joint Registry of England, Wales and Northern Ireland are summarized and commented on in a discussion. | Francesca Di Puccio Lorenza Mattei | 2015 | World Journal of Orthopedics2015，6，1： | 8 |
| 2 | Gastrointestinal neuromuscular apparatus: An underestimated target of gut microbiota显示文摘Over the last few years, the importance of the resident intestinal microbiota in the pathogenesis of several gastrointestinal diseases has been largely investigated. Growing evidence suggest that microbiota can influence gastrointestinal motility. The current working hypothesis is that dysbiosis-driven mucosal alterations induce the production of several inflammatory/immune mediators which affect gut neuro-muscular functions. Besides these indirect mucosal-mediated effects, the present review highlights that recent evidence suggests that microbiota can directly affect enteric nerves and smooth muscle cells functions through its metabolic products or bacterial molecular components translocated from the intestinal lumen. Tolllike receptors, the bacterial recognition receptors, are expressed both on enteric nerves and smooth muscle and are emerging as potential mediators between microbiota and the enteric neuromuscular apparatus. Furthermore, the ongoing studies on probiotics support the hypothesis that the neuromuscular apparatus may represent a target of intervention, thus opening new physiopathological and therapeutic scenarios. | Michele Pier Luca Guarino Michele Cicala Lorenza Putignani Carola Severi | 2016 | World Journal of Gastroenterology2016，22，45： | 8 |
| 3 | Diverticular disease of the colon:New perspectives in symptom development and treatment显示文摘Diverticular disease of the colon is a common disease worldwide. Although the disease is asymptomatic in about 70-80 % of patients, it represents, at least in Western countries, one of the most important gastrointestinal diseases in terms of direct and indirect health costs. Pathocenesis of the disease is still unknown. However, it is the result of complex interactions between colonic structure, intestinal motility, diet and genetic factors. Whilst efficacious preventive strategies remain to be identified, fibre supplementation in the diet is recommended. Why symptoms develop is still unclear. Results of recent experimental studies on irritable bowel syndrome speculated that low grade inflammation of colonic mucosa, induced by changes in bacterial microflora,could affect the enteric nervous system, which is crucial for normal gut function, thus favouring symptom development.This hypothesis could be extrapolated also for diverticular disease, since bacterial overgrowth is present, at least in a subgroup of patients. These perspectives on symptom development are reviewed and new therapeutic approaches are hypothesized. | Antonio Colecchia Lorenza Sandri Simona Caoodicasa Amanda Vestito Giuseppe Mazzella Tommaso Staniscia Enrico Roda Davide Festi | 2003 | World Journal of Gastroenterology2003，9，7： | 7 |
| 4 | Knockdown of MLO genes reduces susceptibility to powdery mildew in grapevine显示文摘Erysiphe necator is the causal agent of powdery mildew(PM),one of the most destructive diseases of grapevine.PM is controlled by sulfur-based and synthetic fungicides,which every year are dispersed into the environment.This is why PM-resistant varieties should become a priority for sustainable grapevine and wine production.PM resistance can be achieved in other crops by knocking out susceptibility S-genes,such as those residing at genetic loci known as MLO(Mildew Locus O).All MLO S-genes of dicots belong to the phylogenetic clade V,including grapevine genes VvMLO7,11 and 13,which are upregulated during PM infection,and VvMLO6,which is not upregulated.Before adopting a gene-editing approach to knockout candidate S-genes,the evidence that loss of function of MLO genes can reduce PM susceptibility is necessary.This paper reports the knockdown through RNA interference of VvMLO6,7,11 and 13.The knockdown of VvMLO6,11 and 13 did not decrease PM severity,whereas the knockdown of VvMLO7 in combination with VvMLO6 and VvMLO11 reduced PM severity up to 77%.The knockdown of VvMLO7 and VvMLO6 seemed to be important for PM resistance,whereas a role for VvMLO11 does not seem likely.Cell wall appositions(papillae)were present in both resistant and susceptible lines in response to PM attack.Thirteen genes involved in defense were less upregulated in infected mlo plants,highlighting the early mlo-dependent disruption of PM invasion. | Stefano Pessina Luisa Lenzi Michele Perazzolli Manuela Campa Lorenza Dalla Costa Simona Urso Giampiero Valè Francesco Salamini Riccardo Velasco Mickael Malnoy | 2016 | Horticulture Research2016，3，1： | 7 |
| 5 | Endoscopic Tri-Modal Imaging Is More Effective Than Standard Endoscopy in Identifying Early-Stage Neoplasia in Barrett’s Esophagus显示文摘 | Wouter L. Curvers Lorenza Alvarez Herrero Michael B. Wallace Louis–Michel Wong Kee Song Krish Ragunath Herbert C. Wolfsen Ganapathy A. Prasad Kenneth K. Wang Venkataraman Subramanian Bas L.A.M. Weusten Fiebo J. Ten Kate Jacques J.G.H.M. Bergman | 2010 | Gastroenterology2010，，4： | 6 |
| 6 | MicroRNA Signature in Metastatic Colorectal Cancer Patients Treated With Anti-EGFR Monoclonal Antibodies显示文摘 | Federico Cappuzzo Andrea Sacconi Lorenza Landi Vienna Ludovini Francesca Biagioni Armida D’Incecco Alessandra Capodanno Jessica Salvini Enrichetta Corgna Samanta Cupini Cecilia Barbara Gabriella Fontanini Lucio Crinò Giovanni Blandino | 2013 | Clinical Colorectal Cancer2013，，： | 3 |
| 7 | Usefulness of alpha-fetoprotein response in patients treated with sorafenib for advanced hepatocellular carcinoma显示文摘 | Nicola Personeni Silvia Bozzarelli Tiziana Pressiani Lorenza Rimassa Maria Chiara Tronconi Francesco Sclafani Carlo Carnaghi Vittorio Pedicini Laura Giordano Armando Santoro | 2012 | Journal of Hepatology2012，，1： | 3 |
| 8 | Gut Microbiota, Lipopolysaccharides, and Innate Immunity in the Pathogenesis of Obesity and Cardiovascular Risk显示文摘 | Melania Manco Lorenza Putignani Gian Franco Bottazzo | 2010 | Endocrine Reviews2010，，6： | 3 |
| 9 | Optimized management of advanced hepatocellular carcinoma:Four long-lasting responses to sorafenib显示文摘The therapeutic options for hepatocellular carcinoma (HCC) have been so far rather inadequate.Sorafenib has shown an overall survival benefit and has become the new standard of care for advanced HCC.Nevertheless,in clinical practice,some patients are discontinuing this drug because of side effects,and misinterpretation of radiographic response may contribute to this.We highlight the importance of prolonged sorafenib ad-ministration,even at reduced dose,and of qualitative and careful radiographic evaluation.We observed two partial and two complete responses,one histologically confirmed,with progression-free survival ranging from 12 to 62 mo.Three of the responses were achieved following substantial dose reductions,and a gradual change in lesion density preceded or paralleled tumor shrinkage,as seen by computed tomography.This report supports the feasibility of dose adjustments to allow prolonged administration of sorafenib,and highlights the need for new imaging criteria for a more appropriate characterization of response in HCC. | Giovanni Abbadessa Lorenza Rimassa Tiziana Pressiani Cynthia Carrillo-Infante Emanuele Cucchi Armando Santoro | 2011 | World Journal of Gastroenterology2011，17，19： | 2 |
| 10 | Prospective evaluation of a new device for the treatment of anal fistulas显示文摘AIM: To evaluate the safety of the implantation of a new device for the treatment of anal fistulas. The short-term clinical efficacy was also assessed. METHODS: This study took place at a tertiary care university hospital. Patients with a complex anal fistula of cryptoglandular origin were enrolled in the study and were treated with insertion of the new device. All patients were evaluated by clinical and physical examination, including an endoanal ultrasound at the baseline, and then at the 2 wk and 1, 2, 3 and 6-mo follow-up visits. RESULTS: Morbidity, continence status, and success rate were the main outcome measures. Ten patients underwent the placement of the new device. The fistulas were transphincteric in eight patients and extrasphincteric in the remaining two. The median duration of the surgical procedure was 34.5(range, 27-42) min. Neither intra- nor postoperative complications occurred, and all patients were discharged the day after the procedure. At the 6-mo follow-up evaluation, the final success rate was 70%. Three failures were registered: a device expulsion(on the 10 th postoperative day), the persistence of inflammatory tissue around the fistula tract(at the 2-mo follow up), and the persistence of serum discharge(at the 6-mo follow up). No patient experienced any change incontinence, as assessed by the Cleveland Clinic Fecal Incontinence score. CONCLUSION: The technical procedure is simple and has low risk of perioperative morbidity. The pre- and post-operative continence status did not change in any of the patients. The initial results at the 6-mo follow up seem to be promising. However, a longer follow-up period and a larger sample size are needed to confirm these preliminary results. | Carlo Ratto Francesco Litta Lorenza Donisi Angelo Parello | 2016 | World Journal of Gastroenterology2016，22，30： | 2 |
| 11 | Anti-tumor necrosis factor α therapy associates to type 17 helper T lymphocytes immunological shift and significant microbial changes in dextran sodium sulphate colitis显示文摘BACKGROUND Anti-tumor necrosis factor α(TNFα) represents the best therapeutic option to induce mucosal healing and clinical remission in patients with moderate-severe ulcerative colitis. On the other side gut microbiota plays a crucial role in pathogenesis of ulcerative colitis but few information exists on how microbiota changes following anti-TNFα therapy and on microbiota role in mucosal healing.AIM To elucidate whether gut microbiota and immune system changes appear following anti TNFα therapy during dextran sulfate sodium(DSS) colitis.METHODS Eighty C57 BL/6 mice were divided into four groups: 'No DSS', 'No DSS + antiTNFα', 'DSS' and 'DSS + anti-TNFα'. 'DSS' and 'DSS + anti-TNFα' were treated for 5 d with 3% DSS. At day 3, mice whithin 'No DSS+anti-TNFα' and'DSS+anti-TNFα' group received 5 mg/kg of an anti-TNFα agent. Forty mice were sacrificed at day 5, forty at day 12, after one week of recovery post DSS. The severity of colitis was assessed by a clinical score(Disease Activity Index), colon length and histology. Bacteria such as Bacteroides, Clostridiaceae, Enterococcaceae and Fecalibacterium prausnitzii(F. prausnitzii) were evaluated by quantitative PCR.Type 1 helper T lymphocytes(Th1), type 17 helper T lymphocytes(Th17) and CD4+ regulatory T lymphocytes(Treg) distributions in the mesenteric lymph node(MLN) were studied by flow cytometry.RESULTS Bacteria associated with a healthy state(i.e., such as Bacteroides, Clostridiaceae and F. prausnitzii) decreased during colitis and increased in course of anti-TNFαtreatment. Conversely, microorganisms belonging to Enterococcaceae genera,which are linked to inflammatory processes, showed an opposite trend.Furthermore, in colitic mice treated with anti-TNFα microbial changes were associated with an initial increase(day 5 of the colitis) in Treg cells and a consequent decrease(day 12 post DSS) in Th1 and Th17 frequency cells. Healthy mice treated with anti-TNFα showed the same histological, microbial and immune features of untreated colitic mice. 'No DSS + anti-TNFα' group showed a lymphomononuclear infiltrate both at 5 th and 12 th d at hematoxylin and eosin staining, an increase of in Th1 and Th17 frequency at day 12, an increase of Enterococcaceae at day 5, a decrease of Bacteroides and Clostridiaceae at day 12.CONCLUSION Anti-TNFα treatment in experimental model of colitis improves disease activity but it is associated to an increase in Th17 pathway together with gut microbiota alteration. | Valentina Petito Cristina Graziani Loris R Lopetuso Marco Fossati Alessandra Battaglia Vincenzo Arena Domenico Scannone Gianluca Quaranta Andrea Quagliariello Federica Del Chierico Lorenza Putignani Luca Masucci Maurizio Sanguinetti Alessandro Sgambato Antonio Gasbarrini Franco Scaldaferri | 2019 | World Journal of Gastroenterology2019，25，12： | 2 |
| 12 | 可降解镁合金支架聚合物涂层剥离的有限元模型及实验研究(英文)显示文摘可降解镁合金支架(MAS)能够改善商用裸支架和药物洗脱支架的长期治疗效果。由于镁合金支架在人体内降解速度太快,限制了其对病变血管的支撑性能。保护性聚合物涂层为镁合金支架提供了一种降低腐蚀速度的有效方法。然而,聚合物涂层在支架扩张时出现的剥离现象是阻碍其运用的一大障碍。在本研究中,分别运用有限元方法和实验方法对一种优化设计的镁合金支架进行了聚合物涂层剥离问题的研究。首先通过90o剥离实验测试,为粘聚区有限元模型提供了临界能量释放率,以此为基础的90o剥离的模拟结果和实验结果吻合良好。运用可靠的粘聚区模型参数,支架-聚合物涂层有限元模型考察了支架在扩张过程中是否会发生涂层剥离现象。本研究为考察支架聚合物涂层剥离现象提供了一种简单可靠的方法,为改善可降解镁合金支架的聚合物涂层性能提出了相应的建议。 | 吴卫 Lorenza Petrini Lina Altomare Silvia Farè Rosaria Tremamunno 于振涛 Francesco Migliavacca | 2014 | 稀有金属材料与工程2014，43，12： | 2 |
| 13 | Targeted agents for second-line treatment of advanced hepatocellular carcinoma显示文摘Over the past ten years,sorafenib,a multikinase inhibitor,has been the standard of care for patients with unresectable hepatocellular carcinoma(HCC)and wellpreserved liver function.Recently,lenvatinib,a different multikinase inhibitor,was shown to be non-inferior to sorafenib,in terms of survival,while all other agents previously tested failed to prove non-inferiority(or superiority)when compared to sorafenib.Similarly,in the second-line setting,most investigational drugs failed to provide better survival outcomes than placebo.However,in the last 2 years three positive phase III trials have been published in this setting.The RESORCE trial,a phase III study evaluating regorafenib in HCC patients who experienced disease progression after first-line treatment with sorafenib,showed better outcomes with regorafenib compared to placebo.More recently,the phase III CELESTIAL trial demonstrated the superiority of cabozantinib,a multikinase inhibitor targeting vascular endothelial growth factor receptor,MET,and AXL,vs placebo in the second-and third-line setting in patients progressing on or intolerant to sorafenib.The survival benefits of a sustained anti-angiogenic inhibition were demonstrated also with ramucirumab in the phase III REACH-2 trial in patients previously treated with sorafenib and who had high baseline alpha-fetoprotein levels.Overall,the adverse events reported in these trials were in line with the known safety profiles of the tested agents.After nearly a decade of a certain degree of stagnation,we are now witnessing a period of novel therapeutic advances with multikinase inhibitors and monoclonal antibodies that will likely change the treatment scenario of HCC. | Nicola Personeni Tiziana Pressiani Silvia Bozzarelli Lorenza Rimassa | 2019 | World Journal of Gastrointestinal Oncology2019，11，10： | 2 |
| 14 | Long-term results of suppressing thyroid-stimulating hormone during radiotherapy to prevent primary hypothyroidism in medulloblastoma/PNET and Hodgkin lymphoma:a prospective cohort study显示文摘Primary hypothyroidism commonly occurs after radiotherapy(RT),and coincides with increased circulating thyroid-stimulating hormone(TSH)levels.We tested therefore the protective effect of suppressing TSH with L-thyroxine during RT for medulloblastoma/PNET and Hodgkin lymphoma(HL)in a prospective cohort study.From 1998 to 2001,a total of 37 euthyroid children with medulloblastoma/PNET plus 14 with HL,scheduled for craniospinal irradiation and mediastinum/neck radiotherapy,respectively,underwent thyroid ultrasound and free triiodothyronine(FT3),free thyroxine(FT4),and TSH evaluation at the beginning and end of craniospinal iiradiation.From 14 days before and up to the end of radiotherapy,patients were administered L-thyroxine checking every 3 days TSH to ensure a value<0.3μIU/mL.During follow-up,blood tests and ultrasound were repeated;primary hypothyroidism was considered an increased TSH level greater than normal range.Twenty-two/37 patients with medulloblastoma/PNET and all the 14 patients with HL were alive after a median 231 months from radiotherapy with 7/22 and 8/14 having correctly reached TSH levels˂0.3μIU/mL and well matched for other variables.Twenty years on,hypothyroidism-free survival rates differed significantly,being 60%±15%and 15.6%±8.2%in TSH-suppressed vs.not-TSH suppressed patients,respectively(P=0.001).These findings suggest that hypothyroidism could be durably prevented in two populations at risk of late RT sequelae,but it should be confirmed in a larger cohort. | Maura Massimino Marta Podda Lorenza Gandola Emanuele Pignoli Ettore Seregni Carlo Morosi Filippo Spreafico Andrea Ferrari Emilia Pecori Monica Terenziani | 2021 | Frontiers of Medicine2021，15，1： | 2 |
| 15 | 24h动态中心动脉收缩压和左心室质量的关系:一项前瞻性多中心研究显示文摘研究者在7个欧洲中心中调查左心室质量与肱动脉诊室血压以及肱动脉压和中心动脉动态收缩压之间的关系。使用校准的示波装置测量,经平均压/舒张压校准和转换函数计算中心动脉收缩压。由不知道血压值的单个操作者通过M型超声心动图测定左心室质量。研究者调查了未使用抗高血压药物的受试者289人(女性137人,平均年龄50.8岁)。 | 黄洁 叶鹏 Weber T Wassertheurer S Schmidt-Trucks?ss A Rodilla E Ablasser C Jankowski P Lorenza Muiesan M Giannattasio C Mang C Wilkinson I Kellermair J Hametner B Pascual JM Zweiker R Czarnecka D Paini A Salvetti M Maloberti A McEniery C | 2017 | 中华高血压杂志2017，25，11： | 2 |
| 16 | Effects of extraction time, temperature and solvent on concentration and antioxidant activityof grape marc phenolics显示文摘 | Giorgia S Lorenza T Dante M D | 2007 | Journal of Food Engineering2007，，81： | 1 |
| 17 | Accelerated Cure of Phe- nol-Formaldehyde Resins: Studies with Model Compounds 显示文摘 | Conner A H Lorenza L F Hirth K C | 2002 | Journalof Applied Polymer Science2002，86，13： | 1 |
| 18 | Changes in the distribution of ZO-1, occludin, and claudins in the rat uterine epithelium during the estrous cycle显示文摘 | C. Adriana Mendoza-Rodríguez Lorenza González-Mariscal Marco Cerbón | 2005 | Cell and Tissue Research2005，，2： | 1 |
| 19 | Crosstalk of tight junction components with signaling pathways显示文摘 | Lorenza González-Mariscal Rocio Tapia David Chamorro | 2007 | BBA - Biomembranes2007，，： | 1 |
| 20 | Randomized trial on endoscopic resection-cap versus multiband mucosectomy for piecemeal endoscopic resection of early Barrett’s neoplasia显示文摘 | Roos E. Pouw Frederike G.I. van Vilsteren Femke P. Peters Lorenza Alvarez Herrero Fiebo J.W. ten Kate Mike Visser Boudewijn E. Schenk Erik J. Schoon Frans T.M. Peters Martin Houben Raf Bisschops Bas L.A.M. Weusten Jacques J.G.H.M. Bergman | 2011 | Gastrointestinal Endoscopy2011，，： | 1 |
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