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| 1 | RTOG 0211:a phase 1/2 study of radiation therapy with concurrent gefitinib for newly diagnosed glioblastoma patients显示文摘PURPOSE: To determine the safety and efficacy of gefitinib,an epidermal growth factor receptor(EGFR) tyrosine kinase inhibitor,in combination with radiation for newly diagnosed glioblastoma(GBM) patients.METHODS AND MATERIALS: Between March 21,2002,and May 3,2004,Radiation Therapy Oncology Group(RTOG) 0211 enrolled 31 and 147GBM patients in the phase 1 and 2 arms,respectively.Treatment consisted of daily oral gefinitnib started at the time of conventional cranial radiation therapy(RT) and continued post RT for 18 months or until progression.Tissue microarrays from 68 cases were analyzed for EGFR expression.RESULTS: The maximum tolerated dose(MTD) of gefitinib was determined to be 500 mg in patients on non-enzyme-inducing anticonvulsant drugs(non-EIAEDs).All patients in the phase 2 component were treated at a gefitinib dose of 500 mg;patients receiving EIADSs could be escalated to 750 mg.The most common side effects of gefitinib in combination with radiation were dermatologic and gastrointestinal.Median survival was 11.5 months for patients treated per protocol.There was no overall survival benefit for patients treated with gefitinib + RT when compared with a historical cohort of patients treated with RT alone,matched by RTOG recursive partitioning analysis(RPA) class distribution.Younger age was significantly associated with better outcome.Per protocol stratification,EGFR expression was not found to be of prognostic value for gefitinib + RT-treated patients.CONCLUSIONS: The addition of gefitinib to RT is well tolerated.Median survival of RTOG 0211 patients treated with RT with concurrent and adjuvant gefitinib was similar to that in a historical control cohort treated with radiation alone. | Chakravarti A Wang M Robins HI Lautenschlaeger T Curran WJ Brachman DG Schultz CJ Choucair A Dolled-Filhart M Christiansen J Gustavson M Molinaro A Mischel P Dicker AP Bredel M Mehta M | 2013 | 中国神经肿瘤杂志2013，11，1： | 8 |
| 2 | The propertiesof HDL in genetically engineered mice 显示文摘 | Schultz J R Rubin E M | 1994 | Curn Opin Lipidol1994，5，： | 2 |
| 3 | Effects of selective decontamination of digestive tract on mortality and acquisition of resistant bacteria in intensive care:a randomised controlled trial 显示文摘 | De Jonge E Schultz M J Spanjaard L | 2003 | Lancet2003，362，9389： | 1 |
| 4 | Singlet oxygen inhibits agonist-induced P-selectin expression and formation of platelet aggregates显示文摘 | Stief TW Jeske WP Walenga J Schultz C Kretschmer V Fareed J | 2001 | Clin Appl Thromb Hemost2001，7，3： | 1 |
| 5 | Structure-property relationships of microfibrillar reinforced blends of linear polycondensates显示文摘 | M Evstatiev J M Schultz M J Oliveira | 2002 | International Journal of Polymeric Materials2002，51，4： | 1 |
| 6 | Starvation induced cross- protection against heat or H2O2 challenge in Escherichia coli 显示文摘 | Jenkins D E Schultz J E Matin A | 1988 | Bacteriology1988，170，： | 1 |
| 7 | Yolk sac ab- sorption and initiation of growth m broilers显示文摘 | Chamblee T N Brake J D Schultz C D | 1992 | Poul Sci1992，71，： | 1 |
| 8 | Transforming growth factor-beta in cardiovascular development and function显示文摘 | Azhar M Schultz Jel J Grupp I | 2003 | Cytokine Growth Factor Rev2003，14，： | 1 |
| 9 | Effects of selective decontamination of digestive tract on mortality and acquisition of resistant bacteria in intensive care: a randomised controlled trial显示文摘 | de Jonge E D Schultz M J Spanjaard L | 2003 | Lancet2003，362，9389： | 1 |
| 10 | Cell cycle analysis and chromosomal localization of human Plk1,a putative homologue of the mitotic kinases Drosophila polo and Saccharomyces cerevisiae Cdc5显示文摘 | Golsteyn RM Schultz SJ Bartek J | 1994 | J Cell Sci1994，107，6： | 1 |
| 11 | Ischemic preconditioning in the intact rat heart is mediated by deltal but not mu-or kappa-opioid receptors显示文摘 | Schultz J E Hsu A K Gross G J | 1998 | Circulation1998，97，13： | 1 |
| 12 | Formation of amorphous alloys with significant supercooled liquid region by mechanical alloying 显示文摘 | Eckert J Seidel M Schultz J | 1996 | J Non-Crystalline Solids1996，，： | 1 |
| 13 | Regulatory T cells in cancer 显示文摘 | Beyer M Schultze J L | 2006 | Blood2006，108，3： | 1 |
| 14 | Phylogenetic relationship of the nonstructural (NS) genes of influenza A viruses显示文摘 | Ludwig S Schultz U Mandler J | 1991 | Virology1991，183，2： | 1 |
| 15 | Effects of selective decontamination of digestive tract on mortality and acquisition of resistant bacteria in intensive care; a randomised controlled trial显示文摘 | De Jonge E Schultz M J Spanjaard L | 2003 | Lancet2003，362，9389： | 1 |
| 16 | The role of policy in improving diets: experiences from the Pacific obesity prevention in communities food policy project显示文摘 | Thow A M Snowdon W Schultz J T | 2011 | Obesity Reviews2011，12，2： | 1 |
| 17 | Cell cycle analysis and chromosomal localization of human Plkl,a putative hom- ologue of the mitotic kinases Drosophila polo and Saceharo- myces cerevisiae Cdc5显示文摘 | Golsteyn R M Schultz S J Bartek J | 1994 | J Cell Sci1994，107，6： | 1 |
| 18 | Management strategies to decrease calf death losses in beef herds显示文摘 | LARSON R L TYLER J W SCHULTZ L G | 2004 | J Am Vet Med Assoc2004，224，1： | 1 |
| 19 | Formation of the microstructure in Cu-Nb alloys 显示文摘 | FREUDENBERGER J BOTCHAROVA E SCHULTZ k | 2004 | Journal of Materials Science2004，39，1617： | 1 |
| 20 | Import of mitochondrial transcription factor A (TFAM) into rat liver mitochondria stimulates transcription of mitochondrial DNA 显示文摘 | GARSTKA H L SCHMITT W E SCHULTZ J | 2003 | Nucleic Acids Res2003，31，17： | 1 |
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