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84篇 您的检索式：作者名="Schramek"

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	题名	作者	年代	出处	被引量
1	RANKL/RANK control Brca1 mutation-driven mammary tumors显示文摘	Verena Sig Kwadwo Owusu-Boaitey Puma A Joshi Anoop Kavirayani Gerald Wimsberger Maria Novatchkova Ivona Kozieradzki Daniel Schramek Nnamdi Edokobi Jerome Hersl Aishia Sampson Ashley Odai-Afotey Conxi Lazaro Eva Gonzalez-Suarez Miguel A Pujaaa for CIMBA Holger Heyn Enrique Vidal Jennifer Cru. ickshank Hal Berman Renu Sarao Melita Tieevic Iris Uribesalgo Luigi Tortola Shuan Rao Yen Tan Georg Pfeiler Eva YHP Lee Zsuzsanna Bago-Horvath Lukas Kenner Helmuth Popper Christian Singer Rama Khokha LaundeRe P Jones Josef M Penninger	2016	Cell Research2016，26，7：	3
2	AIF-regulated oxidative phosphorylation supports lung cancer development显示文摘Cancer is a major and still increasing cause of death in humans. Most cancer cells have a fundamentally different metabolic profile from that of normal tissue. This shift away from mitochondrial ATP synthesis via oxidative phosphorylation towards a high rate of glycolysis, termed Warburg effect, has long been recognized as a paradigmatic hallmark of cancer, supporting the increased biosynthetic demands of tumor cells. Here we show that deletion of apoptosis-inducing factor (AIF) in a Kras^G12D-driven mouse lung cancer model resulted in a marked survival advantage, with delayed tumor onset and decreased malignant progression. Mechanistically, Aif deletion leads to oxidative phosphorylation (OXPHOS) deficiency and a switch in cellular metabolism towards glycolysis in non-transformed pneumocytes and at early stages of tumor development. Paradoxically, although Aif-deficient cells exhibited a metabolic Warburg profile, this bioenergetic change resulted in a growth disadvantage of Kras^G12D-driven as well as Kras wild-type lung cancer cells. Cell-autonomous re-expression of both wild-type and mutant AIF (displaying an intact mitochondrial, but abrogated apoptotic function) in Aif-knockout Kras^G12D mice restored OXPHOS and reduced animal survival to the same level as AIF wild-type mice. In patients with non-small cell lung cancer, high AIF expression was associated with poor prognosis. These data show that AIF-regulated mitochondrial respiration and OXPHOS drive the progression of lung cancer.	Shuan Rao Laura Mondragon Blanka Pranjic Toshikatsu Hanada Gautier Stoll Thomas Kocher Peng Zhang Alexander Jais Alexander Lercher Andreas Bergthaler Daniel Schramek Katharina Haigh Valentina Sica Marion Leduc Nazanine Modjtahedi Tsung-Pin Pai Masahiro Onji Iris Uribesalgo Reiko Hanada Ivona Kozieradzki Rubina Koglgruber Shane J. Cronin Zhigang She Franz Quehenberger Helmut Popper Lukas Kenner Jody J. Haigh Oliver Kepp Malgorzata Rak Kaican Cai Guido Kroemer Josef M. Penninger	2019	Cell Research2019，29，7：	2
3	Prostaglandin E1 in erectile dysfunction efficiency and incidence of priapism 显示文摘	Dorninger R Waldhauser M	1990	Br J Urol1990，65，1：	1
4	Drosophila genome-wide obesity screen reveals hedgehog as a determinant of brown versus white adipose cell fate显示文摘	Pospisilik J A Schramek D Schnidar H et O1	2010	Cell2010，140，1：	1
5	Increased proliferation and altered growth factor dependence of human mammary epithelial cells overexpressing the Gab2 docking protein显示文摘	Brummer T Schramek D Hayes VM	2006	J Biol Chem2006，281，1：	1
6	MAP kinases: from intracellular signals to physiology and disease显示文摘	Schramek H	2002	News Physiol Sci2002，17，2：	1
7	Is the transport of human erythroeytes influenced by ELF-and MF-electromagnetics fields显示文摘	Glaser R Michalsky M Schramek R		0，，：	1
8	Drosophila genome- wide obesity screen reveals hedgehog as a determinant of brown versus white adipose cell fate 显示文摘	Pospisilik JA Schramek D Schnidar H	2010	Cell2010，140，1：	1
9	Selection of chlortetracycline - re- sistant strain of coxiella burnetii 显示文摘	Brezina R Schramek S Kazar J	1975	Acta Virol1975，19，6：	1
10	(2005) Hormetic influ- ence of glucocorticoids on human memory 显示文摘	Lupien SJ Buss C Schramek TE	2005	Nonlinearity Biol Toxicol Med2005，3，：	1
11	The effects of stress and stress hormones on human eognition: Implications for the field of brain and cognition 显示文摘	Lupien S J Maheu F Tu M Fiocco A Schramek T E	2007	Brain Cogn2007，65，：	1
12	The effects of stress and stress hormones on human cognition: Implications for the field of brain and cognition显示文摘	S.J. Lupien F. Maheu M. Tu A. Fiocco T.E. Schramek	2007	Brain and Cognition2007，，3：	1
13	Disruption of the growth hormone - Signal transducer and activator of transcription 5 - Insulinlike growth factor 1 axis severely aggravates liver cir- rhosis in a mouse model of cholestasis显示文摘	Blans L Kornfeld J W Schramek D	2010	Hepatology2010，51，4：	1
14	Cortactin overexpression inhibits ligand-induced down-regulation of the epidermal growth factor receptor显示文摘	Timpson P Lynch DK Schramek D	2005	Cancer Res2005，65，8：	1
15	Sex -dependent uro lithiasis in the portacaval shunt rat显示文摘	Schramek P Heidenreich A Engelmann UH	1993	Part I Urol Int1993，50，：	1
16	The stress kinase MKK7 couples oncogenic stress to p53 stability and tumor suppression显示文摘	SCHRAMEK D KOTSINAS A MEIXNER A	2011	Nat Genet2011，43，3：	1
17	Hormetic influence of glu- cocorticoids on human memory 显示文摘	Lupien SJ Buss C Schramek TE	2005	Nonlinearity Biol Toxicol Med2005，3，1：	1
18	Drosophila genome-wide obesity screen reveals hedgehog as a determinant of brown versus white adipose cell fate 显示文摘	Pospisilik J A Schramek D Schnidar H	2010	Cell2010，140，1：	1
19	Disruption of the growth hormone - Signal transducer and activator of transcription 5 - Insulinlike growth factor 1 axis severely aggravates liver cir- rhosis in a mouse model of cholestasis 显示文摘	Blaas L Kornfeld J W Schramek D	2010	Hepatology2010，51，4：	1
20	Osteoclast differentiation factor RANKL controls development of progestin-driven mammary cancer 显示文摘	Schramek D Leibbrandt A Sigl V	2010	Nature2010，468，7320：	1

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